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Cucurbit[7]uril confined phenothiazine bridged bis(bromophenyl pyridine)activated NIR luminescence for lysosome imaging

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Chinese Chemical Letters 2024年第6期35卷 288-292页

作者： Hui-Juan Wang wen-wen Xing Zhen-Hai Yu Yong-Xue Li Heng-Yi Zhang Qilin Yu Hongjie Zhu yao-yao Wang Yu Liu College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng 252000China Key Laboratory of Molecular Microbiology and Technology College of Life SciencesNankai UniversityTianjin 300071China

Macrocycle confinement induced guest near-infrared(NIR)luminescence was research hotspot *** in,we reported a cucurbit[7]uril(CB[7])confined 3,7-bis((E)-2-(pyridin-4-yl)vinyl)-10-Hphenothiazine bridged bis(4-(4-bromophenyl)pyridine)(G),which not only boosted its NIR luminescence but also realized detection of HClO/ClO^(-)in living cells and lysosome *** spectroscopy experiments were performed to calculate the detection ability of probe G to HClO/ClO^(-)up to 147 nmol/*** compared with G,supramolecular probe G■CB[7]formed after encapsulated by CB[7],the detection ability towards HClO/ClO^(-)was improved to 24 nmol/L which was ascribe to the macrocycle CB[7]confinement increasing the fluorescence intensity to 103 *** the excitation wavelength changing,the fluorescence red-shifted to 820 nm when excited by 570 nm light,which was used to NIR lysosome ***,the supramolecular assembly G■CB[7]was also successfully used to highly sense to exogenous HClO/ClO^(-)in RAW 264.7 cells and live animal.

关键词： Phenothiazine Supramolecular assembly Macrocycle confined Probe HClO/ClO^(-)

Frequency and size change of ice–snow avalanches in the central Himalaya:A case from the Annapurna Ⅱ glacier

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Advances in Climate Change Research 2024年第3期15卷 464-475页

作者： yao LI Yi-Fei CUI jian-Sheng HAO Zheng-Tao ZHANG Hao WANG jian GUO Shuo-Fan WANG State Key Laboratory of Hydroscience and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Hydrosphere Sciences of the Ministry of Water Resources Beijing 100084China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of National Safety and Emergency Management Beijing Normal UniversityBeijing 100875China Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China

Glaciers have retreated and shrunk in High Mountain Asia since the mid-20th century because of global warming,leading to glacier instability and hazardous iceesnow ***,the complex relationship between iceesnow avalanches and factors such as climate and potential triggers are difficult to understand because of the lack of observational ***,we addressed iceesnow avalanches on the Annapurna Ⅱ glacier in Nepal,Central *** constructed an iceesnow avalanche history using long-term multi-source remote sensing images(1988-2021)and mapped the velocity fields of glaciers using cross-correlation analysis on SAR and optical ***,we investigated the impact of climate change and earthquakes on the frequency and size of iceesnow *** results demonstrate that the frequency of iceesnow avalanches has increased from 10 in 1988 to 27 in 2020,but the average area of iceesnow avalanche deposits has decreased by approximately 70%,from 3.4×10^(5) m^(2) in 1988 to 1.2×10^(5) m^(2) in *** evolutionary characteristic of ice avalanches is linked to the impact of glacier retreat(reduction in ice material supply)and increased activity under climate *** glacier movement velocity controls the size of iceesnow avalanches and can be set as an indicator for iceesnow avalanche *** the Annapurna Ⅱ glacier,an iceesnow avalanche occurred when the glacier velocities were greater than 1.5 m d^(-1).These results offer insights into iceesnow avalanche risk assessment and prediction in high-mountain areas,particularly in regions characterised by dense glacier distribution.

