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Chinese Journal of Chemistry 2024年第13期42卷 1474-1480页

作者： Ke-Lan Xu Yu-Heng Wang Xi-Rui Wang pan Hu Bo-wen pan wen-Jing Zhang Zi-Yue Chen Ying Zhou Xiong-Li Liu National&Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food Guizhou UniversityGuiyangGuizhou 550025China College of Pharmaceutical Sciences Guizhou University of Traditional Chinese MedicineGuiyangGuizhou 550025China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China

The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric ***,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that incorporate the advantages of both the phenol skeleton and pyrroloimidazolone-based N-oxide moiety,from readily available L-prolinamides in operationally simple two steps and up to 44%overall *** importantly,using an achiral quinoline derivative as an additive,the newly developed Phenol-2NO ligand could serve as the anioic ligand upon deprotonative activation to coordinate to Zn(II)to form a highly enantioselective catalyst for the asymmetric Michael-type Friedel-Crafts alkylation reaction of indoles with 2,*** yields(up to 90%)and high enantioselectivities(up to 99%ee)are obtained for a wide range of substrates under mild *** and DFT calculations revealed the reaction mechanism and the origins of the *** also represented the first activation of phenol-type ligand/metal complex by an achiral organic base as the additive in asymmetric catalysis.

关键词： Phenol-2NO C_(2)-Symmetric Rigid-featured Tridentate ligand Asymmetric catalysis Alkylation Synthesis design Heterocycles

METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils

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Protein & Cell 2024年第3期15卷 223-229页

作者： Dan Cao Mengyue Lv Chi Hu Shukai Li Siwen Wang Chao Xu wen pan Department of Digestive Disease The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technologyof ChinaHefei230001China Division of Life Sciences and Medicine The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesInstitute of ImmunologyUniversity of Science and Technology of ChinaHefei 230027China Division of Life Sciences and Medicine MOE Key Laboratory for Cellular DynamicsHefei National Center for Cross-Disciplinary SciencesUniversity of Science and Technology of ChinaHefei 230027China

Dear Editor,Protein histidine methylation has been found to be a widespread post-translational modification(PTM)in mammalian cells and represents more than 13%of all protein methylation events in the human methylome(Ning et al.,2016;Kapell and Jakobsson,2021).Recently,we and other groups independently identified METTL9 as the first broad-specificity histidine N1 methyltransferase in mammals(Davydova et al.,2021;Lv et al.,2021).METTL9 methylates a variety of substrates with a common x-His-x-His motif(His is for histidine;the second x is preferably small amino acids:A/C/G/S)and catalyzes methyl transfer to the last histidine.

关键词： S100A9 specificity

A bibliometric analysis of molybdenum-based nanomaterials in the biomedical field

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Tungsten 2024年第1期6卷 17-47页

作者： Zhi-Qiang Wang Ya-wen pan Jing Wu Hong-Bin Qi Shuang Zhu Zhan-Jun Gu School of Science China University of GeosciencesBeijing 100083China CAS Key Laboratory for Biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy PhysicsBeijing 100049China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaChinese Academy of SciencesBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China

Molybdenum(Mo)-based nanomaterials have been widely used in biomedical fields due to their various nanostructures and unique physical/chemical *** various reviews have described the development of Mo-based materials in the biomedical field,an objective and comprehensive summary and analysis of research trends in this field is still ***,we used the bibliometric analysis method to analyze all relevant literature on the biological application of Mobased nanomaterials in recent ***,we use bibliometric tools to analyze the dataset by year,country/region,institution and research hotspot to obtain the research ***,based on objectively identified research hotspots,the biomedical applications of Mo-based nanomaterials are reviewed comprehensively,mainly including sensors,cancer imaging/therapy and antibacterial ***,we discussed the application prospects and challenges of Mo-based *** article provides a new perspective to understand the current research progress and further promote the development of Mobased nanomaterials in biomedical research.

关键词： Molybdenum Nanomaterial Biomedicine Bibliometric analysis

Effect of V on high-temperature mechanical properties of Al-5Cu-1.5Ni alloy

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Journal of Iron and Steel Research International 2024年第7期31卷 1792-1810页

作者： Jun-ge Cui Yong-bin Chen Xiang-zhou Fu Hai-long Yang Han-zhang Wang An-min Li Li-wen pan School of Resources Environment and MaterialsGuangxi UniversityNanning 530004GuangxiChina State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004GuangxiChina Guangxi Higher Education Key Laboratory of Advanced Materials Nanning 530004GuangxiChina

The effects of V on microstructure,room temperature,and high-temperature(350℃)mechanical properties of Al-5Cu-1.5Ni alloy were *** results show that Al-5Cu-1.5Ni-xV alloys mainly compriseα-Al,Al_(2)Cu,Al_(3)(Ni,Cu)_(2),Al_(3)Ni,Al7Cu4Ni,and Al_(10)V *** addition of V can signally refineα-Al dendritic structure,which improves the mechanical properties of the as-cast alloys at room and high *** T6 heat treatment(540℃/12 h/WC+170℃/8 h/AC),α-Al,network skeleton structure Al_(3)(Ni,Cu)_(2),and Al_(10)V phases all show coarsening,while the fine nano-θ'-Al_(2)Cu precipitated from the matrix and dispersed *** introduction of V promotes the quantity of precipitatedθ'-Al_(2)Cu *** ultimate tensile strength of the heat-treated alloys at room and high temperatures is greatly improved compared to that of the as-cast *** highest high-temperature ultimate tensile strength of the alloys with V is 111.8 MPa,21.5%higher than that of the base *** analysis shows that the improvement of high-temperature mechanical properties after heat treatment is mainly due to the introduction of V,increasing the precipitated quantity of nano-θ'-Al_(2)Cu particles and improving its thermal *** dispersion strengthening effect ofθ'-Al_(2)Cu particles exceeds the weakening effect of other adverse microstructures on the mechanical properties.

关键词： Al-Cu-Ni-V alloy θ'-Al_(2)Cu phase Heat treatment Microstructure Mechanical property

The association and underlying mechanism of the digit ratio(2D:4D)in hypospadias

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Asian Journal of Andrology 2024年第4期26卷 356-365页

作者： Yu Ding Zu-Quan Chen wen-Feng pan Hao-Jie Chen Min Wu Yi-Qing Lyu Hua Xie Yi-Chen Huang Zhong-Zhong Chen Fang Chen Department of Urology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Urogenital Development Research Center Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Clinical Research Center for Hypospadias Pediatric CollegeShanghai Jiao Tong University School of MedicineShanghai 200062China.

The second-to-fourth digit(2D:4D)ratio is thought to be associated with prenatal androgen ***,the relationship between the 2D:4D ratio and hypospadias is poorly understood,and its molecular mechanism is not *** this study,by analyzing the hand digit length of 142 boys with hypospadias(23 distal,68 middle,and 51 proximal)and 196 controls enrolled in Shanghai Children’s Hospital(Shanghai,China)from December 2020 to December 2021,we found that the 2D:4D ratio was significantly increased in boys with hypospadias(Ppancy was mainly caused by a shift in *** characterization of a mouse model validated that low testosterone levels during pregnancy can impair the growth and development of *** mechanistic explorations revealed that during the androgen-sensitive window,the downregulation of the androgen receptor(AR)caused by low testosterone levels,as well as the suppressed expression of chondrocyte proliferation-related genes such as Wnt family member 5a(Wnt5a),Wnt5b,Smad family member 2(Smad2),and Smad3;mitochondrial function-related genes in cartilage such as AMP-activated protein kinase(AMPK)and nuclear respiratory factor 1(Nrf-1);and vascular development-related genes such as myosin light chain(MLC),notch receptor 3(Notch3),and sphingosine kinase 1(Sphk1),are responsible for the limitation of 4D growth,which results in a higher 2D:4D ratio in boys with hypospadias via decreased endochondral *** study indicates that the ratio of 2D:4D is a risk marker of hypospadias and provides a potential molecular mechanism.

关键词： androgen receptor digit ratio(2D:4D) endochondral ossification hypospadias testosterone level

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论康德的道德人类学:方案、方法与方向

湖北大学学报（哲学社会科学版） 2024年第3期51卷 22-29页

作者：潘文哲昆明理工大学马克思主义学院云南昆明650000

道德人类学是康德实践哲学的重要部分,然而其在体系方面的必要性和在内容方面的丰富性尚待进一步挖掘。从总体方案上看,道德人类学构成实践哲学的应用环节,是道德形而上学的方法论:它一方面为道德形而上学的形式性原则提供必要的质料性... 详细信息

道德人类学是康德实践哲学的重要部分,然而其在体系方面的必要性和在内容方面的丰富性尚待进一步挖掘。从总体方案上看,道德人类学构成实践哲学的应用环节,是道德形而上学的方法论:它一方面为道德形而上学的形式性原则提供必要的质料性条件,使先验道德法则能够在人性中得到贯彻,构成现实的道德经验;另一方面有助于实践理性克服干扰,与诸能力相互配合,作出准确的道德判断。从具体方法上看,道德人类学在先验哲学的框架下提供了基于“同时是义务的目的”的属人义务推导方法、基于良知的内在道德评价方法、基于情感的促进道德判断的主观方法,这些内容构成一种相对完备的道德判断力理论,从而在层次上丰富了实践哲学。基于道德人类学的定位与内容的独特性,康德为后世“人类学化”哲学研究和“道德化”人类学研究提供了可供探索的开放性路径。

关键词：康德道德人类学道德判断力良知道德情感

Review of 2D Bi_(2)X_(3)(X=S,Se,Te):from preparation to photodetector

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Rare Metals 2024年第6期43卷 2349-2370页

作者： Zhi Zeng Dong-Bo Wang Xuan Fang Jia-Mu Cao Bing-Ke Zhang Jing-wen pan Dong-Hao Liu Si-Hang Liu Shu-Jie Jiao Tian-Yuan Chen Gang Liu Lian-Cheng Zhao Jin-Zhong Wang Department of Optoelectronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Changchun University Science and Technology School of PhysicsThe State Key Laboratory of High Power Semiconductor LasersChangchun 130022China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Detector has become an indispensable part of human *** increasing demand for photodetectors with high performance has promoted the research of novel *** the same time,with the development of rising material system,two-dimensional(2D)materials attract a lot of attention,while the suitable option for fabricating photodetector is still *** prospering of bismuth chalcogenides injected new vitality for material field,thereinto,the unique topological insulator characteristics make the research on bismuth selenide(Bi_(2)X_(3))and bismuth telluride(Bi_(2)X_(3)) intriguing.2D Bi_(2)X_(3) also exhibits unique features among various 2D materials,of which,the adjustable narrow energy band gap and polarization-sensitive photocurrent contribute to the promising application of high performance and broadband *** this review,from a bottom-up perspective,we summarize fundamental properties,synthesis method,photodetector performance of 2D Bi_(2)X_(3) based on the previous study,which provide an overall perspective of 2D Bi_(2)X_(3).Wherein,the section of the photodetector is specifically discu ssed with regard to pure Bi_(2)X_(3) photodetector and heterojunction photodetector.A brief summary and outlook were also explored in the end.

关键词： Bi_(2)X_(3) Preparation 2D Photodetector

Exploring the effect and mechanisms of Epimedium on diabetic testicular injury using network pharmacology,molecular docking,and cell experiments

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TMR Modern Herbal Medicine 2024年第2期7卷 19-27页

作者： Jun-Jun Wei Qiong-Yao Xu Zhao-wen pan Yi-Wei Tu Wei Yu Lan Huang wen-Liang Zha College of Pharmacy Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China

