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基于泛素-蛋白酶体通路研究杜仲提取物治疗动脉粥样硬化的机制

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中华中医药杂志 2020年第10期35卷 5279-5281页

作者：庞军吴强程文立李玲刘承铭刘微黄晶贵州省人民医院贵阳550000 首都医科大学附属北京安贞医院高血压科北京100029

目的:探讨杜仲提取物对小鼠主动脉粥样硬化(AS)模型中泛素-蛋白酶体通路(UPP)关键因子的影响及机制。方法:取载脂蛋白E基因敲除(APOE-/-)小鼠30只给予高脂饲料喂养,另取C57BL/6小鼠10只以普通饲料饲养为对照组。在确认高脂组AS模型建立... 详细信息

目的:探讨杜仲提取物对小鼠主动脉粥样硬化(AS)模型中泛素-蛋白酶体通路(UPP)关键因子的影响及机制。方法:取载脂蛋白E基因敲除(APOE-/-)小鼠30只给予高脂饲料喂养,另取C57BL/6小鼠10只以普通饲料饲养为对照组。在确认高脂组AS模型建立后,采用杜仲提取物治疗组灌胃1、2、4个月,分别测小鼠血清中胆固醇(CH)、甘油三酯(TG)、低密度脂蛋白(LDL)的含量;取小鼠胸主动脉切片光镜下观察,通过免疫组织化学方法检测主动脉组织UPP相关蛋白表达。结果:经过杜仲提取物干预后,治疗组2、4月组小鼠血清CH较高脂组显著降低(P<0.05),MMPS、NF-κB、CD54/ICAM-1、p53、CD40L/CD154、p27蛋白表达程度在干预后1、2、4月呈现降低趋势。结论:杜仲提取物能一定程度上降低APOE-/-小鼠血清CH浓度,其途径可能通过抑制UPP相关蛋白表达实现。

关键词：杜仲提取物泛素-蛋白酶体通路载脂蛋白E基因敲除小鼠动脉粥样硬化机制绿原酸

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang wenwu Zhang Gang li Xing cheng Peiqiang Su Yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan li Peng Hao Hongmei Duan Fei Hao wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin li Xiaowei Zhou Wei Chen Aidong wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

尼非韦罗微乳热敏原位凝胶的稳定性和流变性考察

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中国新药杂志 2014年第9期23卷 1019-1023页

作者：田芳温成丽王玉柱夏敏杰杨凯李卫华丁训诚上海市计划生育科学研究所国家计划生育药具重点实验室上海200032 复旦大学公共卫生学院上海200032 英国马尔文仪器有限公司上海200233

目的：研究Nifeviroc微乳热敏原位凝胶（NFVR／ME-TISG）的稳定性和流变性。方法：通过稳定性试验，考察凝胶在d5和d10的外观性状、pH值、粒径和Zeta电位有无变化；高级流变仪检测在10～45℃内，凝胶的弹性模量G′,黏性模量G″和相位角... 详细信息

目的：研究Nifeviroc微乳热敏原位凝胶（NFVR／ME-TISG）的稳定性和流变性。方法：通过稳定性试验，考察凝胶在d5和d10的外观性状、pH值、粒径和Zeta电位有无变化；高级流变仪检测在10～45℃内，凝胶的弹性模量G′,黏性模量G″和相位角δ的变化及变化特征。结果：稳定性试验显示，在d5和d10的凝胶外观性状、pH值、粒径和Zeta电位无明显变化；流变仪测其相转变温度为30℃；在低温（〈25℃）时为牛顿流体，黏度很小；随着温度升高（30和35℃）时，黏弹性模量升高，相角较低，不随频率增加而改变，表现出典型的假塑性流体特征。结论：NFVR／ME-TISG稳定性较好，具有随温度改变黏弹性流变力学特点。

关键词：尼非韦罗微乳热敏原位凝胶稳定性流变特性

From blocker to booster:Harnessing garnet surface chemistry for advanced solid-state electrolytes

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Nano Research 2025年第1期18卷 323-331页

作者： Jun cheng Xuan Zhou Hongqiang Zhang Zhen Zeng Yuanyuan li Yulong Zhu Yingsheng liao lijie Ci Deping li State Key Laboratory of Precision Welding and Joining of Materials and Structures School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China