关键词： Iceesnow avalanche Glacier instability Climate change Central Himalaya Remote sensing

Detection Method for Cascading Failure of Power Systems Based on Epidemic Model

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1356-1370页

作者： jian Xu Zhonghao He Siyang Liao Yuanzhang Sun Liangzhong yao Deping Ke Jun Yang School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China IEEE

The early detection of cascading failure plays an important role in the safe and stable operation of the power system with high penetration of renewable *** paper proposes a fault propagation dynamic model based on the epidemic model,and further puts forward a method to detect the development of cascading *** the simulation of the IEEE 39-bus and 118-bus systems,this model is proven to be valid and capable of providing practical technical support for the prevention of cascading failures in power systems with high penetration of renewable *** paper also provides an analysis method for the choice of different protection and control measures at each stage of cascading failure,which has critical significance and follow-up value.

关键词： Cascading failure complex network epidemic model fault propagation renewable energy weight method of game theory

A Novel Predictive Model for Edge Computing Resource Scheduling Based on Deep Neural Network

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 259-277页

作者： Ming Gao Weiwei Cai Yizhang jiang wenjun Hu jian yao Pengjiang Qian School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China The Center for Intelligent Systems and Applications Research School of Artificial Intelligence and Computer ScienceJiangnan UniversityWuxi214122China School of Information Engineering Huzhou UniversityHuzhou313000China

Currently,applications accessing remote computing resources through cloud data centers is the main mode of operation,but this mode of operation greatly increases communication latency and reduces overall quality of service(QoS)and quality of experience(QoE).Edge computing technology extends cloud service functionality to the edge of the mobile network,closer to the task execution end,and can effectivelymitigate the communication latency ***,the massive and heterogeneous nature of servers in edge computing systems brings new challenges to task scheduling and resource management,and the booming development of artificial neural networks provides us withmore powerfulmethods to alleviate this ***,in this paper,we proposed a time series forecasting model incorporating Conv1D,LSTM and GRU for edge computing device resource scheduling,trained and tested the forecasting model using a small self-built dataset,and achieved competitive experimental results.

关键词： Edge computing resource scheduling predictive models

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2350-2361页

作者： Min yao Rong-Fei Fang Qun Xie Min Xu wen-Li Sai Deng-Fu yao Department of Immunology Medical School of Nantong University and Research Center of Clinical MedicineThe Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Gastroenterology The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Infectious Diseases Haian People’s HospitalHaian 226600Jiangsu ProvinceChina Research Center of Clinical Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention and early diagnosis of liver cancer remains a global medical *** the malignant transformation of hepatocytes,a variety of oncogenic cellular signalling molecules,such as novel high mobility group-Box 3,angiopoietin-2,Golgi protein 73,glypican-3,Wnt3a(a signalling molecule in the Wnt/β-catenin pathway),and secretory clusterin,can be expressed and secreted into the *** signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma *** article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

关键词： Hepatocarcinogenesis Cell signals Specific biomarkers Early diagnosis

Intelligent Predetermination of Generator Tripping Scheme: Knowledge Fusion-based Deep Reinforcement Learning Framework

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 66-75页

作者： Lingkang Zeng Wei yao Ze Hu Hang Shuai Zhouping Li Jinyu wen Shijie Cheng State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronics EngineeringHuazhong University of Science and TechnologyWuhan 430074China Dispatching and Control Center Central China Branch of State Grid Corporation of ChinaWuhan 430077China. Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996USA

Generator tripping scheme(GTS)is the most commonly used scheme to prevent power systems from losing safety and ***,GTS is composed of offline predetermination and real-time scenario ***,it is extremely time-consuming and labor-intensive for manual predetermination for a large-scale modern power *** improve efficiency of predetermination,this paper proposes a framework of knowledge fusion-based deep reinforcement learning(KF-DRL)for intelligent predetermination of ***,the Markov Decision Process(MDP)for GTS problem is formulated based on transient instability ***,linear action space is developed to reduce dimensionality of action space for multiple controllable ***,KF-DRL leverages domain knowledge about GTS to mask invalid actions during the decision-making *** can enhance the efficiency and learning ***,the graph convolutional network(GCN)is introduced to the policy network for enhanced learning *** simulation results obtained on New England power system demonstrate superiority of the proposed KF-DRL framework for GTS over the purely data-driven DRL method.

