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TypeⅠinositol 1, 4, 5-triphosphate receptors increase in kidney of mice with fulminant hepatic failure

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World Journal of Gastroenterology 2007年第16期13卷 2344-2348页

作者： Ying wen Wei cui Pei Liu Department of Infectious Diseases The First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China

AIM： To delineate the mechanisms of renal vasoconstriction in hepatorenal syndrome （HRS）, we investigated the expression of type I inositol 1, 4, 5-triphosphate receptors （IP3R I） of kidney in mice with fulminant hepatic failure （FHF）. METHODS： FHF was induced by lipopolysaccharide （LPS） in D-galactosamine （GAIN） sensitized BALB/c mice. There were 20 mice in normal saline （NS）-treated group, 20 mice in LPS-treated group, 20 mice in GaIN- treated group, and 60 mice in GalN/LPS-treated group （FHF group）. Liver and kidney tissues were obtained at 2, 6, and 9 h after administration. The liver and kidney specimens were stained with hematoxylin-eosin for studying morphological changes under light microscope. The expression of IP3R I in kidney tissue was tested by immunohistochemistry, Western blot and reverse transcription （RT）-PCR. RESULTS： Kidney tissues were morphologically normal at all time points in all groups. IP3R I proteins were found localized in the plasma region of glomerular mesangial cells （GMC） and vascular smooth muscle cells （VSMC） in kidney by immunohistochemical staining. In kidney of mice with FHF at 6 h and 9 h IP3R I staining was upregulated. Results from Western blot demonstrated consistent and significant increment of IP3R I expression in mice with FHF at 6 h and 9 h （t = 3.16, P 〈 0.05; t = 5.43, P 〈 0.01）. Furthermore, we evaluated IP3R I mRNA expression by RT-PCR and observed marked upregulation of IP3R I mRNA in FHF samples at 2 h, 6 h and 9 h compared to controls （t = 2.97, P 〈 0.05; t = 4.42, P 〈 0.01; t = 3.81, P 〈 0.01）. CONCLUSION： The expression of IP3R I protein increased in GMC and renal VSMC of mice with FHF, possibly caused by up-regulation of IP3R I mRNA.

关键词： Hepatorenal syndrome Fulminant hepatic failure Type Ⅰ inositol 1, 4, 5-trisphophate receptors Glomerular mesangial cells Vascular smooth muscle cells

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石油焦炭基储钠材料层间距扩大与闭孔研究

新型炭材料（中英文） 2024年第3期39卷 549-560页

作者：庄洪坤李文翠何斌吕家贺王敬松申明远陆安慧大连理工大学化工学院精细化工国家重点实验室辽宁大连116024

石油焦(PC)含碳量高,成本低,是一种有价值的钠离子电池(SIB)负极前驱体。易石墨化石油焦基炭的微晶态和孔隙结构的调控对于产生丰富的Na^(+)存储位点至关重要。本研究采用前驱体转化策略,通过酸氧化引入大量氧官能团,然后使用高温炭化... 详细信息

石油焦(PC)含碳量高,成本低,是一种有价值的钠离子电池(SIB)负极前驱体。易石墨化石油焦基炭的微晶态和孔隙结构的调控对于产生丰富的Na^(+)存储位点至关重要。本研究采用前驱体转化策略,通过酸氧化引入大量氧官能团,然后使用高温炭化分解氧官能团,重新排列碳微晶,从而扩大碳层间距,使石油焦基炭形成丰富的闭孔,大幅提高了平台区Na^(+)的储存能力。优化后的样品在0.02 A g^(-1)下可提供356.0 mAh g^(-1)的可逆容量,其中约93%容量低于1.0 V。恒流间歇滴定技术(GITT)和原位X射线衍射(XRD)表明,低电压平台区钠的储存能力涉及层间插入和闭孔填充过程的共同贡献。本研究提出了一种利用低成本和高芳香性的前驱体开发高性能炭基负极的综合方法。

关键词：钠离子电池石油焦炭负极闭孔钠离子存储

胃原发NK/T细胞淋巴瘤4例临床病理特征及文献复习

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诊断病理学杂志 2024年第2期31卷 105-109页

