检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2024年第9期14卷 3949-3963页

作者： Bin Li Qi Xiao Hongmei zhao Jianuo Zhang Chunyan Yang Yucen Zou Bengang Zhang Jiushi Liu Haitao Sun Haitao Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China Institute of Basic Medical Sciences Chinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China

Non-alcoholic fatty liver disease(NAFLD),characterized by hepatic steatosis,is a common metabolic liver disease ***,satisfactory drugs for NAFLD treatment remain *** and diabetes are the leading causes of NAFLD,and compounds with anti-obesity and antidiabetic activities are considered suitable candidates for treating *** this study,biochemical and histological assays revealed that a natural lignan schisanhenol(SAL)effectively decreased lipid accumulation and improved hepatic steatosis in free fatty acid(FFA)-treated HepG2 cells and high-fat diet(HFD)-induced NAFLD ***,molecular analyses,microRNA(miRNA)-seq,and bioinformatics analyses revealed that SAL may improve NAFLD by targeting the miR-802/adenosine monophosphateactivated protein kinase(AMPK)***-specific overexpression of miR-802 in NAFLD mice significantly impaired SAL-mediated liver protection and decreased the protein levels of phosphorylated(p)-AMPK and ***-luciferase assay analysis further confirmed that miR-802 inhibits hepatic AMPK expression by binding to the 3’untranslated region of mouse Prkab1 or human PRKAA1.

关键词： Schisanhenol Non-alcoholic fatty liver disease Hepatic steatosis Lipid metabolism miR-802 AMPK SREBP-1c PPARa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

广义确定性标识网络

电子学报 2024年第1期52卷 1-18页

作者：杨冬程宗荣田伟康王洪超张宏科谭斌赵志勇北京交通大学电子信息工程学院北京100044 中兴通讯股份有限公司上海201203 中兴通讯股份有限公司北京100020

随着智能制造、智能交通等重大国家战略实施,确定性成为信息网络尤其是行业专网的新焦点.现有确定性网络技术始终关注网络传输要素(带宽、时隙等)来保障数据流的确定性传输.然而,仅靠保障传输要素无法支撑新兴行业应用的多样化需求.例如... 详细信息

随着智能制造、智能交通等重大国家战略实施,确定性成为信息网络尤其是行业专网的新焦点.现有确定性网络技术始终关注网络传输要素(带宽、时隙等)来保障数据流的确定性传输.然而,仅靠保障传输要素无法支撑新兴行业应用的多样化需求.例如,在算网融合场景,智算任务要求同时保障传输与计算要素的确定性来实现高性能通信;在绿色通信场景,需要考虑节点能量要素的确定性以维持网络稳定运行.针对上述需求,本文基于前期提出的标识网络技术,研究面向传输、计算、存储、能量等多要素的广义确定性网络.首先提出广义确定性标识网络架构,包括差异化服务层、异构融合网络层和智慧化适配层.差异化服务层和异构融合网络层,分别实现差异化确定性应用需求和异构化确定性网络要素的统一标识和描述,并通过标识解析映射实现确定性信息向智慧化适配层的统一封装和传递;智慧化适配层完成差异化确定性应用需求和异构化确定性网络要素的适配.现有确定性资源适配方法,即使仅考虑单一网络内的基本确定性要素,仍面临计算时间长、求解复杂性高、灵活度低等问题,为了支持更加复杂的多确定性要素、多种异构网络的协同适配,设计了基于深度强化学习的端到端的确定性调度(End-to-end Deterministic resource scheduling,E2eDet)算法,该算法可统一化、端到端地为混合数据流协同分配多种确定性网络资源,满足不同应用的差异化确定性需求.实验表明,E2eDet比DeepCQF和Random算法分别提升了28.4%和6.38倍数据流调度数量,同时E2eDet可以较好地权衡计算时间和调度能力.

关键词：广义确定性网络完备标识空间网络体系架构深度强化学习网络资源调度

高性能梯度纳米钛板的超声表面深滚压制备及组织性能研究

在线全文

学校读者我要写书评

暂无评论

机械工程学报 2024年第6期60卷 227-235页

作者：韩静张政宋元明孙启胜刘志远孙甲鹏曹超赵继云中国矿业大学机电工程学院徐州221116 河海大学力学与材料学院南京221100

低的强度极大限制了工业纯钛的应用。采用超声表面深滚压(Ultrasonic severe surface rolling,USSR)制备了高强度、耐腐蚀、光洁表面的高性能纯钛板材。单次USSR加工在纯钛表面获得了厚度约1.3 mm的梯度硬化层和良好镜面效果的光洁表面;... 详细信息

低的强度极大限制了工业纯钛的应用。采用超声表面深滚压(Ultrasonic severe surface rolling,USSR)制备了高强度、耐腐蚀、光洁表面的高性能纯钛板材。单次USSR加工在纯钛表面获得了厚度约1.3 mm的梯度硬化层和良好镜面效果的光洁表面;USSR试样具有梯度纳米结构表面层,即晶粒尺寸、位错和孪晶密度随深度梯度变化,最表面层晶粒细化至52.2 nm;USSR试样屈服强度和抗拉强度相比未加工试样分别提高了33.8%和10.9%,表面硬度提高了50.9%,同时保持了20.8%的断裂延伸率;USSR试样在Hank’s溶液中的钝化电流密度降低,极化电阻增大,钝化膜稳定性和钝化能力提高。USSR试样的高强度主要来源于晶界强化、位错强化、孪晶强化和异质变形诱导强化;高密度非平衡晶界和光洁表面有利于稳定钝化膜的形成,提高了纯钛钝化能力。研究结果为工业纯钛力学性能和腐蚀阻力的改善提供了新的思路。

关键词：钛梯度纳米强度塑性耐蚀性表面强化

Gravity Wave Activity and Stratosphere-Troposphere Exchange During Typhoon Molave(2020)

在线全文

学校读者我要写书评

暂无评论

Journal of Tropical Meteorology 2024年第3期30卷 306-326页

作者： HUANG Dong WAN Ling-feng WAN Yi-shun CHANG Shu-jie MA Xin zhao Kai-jing College of Ocean and Meteorology/South China Sea Institute of Marine Meteorology/Laboratory for Coastal Ocean Variation and Disaster Prediction/Key Laboratory of Climate Resources and Environment in Continental Shelf Sea and Deep Sea(LCRE)/Key Laboratory of Space Ocean Remote Sensing and ApplicationMinistry of Natural ResourcesGuangdong Ocean UniversityZhanjiangGuangdong 524088 China Frontier Science Center for Deep Ocean Multispheres and Earth System(DOMES) Institute for Advanced Ocean Study(IAOS)Ocean University of ChinaQingdaoShandong 266100 China School of Earth and Environment University of LeedsLeeds LS29JT UK Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030 China

To investigate the stratosphere-troposphere exchange(STE)process induced by the gravity waves(GWs)caused by Typhoon Molave(2020)in the upper troposphere and lower stratosphere,we analyzed the ERA5 reanalysis data provided by the European Centre for Medium-Range Weather Forecasts and the CMA Tropical Cyclone Best Track *** also adopted the mesoscale forecast model Weather Research and Forecasting model V4.3 for numerical *** of the previous studies were about typhoon-induced STE and typhoon-induced GWs,while our research focused on the STE caused by typhoon-induced gravity *** analysis shows that most of the time,the gravity wave signal of Typhoon Molave appeared below the *** was stronger on the east side of the typhoon center(10°-20°N,110°-120°E)than on the west side,suggesting an eastward tilted structure with height *** the GWs in the upper troposphere and lower stratosphere region on the west side of the typhoon center broke up,it produced strong turbulence,resulting in stratosphere-troposphere *** this time,the average potential vorticity vertical flux increased with the average ozone mass mixing *** gravity wave events and STE process simulated by the WRF model were basically consistent with the results of ERA5 reanalysis data,but the time of gravity wave breaking was *** study indicates that after the breaking of the GWs induced by typhoons,turbulent mixing will also be generated,and thus the STE.

关键词： gravity wave typhoon stratosphere-troposphere exchange STE upper troposphere and lower stratosphere UTLS

The root-knot nematode effectorMi2G02 hijacks a host plant trihelix transcription factor to promote nematode parasitism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2024年第2期5卷 151-168页

作者： Jianlong zhao Kaiwei Huang Rui Liu Yuqing Lai Pierre Abad Bruno Favery Heng Jian Jian Ling Yan Li Yuhong Yang Bingyan Xie Michael Quentin Zhenchuan Mao State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China INRAE Universite´Cote d’AzurCNRSISA06903 Sophia AntipolisFrance Department of Plant Pathology and Key Laboratory of Pest Monitoring and Green Management of the Ministry of Agriculture China Agricultural UniversityBeijing 100193China