关键词： Deep reinforcement learning generator tripping scheme graph convolutional network invalid action masking knowledgefusion

Early diagnosis of esophageal cancer:How to put“early detection”into effect?

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3386-3392页

作者： Suolang Pubu Jun-wen Zhang jian Yang Department of Gastroenterology Changdu People’s Hospital of XizangChangdu 854000Tibet Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

This editorial comments on the article by Qu et al in a recent edition of World Journal of Gastrointestinal Oncology,focusing on the importance of early diagnosis in managing esophageal cancer and strategies for achieving“early detection”.The five-year age-standardized net survival for esophageal cancer patients falls short of *** detection and accurate diagnosis are critical strategies for improving the treatment outcomes of esophageal *** advancements in endoscopic technology have been significant,there seems to be an excessive emphasis on the latest high-end endoscopic devices and various endoscopic resection ***,it is imperative to redirect focus towards proactive early detection strategies for esophageal cancer,investigate the most cost-effective screening methods suitable for different regions,and persistently explore practical solutions to improve the five-year survival rate of patients with esophageal cancer.

关键词： Esophageal cancer Early diagnosis Early detection Iodine staining Five-year survival rate

The endogenous antioxidant ability of royal jelly in Drosophila is independent of Keap1/Nrf2 by activating oxidoreductase activity

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Insect Science 2024年第2期31卷 503-523页

作者： Dongjing wen Jiayu Xie yao Yuan Lirong Shen Yufeng Yang wenfeng Chen Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouChina School of Medicine Chongqing UniversityChongqingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina

Royal jelly(RJ)is a biologically active substance secreted by the hypopharyngeal and mandibular glands of worker *** is widely claimed that RJ reduces oxidative ***,the antioxidant activity of RJ has mostly been determined by in vitro chemical detection methods or by external administration drugs that cause oxidative *** RJ can clear the endogenous production of reactive oxygen species(ROS)in cells remains largely ***,we systematically investigated the antioxidant properties of RJ using several endogenous oxidative stress models of *** found that RJ enhanced sleep quality of aging Drosophila,which is decreased due to an increase of oxidative damage with *** supplementation improved survival and suppressed ROS levels in gut cells of flies upon exposure to hydrogen peroxide or to the neurotoxic agent ***,RJ supplementation moderated levels of ROS in endogenous gut cells and extended lifespan after exposure of flies to heat *** deprivation leads to accumulation of ROS in the gut cells,and RJ attenuated the consequences of oxidative stress caused by sleep loss and prolonged ***,RJ prevented cell oxidative damage caused by heat stress or sleep deprivation,with the antioxidant activity in vivo independent of Keap1/Nrf2 *** supplementation activated oxidoreductase activity in the guts of flies,suggesting its ability to inhibit endogenous oxidative stress and maintain health,possibly in humans.

关键词： antioxidant biological oxidations Drosophila oxidative stress royal jelly sleep loss

Postoperative pneumocranium after endoscopic transnasal optic canal decompression

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 973-975页

作者： Sheng-jian Lu Bo Yu wen-Can Wu The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

Dear Editor,We present the first time,a case of a patient developed cerebrospinal fluid(CSF)leak and pneumocranium following optic canal decompression(OCD).INTRODUCTION Indirect traumatic optic neuropathy(ITON)impairs visual functions and quality of *** transnasal optic canal decompression(ETOCD)is one of the standard treatment strategies for the *** the ETOCD,the optic nerve sheath are usually incised for sufficient decompression of optic nerve after removal of optic canal,which is associated with complications like CSF leakage,ophthalmic artery injury,and optic nerve injury[1].Generally,the mild CSF leak is common and can heal spontaneously using conventional treatment,the severe CSF leak requires surgical repair[2].

关键词： decompression nasal traumatic