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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Proactive personality and health literacy among patients with permanent colostomy:an observational study

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Frontiers of Nursing 2025年第1期12卷 91-98页

作者： wen Li Hui Zheng Hai-bo Wang Ye Jiang Zhong-Zhen Yang Soh Kim Lam Department of Nursing Faculty of Medicine and Health SciencesUniversity Putra MalaysiaSerdangSelangor 43400Malaysia Department of Gastrointestinal Surgery Yantai Yuhuangding HospitalYantaiShandong 264000China Department of Vascular Surgery Yantai Yuhuangding HospitalYantaiShandong 264000China

Objective:To investigate the distribution of health literacy(HL)levels and the association of HL with proactive personality in patients with permanent ***:A cross-sectional study was conducted to measure proactive personality and HL using validated scales.A total of 172 patients with permanent colostomy were selected from January 2021 to May 2022 in Yantai City,*** statistics,t-test,ANOVA,Pearson correlation analysis,and multiple linear regression analysis techniques were ***:The results obtained from the study showed that the HL status of the participants was *** correlation between participants’total HL scores and proactive personality scores was 0.417(P-value<0.001).In addition,HL showed statistically significant differences according to education level,place of residence,profession,and average monthly household ***:This study showed that patients with higher proactive personality scores had higher *** key stakeholders require several positive strategies to improve the HL of patients with permanent colostomy by cultivating their proactive personalities,and these important policies will help to improve patient health and quality of life.

关键词： health literacy observational study permanent colostomy proactive personality surgical nursing

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新能源汽车产业的发展逻辑、国际博弈与未来趋势

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新疆师范大学学报(哲学社会科学版) 2025年第3期46卷 123-139页

作者：行伟波武文皓对外经济贸易大学国际经济贸易学院北京100029

新能源汽车产业因显著的减碳优势和对产业升级的巨大带动作用,已成为中国经济高质量发展的重大战略方向。当前,中国已成为全球最大的汽车消费市场,但汽车产业仍处于全球价值链中低端,缺乏核心竞争力。随着新能源技术革命爆发和消费者认... 详细信息

新能源汽车产业因显著的减碳优势和对产业升级的巨大带动作用,已成为中国经济高质量发展的重大战略方向。当前,中国已成为全球最大的汽车消费市场,但汽车产业仍处于全球价值链中低端,缺乏核心竞争力。随着新能源技术革命爆发和消费者认同不断提高,中国通过产业政策培育和支持新能源汽车市场,在夯实市场基础后适时退坡,有为政府和有效市场的充分结合成为中国新能源汽车产业发展的关键逻辑,体现了中国绿色发展的最优政策路径。中国新能源汽车产业为全球绿色发展树立了典范,但传统燃油车产业发达的国家出于自身短期利益考量,针对中国新能源汽车采取了一系列贸易保护主义措施,不仅制约全球新能源汽车产业的长期健康发展,而且对全球合作应对气候变化产生不利影响。面向未来,中国政府应在制定行业标准、保护知识产权、提供研发支持等方面发挥引导作用,通过市场主导、政府引导的模式促进新能源产业可持续发展;中国新能源汽车企业应注重提升盈利能力,融合智能化和网联化技术,通过公平竞争促进全球产业实现绿色转型。

关键词：新能源汽车有为政府有效市场财政补贴贸易保护主义

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Rethinking the diagnosis and treatment of renal anastomotic hemangioma after partial nephrectomy

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World Journal of Clinical Cases 2025年第5期13卷 58-60页

作者： Yun-Peng Guo Gaurab Pokhrel Yu-Yang Wang Quan wen Gai Hang bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina First Affiliated Hospital of Zhengzhou University Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Urinary Surgery Tongliao City HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

Renal anastomotic hemangioma(AH)is a rare,benign vascular tumor with unique histopathological features,a disease that is clinically rare,and existing clinical cases offer different treatment *** reported in the text,this is a very unusual case of renal AH with AH secondary to residual renal tissue after renal clear cell carcinoma,describing a rare renal AH and a history of renal clear cell carcinoma,including ultrasound,computed tomography and magnetic re-sonance ***,the available imaging data and the literature do not provide an effective basis for the diagnosis of the disease,raising the lack of un-derstanding and misdiagnosis,where the patient eventually underwent neph-rectomy,but the author is not the most appropriate surgical *** po-stoperative pathological results of the patient are benign lesions,and it is unde-niable that nephrectomy is suspected to be *** reading the literature,we provide different insights into the treatment of the patient,and we hope that this paper can provide some help for the future clinical diagnosis and treatment.

关键词： Anastomotic hemangioma Renal Ultrasound Computed tomography Case report

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习近平关于民政工作的重要论述的核心要义、逻辑理路与时代价值

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南通大学学报(社会科学版) 2025年第1期41卷 10-20页

作者：邬跃祁文博中国矿业大学(北京)马克思主义学院乡村振兴研究中心苏州大学马克思主义学院

民政工作的本质是以公共服务的形式保障人民群众的生存和发展权益。新时代以来,习近平关于民政工作的重要论述系统阐释了事关民政事业长远发展的根本保证、价值旨归、动力源泉、原则遵循和着力重点等重大问题的核心要义,辩证把握了民政... 详细信息

民政工作的本质是以公共服务的形式保障人民群众的生存和发展权益。新时代以来,习近平关于民政工作的重要论述系统阐释了事关民政事业长远发展的根本保证、价值旨归、动力源泉、原则遵循和着力重点等重大问题的核心要义,辩证把握了民政工作的发展规律,体现了党在民政工作领域的理论创新。习近平关于民政工作的重要论述具有深厚的历史积淀和严密的理论逻辑,是对马克思主义民生观的继承发展,是对中华传统民生民本思想的积淀升华,是对党的民政工作实践的开拓创新。习近平关于民政工作的重要论述把民政工作的规律性认识提升到了新的高度,回应了人民美好生活之需,指导了国家治理方式创新,贡献了解决民生难题的中国智慧。

关键词：民政工作马克思主义民生观习近平新时代中国特色社会主义思想

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The evolution of body size in Odorous Frog(Odorrana grahami) across altitudinal gradients

The evolution of body size in Odorous Frog(Odorrana grahami)...