作者：崔文静丁晓琛空军军医大学第一附属医院病理科西安710032 空军军医大学第一附属医院实验外科西安710032

目的原发胃的NK/T细胞淋巴瘤极为罕见,通过总结其临床病理特征、鉴别诊断及预后,以提高对此疾病的认识。方法回顾性分析空军军医大学第一附属医院病理科2014-01—2023-03年确诊为该疾病的病例。结果4例病例患者年龄为48~71岁(中位年龄61... 详细信息

目的原发胃的NK/T细胞淋巴瘤极为罕见,通过总结其临床病理特征、鉴别诊断及预后,以提高对此疾病的认识。方法回顾性分析空军军医大学第一附属医院病理科2014-01—2023-03年确诊为该疾病的病例。结果4例病例患者年龄为48~71岁(中位年龄61岁),男女比为1∶1。镜下特点以中等大小的淋巴样细胞为主,细胞核不规则、扭曲或成角,核仁明显,可见核分裂、凋亡小体及核碎屑,常可见血管侵犯,伴溃疡及坏死。免疫组化染色显示肿瘤细胞CD3(4/4)、CD56(3/4)、TIA(4/4)、Granzyme B(3/4)及CD30(3/4)阳性,Ki-67增殖指数50%~80%。4例病例原位杂交EBER均为阳性。结论该疾病比较罕见,不要漏诊及误诊。该疾病的预后需要更多的病例随访观察,但CD30的表达可为复发难治患者提供新的希望。

关键词： NK/T细胞淋巴瘤胃鉴别诊断预后

Ammonia-treatment assisted fully encapsulation of Fe_2O_3 nanoparticles in mesoporous carbons as stable anodes for lithium ion batteries

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Journal of Energy Chemistry 2013年第2期22卷 329-335页

作者： Fei Han wen-cui Li Duo Li An-Hui Lu State Key Laboratory of Fine Chemicals School of Chemical Engineering Faculty of Chemical Environmental and Biological Science and Technology Dalian University of Technology

To improve the initial coulombic efficiency and bulk density of ordered mesoporous carbons, active Fe203 nanoparticles were introduced into tubular mesopore channels of CMK-5 carbon, which possesses high specific surface area （〉1700 m2.g-1） and large pore volume （〉1.8 cm3-g-1）. Fine Fe203 nanoparticles with sizes in the range of 5-7 nm were highly and homogenously encapsulated into CMK-5 matrix through ammonia-treatment and subsequent pyrolysis method. The Fe203 loading was carefully tailored and designed to warrant a high Fe203 content and adequate buffer space for improving the electrochemical performance. In particular, such Fe203 and mesoporous carbon composite with 47 wt% loading exhibits a considerably stable cycle performance （683 mAh.g-1 after 100 cycles, 99% capacity retention against that of the second cycle） as well as good rate capability. The fabrication strategy can effectively solve the drawback of single material, and achieve a high-performance lithium electrode material.

关键词： ordered mesoporous carbon Fe203 nanoparticle cycle stability lithium-ion anode

Regulatory mechanisms of retinal ganglion cell death in normal tension glaucoma and potential therapies

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Neural Regeneration Research 2023年第1期18卷 87-93页

作者： wen-cui Shen Bing-Qing Huang Jin Yang Tianjin Eye Hospital&Eye Institute Tianjin Key Laboratory of Ophthalmology and Visual ScienceNankai UniversityTianjinChina State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina

Normal tension glaucoma(NTG)is a multifactorial optic neuropathy characterized by normal intraocular pressure,progressive retinal ganglion cell(RGC)death,and glaucomatous visual field *** studies have described the mechanisms underlying the pathogenesis of *** addition to controlling intraocular pressure,neuroprotection and reduction of RGC degeneration may be beneficial therapies for *** this review,we summarized the main regulatory mechanisms of RGC death in NTG,including autophagy,glutamate neurotoxicity,oxidative stress,neuroinflammation,immunity,and *** can be induced by retinal hypoxia and axonal *** this process,ischemia can cause mutations of optineurin and activate the nuclear factor-kappa B *** neurotoxicity is induced by the over-stimulation of N-methyl-D-aspartate membrane receptors by glutamate,which occurs in RGCs and induces progressive glaucomatous optic *** stress also participates in NTG-related glaucomatous optic *** impairs the mitochondrial and DNA function of RGCs through the apoptosis signal-regulating kinase-JUN N-terminal kinase ***,it increases inflammation and the immune response of *** 1 causes endothelial dysfunction and impairment of ocular blood flow,promoting vasospasm and glaucomatous optic neuropathy,as a result of *** conclusion,we discussed research progress on potential options for the protection of RGCs,including TANK binding kinase 1 inhibitors regulating autophagy,N-methyl-D-aspartate receptor antagonists inhibiting glutamate toxicity,ASK1 inhibitors regulating mitochondrial function,and antioxidants inhibiting oxidative *** NTG,RGC death is regulated by a network of mechanisms,while various potential targets protect ***,these findings provide insight into the pathogenesis of NTG and potential therapeutic strategies.

关键词： autophagy endothelin 1 glutamate neurotoxicity inhibitor nerve regeneration neuroinflammation normal tension glaucoma oxidative stress retinal ganglion cell vasoconstriction

基于患者感知的家庭医生团队医防融合度评价研究

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中国卫生政策研究 2024年第7期17卷 51-58页

作者：李怡霖崔文荟龙雨晨房慧妍陈玮琢肖雯琪陈晶叶婷华中科技大学同济医学院医药卫生管理学院湖北武汉430030 湖北省人文社科重点研究基地农村健康服务研究中心湖北武汉430030

目的:构建患者感知的家庭医生团队服务融合度调查工具,分析医防融合服务现状。方法:通过文献检索和半结构化访谈初步构建调查工具;通过专家咨询修改和完善调查工具;实证研究验证调查工具的适用性并分析医防融合度现状。结果:构建了包括... 详细信息

目的:构建患者感知的家庭医生团队服务融合度调查工具,分析医防融合服务现状。方法:通过文献检索和半结构化访谈初步构建调查工具;通过专家咨询修改和完善调查工具;实证研究验证调查工具的适用性并分析医防融合度现状。结果:构建了包括服务综合性、服务闭环、服务深度、关系连续性、以患者为中心和服务协调性共6个维度、18个条目的调查工具;患者感知家庭医生团队医防融合度总得分为(54.30±12.45)分。结论:本研究构建的调查工具为基层家庭医生团队医防融合度评估提供了患者视角。患者感知医防融合度总体水平较高,但服务协调性和深度欠佳。建议优化服务流程、明晰服务路径、细化服务管理、构建医防融合激励机制,迈向医防深度融合。

关键词：医防融合患者感知调查工具

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'老秋枣'ZjABR1基因克隆及功能验证

农业生物技术学报 2024年第8期32卷 1766-1775页

作者：张鹏飞仇力平晁瑞强崔文静梁晋军温鹏飞山西农业大学园艺学院山西石楼红枣科技小院

AP2/ERF家族广泛参与植物生长发育、激素响应等过程，能够影响果实质地的变化。为了探究AP2/ERF家族成员ABR1 (abscisic acid repressor 1)在枣(Ziziphus jujuba)果实成熟过程中的表达模式和功能，本研究以'老秋枣'(Ziziphus jujuba cv.... 详细信息

AP2/ERF家族广泛参与植物生长发育、激素响应等过程，能够影响果实质地的变化。为了探究AP2/ERF家族成员ABR1 (abscisic acid repressor 1)在枣(Ziziphus jujuba)果实成熟过程中的表达模式和功能，本研究以'老秋枣'(Ziziphus jujuba cv.'Laoqiu zao')为材料，克隆了ZjABR1 (LOC107409847)基因，并进行了生物信息学分析、亚细胞定位分析、表达分析，以及构建过表达载体进行瞬时转化和酵母单杂交实验。结果表明，'老秋枣'ZjABR1基因CDS区全长1 344 bp，编码447个氨基酸，含有1个AP2结合域。亚细胞定位显示，ZjABR1蛋白定位于细胞核。RT-qPCR分析发现，ZjABR1在完熟期枣果实中表达量最高。ZjABR1瞬时过表达增强了多聚半乳糖醛酸酶(polygalacturonase, PG)活性和ZjPG表达。酵母单杂交实验证明，ZjABR1能够直接与ZjPG启动子结合。本研究为进一步阐明枣果实成熟的分子机制提供参考依据。

