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运动性低血色素大鼠小肠铁吸收蛋白DMT1和FPN1表达的变化

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中国运动医学杂志 2009年第5期28卷 515-517,514页

作者：刘玉倩王海涛赵斌袁克星闻剑飞刘树欣河北师范大学体育学院石家庄050016

目的:研究运动性低血色素大鼠小肠铁吸收蛋白二价金属离子转运体1(divalent metal transporter1,DMT1)和膜铁转运蛋白1(ferroportin1,FPN1)表达的变化,探讨运动性低血色素的发生机制。方法:12只雄性Wistar大鼠随机分为对照组(CG)和实验... 详细信息

目的:研究运动性低血色素大鼠小肠铁吸收蛋白二价金属离子转运体1(divalent metal transporter1,DMT1)和膜铁转运蛋白1(ferroportin1,FPN1)表达的变化,探讨运动性低血色素的发生机制。方法:12只雄性Wistar大鼠随机分为对照组(CG)和实验组(EG)。实验组进行5周跑台训练,建立运动性低血色素模型。5周递增负荷跑台运动后,检测两组大鼠血常规和血清铁,采用Western Blot检测小肠上皮细胞DMT1和FPN1表达。结果:(1)实验组Hb显著低于对照组(P<0.01),运动性低血色素造模成功。(2)实验组大鼠小肠上皮细胞DMT1表达比对照组显著降低(P<0.05),FPN1表达比对照组显著下降(P<0.01)。(3)实验组血清铁和转铁蛋白饱合度显著低于对照组(P<0.05,P<0.01)。结论:长时间大强度运动会减少机体肠铁吸收,降低机体运铁能力,是引发运动性低血色素的原因之一。

关键词：运动性低血色素小肠吸收细胞二价金属离子转运体1 膜铁转运蛋白1

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补充白藜芦醇对小鼠抗氧化能力的影响

河北师范大学学报（自然科学版） 2011年第2期35卷 188-191页

作者：闻剑飞于树宏金凤霞刘玉倩袁克星王海涛河北师范大学体育学院河北石家庄050024 合肥师范学院体育科学系安徽合肥230061 河北医科大学药学院河北石家庄050017

观察补充白藜芦醇(resveratrol,Res)对小鼠骨骼肌、心肌、肝脏、脑组织及血清中抗氧化指标的影响.24只雄性昆明种小鼠随机分为安静对照组(C)、运动对照组(M)、运动+白藜芦醇组(R),每组8只.R组每天给予Res10 mg/kg灌胃,连续进行2周;2周后... 详细信息

观察补充白藜芦醇(resveratrol,Res)对小鼠骨骼肌、心肌、肝脏、脑组织及血清中抗氧化指标的影响.24只雄性昆明种小鼠随机分为安静对照组(C)、运动对照组(M)、运动+白藜芦醇组(R),每组8只.R组每天给予Res10 mg/kg灌胃,连续进行2周;2周后M和R组进行一次坡度为0°、速度为18 m/min、持续时间120 min的跑台运动,跑台运动后24 h测定小鼠血清、腓肠肌、心肌、肝脏及脑中超氧化物歧化酶(SOD)、丙二醛(MDA)含量.结果显示:与C组相比,M组除脑组织外,血清、腓肠肌、心肌、肝脏组织中MDA含量均明显升高(P<0.01),SOD活性明显降低(P<0.01);与M组相比,R组除脑组织外,其他各组织中MDA含量明显降低(P<0.05),SOD活性明显升高(P<0.01).由此可知,白藜芦醇可提高小鼠各组织中SOD活性,抑制脂质过氧化,增强机体的抗氧化能力,延缓机体疲劳的发生.