Root-knot nematodes(RKNs)cause huge agricultural losses every *** secrete a repertoire of effectors to facilitate parasitism through the induction of plant-derived giant feeding cells,which serve as their sole source of ***,the mode of action of these effectors and their targeted host pro-teins remain largely *** this study,we investigated the role of the effector Mi2G02 in Meloidogyne incognita ***-derived Mi2G02 RNA interference in Arabidopsis thaliana affected giant cell development,whereas ectopic expression of Mi2G02 promoted root growth and increased plant sus-ceptibility to *** used various combinations of approaches to study the specific interactions between Mi2G02 and *** GT-3a,a trihelix transcription ***-3a knockout in *** affected feeding-site development,resulting in production of fewer egg masses,whereas GT-3a overex-pression in *** increased susceptibility to *** and also root ***,we demon-strated that Mi2G02 plays a role in maintaining GT-3a protein stabilization by inhibiting the 26S proteasome-dependent pathway,leading to suppression of TOZ and RAD23C expression and thus promoting nematode *** work enhances our understanding of how a pathogen effector manipulates the role and regulation of a transcription factor by interfering with a proteolysis pathway to reprogram gene expression for development of nematode feeding cells.

关键词： Meloidogyne incognita effector giant cell Mi2G02 transcription factor interaction

Zones of Openness China’s reforms in its free trade zones offer opportunities to the world

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ChinAfrica 2024年第8期16卷 24-25页

作者： zhao ZHONGXIU KONG QINGFENG ZHU YONGBIAO University of International Business and Economics School of Economics Shandong University Shandong University Free Trade Zone Research Institute School of Politics and International Relations Lanzhou University Research Centre for the Belt and Road of Lanzhou University

Since the 18th National Congress of the Communist Party of China held in 2012,the construction of pilot free trade zone has emerged as a strategically important approach for China’s reform and opening up *** zones exemplify China’s proactive and open strategy,serving as a key driver for promoting high-quality *** September 2013,China launched its first pilot free trade zone,China(Shanghai)Pilot Free Trade *** the past decade,21 additional pilot free trade zones have been established across the *** expansion has created a comprehensive reform and opening up innovation agenda that spans the eastern,western,southern,northern,and central regions,while integrating coastal,inland,and border areas.

关键词： Zone inland integrating

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海底管道校核方法研究分析

船海工程 2024年第4期53卷 107-112页

作者：杨小乐肖辉李翔云赵铭文曾欢中海石油(中国)有限公司天津分公司天津300459

为计算腐蚀海底管道的剩余强度,分析海底管道的在位强度计算方法,提出一种海底管道校核方法。将腐蚀管道的强度校核分为整体强度和局部强度分析,通过ECE5模拟预测海底管道均匀腐蚀深度和局部腐蚀深度,利用原设计规范(DNV OS F101或DNV19... 详细信息

为计算腐蚀海底管道的剩余强度,分析海底管道的在位强度计算方法,提出一种海底管道校核方法。将腐蚀管道的强度校核分为整体强度和局部强度分析,通过ECE5模拟预测海底管道均匀腐蚀深度和局部腐蚀深度,利用原设计规范(DNV OS F101或DNV1981)计算海底管道的整体强度,采用DNV-RP-F101计算海底管道腐蚀点的局部强度,采用有限元方法对腐蚀点的局部强度进行模拟计算,为腐蚀管道的安全性评估提供依据。

关键词：海底管道剩余强度校核方法有限元

在线全文

学校读者我要写书评

暂无评论

基于类金字塔图残差网络的图像超分辨率重建

控制与决策 2024年第3期39卷 786-794页

作者：赵小强王泽宋昭漾蒋红梅兰州理工大学电气工程与信息工程学院兰州730050 甘肃省工业过程先进控制重点实验室兰州730050 兰州理工大学国家级电气与控制工程实验教学中心兰州730050

针对基于深度学习的图像超分辨率重建算法大多侧重于从大量外部训练数据中学习,而忽视图像本身的内部知识以及过于关注局部特征的问题,提出一种基于类金字塔图残差网络的图像超分辨率重建算法.首先,该算法构建的残差图卷积结构利用一种... 详细信息

针对基于深度学习的图像超分辨率重建算法大多侧重于从大量外部训练数据中学习,而忽视图像本身的内部知识以及过于关注局部特征的问题,提出一种基于类金字塔图残差网络的图像超分辨率重建算法.首先,该算法构建的残差图卷积结构利用一种预生成图结构的方式将提取的特征图转换为预生成图结构的顶点来构成图结构数据,从而通过图卷积来学习特征自身内部的拓扑结构,同时使用残差学习适度地加深图卷积网络以提高重建性能;其次,该算法构建的类金字塔多空洞卷积结构,通过充分利用不同大小的感受野,避免了不能完全覆盖所有像素点的缺陷,更好地融合不同尺度的特征信息;最后,经过大量实验验证,所提出的算法显著优于主流超分辨率方法,有着更好的客观和主观度量结果.

