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METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang wen-li zhang Zhi-xuan li Yue liu Jian Tan Hao-zan Yin Zhi-chao zhang Xian-jie Piao Min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

生物炭基改性材料修复土壤氯代烃污染研究进展

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应用化工 2024年第5期53卷 1180-1185页

作者：李文章李法云胡亚茹王玮上海应用技术大学生态技术与工程学院上海201418 美丽中国与生态文明研究院(上海高校智库) 上海201418 上海城市路域生态工程技术研究中心上海201418

基于我国土壤氯代烃污染现状及应用生物炭材料修复的局限性,针对生物炭性能受官能团、吸附位点数量限制和实际场地修复应用的长效性较差等问题,系统综述了生物炭不同改性方法及其对生物炭性能的改进,分析了生物炭基改性材料作为载体固... 详细信息

基于我国土壤氯代烃污染现状及应用生物炭材料修复的局限性,针对生物炭性能受官能团、吸附位点数量限制和实际场地修复应用的长效性较差等问题,系统综述了生物炭不同改性方法及其对生物炭性能的改进,分析了生物炭基改性材料作为载体固定化降解微生物菌剂的特性,并深入阐述酸碱改性、金属改性生物炭及生物炭基材料固定化微生物去除氯代烃的机理与效能,以期为生物炭作为土壤氯代烃污染修复材料提供新思路。

关键词：生物炭改性土壤修复氯代烃微生物

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Numerical simulation on recrystallization behavior and microstructure evolution during hot continuous rolling process of 38CrMoAl steel rod

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Journal of Iron and Steel Research(International) 2022年第10期29卷 1633-1645页

作者： Fei li li-wen zhang Chi zhang Kang-jie Song Pei-gang Mao School of Materials Science and Engineering Dalian University of TechnologyDalian116024LiaoningChina

The control of microstructure during hot rolling process of steel is of great importance and will affect the properties of the steel *** to the production line,a three-dimensional multi-field coupled finite element model of 24-pass continuous hot rolling process of 38CrMoAl steel rod is established using the finite element software *** on the recrystallization kinetics model and the grain growth model,a subroutine written in Fortran is introduced to calculate the recrystallization behavior and microstructure evolution of 38CrMoAl steel during the entire rolling *** distribution and evolution of variables such as strain,temperature and recrystallization fractions during the rolling process are *** temperature variations and grain sizes at both the center and surface of the tested steel are compared with the experimental *** it is found that the simulation results are in good agreement with the experimental ones,confirming the reliability of the established model.

关键词： 38CrMoAl steel Recrystallization Microstructure evolution Hot rolling process Numerical simulation

Photogalvanic effect induced charge and spin photocurrent in group-V monolayer systems

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Frontiers of physics 2023年第6期18卷 253-261页

作者： li-wen zhang Ya-Qing Yang Jun Chen Lei zhang School of Physics and Information Engineering Shanxi Normal UniversityTaiyuan 030031China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Theoretical PhysicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Photogalvanic effect(PGE)occurs in materials with non-centrosymmetric structures when irradiated by linearly or circularly polarized ***,using non-equilibrium Green’s function combined with density functional theory(NEGF-DFT),we investigated the linear photogalvanic effect(LPGE)in monolayers of group-V elements(As,Sb,and Bi)by first-principles ***,by designing a two-probe structure based on the group-V elements,we found a giant anisotropy photoresponse of As between the armchair and zigzag ***,we analyzed Sb and Bi’s charge and spin photocurrent characteristics when considering the spin-orbit coupling(SOC)*** is found that when the polarization direction of linearly polarized light is parallel or perpendicular to the transport direction(θ=0°or 90°),the spin up and spin down photoresponse in the armchair direction has the same magnitude and direction,leading to the generation of net charge ***,in the zigzag direction,the spin up and spin down photoresponse have the same magnitude with opposite directions,leading to the generation of pure spin ***,it is understood by analyzing the bulk spin photovoltaic(BSPV)coefficient from the symmetry point of ***,we found that the net charge current generated in the armchair direction and the pure spin current generated in the zigzag direction can be further tuned with the increase of the material’s buckling *** results highlight that these group-V monolayers are promising candidates for novel functional materials,which will provide a broad prospect for the realization of ultrathin ferroelectric devices in optoelectronics due to their spontaneous polarization characteristics and high Curie temperature.

关键词： group-V monolayers photogalvanic effect pure spin current

Microstructures and properties evolution of Al-Zn-Mg-Cu alloy under electrical pulse assisted creep aging

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Advances in Manufacturing 2022年第4期10卷 596-609页

作者： Tian-Jun Bian Heng li Chao Lei Chang-Hui Wu li-wen zhang State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an710072People’s Republic of China School of Materials Science and Engineering Xi’an University of TechnologyXi’an710048People’s Republic of China

Creep aging(CA)is a promising forming technology for integral panels with complex ***,how to balance excellent corrosion resistance and strength is still a challenge for CA *** synchronously applying electrical pulse(300 Hz,15 A/mm^(2))in the middle of steady-state CA of Al-Zn-Mg-Cu alloy,the electrically assisted CA(ECA)is proposed to induce retrogression rapidly for realizing a three-step aging(retrogression and re-aging,RRA)in CA to tailor the needed properties *** is compared with conventional CA with one-step aging(peak aging,T6 or over aging,T7),two-step aging(over aging,T73)and RRA in hardness,intergranular corrosion and *** the ECA of pre-aging and re-aging for 20 h plus electropulsing for 10 min,the hardness is 10.5%,20.5%and 18.9%higher than those of CA with T6,T7 and T73 processes,respectively,while the corrosion resistance is higher than T6 process and lower than T7 and T73 *** the hardness and corrosion resistance are comparable to those of the CA with the RRA process,ECA takes one hour less due to the accelerated effect of the electropulsing and is not limited by the thick *** improved comprehensive performance of the ECA sample is due to both fine intragranular precipitatesη′and large discontinuous grain boundary precipitatesη.

