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Effect of slow shot speed on externally solidified crystal,porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy

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China Foundry 2024年第1期21卷 11-19页

作者： wen-ning Liu Wei Zhang Peng-yue Wang Yi-xian Liu Xiang-yi Jiao Ao-xiang Wan Cheng-gang Wang Guo-dong Tong Shou-mei Xiong School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Tsinghua UniversityBeijing 100084Beijing China FAW Group Co. Ltd.Changchun 130013China China FAW Foundry Co. Ltd.Changchun 130013China

The effect of slow shot speed on externally solidified crystal(ESC),porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy was investigated by optical microscopy(OM),scanning electron microscopy(SEM)and laboratory computed tomography(CT).Results showed that the newly developed AlSi9MnMoV alloy exhibited improved mechanical properties when compared to the AlSi10MnMg *** AlSi9MnMoV alloy,which was designed with trace multicomponent additions,displays a notable grain refining effect in comparison to the AlSi10MnMg *** elements Ti,Zr,V,Nb,B promote heterogeneous nucleation and reduce the grain size of primaryα-*** a lower slow shot speed,the large ESCs are easier to form and gather,developing into the dendrite net and *** an increase in slow shot speed,the size and number of ESCs and porosities significantly *** addition,the distribution of ESCs is more dispersed and the net-shrinkage *** tensile property is greatly improved by adopting a higher slow shot *** ultimate tensile strength is enhanced from 260.31 MPa to 290.31 MPa(increased by 11.52%),and the elongation is enhanced from 3.72%to 6.34%(increased by 70.52%).

关键词： hypoeutectic Al-Si alloy high pressure die casting porosity externally solidified crystal tensile property

Impact of National Immunization Strategies on Vaccine- Preventable Diseases — China, 1950–2021

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China CDC weekly 2024年第16期6卷 339-343页

作者： Quanwei Song Yixing Li Lei Cao Lixin Hao ning wen Fuzhen Wang Chao Ma Guomin Zhang Hui Zheng wenzhou Yu Zhijie An Zundong Yin Huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The incidences of vaccine-preventable diseases(VPDs)included in the Expanded Program on Immunization in China have decreased significantly in recent *** is added by this report?This study summarizes the national incidences of nine VPDs and the seroprevalence of hepatitis B surface antigen(HBsAg)under different immunization strategies from 1950 through 2021 in *** sharpest decreases in VPD incidence and under-5-year HBsAg seroprevalence occurred during the latest stage of the National Immunization *** decreases in VPD incidence were most prominent among children under five years of *** are the implications for public health practice?These findings provide valuable insights for vaccine value assessment and emphasize the importance of implementing immunization strategies in targeted populations.

关键词： vaccine diseases Impact

The Epidemiological Characteristics and Spatiotemporal Clustering of Measles—China,2005-2022

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China CDC weekly 2024年第27期6卷 665-669页

作者： Qianqian Liu Jiuhong Li Siyu Liu Lin Tang Xiaoqi Wang Aodi Huang Xia Xu Yuexin Xiu Hong Yang ning wen Lance Rodewald Fuzhen Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Immunization ProgramChinese Center for Disease Control and PreventionBeijingChina

Introduction:In recent years,the incidence of measles in China has consistently remained below 1 per 100,000 population,yet the disease has not been *** study aims to comprehensively analyze the epidemiological characteristics of measles from 2005 to 2022,identify high-risk populations and areas,and propose targeted ***:We utilized data from the China Disease Prevention and Control Information System for our comprehensive *** autocorrelation was employed to examine the spatial clustering of measles,while spatiotemporal scanning analysis was used to detect spatiotemporal clustering to describe measles epidemiology during the study ***:Between 2005 and 2022,732,218 measles cases were reported in ***,the incidence of measles exhibited a downward trend,particularly during the periods of 2008-2011 and *** 2022,the incidence rate reached its historical low at 0.039 per 100,000 *** predominantly affects young *** 2017,global spatial clustering has diminished,although hotspot areas persist in the western ***-temporal scanning identified a high-incidence cluster from 2005 to 2008,comprising 15 provinces in the western,central,and northern regions of ***,from 2016 to 2022,a low-incidence cluster was detected in the southern and central ***:China has made significant progress in measles prevention and *** recent low incidence and absence of substantial spatiotemporal clustering indicate that China is nearing measles ***,there is a continuing need to enhance prevention and control efforts among very young children and in historic incidence hotspots in western ***,improving the diagnosis of vaccine-associated rash illnesses is essential.