关键词：图像复原超分辨率重建图卷积网络空洞卷积残差学习金字塔结构

Precisely Tailoring the First Coordination Shell of Metal Centers in Porous Nitrogen-Doped Carbon Promoting Electroreduction of CO^(2)Under Neutral Condition

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第8期6卷 1978-1986页

作者： Cheng-Peng Liang Jia-Run Huang Hao-Lin Zhu Zhen-Hua zhao Can Yu Pei-Qin Liao Xiao-Ming Chen MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular EngineeringSchool of ChemistrySun Yat-sen UniversityGuangzhouGuangdong 510275 Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049

Precise regulation of the coordination environment of a metal active center is very important but remains a ***,single-atom Ni catalysts with a combined N-and C-coordination structure(Ni-NC_(3))and N-coordination structure(Ni-N4)were prepared by modulating the side groups of organic ligands in the corresponding precursor metal–azolate *** with the Ni-N4 site,the d-band center of 3d orbitals of the Ni atom in Ni-NC_(3)was more significantly shifted to the Fermi energy level;thus,the Ni-NC_(3)catalytic site was superior to activating CO_(2)molecule into the*COOH *** a result,Ni-NC_(3)exhibited an exceptionally high performance for CO_(2)-to-CO conversion with a Faradaic efficiency of 98.4%,an energy efficiency of>50%,as well as an industrial current density of∼300 mA cm^(−2) in neutral *** high performance could be retained for at least 70 *** work reveals the importance of modulating the coordination environment in the electrochemical CO_(2)reduction reaction and provides a possible way to rational design of electrocatalysts for highly efficient conversion of CO_(2)to target products.

关键词： single-atom Ni catalysts first coordination shell porous nitrogen-doped carbon electrochemical CO_(2)reduction reaction coordination environment

Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第4期22卷 493-502页

作者： Qian-zhuo Liu Hui Han Xin-ru Fang Lu-yao Wang Dan zhao Miao-zhu Yin Nian Zhang Peng-yu Jiang Zhi-hui Ji Li-min Wu Department of Neurology the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Center for Reproduction and Genetics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031Anhui ProvinceChina

Objective:Hepatolenticular degeneration (HLD) is an autosomal recessive disorder that manifests as multiorgan damage due to impaired copper (Cu) metabolism. Female patients with HLD often experience reproductive impairments. This study investigated the protective effect of berberine against ovarian damage in toxic-milk (TX) mice, a murine model for ***:Mice were categorized into control group, HLD TX group (HLD group), penicillamine (Cu chelator)-treated TX group and berberine-treated TX group. Body weight, ovary weight and the number of ovulated eggs were recorded. Follicular morphology and cellular ultrastructure were examined. Total iron, ferrous iron (Fe2+) and trivalent iron (Fe3+) levels, as well as malondialdehyde (MDA), glutathione(GSH) and oxidized glutathione (GSSG), were measured in the ovaries. Western blot analysis was used to analyze the expression of proteins related to ferroptosis and endoplasmic reticulum (ER) ***:Ovarian tissue damage was evident in the HLD group, with a significant increase in ferroptosis and ER stress compared to the control group. This damage was inhibited by treatment with penicillamine,a Cu chelator. Compared with the HLD group, berberine increased the number of ovulations, and improved ovarian morphology and ultrastructure. Further, we found that berberine reduced total iron,Fe2+, MDA and GSSG levels, elevated GSH levels, decreased the expression of the ferroptosis marker protein prostaglandin-endoperoxide synthase 2 (PTGS2), and increased glutathione peroxidase 4 (GPX4)expression. Furthermore, berberine inhibited the expression of ER stress-associated proteins mediated by the protein kinase RNA-like ER kinase (PERK) ***:Ferroptosis and ER stress are involved in Cu-induced ovarian damage in TX mice. Berberine ameliorates ovarian damage in HLD TX mice by inhibiting ferroptosis and ER stress.

关键词： Berberine Hepatolenticular degeneration Copper deposition Ferroptosis Endoplasmic reticulum stress