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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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Pronounced impact of size and shape effects on creep rupture life of a K439B superalloy combustion chamber casting simulator

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China Foundry 2025年

作者： wen-tong Liu Yi-dong Wu Lei Gao Jing-yang Chen Cheng-bo Xiao Xi-dong Hui State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical Materials

The size and shape effect(SSE) of components has become a critical issue for mechanical properties, application reliability, and processing. In this study, the creep rupture life(CRL) of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated. The intrinsic mechanisms of the SSE were explored from the dendrite structure, volume fraction and size of the γ' phase, and element segregation, etc. It is shown that this casting exhibits a strong SSE of creep rupture life, characterized by a significant difference in the CRL values up to 60% with the variation of wall thickness and position in the casing. In terms of casting technology, the influence of SSE on CRL is actually determined by the cooling rate. The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing), volume fraction size of the γ' phase in the dendrite trunk, and elements segregation rate. This work may have implications for the design and application of engineering components with large sizes and complex structures.

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Comparison analysis of testis asymmetry and sperm length in Rhacophorus omeimontis

Comparison analysis of testis asymmetry and sperm length in ...

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第七届全国野生动物生态与资源保护学术研讨会

作者： Zhi Ping Mi~1 wen bo liao~(*1) Long Jin~1 Shang Ling Lou~1 Jian Cheng~2 and Hua Wu~(2*) (1 Key Laboratory of Southwest China Wildlife Resources Conservation Ministry of Education,China West Normal University,Nanchong,637009,China 2 Laboratory of Ecology and Evolutionary Biology,College of Life Sciences,Central China Normal University,Wuhan 430079,China)

Theory predicts that the degree of testes asymmetry should be positively correlated with male body condition only when species in which there is an overall directional testis asymmetry. We tested if the above prediction from theoretical models can be applied to Rhacophorus omeimontis,a species where females mate with more than one *** results showed a non-significant difference in testes mass between left and right testes,and the treefrog did not exhibit directional testis asymmetry,but fluctuating testis ***,we also tested the difference in body size and mass,relative testis mass,testis asymmetry and sperm size among initially paired,joiner and unpaired *** found that body size and mass,testis mass,testis asymmetry and sperm length did not differ significantly among initially paired,joiner and unpaired *** mass showed a positive relationship with soma mass,but there were non-significant correlations between fluctuating testis asymmetry and sperm length and between testis mass and sperm length.

关键词： External fertilization sperm length sperm competition testis asymmetry

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao liao Wei-bo wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao wen-bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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The evolution of body size in Odorous Frog(Odorrana grahami) across altitudinal gradients

The evolution of body size in Odorous Frog(Odorrana grahami)...

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第七届全国野生动物生态与资源保护学术研讨会

作者： Shang Ling Lou~(1,2),wen bo liao~(1,2*),Zhi Ping Mi~(1,2) (1 Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of ducation),China West Normal University,Nanchong,637009,China. 2 Institute of Rare Animals and Plants,China West Normal University,Nanchong,637009,China.)

We used skeletochronology to determine the ages of 134(58 females,64 males and 12 juveniles)Odorous Frog(Odorrana grahami)from 4 locations(covering an altitudinal span of 1180-1710m)in montane regions of Sichuan province in western *** were distinct lines of arrested growth(LAGs)from excised toe bone within each frog,and each LAG was assumed to represent one year of *** size of four *** populations did not vary clinaly along a 530-m altitudinal gradient,not agreeing with Bergmann’s *** age was significantly different among four populations within each *** females,average SVL differed significantly among populations, but not in *** both sexes,age significantly affected body size among the *** removing the effects of age,differences in body size still remained in females,but not in males. Post-metamorphic growth rate of male frogs living in the lowest site was *** contrary,female frogs from the highest site-had greatest growth *** findings suggest that other factors(*** resources,metabolic properties,interspecific competition,predator risk,precipitation and humidity) other than age and growth rate may play a role in shaping size differences both among populations and between sexes.

关键词： Age altitudinal gradients body size skeletochronology Odorous Frog

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CT判断不同密度同种异体骨犬椎体间融合效果研究

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中国现代医学杂志 2016年第14期26卷 32-36页

作者：曹广如廖文波蔡玉强王霞陈太勇陈琦王翀遵义医学院附属医院脊柱外科贵州遵义563003

目的计算机断层扫描(CT)判断不同密度同种异体骨在犬椎体间融合情况,为临床椎体间植骨融合术中植入合适密度骨提供依据。方法将21只健康中华田园犬随机分成3组,每组7只。所有动物均行经前路腰椎间盘摘除椎体间植骨融合术。3组分别予高... 详细信息

目的计算机断层扫描(CT)判断不同密度同种异体骨在犬椎体间融合情况,为临床椎体间植骨融合术中植入合适密度骨提供依据。方法将21只健康中华田园犬随机分成3组,每组7只。所有动物均行经前路腰椎间盘摘除椎体间植骨融合术。3组分别予高密度植骨(甲组),正常密度植骨(乙组),空白对照(丙组)。于术后12周行腰椎CT平扫+三维重建观察椎间融合效果。应用Photoshop软件测量融合骨横截面CT图形面积,计算椎体间融合程度。结果术后12周,3组椎体间融合的比例分别为甲组(75.91±8.25)、乙组(94.67±3.35)、丙组(37.78±1.16)。植骨组(甲组、乙组)与空白对照组(丙组)比较,差异有统计学意义(P<0.05),正常密度植骨组(乙组)椎间融合效果优于其他两组(P<0.05)。结论椎体间融合术中移植未经压缩的同种异体骨,有利于促进椎体间融合。

关键词：同种异体骨骨移植骨密度脊柱融合术

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缺陷对单层硅烯纳米梁振动频率的影响

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原子与分子物理学报 2025年第6期42卷 76-82页

作者：张文博王静新疆大学物理科学与技术学院乌鲁木齐830017

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动... 详细信息

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动频率随着纳米梁长度的增加而减小.单元素、双元素掺杂均会导致单层硅烯纳米梁的振动频率的增加,且随着掺杂浓度的增加纳米梁的振动频率整体呈现增大的趋势.此外,单空位缺陷会导致单层硅烯纳米梁的振动频率随着缺陷浓度的增加而减小.掺杂-单空位缺陷的单层硅烯纳米梁的振动频率则呈现了随着掺杂浓度的增加先减小后增加的变化趋势.这些变化规律均是由掺杂元素、空位缺陷以及它们共同作用的结果.此研究结果对硅烯纳米谐振器,振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：硅烯掺杂振动频率分子动力学

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng bo Shao Chao-Min Xu Ke Wang Jia-Zhu wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Divergent Syntheses of Pyridoacridine Alkaloids via Palladium-Catalyzed Reductive Cyclization with Nitro-Biarenes

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Chinese Journal of Chemistry 2021年第7期39卷 1905-1910页

作者： bo Liu Shuping Wang Changhao Bian Hongze liao Hou-wen Lin Research Center for Marine Drugs State Key Laboratory of Oncogene and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127 China

Main observation and conclusion A divergent and novel protocol for the preparation of both pyrido[2,3,4-kl]acridine and pyrido[4,3,2-kl]acridine alkaloids was *** method featured the remote palladium-catalyzed reductive cyclization with Mo(CO)_(6) as reductant.A wide range of substrates including three types of nitro arenes were tolerated and afforded corresponding products in good to excellent yields.

关键词： Polycyclic heteroaromatics Palladium-catalyzed reductive cyclization Marine nature alkaloids Divergent syntheses Pyridoacridine

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