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Enhancements of the Gaussian network model in describing nucleotide residue fluctuations for RNA

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Chinese Physics B 2021年第5期30卷 176-183页

作者： wen-jing wang Ji-Guo Su Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

Gaussian network model(GNM)is an efficient method to investigate the structural dynamics of ***,the application of GNM on RNAs is not as good as that on proteins,and there is still room to improve the *** this study,two novel approaches,named the weighted GNM(wGNM)and the force-constant-decayed GNM(fcdGNM),were proposed to enhance the performance of ENM in investigating the structural dynamics of *** wGNM,the force constant for each spring is weighted by the number of interacting heavy atom pairs between two *** fcdGNM,all the pairwise nucleotides were connected by springs and the force constant decayed exponentially with the separate distance of the nucleotide *** performance of these two proposed models was evaluated by using a non-redundant RNA structure database composed of 51 RNA *** calculation results show that both the proposed models outperform the conventional GNM in reproducing the experimental B-factors of RNA *** with the conventional GNM,the Pearson correlation coefficient between the predicted and experimental B-factors was improved by 9.85%and 6.76%for wGNM and fcdGNM,*** studies provide two candidate methods for better revealing the dynamical properties encoded in RNA structures.

关键词： Gaussian network model(GNM) B-factor RNA molecules

Multi-scale morphology analysis of acoustic emission signal and quantitative diagnosis for bearing fault

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Acta Mechanica Sinica 2016年第2期32卷 265-272页

作者： wen-jing wang Ling-Li Cui Dao-Yun Chen School of Mechanical Electronic and Control EngineeringBeijing Jiaotong University College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology

Monitoring of potential bearing faults in operation is of critical importance to safe operation of high speed *** of the major challenges is how to differentiate relevant signals to operational conditions of bearings from noises emitted from the surrounding *** this work,we report a procedure for analyzing acoustic emission signals collected from rolling bearings for diagnosis of bearing health conditions by examining their morphological pattern spectrum（MPS） through a multi-scale morphology analysis *** results show that acoustic emission signals resulted from a given type of bearing faults share rather similar MPS *** examinations in terms of sample entropy and Lempel-Ziv complexity of MPS curves suggest that these two parameters can be utilized to determine damage modes.

关键词： Bearing fault Acoustic emission Morphological pattern spectrum(MPS) Sample entropy Lempel-Ziv complexity

Gut microbiota in gastrointestinal diseases during pregnancy

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World Journal of Clinical Cases 2022年第10期10卷 2976-2989页

作者： Zhong-Zhen Liu jing-Hua Sun wen-jing wang BGI-Shenzhen Shenzhen 518083Guangdong ProvinceChina College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Gut microbiota(GM)is a micro-ecosystem composed of all microorganisms in the human *** interaction between GM and the host plays an important role in maintaining normal physiological functions in the *** of the GM may cause various *** has been demonstrated to be associated with human health and disease,and changes during individual development and *** is a complicated physiological ***,the immune system,metabolism,and GM undergo drastic changes during *** diseases during pregnancy,such as hepatitis,intrahepatic cholestasis of pregnancy,and pre-eclampsia,can affect both maternal and fetal *** dysregulation of GM during pregnancy may lead to a variety of diseases,including gastrointestinal ***,we review recent research articles on GM in pregnancy-related gastrointestinal diseases,discuss the interaction of the GM with the host under normal physiological conditions,gastrointestinal diseases,and pregnancy-specific *** more attention is paid to reproductive health,the pathogenic mechanism of GM in gastrointestinal diseases during pregnancy will be further studied to provide a theoretical basis for the use of probiotics to treat these diseases.

关键词： Gut microbiota Microbiome Pregnancy Gastrointestinal diseases Hormones Immunity Metabolites

Synthesis and Anti-leukemia Evaluation of Tetrahydro-4H-pyrano[3,2-c]pyridines and Corresponding Anti-CD14 Monoclonal Antibody Conjugates

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Chemical Research in Chinese Universities 2013年第6期29卷 1104-1109页

作者： SUN Chuan-wen wang jing PANG Chun-cheng LI jing XIAO Di College of Life and Environment Sciences Shanghai Normal University Shanghai 200234 P.R.China

A series of novel tetrahydro-4H-pyrano[3,2-c]pyridines（3a-3p） were synthesized and found to possess potent antiproliferative activity against leukemia K562 cells in vitro. Preliminary bioassay indicates that compounds 3a and 3e afford the best activity, the IC50 values of them were 6.93 and 7.51μg/mL, respectively, which were lower than that of the anticancer drug 5-FU（1C50=8.56μg/mL）. To reduce the toxicity of compounds 3a-3p to the prolife- ration of normal bematopoietic cells, a tumor targeted CD14 monoclonal antibody（McAb） was used in conjugation with compounds 3a--3p to get conjugates 4a--4p, respectively. The inhibitory activities of conjugates 4a--4p toward K562 cells were discovered to approach those of compounds 3a--3p. In the presence of CD14 McAb, tumor cells were found to be much more susceptible to conjugates 3a--3p than normal hematopoietic cells. Therefore, the toxicity of conjugates 4a--4p to normal hematopoietic cells declined obviously. For example, as for the toxicity of compound 3a compared with that of compound 4a, the value of ICs0 increased from 35.90 μmol/L to 39.52 μmol/L.

关键词： Tetrahydro-4H-pyrano[3,2-c]pyridine Leukemia K562 cell Anti-CDl4 monoclonal antibody(McAb) Conjugate Inhibitory Toxicity

Clinical application of hepatic CT perfusion

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World Journal of Gastroenterology 2009年第8期15卷 907-911页

作者： Liang Zhong wen-jing wang Jian-Rong Xu Department of Radiology Affiliated Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200001 China

Complicated changes occur in hemodynamics of hepatic artery and vein, and portal vein under various kinds of pathologic status hepatic blood supply. This because of distinct double article reviews the clinical applica... 详细信息

关键词： X-ray computed tomography Perfusion Liver Hemodynamics

Macrocyclic peptides:up-and-coming weapons to combat antimicrobial resistance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1786-1787页

作者： wen-jing wang Xiang-Min Dong Guo-Bo L Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengduSichuanChina

Recently,two companion papers published in Nature reported a first-in-class tethered macrocyclic peptide antibiotic targeting carbapenem-resistant ***(CRAB)and unveiled their unique antibacterial mechanism,which invol... 详细信息

关键词： outer macrocyclic Macrocyclic

Formation of interfacial Al-Ce-Cu-W amorphous layers in aluminum matrix composite through thermally driven solid-state amorphization

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International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 970-979页

作者： Zheng Lü Chang-hui Mao Jian wang Qiu-shi Liang Shu-wang Ma wen-jing wang Advanced Electronic Materials Institute GRIMAT Engineering Institute Co.Ltd.Beijing 101407China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

Interfacial Al-Ce-Cu-W amorphous layers formed through thermally driven solid-state amorphization within the(W+Ce O2)/2024 Al composite were *** elemental distributions and interfacial microstructures were examined with an electron probe microanalyzer and a high-resolution transmission electron microscope,*** consolidation of composites consisted of two thermal processes:vacuum degassing(VD)and hot isostatic pressing(HIP).During consolidation,not only the three major elements(Al,W,and Ce)but also the alloying elements(Mg and Cu)in the Al matrix contributed to *** VD and HIP temperatures of 723 K and763 K,interfacial amorphous layers were formed within the *** diffusion processes were necessary for interfacial amorphization:(a)long-range diffusion of Mg from the Al matrix to the interfaces during VD;(b)long-range diffusion of Cu from the Al matrix to the interfaces during HIP;(c)short-range diffusion of W toward the Al matrix during *** newly formed interfacial Al-Ce-Cu-W amorphous layers can be categorized under the Al-Ce-TM(TM:transition metals)amorphous system.

关键词： aluminum matrix composite consolidation interfaces diffusion solid-state amorphization

Intermolecular Stetter reaction of aromatic aldehydes with(E)-(2-nitrovinyl)cyclohexane induced by N-heterocyclic carbene and thiourea

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Chinese Chemical Letters 2016年第7期27卷 1032-1035页

作者： Qing-Fang Cheng jing-wen wang Qi-Fa wang Zhou Liu Jiangsu Key Laboratory of Marine Biotechnology Huaihai Institute of Technology School of Chemical Engineering Huaihai Institute of Technology

Intermolecular Stetter reaction of aromatic aldehydes with（E）-（2-nitrovinyl）cyclohexane catalyzed by thiazolium A has been *** reaction rate and efficiency are profoundly impacted by the presence of thiourea *** r... 详细信息

关键词： Intermolecular Stetter reaction N-heterocyclic carbene Thiourea Thiazolium Nitroalkene β-Nitro ketone

The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第3期17卷 594-600页

作者： jing-Jun Zhao Zheng-Hui wang Ying-Jie Zhang wen-jing wang Ai-Fang Cheng Pei-jing Rong Chun-Lei Shan Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Center of Rehabilitation Medicine the First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Shanghai Research Institute of Acupuncture and Meridian ShanghaiChina Institute of Acupuncture and Moxibustion Chinese Academy of Chinese Medical SciencesBeijingChina

Previous studies have shown that vagus nerve stimulation can improve patients' locomotor *** stimulation of the auricular vagus nerve,which is the only superficial branch of the vagus nerve,may have similar effects to vagus nerve ***,the precise mechanisms remain poorly *** this study,rat models of cerebral ischemia/reperfusion injury were established by modified Longa ***-four hours later,7-day auricular vagus nerve stimulation was *** results showed that auricular vagus nerve stimulation promoted the secretion of acetylcholine,inhibited the secretion of interleukin-1β,interleukin-6,and tumor necrosis factor-α,and reduced connexin 43 phosphorylation in the ischemic penumbra and motor cortex,promoting locomotor function recovery in rats with cerebral ischemia/reperfusion *** findings suggested that auricular vagus nerve stimulation promotes the recovery of locomotor function in rats with cerebral ischemia/reperfusion injury by altering the secretion of acetylcholine and inflammatory factors and the phosphorylation of connexin *** study was approved by the Animal Use and Management Committee of Shanghai University of Traditional Chinese Medicine on November 8,2019(approval ***191108014).

关键词： auricular vagus nerve stimulation connexin 43 gap junction inflammatory factor ischemia/reperfusion injury neurological function neuroprotection stroke