关键词：枣 ZjABR1 克隆果实成熟功能验证

Effect of long intermittent hemodialysis on improving dialysis adequacy of maintenance hemodialysis patients

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Chinese Medical Journal 2013年第24期126卷 4655-4659页

作者： DAI wen-di ZHANG Dong-liang cui wen-ying LIU wen-hu Department of Nephrology Beijing Friendship Hospital Faculty ofKidney Diseases Capital Medical University Beijing 100050 China

Background With the increase in hemodialysis （HD） patients, the blood dialysis patient＇s quality of life （QoL） and long- term survival are still a challenge for clinicians. Recent studies have found that most of the HD patients have sleep disorders, which have a certain correlation with long-term survival and QoL. But there are few studies of Chinese in this field. This study aimed to investigate whether increasing the dialysis dose can improve sleep quality, so we treated HD patients on long intermittent hemodialysis （LIHD）. Methods Forty patients who were treated by conventional HD at the Beijing Friendship Hospital Blood Purification Center were offered the option of LIHD. The patients＇ laboratory data, medication use, and questionnaire answers were analyzed. Conventional HD was delivered thrice weekly with 4 hours per treatment, and LIHD was delivered thrice weekly with 8 hours per treatment. The study lasted 6 months. Questionnaires included sleep quality survey and QoL SF-36; the former includes the Athens Insomnia Scale, Pittsburgh Sleep Quality Index （PSQI）, and Epworth Sleepiness Scale （ESS）. Results After conversion to LIHD the dialysis efficiency （K~/V） significantly increased than before （P 〈0.05） and clearance rate of urea nitrogen also increased from 67 to 78% （P 〈0.01）. After conversion, median values for Hb increased from 108.95 to 126.55 g/L （P 〈0.01）; albumin increased from 38.85 to 40,05 g/L （P 〈0.01）. Phosphorus decreased from 2.69 to 1.54 mmol/L （P 〈0.01）, but there was no alteration in blood calcium; phosphorus and calcium-phosphate product levels were under more control, but parathyroid hormone （iPTH） level did not change after conversion to LIHD. After conversion, blood pressure （BP） was better controlled than before and the mean number of antihypertensive drugs prescribed declined from 2.9 to 0.5 （P 〈0.01）. There was a significant reduction in the use of erythropoietin-stimulating agent of 5250 U/w （P 〈0.01）. Sleep quality significantly impr

关键词： maintenance hemodialysis dialysis adequacy, sleep quality, quality of life, long intermittent hemodialysis

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硅基光电极光电催化制氢

分子催化（中英文） 2024年第1期38卷 93-98,I0004页

作者：王盼盼王欢安伟佳崔文权韩炳旭华北理工大学化学工程学院河北唐山063210 唐山开滦化工科技有限公司河北唐山063611

硅(Si)半导体材料作光电极用于光电催化(PEC)分解水制氢被认为是解决新能源问题比较有希望的措施之一.但目前Si基光电极也面临着光利用率低、不稳定、表面反应动力学缓慢等瓶颈.我们总结了目前Si基光电极材料的发展现状,从表面微纳米结... 详细信息

硅(Si)半导体材料作光电极用于光电催化(PEC)分解水制氢被认为是解决新能源问题比较有希望的措施之一.但目前Si基光电极也面临着光利用率低、不稳定、表面反应动力学缓慢等瓶颈.我们总结了目前Si基光电极材料的发展现状,从表面微纳米结构的设计、保护层的选择、助催化剂的改性3个提高光电极效率的途径,对Si基光电极材料的性能进行了介绍,并对其在该领域的发展前景进行展望.

关键词：光电催化制氢 Si基光电极微纳米结构助催化剂