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Postoperative adjuvant transarterial chemoembolization for multinodular hepatocellular carcinoma within the Barcelona Clinic Liver Cancer early stage and microvascular invasion

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 418-428页

作者： Han Wang Peng-cheng Du Meng-chao Wu wen-Ming Cong Department of Pathology Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityYangpuShanghai 200438China Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer(Second Military Medical University)Ministry of Education YangpuShanghai 200438China Shanghai Key Laboratory of Hepatobiliary Tumor Biology(Eastern Hepatobiliary Surgery Hospital) YangpuShanghai 200438China Department of Vascular Surgery Changhai Hospital5Department of SurgeryEastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityYangpuShanghai 200433China

Background:The survival benefit of postoperative adjuvant transcatheter arterial chemoembolization(PA-TACE)remained *** aimed to investigate the prognosis effect of PA-TACE on the Barcelona Clinic Liver Cancer(BCLC)early stage multinodular hepatocellular carcinoma(MHCC)patients with/without microvascular invasion(MVI).Methods:Two hundred and seventy-one patients from January 2010 to December 2014 undergoing curative hepatectomy were included in this ***-free survival(DFS)rates and overall survival(OS)rates as well as prognostic factors were analyzed by the Kaplan-Meier method,the log-rank test and the Cox proportional hazard ***:Thirty-four point four percent(44/128)MVI positive and 55.2%(79/143)MVI negative patients underwent *** analysis revealed that HBV DNA load>103 copy/Ml,>three tumors,MVI,and without PA-TACE were independent risk factors for poor *** alkaline phosphatase(ALP),three tumors,MVI,and without PA-TACE were independent risk factors for poor *** DFS and OS were significantly improved in patients with MVI who received PA-TACE as compared to those who underwent hepatic resection alone(5-year DFS,26.3%vs.20.7%,P=0.038;5-year OS,73.6%vs.47.7%,P=0.005).No differences were noted in DFS and OS among MVI negative patients with or without PA-TACE(5-year DFS,33.7%vs.33.0%,P=0.471;5-year OS,84.1%vs.80.3%,P=0.523).Early recurrence was more likely to occur in patients without PA-TACE(P=0.001).Conclusions:PA-TACE was a safe intervention and could effectively prevent tumor recurrence and improve the survival of the BCLC early stage MHCC patients with MVI.

关键词： Hepatocellular carcinoma(HCC) microvascular invasion(MVI) clonal origin postoperative adjuvant transcatheter arterial chemoembolization(PA-TACE)

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农业决策咨询信息网络化特征的分析研究

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石河子大学学报（哲学社会科学版） 2002年第1期2卷 75-78页

作者：吴曙雯王人潮程家安黄明祥浙江大学农业遥感与信息技术应用研究所浙江杭州310029

决策咨询信息网络化在农业上的应用正成为农业研究的热点。精确农业、专家系统、网络服务正在改变着传统的农作方式 ,及时掌握这方面的发展动向 ,加快建立和完善我国农业信息体系 ,对实现跨世纪农业的发展无疑具有重要意义。该文简要论... 详细信息

决策咨询信息网络化在农业上的应用正成为农业研究的热点。精确农业、专家系统、网络服务正在改变着传统的农作方式 ,及时掌握这方面的发展动向 ,加快建立和完善我国农业信息体系 ,对实现跨世纪农业的发展无疑具有重要意义。该文简要论述了知识经济时代下国内外农业决策咨询信息网络化发展现状、分析比较存在的问题 ,提出适合我国国情的农业信息网络化发展方向和对策。

关键词：农业决策咨询信息网络化特征分析

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Fabrication, Structure and Optical Properties of Zr4+ Doped Ba（Mg, Ta） O3 Transparent Ceramics with High Refractive Index

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Chinese Journal of Structural Chemistry 2019年第6期38卷 941-946页

作者： wen Zi-cheng MA chao-Yang ZHAO Chong CAO Yong-Ge Department of Physics Renmin University of ChinaBeijing 100872China Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-nano Devices Beijing Municipal Science and Technology CommissionBeijing 100872China

Novel transparent ceramics of Zr4+ doped Ba(Mg,Ta)O3(BMT)with a high refractive index of 2.037 at 587.56 nm were successfully fabricated via high temperature solid-state-reaction sintering *** make it transparent,the pure cubic Ba(Zr,Mg,Ta)O3 phases(BZMT)were realized in advance by skillfully modulating the lattice structure of BMT from trigonal symmetric to cubic symmetric through doping Zr4+ into the lattice of BMT *** optical transmittance of 74% at 650 n,,which hit the upper limit of the theory,was achieved for *** abbe number of 23.4 and the bandgap Eg of 3.22 eV have been calculated.

关键词： BZMT transparent ceramics refractive index optical materials mechanical properties

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Coupling potential and viscous flow models with domain decomposition for wave propagations

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Journal of Hydrodynamics 2022年第5期34卷 826-848页

作者： wen-jie Zhong wen-tao Wang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China China Ship Scientific Research Center Wuxi214082China

Either potential flow or viscous flow based model may be flawed for numerical wave *** two-way coupling of potential and viscous flow models with the domain decomposition utilizing respective strengths has been a trending research *** contrast to existing literatures in which closed source potential models were used,the widely used open source OceanWave3D,OpenFOAM-v2012 are used in the present *** innovative overlapping two-way coupling strategy is developed utilizing the ghost points in *** guarantee computational stability,a relaxation zone used both for outlet damping and data transfer is built over the overlapping region in *** free surface elevation in the relaxation zone is directly probed in OpenFOAM while the velocity potential is indirectly built upon its temporal variation which is calculated by the free surface boundary condition using the probed *** coupling is achieved based on the fourth-order Runge-Kutta(RK)*** two-and three-dimensional tests including linear,nonlinear,irregular,and multi-directional irregular waves,are *** effectiveness of the coupling procedure in bidirectional data transfer is fully demonstrated,and the model is validated to be accurate and efficient,thus providing a competitive alternative for ocean wave simulations.

关键词： Domain decomposition numerical wave tank potential/viscous flow coupling irregular waves wave-structure interaction

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Investigation of Linarinic acid and one of its derivatives against cerebral ischemia in mice

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 165-171页

作者： Yihan Wang chao Zhao Qiujv Wang Huimin wen Yaru Gu Linlin Fan chao Ma Maosheng cheng Yuyang Zhang School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China Key Laboratory of Structure-Based Drug Design and Discovery Shenyang Pharmaceutical UniversityMinistry of EducationNo.103Wenhua RoadShenyang110016China

The study aims to investigate the effects of(-)-Linarinic acid(LA) and one of its derivatives(LAd) on brain injury induced by ischemia. Malonaldehyde(MDA) is determined as an index for lipid peroxidation both in vitro and vivo. Mice were pre-treated with LA and LAd for 3 ***, they were induced to have incomplete cerebral ischemia with both bilateral carotid artery occlusion and hypotension(BCAOH). In the first part of the in vivo experiment, mice were divided into four groups: sham(control), ischemia, ischemia + LA(200 mg/kg, i.g.) and ischemia + LAd(200 mg/kg, i.g.). In the second part, the dose-response of LAd was investigated at 100, 200 and 400 mg/kg i.g., respectively. A modified neurological severity score was developed for evaluating behavioral deficits of the mice with ischemia. Brains of the mice were excised in order to determinate MDA after ischemia for 6 h. Survival time, survival rate, neurological injury score and MDA level in brains were observed. Results were: 1) The data in vitro showed that both LA and LAd could inhibit the generation of MDA. IC50 values obtained by Probit analysis were 2.9 mM for LAd and 4.88 mM for LA;2) BCAOH could significantly shorten the survival span, reduce the survival rate and cause neurological deficits,which were associated with high level of lipid hydroperoxide production in cerebral tissues;3) LAd decreased lipid peroxidation and improved the neurological outcome more than *** is concluded that LAd offers a better neuroprotection than LA against brain damage caused by cerebral ischemia.

关键词： (-)-Linarinic acid Cerebral ischemia Malonaldehyde Mice

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Orientation variation along growth direction of millimeter free-standing CVD diamond thinned by mechanical grinding

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International Journal of Minerals,Metallurgy and Materials 2014年第8期21卷 839-844页

作者： Xing-kai wen Jun-jun Wei Jin-long Liu Jian-chao Guo Liang-xian Chen cheng-ming Li Institute of Advanced Materials and Technology University of Science and Technology Beijing

A free-standing diamond film with millimeter thickness prepared by DC arc plasma jet was thinned successively by mechanical grinding. The orientation and quality of the diamond films with different thicknesses were characterized by X-ray diffraction and Raman spectroscopy, respectively. The results show a random grain-orientatinn distribution during the initial growth stage. As the film thickness increases, the preferred orientation of the diamond film changes from （111） to （220）, due to the competitive growth mechanism. Twinning generated during the nucleation stage appears to stabilize the preferential growth along the 〈110〉 direction. The interplanar spacing of the （220） plane is enlarged as the film thickness increases, which is caused by the increase of non-diamond-phase carbon and impurities under the cyclic gas. In addition, the quality of the diamond film is barely degraded during the growth process. Furthermore, the peak shift demonstrates a significant inhomogeneity of stress along the film growth direction, which results from competitive growth.