关键词： Creep aging(CA) Electrical pulse Retrogression Corrosion Hardness Al-Zn-Mg-Cu alloy

An analytical model of hot rolling force for a thick plate by combining globally optimal approximation yield criterion and egg-circular velocity field

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Journal of Iron and Steel Research(International) 2024年第3期31卷 647-659页

作者： Shun-hu zhang Yi zhang wen-hao Tian Yan li Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

For the sake of solving the problem that it is difficult to be integrated for the Mises specific plastic power due to its nonlinearity,a new linear criterion,named the globally optimal approximation criterion,is constructed by the polygonal approximation to the Mises *** new criterion is proved to be the linear function of the principal stress componentsσ1,σ2 andσ3 and the trajectory of it on theπ-plane is a non-equiangular but equilateral dodecagon intersecting the Mises *** theoretical results of the current criterion described by the Lode stress parameters are in excellent accordance with the experimental ***,according to the trend that the metallic flow velocity between rollers aggrandizes gradually from the inlet to the outlet during the hot rolling of a thick plate,a biomimetic velocity field is proposed in which the horizontal velocity component fits the egg-circular curve *** velocity field and its simulated results agree quite ***,using the determined linear criterion,energy analysis of the constructed velocity field is utilized to obtain the interior deformation power,while the vector decomposition approach is utilized to obtain the frictional power and shear *** this basis,the overall power is obtained and the analytical solutions are generated for the rolling torque,rolling force and the coefficient of the stress state under different egg curves by minimizing the neutral ***,the parameter optimization of the characteristic parameterρwhich affects the slope of the egg-circular curve is carried out and the best egg-circular curve which can minimize the energy consumption is *** best agreement between the theoretical and observed values of rolling force and rolling torque is under this curve,and the mean relative errors of the rolling torque and rolling force are no more than 2.93%,while the maximum error is no more than 8.35%.

关键词： Yield criterion Plastic deformation Rolling force Velocity field Analytical solution

Magnetic and luminescent properties of bifunctional composite Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+)

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Journal of Rare Earths 2024年第8期42卷 1568-1576,I0006页

作者： Zhiqi liang Zhili zhang liu li wen Xu Decai li School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBejing100044China Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale Bejing100044China State Key Laboratory of Tribology Tsinghua UniversityBejing100084China

As a kind of non-destructive testing method,magnetic particle inspection is widely used in the fields of aviation and high-speed *** properties of magnetic fluorescent bifunctional composites,such as fluorescence intensity and magnetic properties,have increasing demands in magnetic particle *** earth compounds offer potential as novel materials for fluorescent magnetic bifunctional composites due to their excellent optical properties and extremely narrow emission *** this work,the rare earth fluorescent material Y_(2)O_(2)S:Eu^(3+) was synthesized by solid-state reaction ***_(3)O_(4)nanoparticles prepared by hydrothermal method were uniformly coated on the Y_(2)O_(2)S:Eu^(3+) particles through physical adsorption of *** obtained Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) exhibits dark red color under the ultraviolet *** additio n,X-ray diffractio n,morphology,photoluminescence and hyste resis loop of Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) were *** luminescence mechanism of Y_(2)O_(2)S:Eu^(3+) is described in detail Fe_(3)O_(4)@Y_(2)O_(2)S:Cu^(3+) displays good paramagnetism and has a good controllability under a magnetic *** magnetic particle inspection of Fe_(3)O_(4)@Y_(2)O_(2)S:Eu^(3+) was performed using a 4-pole electromagnet and a test piece *** magnetic fluorescent bifunctional composite presented in this work can be applied for non-destructive testing.

关键词： Bifunctional material Fe_(3)O_(4) Y_(2)O_(2)S:Eu^(3+) Luminescence Solid-state reaction Rare earths

Reversible isomerization of donor-acceptor Stenhouse adduct derivatives in water through dendritic confinement

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Science China Chemistry 2024年第5期67卷 1636-1646页

作者： Jiaxing zhang Qingyun Zhao Xinyan Su Afang zhang wen li International Joint Laboratory of Biomimetic and Smart Polymers School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

Modulating reversible isomerization of hydrophobic dyes in aqueous solutions is greatly desired. Here we report on reversible isomerization of solvatochromic donor-acceptor Stenhouse adducts(DASAs) in water through the confinement from dendritic oligoethylene glycols(OEGs). Dendronization of DASAs with dendritic OEGs affords them characteristic thermoresponsiveness. These dendronized DASAs spontaneously isomerize in water from hydrophobic linear state into hydrophilic cyclic state at room temperature due to the strong hydration. However, hydrophobic microenvironment through thermally dehydration and collapse of the dendritic OEGs at elevated temperatures confines hydration of the DASA moieties and mediates their interactions with the collapsed hydrophobic OEG domains, affording their isomerization recovery in water efficiently from the hydrophilic cyclic state into the hydrophobic linear state. The confinement-mediated reversible isomerization of DASA moieties in water can be repeated through alternative photo-irradiation and thermal dehydrations, exhibiting excellent fatigue resistance.

关键词： dendrimers donor-acceptor Stenhouse adducts isomerization confinement thermoresponsiveness

A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding Ya-wen Wang Qiu-wen li li-li zhang Ai-Zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization