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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei liu liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

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Large deviation rates for supercritical multitype branching processes with immigration

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Acta Mathematica Sinica,English Series 2024年

作者： liu Yan LI Jun Ping LI School of Statistics and Mathematics Guangdong University of Finance and Economics School of Mathematics and Statistics Central South University Guangdong university of science and technology

Let{X_n}n≥0be a p-type （p≥2） supercritical branching process with immigration and mean matrix *** that M is positively regular andρis the maximal eigenvalue of M with the corresponding left and right eigenvectors v and ***ρ>1 and ■,where the vectorλdenotes the mean immigration *** this paper,we will show that Ynis a martingale and converges to a r.v.Y as n→∞.We study the rates of convergence to 0 as n→∞of ■ for any ε>0,i=1,···,p,1=（1,···,1） and l∈Rp,the p-dimensional Euclidean *** is shown that under certain moment conditions,the first two decay geometrically,while conditionally on the event Y≥α （α>0） *** decay rate of the last probability is always supergeometric under a finite moment generating function assumption.

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Lithium isotopic fractionation in minerals from pegmatites: Perspective of crystal chemistry

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Journal of Earth Science 2024年

作者： Shan-Ke liu Ben-xun Su Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences

Lack of information regarding lithium (Li) crystal chemistry in numerous minerals， especially those containing trace amounts of Li (ranging from few to tens of ppm)， limits our understanding of Li isotopic fractionation in pegmatites. In this study， we examined the Li isotopic composition and Li content in various Li-poor (e.g.， quartz or feldspar) together with Li-rich (sopdumene or lepidolite) mineral phases within granitic pegmatites. We compiled a comprehensive dataset， encompassing a broad spectrum of Li contents (ranging from a few to tens of thousands of ppm) and Li isotopic values (-8‰ to 41‰). The minerals exhibited distinct Li isotopic signatures. Specifically， elbaite and beryl showed the highest values， while biotite displayed a negative average. Compared to individual minerals， whole rocks demonstrated lower Li isotopic values， with pegmatites exhibiting the highest and non-granitic pegmatite wall rocks showing the lowest. Our study also uncovered a clear "V" shape relationship between Li isotopic values and logarithm of Li content， with different mineral groups occupying specific regions within this shape. Furthermore， a significant correlation was observed between average Li isotopic values and Li-O(OH， F) bond lengths in various minerals. These discoveries underscore the crucial role of crystal chemistry in shaping the Li isotopic behavior in pegmatites from a statistical perspective.

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Research on Low-frequency Multi-directional Piezoelectric Energy Harvester with Combined Cantilever Beam

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Chinese Journal of Electronics 2024年

作者： Qingying REN Yuxuan liu Debo WANG College of Electronic and Optical Engineering Nanjing University of Posts and Telecommunications College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications

In order to realize the collection and utilization of low-frequency vibration energy, a multi-directional piezoelectric energy harvester is proposed, which consists of a lower circular arc beam and an upper L-shaped *** the lower and upper beams can achieve multi-directional energy harvesting, and the upper L-shaped beam can also act as a mass block to reduce the resonant frequency. The structure of this energy harvester is optimized. Four different structures are studied with varying combination angles between the upper and lower layers to acquire data related to resonant frequency, vibration shape, stress distribution, open-circuit voltage, and output power. Additionally, the performance of each structure is comprehensively prepared and measured to verify its effectiveness. The optimal structure achieved a resonant frequency of 11 Hz and an output power of 57.1 μW at the optimal load resistance of 201 kΩ. Consequently, this work provides valuable reference for the study of low-frequency vibration energy harvesting technology.

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Boosted Electrocatalytic Glucose Oxidation Reaction on Noble-Metal-Free MoO_(3)-Decorated Carbon Nanotubes

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Transactions of Tianjin University 2024年第1期30卷 63-73页

作者： Yu-Long Men Ning Dou Yiyi Zhao Yan Huang Lei Zhang Peng liu Department of Chemical Engineering School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Thyroid Breast and Vascular Surgery Shanghai Fourth People’s Hospital Affi liated to Tongji University School of MedicineShanghai 200081China Department of Vascular Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China

Electrocatalytic glucose oxidation reaction(GOR)has attracted much attention owing to its crucial role in biofuel cell ***,we load MoO_(3)nanoparticles on carbon nanotubes(CNTs)and use a discharge process to prepare a noblemetal-free MC-60 catalyst containing MoO_(3),Mo_(2)C,and a Mo_(2)C–MoO_(3)*** the GOR,MC-60 shows activity as high as 745μA/(mmol/L cm^(2)),considerably higher than those of the Pt/CNT(270μA/(mmol/L cm^(2)))and Au/CNT catalysts(110μA/(mmol/L cm^(2))).In the GOR,the response minimum on MC-60 is as low as 8μmol/L,with a steady-state response time of only 3 ***,MC-60 has superior stability and anti-interference ability to impurities in the *** better performance of MC-60 in the GOR is attributed to the abundant Mo sites bonding to C and O atoms at the MoO_(3)–Mo_(2)C *** Mo sites create active sites for promoting glucose adsorption and oxidation,enhancing MC-60 performance in the ***,these results help to fabricate more effi cient noble-metal-free catalysts for the fabrication of glucose-based biofuel cells.