关键词： prevention Spatial utilized

Investigation of the quality of life,mental status in patients with gynecological cancer and its influencing factors

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World Journal of Psychiatry 2024年第7期14卷 1053-1061页

作者： Hai-Xia Shang wen-Ting ning Jin-Fen Sun Nan Guo Xin Guo Jan-Nan Zhang Hong-Xin Yu Su-Hui Wu Department of Gynaecology and Obstetrics The Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Having a gynecological tumor or undergoing treatment can be a traumatic experience for women,as it affects their self-image and sexual relationships and can lead to psychological *** adjustment following cancer occurrence remains a key issue among the *** To examine the current status of quality of life(QoL),anxiety,and depression in patients with gynecological cancer and to analyze the factors associated with *** Data for 160 patients with gynecological malignancies treated at Shanxi Bethune Hospital from June 2020 to June 2023 were collected and analyzed ***’QoL was assessed using the European Organization for Research on Treatment of Cancer Quality of Life Questionnaire Core 30 and the Functional Assessment of Cancer Therapy-General *** emotional status was evaluated using the Self-Rating Anxiety/Depression *** associated factors of anxiety and depression were *** The overall QoL score of the patients 6 months after surgery was 76.39±3.63 *** included low levels of social and emotional function and severe fatigue and *** scores for physiological,functional,emotional,social,and family well-being exhibited an upward trend following surgery compared with those before *** month after surgery,some patients experienced anxiety and depression,with an incidence of 18.75%and 18.13%,*** analysis revealed that good sleep was a protective factor against anxiety and depression in patients with gynecological tumors,whereas physical pain was a risk *** Patients with gynecological malignancies often experience anxiety and *** analyzing the factors that affect patients’QoL,effective nursing measures can be administered.

关键词： Gynecological Tumors Quality of life Anxiety Depression

Thirty Years of Experience of Acute Flaccid Paralysis Surveillance for Polio — China, 1993–2022

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China CDC weekly 2024年第16期6卷 344-349页

作者： Hong Yang ning wen Chunxiang Fan Fuzhen Wang Yong Zhang Lei Cao Shuangli Zhu Lixin Hao Dongmei Yan Lei Wang Quanwei Song Miao Wang Yifan Song Chao Ma Zhijie An Lance ERodewald Huaqing Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Detecting poliovirus infections proves to be highly challenging due to their asymptomatic nature and infectious potential,highlighting the crucial importance of effective detection methods in the context of polio eradication *** many countries,including China,the primary approach for identifying polio outbreaks has been through acute flaccid paralysis(AFP)*** this study,we conducted an evaluation spanning three decades(1993–2022)to assess the effectiveness of AFP surveillance in ***:Data on all AFP cases identified since 1993 and national-level AFP surveillance system quality indicators aligned with the World Health Organization(WHO)standards were collected for *** quality indicators assess surveillance sensitivity,completeness,timeliness of detection notification,case investigation,and laboratory *** sensitivity is determined by the non-polio AFP(NPAFP)detection rate among children under 15 years of ***:Between 1993 and 2022,a total of 150,779 AFP cases were identified and *** this pool,surveillance identified 95 cases of wild poliovirus(WPV)and 24 cases due to vaccinederived *** 1995 onwards,the detection rate of NPAFP cases consistently adhered to the WHO and national standards of≥1 case per 100,000,falling between 1.38 and *** in 1997,all timeliness indicators consistently achieved the criteria of 80%,apart from the consistency in meeting standards set for the rate of positive specimens sent to the national ***:AFP surveillance has been instrumental in China’s accomplishment of maintaining a polio-free *** ongoing adherence to key performance indicators,ensuring sensitivity and prompt specimen collection,demonstrates that AFP surveillance is proficient in detecting poliovirus in *** we move into the post-eradication phase,AFP surveillance remains crucial for the sustained absence of polioviruses in the long term.

关键词： sustained prompt surveillance

乡村振兴战略下农村居民生活垃圾的合作治理研究

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黑龙江环境通报 2024年第5期37卷 117-119页

作者：温宁洛阳理工学院经济与管理学院河南洛阳471000

随着经济发展和社会进步,农村居民生活质量已明显提高,城乡共同发展被逐渐重视。农村居民环境治理问题成为社会重点关注内容。随着乡村振兴战略文件的颁发,各级相关部门逐步开展农村居民生活垃圾有效治理,以提升农村居民生活质量为目标... 详细信息

随着经济发展和社会进步,农村居民生活质量已明显提高,城乡共同发展被逐渐重视。农村居民环境治理问题成为社会重点关注内容。随着乡村振兴战略文件的颁发,各级相关部门逐步开展农村居民生活垃圾有效治理,以提升农村居民生活质量为目标,实现农村绿色发展。但对当前阶段,农村居民生活垃圾治理工作中存在治理力度不足、垃圾处理基础设施落后等问题,需要提出创新性治理策略,推进高效改革。基于此,本文首先阐述农村居民生活垃圾治理的意义,提出当前阶段生活垃圾治理中存在的问题,并提出相应合作治理策略,为贯彻落实乡村振兴战略、推动垃圾治理工作顺利开展提供参考。

关键词：乡村振兴战略农村居民生活垃圾合作治理

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三特异性抗体在肿瘤免疫治疗中的研究进展

生命科学 2024年第4期36卷 433-447页

作者：许林宁文静刘雪罗文新厦门大学公共卫生学院国家传染病诊断试剂与疫苗工程技术研究中心厦门361102

三特异性抗体(trispecific antibodies, TsAbs)是一种可以同时靶向肿瘤细胞或免疫效应细胞三种不同抗原结合位点的创新疗法。与单克隆抗体和双特异性抗体相比,三特异性抗体可增加结合特异性,降低脱靶毒性,在肿瘤免疫治疗领域具有广阔的... 详细信息

三特异性抗体(trispecific antibodies, TsAbs)是一种可以同时靶向肿瘤细胞或免疫效应细胞三种不同抗原结合位点的创新疗法。与单克隆抗体和双特异性抗体相比,三特异性抗体可增加结合特异性,降低脱靶毒性,在肿瘤免疫治疗领域具有广阔的应用前景。本文主要介绍了三特异性抗体的发展进程、主要构建形式及其作用机制,总结了不同靶点组合的代表性药物的最新研究进展,并讨论了其存在的挑战和未来发展方向,旨在为三特异性抗体药物的发展提供新思路。

关键词：三特异性抗体肿瘤免疫疗法 CD3 T细胞接合器免疫检查点

ESG表现对于企业投资效率研究——基于A股上市公司的经验证据

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生产力研究 2024年第6期 154-160页

作者：许文宁江苏大学财经学院江苏镇江212013

文章选用面板效应模型,基于沪深A股上市公司2013—2022年数据研究ESG对企业投资效率的促进效应。经研究发现ESG对企业投资效率起到正相关关系,且通过降低代理成本,相对减少选用四大作为审计单位共同促进投资效率,此外内部控制与媒体关... 详细信息

文章选用面板效应模型,基于沪深A股上市公司2013—2022年数据研究ESG对企业投资效率的促进效应。经研究发现ESG对企业投资效率起到正相关关系,且通过降低代理成本,相对减少选用四大作为审计单位共同促进投资效率,此外内部控制与媒体关注起到正向调节作用,经过以下检验均成立。依次选用前5大股东持股比例,机构投资者持股比例,投资水平作为门限变量,构建门槛检验。通过工具变量法选用地级市到杭州的球面距离和每百万人邮局数量作为工具变量,与1:1近邻匹配方法的倾向得分作为内生性检验证明原假设成立。且通过替换被解释变量、滞后一期检验均证明结论成立且稳健。通过异质性分组检验,国企、非重污染、衰退期企业,回归效果更为明显。

关键词： ESG表现投资效率代理成本审计质量

经DCAG方案化疗后AML患者血清HOXA9、PCⅢ、SE-CAD水平的变化及其与预后的关系

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中国实验血液学杂志 2024年第4期32卷 987-992页

作者：苏欢文宁向婕王能勇广元市中心医院检验科四川广元628400

目的:探讨急性髓系白血病(AML)患者采用DCAG方案化疗后血清同源盒基因A9(HOXA9)、可溶性E钙黏蛋白(SE-CAD)及Ⅲ型前胶原蛋白(PCⅢ)水平的变化及其与预后的关系。方法:回顾性分析2018年3月至2021年12月经本院确诊并收治的80例复发难治性... 详细信息

目的:探讨急性髓系白血病(AML)患者采用DCAG方案化疗后血清同源盒基因A9(HOXA9)、可溶性E钙黏蛋白(SE-CAD)及Ⅲ型前胶原蛋白(PCⅢ)水平的变化及其与预后的关系。方法:回顾性分析2018年3月至2021年12月经本院确诊并收治的80例复发难治性AML患者的资料,按照治疗方案不同将其分为DCAG组(n=40)与CAG组(n=40),对比治疗前后各组的临床疗效及HOXA9、SE-CAD、PCⅢ水平的变化;另按照临床疗效将所有患者分为缓解组(n=58)与未缓解组(n=22),通过单因素和多因素分析影响AML患者预后的危险因素;采用ROC曲线分析HOXA9、SE-CAD、PCⅢ三项单一指标及三者联合对预后的预测效能。结果:相比于治疗前,DCAG组与CAG组患者在治疗后的HOXA9、SE-CAD、PCⅢ水平均有所下降,但DCAG组患者各指标的改善效果明显优于CAG组,且DCAG组患者在治疗后的临床疗效显著优于CAG组(均P<0.05);多因素分析结果显示,骨髓原始细胞比率、HOXA9 m RNA、SE-CAD及PCⅢ水平升高是影响AML患者化疗疗效的独立危险因素(均P<0.05);ROC曲线分析显示,HOXA9 m RNA、SE-CAD及PCⅢ联合能够有效预测AML预后情况,其敏感度为84.80%、特异度为88.20%。结论:应用DCAG的化疗方案能够显著改善AML患者的HOXA9 m RNA、SE-CAD及PCⅢ水平;且这三项指标作为影响AML患者预后的危险因素,通过联合检测能够对AML患者的预后情况进行有效预测。

关键词：急性髓系白血病同源盒基因A9 可溶性E钙黏蛋白 Ⅲ型前胶原蛋白 DCAG化疗方案