关键词：白藜芦醇自由基抗氧化能力

健脾益肾泄浊活血方治疗糖尿病肾病Ⅳ期临床研究

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新中医 2022年第10期54卷 110-115页

作者：刘刚王小强张俊峰戴丹霞李林温建飞北京市怀柔区中医医院内分泌肾病科北京101400

目的:观察健脾益肾泄浊活血方对糖尿病肾病Ⅳ期尿微量白蛋白/尿肌酐、血肌酐(SCr)、血清胱抑素C(Cys-C)的临床疗效。方法:将80例2型糖尿病肾病Ⅳ期患者随机分为治疗组和对照组各40例。对照组采用西医基础治疗,治疗组在对照组治疗方案的... 详细信息

目的:观察健脾益肾泄浊活血方对糖尿病肾病Ⅳ期尿微量白蛋白/尿肌酐、血肌酐(SCr)、血清胱抑素C(Cys-C)的临床疗效。方法:将80例2型糖尿病肾病Ⅳ期患者随机分为治疗组和对照组各40例。对照组采用西医基础治疗,治疗组在对照组治疗方案的基础上加用健脾益肾泄浊活血方治疗,2组疗程均为3个月,观察2组治疗前后中医证候评分、尿微量白蛋白/尿肌酐、血白蛋白、SCr、Cys-C的变化情况。结果:治疗后,治疗组尿微量白蛋白/尿肌酐明显低于治疗前,差异有统计学意义(P0.05)。治疗组40~49岁、50~59岁患者治疗后SCr及Cys-C均有下降,治疗前后比较,差异均有统计学意义(P0.05)。对照组40~49岁、50~59岁、60~70岁患者SCr及Cys-C治疗前后比较,差异均无统计学意义(P>0.05)。治疗后,治疗组40~49岁、50~59岁患者SCr及Cys-C分别与对照组同年龄段比较,差异均有统计学意义(P0.05)。治疗后,中医证候总有效率治疗组92.5%,对照组62.5%,差异有统计学意义(P<0.01)。临床疗效总有效率治疗组90.0%,对照组65.0%,差异有统计学意义(P<0.01)。结论:在西医基础治疗方案的基础上加用健脾益肾泄浊活血方可明显改善糖尿病肾病Ⅳ期的临床症状,减少蛋白尿,可以降低60岁以下患者SCr、Cys-C水平,延缓肾病进展。

关键词：糖尿病肾病Ⅳ期健脾益肾泄浊活血方尿微量白蛋白/尿肌酐血肌酐胱抑素

Changes in Vegetation and Assessment of Meteorological Conditions in Ecologically Fragile Karst Areas

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Journal of Meteorological Research 2021年第1期35卷 172-183页

作者： Yanli CHEN Weihua MO Yonglin HUANG jianfei MO Xiaohan HUANG Xiumei wen Institute of Meteorological Sciences Guangxi Zhuang Autonomous Region(GZAR)Meteorological BureauNanning 530022 Hechi Meteorological Service GZAR Meteorological BureauHechi 547000 College of Geography and Planning Nanning Normal UniversityNanning 530001

Meteorological conditions have an important impact on changes of vegetation in ecologically fragile karst *** study aims to explore a method for quantitative evaluation of these meteorological conditions. We analyzed the changing trend of vegetation during 2000–2018 and the correlations between vegetation changes and various meteorological factors in karst rocky areas of Guangxi Zhuang Autonomous Region, China. Key meteorological factors in vegetation areas with varying degrees of improvement were selected and evaluated at seasonal timescale. A quantitative evaluation model of comprehensive influences of meteorological factors on vegetation was built by using the partial least-square regression(PLS). About 91.45% of the vegetation tended to be improved, while only the rest 8.55% showed a trend of degradation from 2000 to 2018. Areas with evident vegetation improvement were mainly distributed in the middle and northeast, and those with obvious vegetation degradation were scattered. Meteorological factors affecting vegetation were significantly different among the four seasons. Overall, high air humidity, small temperature difference in spring and autumn, and low daily minimum temperature and air pressure were favorable conditions. Low temperature in winter as well as high temperature in summer and autumn were unfavorable conditions. The Climate Vegetation Index(CVI) model was established by PLS using the maximum, minimum, and average temperatures;vapor pressure;rainfall;and air pressure as key meteorological factors. The Enhanced Vegetation Index(EVI) was well fitted by the CVI model, with the average coefficient of determination(r2) and root mean square error(RMSE) of 0.856 and 0.042, respectively. Finally, an assessment model of comprehensive meteorological conditions was built based on the interannual differences in CVI. The meteorological conditions in the study area in 2014 were successfully evaluated by combining the model and selected seasonal key meteo