关键词： Interface eff ect Electrocatalysis Molybdenum oxide Glucose Oxidation reaction

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气相色谱-质谱法测定饲料中的二氢吡啶

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中国标准化 2024年第4期 185-189页

作者：刘文秋董宁孙莹莹华测检测认证集团股份有限公司

本文建立一种气相色谱-质谱法(GC-MS)测定饲料产品中二氢砒啶含量的方法。采用避光的环境,在饲料样品中添加保护剂降低二氢砒啶的光化学反应,采用乙腈提取待测物,经浓缩和固相微萃取净化,采用BSTFA进行衍生,衍生物通过GCMS气化分离以及... 详细信息

本文建立一种气相色谱-质谱法(GC-MS)测定饲料产品中二氢砒啶含量的方法。采用避光的环境,在饲料样品中添加保护剂降低二氢砒啶的光化学反应,采用乙腈提取待测物,经浓缩和固相微萃取净化,采用BSTFA进行衍生,衍生物通过GCMS气化分离以及选择离子监测(SIM)模式进行检测。对二氢吡啶衍生物的电子轰击(EI)质谱碎片进行解析,特征碎片离子(m/z)206、178、251、151、150、195为定性离子,206为定量离子。该分析方法中二氢吡啶在3~150 mg/kg范围内呈良好线性关系,样品分析精密度RSD<3%,样品中二氢吡啶的检出限0.3 mg/kg。结果表明,这项方法灵敏、稳定、可靠,有效避免了饲料中二氢吡啶在处理过程中的降解,并有效排除了主要杂质的干扰,适用于饲料产品中二氢吡啶的定量分析与确证。

关键词：二氢吡啶气相色谱质谱避光衍生饲料

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血清白蛋白水平与男性尘肺患者重度以上肺通气功能障碍发生风险的关联研究

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现代预防医学 2024年第10期51卷 1914-1920页

作者：魏宇豪彭姗姗刘丽芳喻文鳌周丁子廖加强张勤姚于勤张本杜文四川大学华西公共卫生学院/华西第四医院华西职业性尘肺病队列工作组

目的通过研究血清白蛋白水平与男性尘肺患者重度以上肺通气功能障碍发生风险的关联，为控制或延缓男性尘肺患者肺通气功能的下降提供参考依据。方法本研究采用回顾性队列设计，选取2012年1月—2021年12月间于华西第四医院住院，且基... 详细信息

目的通过研究血清白蛋白水平与男性尘肺患者重度以上肺通气功能障碍发生风险的关联，为控制或延缓男性尘肺患者肺通气功能的下降提供参考依据。方法本研究采用回顾性队列设计，选取2012年1月—2021年12月间于华西第四医院住院，且基线未合并肺通气功能障碍的男性尘肺患者为研究对象，采用Cox比例风险回归模型计算HR及95%CI以评估基线血清白蛋白水平与重度以上肺通气功能障碍发生风险的关联，采用限制性立方样条图来探究基线血清白蛋白浓度与重度以上肺通气功能障碍发生风险是否存在剂量反应关系。结果本研究共纳入746名研究对象。Cox比例风险回归分析的完全调整模型结果显示，与血清白蛋白低于34.4 g/L的男性尘肺患者相比，血清白蛋白高于40.8g/L的男性尘肺患者发生重度以上肺通气功能障碍的风险降低(HR=0.660, 95%CI:0.439～0.992)。限制性立方样条图显示，随着血清白蛋白浓度的逐渐增加，男性尘肺患者发生重度以上肺通气功能障碍的风险逐渐降低，男性尘肺患者的基线血清白蛋白浓度与重度以上肺通气功能障碍的发生风险呈线性负相关(P<0.05)。结论高血清白蛋白是男性尘肺患者发生重度以上肺通气功能障碍的保护因素，维持其血清白蛋白浓度高于40.8 g/L,可降低其重度以上肺通气功能障碍的发生风险。

关键词：高血清白蛋白男性尘肺患者重度以上肺通气功能障碍保护因素

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Mediating Effect of Mindfulness,Self-Esteem and Psychological Resilience in the Relation between Childhood Maltreatment and Life Satisfaction

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International Journal of Mental Health Promotion 2024年第6期26卷 481-489页

作者： He Zhong Yaping Zhou Chenwei liu Yintao Cao Beijing Huijia Private School Beijing102299China Department of Psychology Hunan Normal UniversityChangsha410081China School of Education Hunan University of Science and TechnologyXiangtan411100China

Childhood maltreatment,as a typical early adverse environment,is known to have a negative impact on one’s life ***,on the other hand,may serve as a protective *** study explored the mediating role of mindfulness and its related variables–positive thoughts,psychological resilience and *** order to testify the mechanism,we administered Childhood Trauma Questionnaire(CTQ),Satisfaction with Life Scale(SWLS),Mindful Attention Awareness Scale(MAAS),Connor–Davidson Resilience Scale(CD-RISC)and Rosenberg Self-Esteem Scale(RSES)to a non-clinical sample of Chinese university students(N=1021).The results indicated that positive thoughts did not mediate the relationship between childhood maltreatment and life satisfaction,but self-esteem(β=−0.194,95%CI=[−0.090,−0.040])and psychological resilience(β=−0.063,95%CI=[−0.059,−0.020])mediated the relationship,as well as the“mindfulness-selfesteem”(β=−0.061,95%CI=[−0.287,−0.126])and“mindfulness-psychological resilience”(β=−0.035,95%CI=[−0.115,−0.034]).The results of this study were helpful to understand the relationship between childhood maltreatment and life satisfaction and provided a theoretical basis for the development of mindfulness intervention programs from the perspective of positive psychology.

关键词： Mindfulness childhood maltreatment life satisfaction self-esteem resilience

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Enhancing the crystallinity and stability of perovskite solar cells with 4-tert-butylpyridine induction for efficiency exceeding 24%

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Journal of Energy Chemistry 2024年第6期93卷 1-7,I0001页

作者： You liu Lishuang Zheng Kuanxiang Zhang Kun Xu Weicheng Xie Jue Zhang Yulu Tian Tianyuan liu Hanzhong Xu Ruoming Ma Wei Huang Jiahui Chen Jusheng Bao Chen Chen Yongsheng Zhou Xuchun Wang Junming Chen Jungan Wang College of Chemistry and Materials Engineering Anhui Science and Technology UniversityBengbu 233000AnhuiChina Anhui Province Quartz Sand Purification and Photovoltaic Glass Engineering Research Center Chuzhou 233100AnhuiChina Triumph Photovoltaic Materials Co.Ltd BengbuAnhuiChina National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210009JiangsuChina JinkoSolar Holding Co.Ltd HainingZhejiangChina

Perovskite solar cells(PSCs)have emerged as a promising photovoltaic technology because of their high light absorption coefficient,long carrier diffusion distance,and tunable ***,PSCs face challenges such as hysteresis effects and stability *** this study,we introduced a novel approach to improve film crystallization by leveraging 4-tert-butylpyridine(TBP)molecules,thereby enhancing the performance and stability of *** findings demonstrate the effective removal of PbI_(2)from the perovskite surface through strong coordination with TBP ***,by carefully adjusting the concentration of the TBP solution,we achieved enhanced film crystallinity without disrupting the perovskite *** TBP-treated perovskite films exhibit a low defect density,improved crystallinity,and improved carrier *** a result,the PSCs manufactured with TBP treatment achieve power conversion efficiency(PCE)exceeding 24%.Moreover,we obtained the PCE of 21.39%for the 12.25 cm^(2)module.

关键词： 4-tert-butylpyridine Film crystallization Perovskite solar cells Power conversion efficiency Stability improvement

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减载伸长路径下棕榈纤维加筋砂力学响应

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科学技术与工程 2024年第18期24卷 7792-7803页

作者：刘昆钰唐玉肖刘问刘学彦魏少伟刘睿迪云南省建设投资控股集团有限公司昆明650000 北京林业大学水土保持学院北京100083 中国铁道科学研究院集团有限公司铁道建筑研究所北京100081 北京铁科特种工程技术有限公司北京100081

为探究棕榈纤维对石英砂力学性能的增强作用,采用减载三轴伸长试验方法测试了饱和状态下棕榈纤维加筋石英砂的剪切力学性能,计算了棕榈纤维加筋石英砂在不同纤维长度和掺量下的应力-应变曲线、初始弹性模量和割线模量,基于摩尔库伦准则... 详细信息

为探究棕榈纤维对石英砂力学性能的增强作用,采用减载三轴伸长试验方法测试了饱和状态下棕榈纤维加筋石英砂的剪切力学性能,计算了棕榈纤维加筋石英砂在不同纤维长度和掺量下的应力-应变曲线、初始弹性模量和割线模量,基于摩尔库伦准则分析了棕榈纤维加筋石英砂剪切强度随纤维配比的变化规律,通过对比素砂和加筋砂在剪切过程中的体积应变及孔隙得出了棕榈纤维对石英砂力学性能的增强作用。结果表明:纤维加筋会增强石英砂在伸长破坏中的应力应变强度,对石英砂峰值应力和残余应力提升效果最佳的纤维掺量和长度为0.9%和12 mm;棕榈纤维加筋石英砂的初始弹性模量和峰值割线模量均随有效围压的增大而增大,整体刚度与有效围压呈正相关关系;纤维对石英砂剪切强度的增强效果只能在低围压状态时显现;在石英砂中添加棕榈纤维减小了石英砂的临界孔隙比及剪胀性。研究结果有助于促进纤维加筋砂的工程应用并提供相应理论参考。

关键词：棕榈纤维加筋砂减载伸长剪切强度孔隙比

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