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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling wen jian-xuan WU Li-yan ZENG hui-yan ZHANG jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE jia-li XIE wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG jie-er GAO Zhi-juan wen Ze-huai LI Chun-ji OUYANG wen-wei LI Geng WU Ming-hui LI An-xiang HUANG jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

Effect of SARS-CoV-2 infection on semen parameters in sperm bank volunteers with normal sperm concentration

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Asian Journal of Andrology 2024年第3期26卷 328-332页

作者： Li Wang wen-Kai Han Xiao-hui Song Qi-Lin Zhang An-Quan Guan Yuan Gao jin-Long Ma Center for Reproductive Medicine Shandong UniversityJinan 250001China State Key Laboratory of Reproductive Medicine and Offspring Health ShandongUniversityJinan 250001China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250001China Shandong KeyLaboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250001China Shandong Provincial Clinical Research Center for Reproductive Health Jinan 250001China Shandong Technology Innovation Center for Reproductive Health Jinan 250001China NationalResearch Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250001China Research Unit of Gametogenesis andHealth of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250001China

In this study,we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection on *** study comprised 110 sperm volunteers who self-reported SARS-CoV-2 infection from the Human Sperm Bank ofthe Center for Reproductive Medicine,Shandong University(jinan,China).The volunteers had normal sperm concentration *** volunteer provided semen samples before and after *** selected 90 days after infection as the cutoff *** parameters within 90 days after infection of 109 volunteers(group A)were compared with semen parameters before ***,semen parameters on or after 90 days after infection of 36 volunteers(group B)were compared with semen parameters ***,based on whether the volunteers had completed the three-dose SARS-CoV-2 vaccination booster,volunteersin group A and B were further divided into two subgroups *** parameters were compared before and after infection ineach *** results showed that in this cohort population,the semen quality in volunteers with normal sperm concentrationsbefore infection decreased after SARS-CoV-2 infection within 90 days,while the semen quality returned to preinfection levels after *** completion of a three-dose SARS-CoV-2 vaccination booster may exert a protective effect on semen quality after infection.

关键词： SARS-CoV-2 SARS-CoV-2 vaccination semen quality sperm donation sperm parameters

Basic Survey Scheduling for the Wide Field Survey Telescope(WFST)

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Research in Astronomy and Astrophysics 2024年第1期24卷 59-69页

作者： Yan-Peng Chen ji-An jiang wen-Tao Luo Xian-Zhong Zheng Min Fang Chao Yang Yuan-Yu Hong Zong-Fei Lü Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Astronomy University of Science and Technology of ChinaHefei 230026China National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China

Aiming at improving the survey efficiency of the Wide Field Survey Telescope, we have developed a basic scheduling strategy that takes into account the telescope characteristics, observing conditions, and weather conditions at the Lenghu site. The sky area is divided into rectangular regions, referred to as “tiles,” with a size of2°. 577 × 2°. 634 slightly smaller than the focal area of the mosaic CCDs. These tiles are continuously filled in annulars parallel to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, plays a significant role in determining the accessible survey fields. Approximately 50connected tiles are grouped into one block for observation. To optimize the survey schedule, we perform simulations by taking into account the length of exposures, data readout, telescope slewing, and all relevant observing conditions. We utilize the Greedy Algorithm for scheduling optimization. Additionally, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are located outside of the 3° field of view. This dithering pattern helps to achieve relatively uniform exposure maps for the final survey outputs.

关键词： telescopes surveys Moon

泵导叶出口宽度改型设计的变工况计算及实验研究

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热科学与技术 2014年第1期13卷 81-86页

作者：冀春俊赵宝德冀文慧孙琦大连理工大学能源与动力学院辽宁大连116024 大连中意透平科技发展有限公司辽宁大连116024

利用先进的CFD数值模拟软件NUMECA,对某余热排出泵的原模型进行了设计工况下的内部流场全通道数值模拟,结合对数值结果的分析,发现泵导叶出口宽度对泵的性能和内部流动有较大的影响,通过对泵导叶出口宽度的改型设计得到了较为理想的导... 详细信息

利用先进的CFD数值模拟软件NUMECA,对某余热排出泵的原模型进行了设计工况下的内部流场全通道数值模拟,结合对数值结果的分析,发现泵导叶出口宽度对泵的性能和内部流动有较大的影响,通过对泵导叶出口宽度的改型设计得到了较为理想的导叶宽度,进而对原模型和优化模型进行了变工况计算并与实验结果进行了对比分析。结果表明,经过改进的导叶在设计点附近的变工况性能得到了提高,验证了对导叶出口宽度改型设计的合理性。

关键词：余热排出泵导叶宽度改型变工况计算实验研究

Regulating Actuations and Shapes of Liquid Crystal Elastomers through Combining Dynamic Covalent Bonds with Cooling-Rate-Mediated Control

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Chinese Journal of Polymer Science 2024年第10期42卷 1442-1448,I0008页

作者： Ya-wen Liu Huan Liang Hong-Tu Xu En-jian He Zhi-Jun Yang Yi-Xuan Wang Yen Wei Zhen Li Yan ji The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China Advanced Materials and Energy Center Academy of Aerospace Science and InnovationBeijing100088China

Realizing multiple locked shapes in pre-oriented liquid crystal elastomers(LCEs)is highly desired for diversifying deformations and enhancing ***,conventional LCEs only deform between two shapes for each actuation cycle upon liquid crystal-isotropic phase transitions induced by external ***,we propose to regulate the actuation modes and the locked shapes of a pre-orientated epoxy LCE by combining dynamic covalent bonds with cooling-rate-mediated *** actuation modes can be adjusted on demand by exchange reactions of dynamic covalent *** from the established actuation modes,such as elongation,bending,and spiraling,the epoxy LCE displays varied locked shapes at room temperature under different cooling *** mediums are utilized to control the cooling rate,including water,silicone oil,and copper *** approach provides a novel way for regulating the actuation modes and locked shapes of cuttingedge intelligent devices.

