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The putative NAD(P)H Nitroreductase,Rv3131,is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis

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Biomedical and Environmental Sciences 2022年第7期35卷 652-656页

作者： DONG wen Zhu SHI Jin CHU Ping LIU Rong mei wen Shu An ZHANG ting ting PANG Yu LU Jie Department of Infectious Diseases The First People's Hospital of ZiyangZiyang 641300SichuanChina Department of Bacteriology and Immunology Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteBeijing 101149China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing 101149China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryMOE Key Laboratory of Major Diseases in ChildrenBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 101149China

Tuberculosis(TB),which is caused by the intracellular pathogen,Mycobacterium tuberculosis(Mtb),remains one of the deadliest infectious diseases worldwide,accounting for 1.45 million deaths in 2018[1].Thus,there is an increasing need to develop new antibiotics or to repurpose old drugs that have the potential to shorten the current duration of ***(MTZ)is a 5-nitroimidazole antibiotic that is mainly used in the treatment of anaerobic and protozoal infections[2].The action of mechanism for metronidazole has not been fully *** a prodrug,MTZ is inactive until taken up and reduced by anaerobic bacteria and *** is possible that the reduction of Mtz leads to the production of toxic metabolites,which bind to deoxyribonucleic acid and electron-transport proteins of microbial pathogens,thus blocking nucleic acid synthesis[3].The impressive potency of MTZ against anaerobic bacteria indicates the potential for killing Mtb under anaerobic conditions.A previous in vitro study demonstrated that MTZ has potent activity against tubercle bacilli under anaerobic conditions[4].In a non-human primate model,MTZ has been shown to prevent reactivation of latent Mtb infection,indicating the in vivo role in targeting Mtb within an anaerobic environment[5].Although there is strong evidence for the role of MTZ in affecting anaerobic bacilli,the mechanism of action has not been elucidated in Mtb considering that MTZ must be catalyzed to a nitro-free radical form with endogenous *** provide insight=into how MTZ is activated in anaerobic Mtb bacilli,we first characterized the nitroreductase gene,Rv3131,and identified the key residue conferring the activation of MTZ in Mtb.

关键词： Tuberculosis action latent

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微塑料与氯氰菊酯农药复合污染对上海青生长的影响

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陕西科技大学学报 2025年第1期43卷 15-22页

作者：花莉王美婷赵丹洋陕西科技大学环境科学与工程学院陕西西安710021 陕西诺正生物科技有限公司陕西渭南715500

针对微塑料与农药复合污染问题,以上海青(Brassica chinensis L)为供试植物,研究传统微塑料聚乙烯(PE MPs)和可降解微塑料聚乳酸(PLA MPs)单独存在及与氯氰菊酯农药复合作用对植物生长影响的差异.结果显示,PE MPs处理组对上海青生长表... 详细信息

针对微塑料与农药复合污染问题,以上海青(Brassica chinensis L)为供试植物,研究传统微塑料聚乙烯(PE MPs)和可降解微塑料聚乳酸(PLA MPs)单独存在及与氯氰菊酯农药复合作用对植物生长影响的差异.结果显示,PE MPs处理组对上海青生长表现出“低促高抑”的规律.而低添加量PLA MPs处理就会对上海青生长产生抑制作用,且抑制效应随微塑料添加量增加而增加.相比微塑料单独污染,氯氰菊酯农药联合作用对上海青生长的抑制作用影响更显著.PLA MPs对上海青的胁迫作用大于PE MPs,需要对可降解微塑料的环境行为开展进一步评估.

关键词：微塑料氯氰菊酯农药复合污染生物量生理生化指标

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Phase-matching quantum key distribution with light source monitoring

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Chinese Physics B 2022年第5期31卷 165-172页

作者： wen-ting Li Le Wang Wei Li Sheng-mei Zhao Institute of Signal Processing Transmission Nanjing University of Posts and TelecommunicationsNanjing 210003China Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Ministry of EducationNanjing 210003China

The transmission loss of photons during quantum key distribution(QKD)process leads to the linear key rate bound for practical QKD systems without quantum *** matching quantum key distribution(PM-QKD)protocol,an novel QKD protocol,can overcome the constraint with a measurement-device-independent structure,while it still requires the light source to be *** assumption is not guaranteed in practice,leading to practical secure *** this paper,we propose a modified PM-QKD protocol with a light source monitoring,named PM-QKD-LSM protocol,which can guarantee the security of the system under the non-ideal source *** results show that our proposed protocol performs almost the same as the ideal PM-QKD protocol even considering the imperfect factors in practical ***-LSM protocol has a better performance with source fluctuation,and it is robust in symmetric or asymmetric cases.

关键词： phase-matching quantum key distribution source fluctuation light source monitoring

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福建冠豸山野生铁皮石斛的显微鉴定

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亚热带植物科学 2015年第2期44卷 123-126页

作者：黄泽豪温婷梅郭家欣梁一池福建中医药大学药学院福建福州350122 福建中医药大学附属第二人民医院福建福州350003 厦门市海沧区新阳街道社区卫生服务中心福建厦门360122

对福建连城冠豸山开展野生铁皮石斛Dendrobium officinale实地调查,发现当地有铁皮石斛分布。对其茎、叶组织构造及茎的显微粉末特征等进行观察,结果表明,铁皮石斛茎维管束外侧的纤维群呈帽状,草酸钙针晶束于近表皮处多见,粉末中含针晶... 详细信息

对福建连城冠豸山开展野生铁皮石斛Dendrobium officinale实地调查,发现当地有铁皮石斛分布。对其茎、叶组织构造及茎的显微粉末特征等进行观察,结果表明,铁皮石斛茎维管束外侧的纤维群呈帽状,草酸钙针晶束于近表皮处多见,粉末中含针晶束的黏液细胞以及纤维束外具有含硅质块的细胞等特征可作为该药正确鉴别的依据。

关键词：铁皮石斛显微鉴定福建冠豸山

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Persistent postoperative hypotension caused by subclinical empty sella syndrome after a simple surgery:A case report

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World Journal of Clinical Cases 2023年第24期11卷 5817-5822页

作者： Kang-mei Zhao Jia-Sheng Hu Sheng-mei Zhu ting-ting wen Xiang-Ming Fang Department of Anesthesiology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Anesthesiology Sanmen People’s HospitalSanmen 317100Zhejiang ProvinceChina

BACKGROUND Empty sella is an anatomical and radiological finding of the herniation of the subarachnoid space into the pituitary fossa leading to a flattened pituitary *** with empty sella may present with various symptoms,including headache due to intracranial hypertension and endocrine symptoms related to the specific pituitary hormones ***,we report a female patient who developed persistent postoperative hypotension caused by subclinical empty sella syndrome after a simple *** SUMMARY A 47-year-old woman underwent vocal cord polypectomy under general anesthesia with endotracheal *** denied any medical history,and her vital signs were normal before the *** and surgery were ***,she developed dizziness,headache and persistent hypotension in the ***,intravenous dopamine was started to maintain normal blood pressure,which improved her ***,she remained dependent on dopamine for over 24 h without any obvious anesthesia-and surgery-related *** endocrine etiology was then suspected,and further examination showed a high prolactin level,a low normal adrenocorticotropic hormone level and a low cortisol *** resonance imaging of the brain revealed an empty ***,she was diagnosed with empty sella syndrome and secondary adrenal *** symptoms disappeared one week later after daily glucocorticoid *** Endocrine etiologies such as pituitary and adrenal-related dysfunction should be considered in patients showing persistent postoperative hypotension when anesthesia-and surgery-related factors are excluded.

关键词： Empty sella syndrome Perioperative hypotension Secondary adrenal insufficiency Adrenocorticotropic hormone Cortisol Case report

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云南省城市土地利用效率与土地生态安全耦合协调研究

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国土与自然资源研究 2025年第1期 1-7页

作者：温婷杨诗琴云南财经大学国土资源与持续发展研究所云南昆明650221

为深入探究城市土地利用效率与土地生态安全之间的关系,探索出一条既能实现土地高效合理利用又能保护土地生态安全的可持续发展之路。以云南省为例,在构建城市土地利用效率及土地生态安全相应指标体系的基础上,综合运用SBM-Undesirable... 详细信息

为深入探究城市土地利用效率与土地生态安全之间的关系,探索出一条既能实现土地高效合理利用又能保护土地生态安全的可持续发展之路。以云南省为例,在构建城市土地利用效率及土地生态安全相应指标体系的基础上,综合运用SBM-Undesirable模型、综合指数法及耦合协调度模型测算云南省城市土地利用效率与土地生态安全水平及两者的耦合协调度及其时空变化特征。结果表明,(1)2006-2021年云南省城市土地利用效率呈现波动上升的变化趋势,研究期间均值为0.92,总体状况较好。(2)2006-2021年云南省城市土地生态安全水平总体呈现上升趋势,经历了“不安全-较不安全-临界安全-较安全”四个阶段,由2006年的0.18提升至2021年的0.77,土地生态安全水平显著提升。(3)2006-2021年,云南省城市土地利用效率与土地生态安全耦合协调度呈现波动上升的趋势,经历“轻度失调-初步协调-中级协调-良好协调-优质协调”5个阶段,空间格局上呈现西北、中部高,西南、东部地区较低的特征。总体来看,研究期间云南省大部分地区城市土地利用效率与土地生态安全处于协调阶段。

关键词：城市土地利用效率城市土地生态安全耦合协调

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2D/2D Heterostructures:Rational Design for Advanced Batteries and Electrocatalysis

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Energy & Environmental Materials 2022年第1期5卷 115-132页