Garnet electrolytes with high ionic conductivity and electrochemical stability are widely used as fillers to fabricate composite solid electrolytes(CPEs)within polymer ***,the performance of CPEs is significantly influenced by the surface characteristics of the garnet ***,the impact of garnet surface characteristics on CPEs was systematically investigated and a conversion from a typically unstable and Lewis basic surface to a more stable Lewis acidic surface was realized,which is shown to be more conductive to the improved performance of *** simultaneously removing the li_(2)CO_(3)layer and applying a li-Al-O coating,the influence of surface characteristics on CPEs was *** Lewis acid li-Al-O surface coating not only promotes lithium salt dissociation,improving the ionic conductivity and ionic transfer number,but also prevents the reformation of the passive Lewis basic li_(2)CO_(3)*** to garnet with a Lewis basic li_(2)CO_(3)surface,the garnet modified with a Lewis acid li-Al-O coating enhances CPEs,which exhibit an improved critical current density of 1.0 mA·cm^(-2)and highly stable lithium symmetric cell cycling for 400 h at 0.2 mA·cm^(-2).This research highlights the importance of surface chemistry in the design of high-performance solid-state batteries and presents a strategic modification approach for garnetbased CPEs.

关键词： garnet electrolyte composite solid electrolyte surface chemistry all-solid-state batteries

Unexpected pnicogen bonds involved with XH2P:A new radical receptor

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Unexpected pnicogen bonds involved with XH2P:A new radical r...

第十六届全国化学热力学和热分析学术会议

作者： Hong-Ying Zhuo,Qing-Zhong li~*,Jian-Bo cheng~*,wen-Zuo li The Laboratory of Theoretical and Computational Chemistry,School of Chemistry and Chemical Engineering,Yantai University,Yantai 264005,People’s Republic of China

Pnicogen bonds,***-covalent interactions between an electron donor and a covalently-bound pnicogen atom acting as an electron acceptor,have gained increased interest *** has been demonstrated that this new type of intermolecular interaction can act as a new molecular linker and would be useful for chiral *** hydrogen and halogen bonds, this interaction also displays cooperativity,which is responsible for its applications in crystal ***,the electron donors in pnicogen bonds can be molecules with lone pair electrons,unsaturated compounds with πelectrons or metal *** has been evidenced that radicals can participate in hydrogen bond and halogen bond,which are much weaker than those with lone pair electrons as the electron ***,when we performed an ab initio study on the interaction between HP and HC radical(Figure 1),we found that the interaction between them is so strong that it is larger than those with lone pair electrons as the electron donors,and the binding energy amounts to more than 40 kcal/mol in some *** we think HP and its derivatives can serve as a good radical *** to the single-electron hydrogen bond and halogen bond,we presumed that the single-electron pnicogen bond has a new formation *** also found some unexpected trends in the single-electron pnicogen *** example,with the increase of X electronegativity in the Lewis acid XHP(X = F,Cl,Br),the binding energy with the methyl radical is decreased.

关键词： pnicogen bonds substitutent effect radicals

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爆破施工现场安全管理工作的几点体会

爆破 2010年第2期27卷 109-111页

作者：表永一肖昆明文成立中国航空港建设第二总队重庆401100

随着城市建设的发展,爆破作业己成为重要的施工技术手段,爆破施工现场安全管理工作也相应的提到了重要地位,对爆破安全管理的力度提出了更高的要求。重庆江北国际机场第二跑道改扩建工程需要钻爆土石方约70×104m3,具有开挖强度高、周... 详细信息

随着城市建设的发展,爆破作业己成为重要的施工技术手段,爆破施工现场安全管理工作也相应的提到了重要地位,对爆破安全管理的力度提出了更高的要求。重庆江北国际机场第二跑道改扩建工程需要钻爆土石方约70×104m3,具有开挖强度高、周边环境复杂等特点。论文讨论了爆破安全管理工作中成功经验,对类似工程有参考应用价值。

关键词：浅孔爆破安全管理技术措施

A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie Zi-Meng Han Hao-cheng liu Chong-Han Yin wen-Bin Sun Zhang-Chi ling Huai-Bin Yang De-Han li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety