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The evolution of body size in Odorous Frog(Odorrana grahami) across altitudinal gradients

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The evolution of body size in Odorous Frog(Odorrana grahami)...

CT判断不同密度同种异体骨犬椎体间融合效果研究

第七届全国野生动物生态与资源保护学术研讨会

作者： Shang Ling Lou~(1,2),wen bo liao~(1,2*),Zhi Ping Mi~(1,2) (1 Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of ducation),China West Normal University,Nanchong,637009,China. 2 Institute of Rare Animals and Plants,China West Normal University,Nanchong,637009,China.)

We used skeletochronology to determine the ages of 134(58 females,64 males and 12 juveniles)Odorous Frog(Odorrana grahami)from 4 locations(covering an altitudinal span of 1180-1710m)in montane regions of Sichuan province in western *** were distinct lines of arrested growth(LAGs)from excised toe bone within each frog,and each LAG was assumed to represent one year of *** size of four *** populations did not vary clinaly along a 530-m altitudinal gradient,not agreeing with Bergmann’s *** age was significantly different among four populations within each *** females,average SVL differed significantly among populations, but not in *** both sexes,age significantly affected body size among the *** removing the effects of age,differences in body size still remained in females,but not in males. Post-metamorphic growth rate of male frogs living in the lowest site was *** contrary,female frogs from the highest site-had greatest growth *** findings suggest that other factors(*** resources,metabolic properties,interspecific competition,predator risk,precipitation and humidity) other than age and growth rate may play a role in shaping size differences both among populations and between sexes.

关键词： Age altitudinal gradients body size skeletochronology Odorous Frog

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中国现代医学杂志 2016年第14期26卷 32-36页

作者：曹广如廖文波蔡玉强王霞陈太勇陈琦王翀遵义医学院附属医院脊柱外科贵州遵义563003

目的计算机断层扫描(CT)判断不同密度同种异体骨在犬椎体间融合情况,为临床椎体间植骨融合术中植入合适密度骨提供依据。方法将21只健康中华田园犬随机分成3组,每组7只。所有动物均行经前路腰椎间盘摘除椎体间植骨融合术。3组分别予高... 详细信息

目的计算机断层扫描(CT)判断不同密度同种异体骨在犬椎体间融合情况,为临床椎体间植骨融合术中植入合适密度骨提供依据。方法将21只健康中华田园犬随机分成3组,每组7只。所有动物均行经前路腰椎间盘摘除椎体间植骨融合术。3组分别予高密度植骨(甲组),正常密度植骨(乙组),空白对照(丙组)。于术后12周行腰椎CT平扫+三维重建观察椎间融合效果。应用Photoshop软件测量融合骨横截面CT图形面积,计算椎体间融合程度。结果术后12周,3组椎体间融合的比例分别为甲组(75.91±8.25)、乙组(94.67±3.35)、丙组(37.78±1.16)。植骨组(甲组、乙组)与空白对照组(丙组)比较,差异有统计学意义(P<0.05),正常密度植骨组(乙组)椎间融合效果优于其他两组(P<0.05)。结论椎体间融合术中移植未经压缩的同种异体骨,有利于促进椎体间融合。

关键词：同种异体骨骨移植骨密度脊柱融合术

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缺陷对单层硅烯纳米梁振动频率的影响

原子与分子物理学报 2025年第6期42卷 76-82页

作者：张文博王静新疆大学物理科学与技术学院乌鲁木齐830017

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动... 详细信息

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动频率随着纳米梁长度的增加而减小.单元素、双元素掺杂均会导致单层硅烯纳米梁的振动频率的增加,且随着掺杂浓度的增加纳米梁的振动频率整体呈现增大的趋势.此外,单空位缺陷会导致单层硅烯纳米梁的振动频率随着缺陷浓度的增加而减小.掺杂-单空位缺陷的单层硅烯纳米梁的振动频率则呈现了随着掺杂浓度的增加先减小后增加的变化趋势.这些变化规律均是由掺杂元素、空位缺陷以及它们共同作用的结果.此研究结果对硅烯纳米谐振器,振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：硅烯掺杂振动频率分子动力学

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng bo Shao Chao-Min Xu Ke Wang Jia-Zhu wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Divergent Syntheses of Pyridoacridine Alkaloids via Palladium-Catalyzed Reductive Cyclization with Nitro-Biarenes

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Chinese Journal of Chemistry 2021年第7期39卷 1905-1910页

作者： bo Liu Shuping Wang Changhao Bian Hongze liao Hou-wen Lin Research Center for Marine Drugs State Key Laboratory of Oncogene and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127 China

Main observation and conclusion A divergent and novel protocol for the preparation of both pyrido[2,3,4-kl]acridine and pyrido[4,3,2-kl]acridine alkaloids was *** method featured the remote palladium-catalyzed reductive cyclization with Mo(CO)_(6) as reductant.A wide range of substrates including three types of nitro arenes were tolerated and afforded corresponding products in good to excellent yields.

关键词： Polycyclic heteroaromatics Palladium-catalyzed reductive cyclization Marine nature alkaloids Divergent syntheses Pyridoacridine

Homographic Solutions of the N-body Generalized Lennard-Jones System

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Acta Mathematica Sinica,English Series 2020年第5期36卷 597-604页

作者： bo wen LIU School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai 200240P.R.China Chern Institute of Mathematics Nankai UniversityTianjin 300071P.R.China

In this paper,we obtain the existence of non-planar circular homographic solutions and non-circular homographic solutions of the(2+N)-and(3+N)-body problems of the Lennard-Jones *** results show the essential differen... 详细信息

关键词： Homographic solution Lennard-Jones potential non-planar circular solution

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Experimental Study on the Wavelengths of Two-Dimensional and Three-Dimensional Freak Waves

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China Ocean Engineering 2023年第1期37卷 154-164页

作者： CUI Cheng PAN wen-bo National Engineering Research Center for Port Hydraulic Construction Technology M.O.T.Tianjin Research Institute of Water Transport EngineeringTianjin 300456China

Freak waves are commonly characterized by strong-nonlinearity, and the wave steepness, which is calculated from the wavelength, is a measure of the degree of the wave nonlinearity. Moreover, the wavelength can describe the locally spatial characteristics of freak waves. Generally, the wavelengths of freak waves are estimated from the dispersion relations of Stokes waves. This paper concerns whether this approach enables a consistent estimate of the wavelength of freak waves. The two-(unidirectional, long-crested) and three-dimensional(multidirectional, shortcrested) freak waves are simulated experimentally through the dispersive and directional focusing of component waves, and the wavelengths obtained from the surface elevations measured by the wave gauge array are compared with the results from the linear, 3rd-order and 5th-order Stokes wave theories. The comparison results suggest that the 3rd-order theory estimates the wavelengths of freak waves with higher accuracy than the linear and 5th-order theories. Furthermore, the results allow insights into the dominant factors. It is particularly noteworthy that the accuracy is likely to depend on the wave period, and that the wavelengths of longer period freak waves are overestimated but the wavelengths are underestimated for shorter period ones. In order to decrease the deviation, a modified formulation is presented to predict the wavelengths of two-and three-dimensional freak waves more accurately than the 3rd-order dispersion relation, by regression analysis. The normalized differences between the predicted and experimental results are over 50% smaller for the modified model suggested in this study compared with the 3rd-order dispersion relation.

关键词： freak wave rogue wave wavelength three-dimension directional spread multidirectional wave

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