关键词： diamond films chemical vapor deposition grinding orientation growth mechanisms quality

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Reconstructing early transmission networks of SARS-CoV-2 using a genomic mutation model

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Zoological Research 2023年第3期44卷 494-504页

作者： chao-Yuan cheng Zhi-Bin Zhang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China

The coronavirus disease 2019(COVID-19)pandemic has greatly damaged human society,but the origins and early transmission patterns of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pathogen remain ***,we reconstructed the transmission networks of SARS-CoV-2 during the first three and six months since its first report based on ancestor-offspring relationships using BANAL-52-referenced *** explored the position(i.e.,root,middle,or tip)of early detected samples in the evolutionary tree of *** total,6799 transmission chains and 1766 transmission networks were reconstructed,with chain lengths ranging from 1-9 *** root node samples of the 1766 transmission networks were from 58 countries or regions and showed no common ancestor,indicating the occurrence of many independent or parallel transmissions of SARS-CoV-2 when first detected(i.e.,all samples were located at the tip position of the evolutionary tree).No root node sample was found in any sample(n=31,all from the Chinese mainland)collected in the first 15 days from 24 December *** using six-month data or RaTG13-referenced mutation data were *** reconstruction method was verified using a simulation *** results suggest that SARS-CoV-2 may have already been spreading independently worldwide before the outbreak of COVID-19 in Wuhan,***,a comprehensive global survey of human and animal samples is essential to explore the origins of SARS-CoV-2 and its natural reservoirs and hosts.

关键词： SARS-CoV-2 Transmission chain Transmission network Ancestor-offspring relationship De novo mutation Back mutation Secondary mutation

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Constraints on the extensions to the base ΛCDM model from BICEP2, Planck and WMAP

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Science China(Physics,Mechanics & Astronomy) 2014年第8期57卷 1460-1465页

作者： cheng cheng HUANG QingGuo ZHAO wen State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences University of the Chinese Academy of Sciences Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of China

Recently Background Imaging of Cosmic Extragalactic Polarization （B2） discovered the relic gravitational waves at 7.00- confi- dence level. However, the other cosmic microwave background （CMB） data, for example Planck data released in 2013 （P13）, prefer a much smaller amplitude of the primordial gravitational waves spectrum if a power-law spectrum of adiabatic scalar perturbations is assumed in the six-parameter ACDM cosmology. In this paper, we explore whether the wCDM model and the running spectral index can relax the tension between B2 and other CMB data. Specifically we found that a positive running of running of spectral index is preferred at 1.70- level from the combination of B2, P 13 and WMAP Polarization data.

关键词： relic gravitational waves spectral index dark energy

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao cheng Chuankai Fu Geping Yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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The tissue expression level of BPI gene in piglets from newborn to weaning and its relationship with Gram-negative bacterial infection

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Journal of Integrative Agriculture 2020年第12期19卷 3065-3073页

作者： DAI chao-hui CAO Yue GAO Zhong-cheng ZHU Guo-qiang WU Sheng-long BAO wen-bin Key Laboratory for Animal Genetics BreedingReproduction and Molecular Design of Jiangsu ProvinceCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009P.R.China Joint International Research Laboratory of Agriculture and Agri-Product Safety Ministry of Education/Yangzhou UniversityYangzhou 225009P.R.China College of Veterinary Medicine Yangzhou UniversityYangzhou 225009P.R.China

The bactericidal/permeability increasing protein (BPI) has an important function of nonspecific killing of Gram-negative bacteria. In this study, qPCR was used to detect the expression of the BPI gene in twelve tissues of Meishan piglets from birth to weaning. BPI gene overexpression, bacterial adhesions count and indirect immunofluorescence were applied to analyze the relationship between BPI gene expression and the infectivity of Escherichia coli and Salmonella. The results showed that the BPI gene was expressed highly in duodenum, jejunum and ileum (fold changes of relative expression levels were more than 10 000, 500 and 200, respectively). The expression of the BPI gene at 35 days of age was significantly higher (P<0.01) than that at all other days. Transcription of the BPI gene was up-regulated 2 401-fold in porcine intestinal epithelial (IPEC-J2) cells that were transfected with the BPI gene overexpression lentivirus (IPEC-J2-BPI), and significantly higher (P<0.01) than that in negative control cells (IPEC-J2-NC). Protein expression levels in IPEC-J2-BPI cells were also increased. When IPEC-J2 cells were incubated with E. coli and Salmonella, respectively, for 2, 4, 6, 8, 10 and 12 h, the number of bacterial adhesions in IPEC-J2-BPI cells was significantly less (P<0.05) than that in IPEC-J2-NC cells. The results of indirect immunofluorescence analysis showed that the number of bacterial adhesions in IPEC-J2-BPI cells was significantly less (P<0.01) than that in IPEC-J2-NC cells. These results demonstrated that the BPI gene might play an important role in regulating weaning stress especially intestinal-mediated immune response. Overexpression of the BPI gene at the cellular level could significantly enhance the anti-bactericidal ability against Gram-negative bacteria such as E. coli and Salmonella. This has important biological significance in piglet resistance to bacterial diarrhea.

关键词： pig BPI gene Escherichia coli Salmonella disease-resistant breeding

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