Background:Studying the potential targets and mechanisms of Epimedium for anti-diabetic testicular injury using network pharmacology,molecular docking,and cell ***:Acquisition of major components and targets of Epimedium was based on TCMSP,TCMID,and Symmap databases and retrieval of diabetic testicular injury targets by OMIM,GeneCards,Pharmgkb,and Drugbank *** targets were obtained from the Venny 2.1.0 database and input SRTING data to construct a protein-protein interaction(PPI)network,and key targets were screened in Cytoscape 3.8.0 *** the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of intersecting targets were conducted through the DAVID ***,AutoDock software was used to verify docking between the main components and the core target *** addition,a Cell Counting Kit-8(CCK-8)assay was used to determine the survival effect of quercetin,the main component of Epimedium,on TM4 sertoli-like cells exposed to palmitic acid(PA).Results:Quercetin,kaempferol and luteolin in epimedium were identified as the main components in the treatment of diabetic testicular *** has core target proteins including MMP9,AKT1,and *** biological process mainly involves the regulation of the apoptotic signaling *** key pathways of KEGG are the AGE-RAGE signaling pathway in diabetic complications,PI3K-Akt and MAPK signaling *** docking results showed that quercetin had the strongest binding ability to ***,PA-challenged cells had a lower survival rate,which was alleviated by the administration of ***:Our findings suggest that Epimedium attenuates diabetes mellitus(DM)-induced testicular injury through AGE-RAGE,PI3K-Akt and MAPK signaling *** insights offer a potential therapeutic strategy for managing DM-induced testicular injury,will be the basis for future clinical research.

关键词： Epimedium diabetic testicular injury network pharmacology molecular docking

基于刚度矩阵分析法的变刚度橡胶支座力学性能研究

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振动与冲击 2024年第20期43卷 106-118页

作者：杨静潘文张岩岩蔡正昆明理工大学建筑工程学院昆明650500 云南省抗震工程技术研究中心昆明650500 云南省设计院集团有限公司科技研发中心昆明650500

在橡胶支座力学行为基础上提出了一种适合隔离三维地震或竖向振动的新型变刚度橡胶支座,并阐述了能解决变刚度支座非均质体力学问题的刚度矩阵分析法。首先,基于常用橡胶支座解析解和压剪试验的非线性响应分析,采用刚度矩阵分析法对该... 详细信息

在橡胶支座力学行为基础上提出了一种适合隔离三维地震或竖向振动的新型变刚度橡胶支座,并阐述了能解决变刚度支座非均质体力学问题的刚度矩阵分析法。首先,基于常用橡胶支座解析解和压剪试验的非线性响应分析,采用刚度矩阵分析法对该支座进行计算,其结果和试验值高度一致验证了该方法计算精度较高。接着,对比三种支座结果:在相同外部荷载和材料参数下,厚层支座力和变形最大,变刚度支座和普通支座力和变形显著低于厚层支座;不同轴压下,P-Δ效应表现为厚层支座力和变形及水平刚度受轴压影响最为显著,而变刚度支座与普通支座受轴压影响较小。通过算例表明,可通过调整变刚度支座实现竖向刚度的优化。综合而言,变刚度支座对力和变形的承载能力较好,为三维隔震(振)提供了一种简单实用的解决方案。

关键词：变刚度橡胶支座刚度矩阵分析法厚层橡胶支座三维隔震(振) P-Δ效应

跨越世纪的译事对话——从罗选民《文学通诠》谈严复的翻译

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外语导刊 2024年第1期47卷 88-97,160页

作者：潘文国华东师范大学国际汉语文化学院上海200062

罗选民的新著《文学通诠》含倭斯弗原文、严复节译、罗选民全译及译者长序四个内容,为翻译研究提供了极好的跨世纪对话样本。本文从分析这一对话发生的历史场景着手,以“通诠”“美术”“达”/“达旨”为关键词,对处于两端之间的20世纪... 详细信息

罗选民的新著《文学通诠》含倭斯弗原文、严复节译、罗选民全译及译者长序四个内容,为翻译研究提供了极好的跨世纪对话样本。本文从分析这一对话发生的历史场景着手,以“通诠”“美术”“达”/“达旨”为关键词,对处于两端之间的20世纪译论译事展开了论述。并以此为背景,对翻译中的“互文关系”展开了深一层的探讨。

关键词：罗选民文学通诠严复美术达旨互文关系