作者： Jun mei ting Liao Ziqi Sun School of Chemistry and Physics Queensland University of Technology2 George StreetBrisbane Qld 4000Australia School of Mechanical Medical and Process Engineering Queensland University of Technology2 George StreetBrisbane Qld 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbane Qld 4000Australia

Two-dimensional/two-dimensional(2D/2D)heterostructures consisting of two or more 2D building blocks possess intriguing electronic features at the nanosized interfacial regions,endowing the possibility for effectively modulating the confinement,and transport of charge carriers,excitons,photons,phonons,*** bring about a wide range of extraordinary physical,chemical,thermal,and/or mechanical *** rational design and synthesis of 2D/2D heterostructures,electrochemical properties for advanced batteries and electrocatalysis can be well regulated to meet some practical *** this review,a summary on the commonly employed synthetic strategies for 2D/2D heterostructures is first given,followed by a comprehensive review on recent progress for their applications in batteries and various electrocatalysis ***,a critical outlook on the current challenges and promising solutions is presented,which is expected to offer some insightful ideas on the design principles of advanced 2D-based nanomaterials to address the current challenges in sustainable energy storages and green fuel generations.

关键词： 2D heterostructures 2D nanomaterials battery electrocatalysis energy storage

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Adaptive strategy of Nitraria sibirica to transient salt,alkali and osmotic stresses via the alteration of Na+/K+fluxes around root tips

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Journal of Forestry Research 2023年第2期34卷 425-432页

作者： Xindi mei ting Dai Yingbai Shen Xinjiang Key Laboratory of Biological Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqi 830046People’s Republic of China National Engineering Laboratory for Tree Breeding Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental PlantsMinistry of EducationThe Tree and Ornamental Plant Breeding and Biotechnology Laboratory of National Forestry and Grassland AdministrationCollege of Biological Sciences and BiotechnologyBeijing Forestry UniversityBeijing 100083People’s Republic of China

Nitraria sibirica *** an important shrub with a strong salt-alkali tolerance,but the mechanism underlying this tolerance remains *** this study,***,with salt-sensitive Vigna radiata(Linn.)Wilczek as the control,was subjected to transient salt stress(100 mM NaCl),alkali stress(50 mM Na_(2)CO_(3)),and osmotic stress(175 mM mannitol).The ionic fluxes of Na^(+)and K^(+)in the root apical region were *** show that,under salt and alkali stress,*** roots exhibited higher capacities to limit Na+influx and reduce K+efflux,thereby resulting in lower Na^(+)/K^(+)ratios compared with *** *** stress induced stronger Na^(+)influx and K+efflux in the root salt stress treatment;Na^(+)influx was mainly observed in the root cap,while K^(+)efflux was mainly observed in the elongation *** under osmotic stress,*** roots showed stronger Na+efflux and weaker K+efflux than *** ***+efflux was mainly observed in the root elongation zone,while K+efflux was in the root *** results reveal the ionic strategy of *** in response to transient salt,alkali,and osmotic stresses through the regulation of Na+/K+flux homeostasis.

关键词： Nirtaria sibirica Na^(+)/K^(+)fl uxes Na^(+)/K^(+)ratios Salt stress Alkali stress Osmotic stress

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-mei Song Yu-Ze Li wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Permafrost change in Northeast China in the 1950s-2010s

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Advances in Climate Change Research 2021年第1期12卷 18-28页

作者： ZHANG Zhong-Qiong WU Qing-Bai HOU mei-ting TAI Bo-wen AN Yu-Ke State Key Laboratory of Frozen Soils Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou730000China China Meteorological Administration Training Centre Beijing100081China Gansu Province Transportation Planning Survey&Design Institute Limited Liability CompanyLanzhou730000China

Permafrost in Northeast China is highly sensitive to climate *** degradation significantly affects forest and vegetation ecosystems,as well as the safety of engineering projects and other man-made ***,the permafrost change in the region is still *** study uses metrological data from 258 weather stations,alongside reanalysis data,and other environmental data to investigate permafrost degradation and its related environmental impacts in Northeast China from the 1950s to *** show that the total permafrost area decreased from 4.8×10^(5)to 3.1×10^(5)km^(2)from the 1950s to the *** southern limit of permafrost moved 0.1-1.1°northward,and its average elevation rose 160.5 *** the study period,the degradation of predominantly continuous permafrost,and discontinuous and island permafrost was more pronounced than that of sparsely island *** south boundary of those three permafrost zones northward by 0-3.4°,0-5.5°and 0.4-1.1°,the average altitude raised by 339.2 m,208.3 m,67.1 *** permafrost degradation shows the elevation and latitude *** degradation is mainly caused by the rising of surface temperatures and the impacts of other environmental *** snowfall warming the ground of 1.1-10.2℃in cold seasons and rainfall cooling on surface conditions in warm seasons,those may result in temporal and spatial differences in permafrost ***,there are lack of researches in the impact of environment factors on soil temperatures,moisture and permafrost degradation.

关键词： Northeast China Climate warming Permafrost degradation Impact of environmental factors

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