关键词： karst rocky area vegetation change ecologically fragile meteorological conditions

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AI赋能的生物医学研究

科学 2024年第3期76卷 26-31页

作者：温砚中韩樾夏孙剑飞东南大学生物科学与医学工程学院南京211189 中国科学院空间应用工程与技术中心北京100094

近十多年来,以机器学习和深度学习为代表的AI技术迎来了蓬勃发展期,广泛赋能于多个学科领域。与此同时,面向生物医学领域的AI应用研究在科学家们的不懈努力下逐渐成熟。生物医学迈入了AI赋能的新时代,未来的科学实践和创新发现迎来了更... 详细信息

近十多年来,以机器学习和深度学习为代表的AI技术迎来了蓬勃发展期,广泛赋能于多个学科领域。与此同时,面向生物医学领域的AI应用研究在科学家们的不懈努力下逐渐成熟。生物医学迈入了AI赋能的新时代,未来的科学实践和创新发现迎来了更多机遇与挑战。

关键词：人工智能生物医学大数据自动分析预测

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低氧训练对青年女性骨密度的影响研究

阜阳师范大学学报（自然科学版） 2020年第3期37卷 96-100页

作者：邵梦霓闻剑飞况敬凯王波王志红李佳锡合肥师范学院体育科学学院安徽合肥230601

为分析低氧训练对青年女性骨密度的影响,本文将29名女大学生随机分成持续低氧组、持续常氧组,每周训练3次,每次持续40 min的中等强度低氧或常氧跑台训练,6周后观察运动前后体成分和骨密度相关指标的变化。结果表明6周运动后两组体重未... 详细信息

为分析低氧训练对青年女性骨密度的影响,本文将29名女大学生随机分成持续低氧组、持续常氧组,每周训练3次,每次持续40 min的中等强度低氧或常氧跑台训练,6周后观察运动前后体成分和骨密度相关指标的变化。结果表明6周运动后两组体重未有明显变化(P>0.05),两组的骨密度指标与运动前相较均有升高(P0.05)。因此,持续6周中等强度的低氧训练在控制青年女性体重的同时可以提高跟骨的骨密度。

关键词：低氧训练青年女性骨密度控制体重

Mesopause temperatures and relative densities at midlatitudes observed by the Mengcheng meteor radar

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Earth and Planetary Physics 2023年第6期7卷 665-674页

作者： wen Yi XiangHui Xue MaoLin Lu Jie Zeng HaiLun Ye jianfei Wu Chong Wang TingDi Chen Chinese Academy of Sciences Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China Mengcheng National Geophysical Observatory School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for the Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Hefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The atmospheric temperatures and densities in the mesosphere and lower thermosphere(MLT)region are essential for studying the dynamics and climate of the middle and upper *** this study,we present more than 9 years of mesopause temperatures and relative densities estimated by using ambipolar diffusion coefficient measurements observed by the Mengcheng meteor radar(33.4°N,116.5°E).The intercomparison between the meteor radar and Thermosphere Ionosphere Mesosphere Energetics and Dynamics/Sounding of the Atmosphere by Broadband Emission Radiometry(TIMED/SABER)and Earth Observing System(EOS)Aura/Microwave Limb Sounder(MLS)observations indicates that the meteor radar temperatures and densities agree well with the simultaneous satellite *** variations dominate the mesopause temperatures,with the maximum during winter and the minimum during *** mesopause relative densities also show annual variations,with strong maxima near the spring equinox and weak maxima before the winter solstice,and with a minimum during *** addition,the mesopause density exhibits a structure similar to that of the zonal wind:as the zonal wind flows eastward(westward),the mesopause density decreases(increases).At the same time,the meridional wind shows a structure similar to that of the mesopause temperature:as the meridional wind shows northward(southward)enhancements,the mesopause temperature increases(decreases).Simultaneous horizontal wind,temperature,and density observations provide multiple mesospheric parameters for investigating mesospheric dynamics and thermodynamic processes and have the potential to improve widely used empirical atmospheric models.