关键词： Liquid crystal elastomer Epoxy Dynamic covalent bond Vitrimer Cooling rate

黄色粘虫板对温室黄瓜烟粉虱成虫的诱集作用和控制效果

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中国农业科学 2006年第9期39卷 1934-1939页

作者：侯茂林卢伟文吉辉中国农业科学院植物保护研究所/植物病虫害生物学国家重点实验室中国农业科学院植物保护研究所/植物病虫害生物学国家重点实验室北京100094

【目的】提高黄色粘虫板(黄板)对温室黄瓜烟粉虱成虫的诱集效果。【方法】设置黄板方向、大小、高度和密度不同处理,研究了黄板对烟粉虱成虫诱集量的影响及对烟粉虱成虫种群的控制效果。【结果】黄板方向对诱集量没有显著影响,但是平行... 详细信息

【目的】提高黄色粘虫板(黄板)对温室黄瓜烟粉虱成虫的诱集效果。【方法】设置黄板方向、大小、高度和密度不同处理,研究了黄板对烟粉虱成虫诱集量的影响及对烟粉虱成虫种群的控制效果。【结果】黄板方向对诱集量没有显著影响,但是平行作物行垂直悬挂黄板的诱集量稍高于垂直作物行垂直悬挂和水平悬挂黄板的诱集量(分别高28.5%和21.0%)。黄板大小对诱集量有显著影响,25cm×30cm黄板诱集量显著高于15cm×20cm黄板,单位面积诱集量20cm×25cm黄板最高。黄板高度对诱集量也有显著影响,黄瓜冠层和冠层下部15cm处黄板诱集量显著高于冠层上部50cm处的诱集量。黄板对温室内烟粉虱成虫种群具有明显的控制效果,每10m2设置1.5块黄板第5天和第10天的烟粉虱成虫减退率分别为56.0%和83.8%,校正防治效果分别达到71.1%和88.1%。【结论】黄板诱杀可有效控制温室黄瓜烟粉虱成虫种群。

关键词：黄色粘虫板烟粉虱温室黄瓜诱杀

Risk Factors and Predictive Nomogram for Survival in Elderly Patients with Brain Glioma

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Current Medical Science 2024年第4期44卷 759-770页

作者： Zhi-cheng FAN wen-jian ZHAO Yang jiAO Shao-chun GUO Yun-peng KOU Min CHAO Na WANG Chen-chen ZHOU Yuan WANG jing-hui LIU Yu-long ZHAI Pei-gang ji Chao FAN Liang WANG Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China Department of Neurosurgery Shannxi University of Chinese MedineXianyang 712046China Department of Neurosurgery Xi'an Medical UniversityXi'an 710021China

Objective To determine the factors that contribute to the survival of elderly individuals diagnosed with brain glioma and develop a prognostic *** Data from elderly individuals(age≥65 years)histologically diagnosed with brain glioma were sourced from the Surveillance,Epidemiology,and End Results(SEER)*** dataset was randomly divided into a training cohort and an internal validation cohort at a 6:4 ***,data obtained from Tangdu Hospital constituted an external validation cohort for the *** identification of independent prognostic factors was achieved through the least absolute shrinkage and selection operator(LASSO)and multivariate Cox regression analysis,enabling the construction of a *** performance was evaluated using C-index,ROC curves,calibration plot and decision curve analysis(DCA).Results A cohort of 20483 elderly glioma patients was selected from the SEER *** prognostic factors(age,marital status,histological type,stage,and treatment)were found to significantly impact overall survival(OS)and cancer-specific survival(CSS),with tumor location emerging as a sixth variable independently linked to ***,nomogram models were developed to predict the probabilities of survival at 6,12,and 24 *** assessment findings from the validation queue indicate a that the model exhibited strong *** Our nomograms serve as valuable prognostic tools for assessing the survival probability of elderly glioma *** can potentially assist in risk stratification and clinical decision-making.

关键词： elderly brain glioma Surveillance,Epidemiology,and End Results(SEER) nomogram prognosis prediction model

Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： HONG Geum-Lan KIM Kyung-Hyun CHO Sung-Pil LEE hui-Ju KIM Yae-ji JUNG Ju-Young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

Floquet-Engineering Topological Phase Transition in Graphene Nanoribbons by Light

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Chinese Physics Letters 2024年第9期41卷 69-87页

作者： Anhua Huang Shasha Ke ji-Huan Guan Jun Li wen-Kai Lou SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-electronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Department of Physics School of Physical Science and TechnologyXiamen UniversityXiamen 361005China

Quasi-one-dimensional(1D)graphene nanoribbons(GNRs)play a crucial role in advancement of nextgeneration *** studies have suggested their potential to exhibit unique symmetry-protected topological phases defined by a𝑍2 *** employing both the tight-binding model and the Floquet theory,our investigation demonstrates the effective control of the topological phase within quasi-1D armchair GNRs(AGNRs)using elliptically polarized light,unveiling rich topological phase ***,we observe that varying the amplitude of the light can induce transitions in the band gap(𝐸g)of AGNRs,leading to multiple changes in the system’s𝑍2 ***,for heterojunctions composed of different AGNR segments,the junction state can be either created or eliminated by the application of elliptically polarized light.

关键词： topological polarized Transition