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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi han Jun Xiao Jian-Feng Ma wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang Cheng Yu-han Wang wen-Chao Cheng De-Zhi Yuan wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu wen-Chang Jia Jing wen Xue-Lin Cheng Yan han Ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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基于地理分区的陕北黄土高原生态系统服务权衡/协同的尺度效应研究

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水土保持研究 2025年第1期32卷 305-315页

作者：温昕王继军韩晓佳中国科学院水土保持与生态环境研究中心中国科学院水利部水土保持研究所中国科学院大学西北农林科技大学水土保持研究所中国科学院生态环境研究中心

[目的]明晰生态系统服务的权衡/协同关系，保证生态系统服务长期有效供应，实现流域生态保护与高质量发展。[方法]以典型退耕区陕北黄土高原为例，利用1990—2020年土地利用变化数据，基于InVEST模型量化4种关键生态系统服务即碳储量、... 详细信息

[目的]明晰生态系统服务的权衡/协同关系，保证生态系统服务长期有效供应，实现流域生态保护与高质量发展。[方法]以典型退耕区陕北黄土高原为例，利用1990—2020年土地利用变化数据，基于InVEST模型量化4种关键生态系统服务即碳储量、产水量、土壤保持量和生境质量的时空分布特征，通过相关性分析探讨了各类生态系统服务间的权衡/协同关系和呈现的尺度特征。[结果](1) 1990—2020年碳储量和生境质量处于不断增加的趋势，产水量和土壤保持量呈现先降低后增加总体增加的趋势，空间上呈东南略低西北略高的分布。(2)陕北黄土高原生态系统服务以协同作用为主，且在1990—2020年协同效应不断增强，权衡作用主要发生在产水量与其他生态系统服务之间，权衡作用的区域主要分布在研究区西部和东北部地区。(3)生态系统服务间的权衡/协同作用存在着空间尺度效应，随着空间尺度的增加，相关性逐渐增强而显著性有所下降，且作用关系的方向性会发生改变。[结论]陕北黄土高原生态系统服务以协同为主，生态系统服务间的权衡/协同作用存在着空间尺度效应。

关键词：生态系统服务权衡/协同作用尺度效应地理分区陕北黄土高原

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The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun wen-Biao han Yi-Yang Guo He Wang Minghui Du hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Possibility of measuring spin precession of the nearest supermassive black hole by using S stars

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Research in Astronomy and Astrophysics 2014年第11期14卷 1415-1422页

作者： wen-Biao han Shanghai Astronomical Observatory

The supermassive black hole （SMBH） with a mass of 4 million M⊙ inside the radio source Sgr A＊ in our Galactic center is the nearest SMBH. Once S stars with a shorter period are observed, relativistic precessions especially the Lense-Thirring effect can be measured by astronomical observations at the 10 ~tas level in the future. An interesting but so far unaddressed problem is that the SMBH not only has spin but also spin precession like similar objects. We study the effect of such spin precession on the orbital precessions of orbiting stars. Our results show that the spin precession can produce a periodic oscillation in the precession of the star＇s orbital plane, but has no obvious effect on the periapse shift. For stars with an orbital period of O（0.1） yr or less, such visible oscillations occur when the SMBH＇s spin-precession period ranges from about a few tens of years to hundreds of years. The period of oscillation is the same as the one of the spin precession. In principle, the precession of this oscillating orbital plane can be observed and then the spin and spin precession of the nearest SMBH can be determined.

关键词： black hole physics -- Galaxy center -- relativity

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Distribution and contamination status of chromium in surface sediments of northern Kaohsiung Harbor, Taiwan

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Journal of Environmental Sciences 2013年第7期25卷 1450-1457页

作者： Cheng-Di Dong chiu-wen Chen Chih-Feng Chen Department of Marine Environmental Engineering "National" Kaohsiung Marine University

Thedistribution, enrichment, accumulation, and potential ecological risk of chromium （Cr） in the surface sediments of northern Kaohsiung Harbor, Taiwan, Chinawere investigated. Sediment samples from ten locations located between the river mouths and harbor entrance of northern Kaohsiung Harborwere collected quarterly in 2011 and characterized for Cr, aluminum,water content, organic matter, total nitrogen, total phosphorous, total grease, and grain size. Results showed that the Cr concentrations varied from 27.0 to361.9 mg/kgwith an average of （113.5 ± 87.0） mg/kg. High Cr concentrationwas observed near the Jen-Gen River mouth. The mean Cr concentrationwas high at 255.5 mg/kg,whichwas at least 2 to 7 times than that of other sites. This might imply significant Cr contribution from upstream receiving tannerieswastewater into the Jen-Gen River. The spatialdistribution of Cr reveals relatively high in the river mouth region, especially in Jen-Gen River, and graduallydiminishes toward the harbor entrance region. This indicates that the major sources of Cr pollution from upstream industrial and municipalwastewatersdischarged along the river bank; and Cr maydriftwith sea current and bedispersed into open sea. Moreover, Cr concentrations correlated closely to the physical-chemical properties of the sediments,which suggested the influence of industrial and municipalwastewatersdischarged from the neighboring industrial parks and river basins. Results from the enrichment factor andgeo-accumulation index analyses imply that the Jen-Gen River sediments can be characterized as moderate enrichment and none to medium accumulation of Cr, respectively. However, results of potential ecological risk index indicate that the sediment has low ecological potential risk. The results can provide valuable information todeveloping future strategies for the management of river mouth and harbor.

关键词： accumulation chromium ecological risk enrichment sediment

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Sulfidization regulation of cuprite by pre-oxidation using sodium hypochlorite as an oxidant

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International Journal of Mining Science and Technology 2021年第6期31卷 1117-1128页

作者： Guang han Shuming wen han Wang Qicheng Feng State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resources EngineeringKunming University of Science and TechnologyKunming 650093China

The direct sulfidization of cuprite is inefficient because cuprite is a copper-oxide mineral with a strong surface *** this study,oxidant was used to modify cuprite surfaces to regulate the sulfidization of *** tests showed that the flotation recovery of pre-oxidized cuprite was nearly25% higher than that of direct sulfidization flotation,which indicates that the cuprite surface activity was enhanced after pre-oxidation by Cu(Ⅰ) species(weak affinity with sulfur ions) transformation to Cu(Ⅱ)species(strong affinity with sulfur ions).Zeta potential,scanning electron microscopy-energy dispersive X-ray spectroscopy,X-ray photoelectron spectroscopy,and time-of-flight secondary ion mass spectrometry results showed that pre-oxidation improved cuprite sulfidization and promoted the formation of copper-sulfide species on the cuprite *** mineral surface stability and thus,xanthate species adsorption on the cuprite surfaces were *** surface-adsorption measurements and infrared spectroscopy showed that a large amount of xanthate species was adsorbed onto the sulfidized cuprite surfaces after pre-oxidation,which enhanced the cuprite hydrophobicity and improved the cuprite flotation.

关键词： Cuprite Pre-oxidation Enhanced sulfidization Xanthate adsorption

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