关键词： meteor radar mesopause horizontal wind temperature density

A comparison of MLT wind between meteor radar chain data and SDWACCM results

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Earth and Planetary Physics 2022年第5期6卷 451-464页

作者： BaoZhu Zhou XiangHui Xue wen Yi HaiLun Ye Jie Zeng JinSong Chen jianfei Wu TingDi Chen XianKang Dou CAS Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China Mengcheng National Geophysical Observatory School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for the Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Hefei 230026China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Electronic Information School Wuhan UniversityWuhan 430072China

A meteor radar chain located along the 120°E meridian in the Northern Hemisphere from low to middle latitudes provides longterm horizontal wind observations of the mesosphere and lower thermosphere(MLT)*** this study,we report a seasonal variation and its latitudinal feature in the horizontal mean wind in the MLT region observed by six meteor radar instruments located at Mohe(53.5°N,122.3°E),Beijing(40.3°N,116.2°E),Mengcheng(33.4°N,116.5°E),Wuhan(30.6°N,114.4°E),Kunming(25.6°N,108.3°E),and Fuke(19.5°N,109.1°E)*** addition,we compare the wind in the MLT region measured by the meteor radar stations with those simulated by the Whole Atmosphere Community Climate Model(WACCM).In general,the WACCM appears to capture well the seasonal and latitudinal variations in the zonal wind *** particular,the temporal evolution of the eastward zonal wind maximum shifts from July to May as the latitude ***,the simulated WACCM meridional wind exhibits differences from the meteor radar observations.

关键词： meteor radar chain MLT horizontal wind tide SD-WACCM

Effects of mepiquat chloride and plant population density on leaf photosynthesis and carbohydrate metabolism in upland cotton

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Journal of Cotton Research 2023年第4期6卷 250-265页

作者： LUO Haihua ZHANG Zhengxian WU jianfei WU Zhenjiang wen Tianwang TANG Feiyu Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of EducationCollege of AgronomyJiangxi Agricultural UniversityNanchang 330045China Jiangxi Institute for Industrial Crops Research Jiujiang 332005China

Background Mepiquat chloride(MC)application and plant population density(PPD)increasing are required for modern cotton ***,their interactive effects on leaf physiology and carbohydrate metabolism remain *** study aimed to examine whether and how MC and PPD affect the leaf morpho-physiological characteristics,and thus final cotton *** of three levels(D1:2.25 plants·m^(-2),D2:4.5 plants·m^(-2),and D3:6.75 plants·m^(-2))and MC dosage of two levels(MC0:0 g·ha^(-2),MC1:82.5 g·ha^(-2))were combined to create six *** dynamics of nonstructual carbohydrate concentration,carbon metabolism-related enzyme activity,and photosynthetic attributes in cotton leaves were examined during reproductive growth in 2019 and *** Among six treatments,the high PPD of 6.75 plants·m^(-2)combined with MC application(MC1D3)exhibited the greatest seed cotton yield and biological *** sucrose,hexose,starch,and total nonstructural carbohydrate(TNC)concentrations peaked at the first flowering(FF)stage and then declined to a minimum at the first boll opening(FBO)*** with other treatments,MC1D3 improved starch and TNC concentration by 5.4%~88.4%,7.8%~52.0% in 2019,and by 14.6%~55.9%,13.5%~39.7% in 2020 at the FF stage,***,MC1D3 produced higher transformation rates of starch and TNC from the FF to FBO stages,indicating greater carbon production and utilization ***1D3 displayed the maximal specific leaf weight(SLW)at the FBO stage,and the highest chlorophyll a(Chl a),Chl b,and Chl a+b concentration at the mid-late growth phase in both *** Rubisco activity with MC1D3 was 2.6%~53.2% higher at the flowering and boll setting stages in both years,and 2.4%~52.7% higher at the FBO stage in 2020 than those in other *** results provided a explanation of higher leaf senescence-resistant ability in *** Increasing PPD coupled with MC application improves cotton yield by enhancing leaf car

关键词： Gossypium hirsutum L. Mepiquat chloride Plant population density Carbohydrate metabolism Photosynthesis