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第七届全国野生动物生态与资源保护学术研讨会

作者： Shang Ling Lou~(1,2),wen bo liao~(1,2*),Zhi Ping Mi~(1,2) (1 Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of ducation),China West Normal University,Nanchong,637009,China. 2 Institute of Rare Animals and Plants,China West Normal University,Nanchong,637009,China.)

We used skeletochronology to determine the ages of 134(58 females,64 males and 12 juveniles)Odorous Frog(Odorrana grahami)from 4 locations(covering an altitudinal span of 1180-1710m)in montane regions of Sichuan province in western *** were distinct lines of arrested growth(LAGs)from excised toe bone within each frog,and each LAG was assumed to represent one year of *** size of four *** populations did not vary clinaly along a 530-m altitudinal gradient,not agreeing with Bergmann’s *** age was significantly different among four populations within each *** females,average SVL differed significantly among populations, but not in *** both sexes,age significantly affected body size among the *** removing the effects of age,differences in body size still remained in females,but not in males. Post-metamorphic growth rate of male frogs living in the lowest site was *** contrary,female frogs from the highest site-had greatest growth *** findings suggest that other factors(*** resources,metabolic properties,interspecific competition,predator risk,precipitation and humidity) other than age and growth rate may play a role in shaping size differences both among populations and between sexes.

关键词： Age altitudinal gradients body size skeletochronology Odorous Frog

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基于电压-功率灵敏度的有源配电网数据驱动电压协调控制策略

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电力系统及其自动化学报 2025年第1期37卷 35-42页

作者：张波文晓君吴璇华北电力大学河北省分布式储能与微网重点实验室保定071003

随着分布式光伏渗透率的不断提高,实现配电网电压的快速精确调控变得愈加重要。首先,建立多输入-多输出的电压-功率灵敏度BP神经网络回归预测模型,得到功率参数、节点电压与电压-功率灵敏度间的非线性映射关系;其次,构建高比例光伏有源... 详细信息

随着分布式光伏渗透率的不断提高,实现配电网电压的快速精确调控变得愈加重要。首先,建立多输入-多输出的电压-功率灵敏度BP神经网络回归预测模型,得到功率参数、节点电压与电压-功率灵敏度间的非线性映射关系;其次,构建高比例光伏有源配电网电压协调控制策略,基于电压-功率灵敏度降序调控原则,通过无功补偿和有功削减结合的两阶段电压调控模式实现配电网节点电压的快速调控;最后,利用IEEE 33和IEEE 141节点典型配电系统的仿真,计算分析验证所提方法的正确性和有效性。

关键词： BP神经网络数据驱动电压-功率灵敏度电压协调控制有源配电网

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CT判断不同密度同种异体骨犬椎体间融合效果研究

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中国现代医学杂志 2016年第14期26卷 32-36页

作者：曹广如廖文波蔡玉强王霞陈太勇陈琦王翀遵义医学院附属医院脊柱外科贵州遵义563003

目的计算机断层扫描(CT)判断不同密度同种异体骨在犬椎体间融合情况,为临床椎体间植骨融合术中植入合适密度骨提供依据。方法将21只健康中华田园犬随机分成3组,每组7只。所有动物均行经前路腰椎间盘摘除椎体间植骨融合术。3组分别予高... 详细信息

目的计算机断层扫描(CT)判断不同密度同种异体骨在犬椎体间融合情况,为临床椎体间植骨融合术中植入合适密度骨提供依据。方法将21只健康中华田园犬随机分成3组,每组7只。所有动物均行经前路腰椎间盘摘除椎体间植骨融合术。3组分别予高密度植骨(甲组),正常密度植骨(乙组),空白对照(丙组)。于术后12周行腰椎CT平扫+三维重建观察椎间融合效果。应用Photoshop软件测量融合骨横截面CT图形面积,计算椎体间融合程度。结果术后12周,3组椎体间融合的比例分别为甲组(75.91±8.25)、乙组(94.67±3.35)、丙组(37.78±1.16)。植骨组(甲组、乙组)与空白对照组(丙组)比较,差异有统计学意义(P<0.05),正常密度植骨组(乙组)椎间融合效果优于其他两组(P<0.05)。结论椎体间融合术中移植未经压缩的同种异体骨,有利于促进椎体间融合。

关键词：同种异体骨骨移植骨密度脊柱融合术

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缺陷对单层硅烯纳米梁振动频率的影响

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原子与分子物理学报 2025年第6期42卷 76-82页

作者：张文博王静新疆大学物理科学与技术学院乌鲁木齐830017

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动... 详细信息

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动频率随着纳米梁长度的增加而减小.单元素、双元素掺杂均会导致单层硅烯纳米梁的振动频率的增加,且随着掺杂浓度的增加纳米梁的振动频率整体呈现增大的趋势.此外,单空位缺陷会导致单层硅烯纳米梁的振动频率随着缺陷浓度的增加而减小.掺杂-单空位缺陷的单层硅烯纳米梁的振动频率则呈现了随着掺杂浓度的增加先减小后增加的变化趋势.这些变化规律均是由掺杂元素、空位缺陷以及它们共同作用的结果.此研究结果对硅烯纳米谐振器,振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：硅烯掺杂振动频率分子动力学

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng bo Shao Chao-Min Xu Ke Wang Jia-Zhu wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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