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Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

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Nano Research 2025年第1期18卷 642-652页

作者： wen luo Shiyu Du Yateng Jiang Bangshun He Jun Tang Jingjing Yang Yujun Song Jiangsu Key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(ROS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

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Light tuning CO/H_(2)composition on Ag:Unraveling CO_(2)mass transfer and electron-phonon coupling in plasmon-enhanced electrocatalysis

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Nano Research 2025年第1期18卷 173-185页

作者： Rui Lin Dong Fan Luca MBerger Thomas Possmayer Yu Zhou Jiexin Zhu Xingbao Chen wen luo Lars Allmendinger Andreas Tittl Leonardo de Souza Menezes Guillaume Maurin Shihe Yang and Stefan AMaier Nanoinstitute Munich Faculty of PhysicsLudwig-Maximilians-Universität München80539 MunichGermany Institut Charles Gerhardt Montpellier UMR 5253 CNRS ENSCM UniversitéMontpellierPlace E.Bataillon34090 MontpellierFrance Guangdong Provincial Key Lab of Nano-Micro Material Research School of Advanced MaterialsPeking University Shenzhen Graduate SchoolShenzhen 518055China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Faculty of Chemistry and Pharmacy Ludwig-Maximilians-Universität München81377 MunichGermany Departamento de Física Universidade Federal de Pernambuco50670-901 Recife-PEBrazil School of Physics and Astronomy Monash University Clayton CampusMelbourneVictoria 3800Australia Department of Physics Imperial College LondonSW72AZ LondonUK

Plasmon-enhanced electrocatalysis(PEEC)is an emerging approach to mitigate CO_(2)*** mechanisms behind CO_(2)adsorption and reduction at the catalyst-electrolyte interface in PEEC still need to be further ***,we employ a well-defined Ag nanostructure to elucidate these pivotal *** shining light with wavelengths of 625,525,405 nm on Ag,an adjustable CO/H_(2)ratio from 35 to 1 can be *** reaction pathway changing under plasmonic excitation does not originate from the lowered CO_(2)mass transfer in the vicinity of Ag,as the electrochemical quartz crystal microbalance results unravel that a slightly elevated temperature in bulk electrolyte caused by light irradiation cannot weaken the CO_(2)adsorption at the Ag catalyst-electrolyte *** calculations reveal that optical excitation towards shorter wavelengths leads to a progressive lowered energy barrier for H_(2)formation together with an enhanced energy barrier for^(*)COOH *** thermodynamically suppressed,CO_(2)reduction can still be improved kinetically by optimizing the excitation wavelength and intensity,being accompanied with the enhanced *** absorption spectroscopy results further correlate the higher photocurrent with a prolonged electron-phonon coupling time,verifying that the improvement of CO_(2)reduction kinetics in PEEC can be realized by hot electron harnessing.

关键词： plasmonic catalysis photoelectrochemical CO_(2)reduction CO/H_(2)ratio hot electron generation electronphonon coupling thermal effect

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Production of medical radioisotope ^(64)Cu by photoneutron reaction using ELI-NP γ-ray beam

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Nuclear Science and Techniques 2016年第4期27卷 147-151页

作者： wen luo School of Nuclear Science and Technology University of South China Extreme Light Infrastructure - Nuclear Physics (ELI-NP)/‘‘Horia Hulubei’’ National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH)

Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work,we investigated the possibility of producing the^(64)Cu isotope through a^(65)Cu(γ,n) reaction using high-intensity γ-beams produced at the Extreme Light InfrastructureNuclear Physics facility(ELI-NP). The specific activity for^(64)Cu was obtained as a function of target geometry, irradiation time, and electron beam energy, which translates into γ-beam energy. Optimized conditions for the generation of^(64)Cu isotopes at the ELI-NP were discussed. We estimated that an achievable saturation specific activity is of the order of 1–2 m Ci/g for thin targets(radius 1–2 mm,thickness 1 cm) and for a γ-beam flux of 10^(11) s ~1. Based on these results, the ELI-NP could provide great potential for the production of some innovative radioisotopes of medical interest in sufficient quantities suitable for nuclear medicine research.

关键词：放射性同位素设施生产中子反应射线束正电子发射断层成像医用靶向治疗基础设施

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Medium-Mn steels for hot forming application in the automotive industry

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 741-753页

作者： Shuo-shuo Li Hai-wen luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Advanced high-strength steels have been widely used to improve the crashworthiness and lightweight of *** from the popular cold stamping,hot forming of boron-alloyed manganese steels,such as 22MnB5,could produce ultra-high-strength steel parts without springback and with accurate control of ***,hot-formed medium-Mn steels could have many advantages,including better mechanical properties and lower production cost,over hot-formed *** paper reviews the hot forming process in the automotive industry,hot-formed steel grades,and medium-Mn steel grades and their application in hot forming in *** particular,the adaptabilities of medium-Mn steels and the presently popular 22MnB5 into hot forming were compared *** research should focus on the technological issues encountered in hot forming of medium-Mn steels to promote their commercialization.

关键词： medium-Mn transformation-induced plasticity steel hot forming mechanical properties retained austenite baking

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A thermodynamic model on predicting density of medium-Mn steels with experimental verification

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Journal of Iron and Steel Research International 2017年第11期24卷 1078-1084页

作者： Guo-hui Shen Peng-yu wen Hal-wen luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

A new model on predicting the density of hot-rolled multi-phased medium-Mn steel has been presen ted on the basis of thermodynamic calculations. This is an integrated model, which includes one for calculating the retained austenite （RA） fraction and the other for volume expansion during the aus tenite-to martensite transformation, because both of them are key parameters for calculating the den- sity of steel at ambient temperature. The existing empirical equations for calculating Mx temperature and lattice constants of both martensite and austenite have been all rcassessed by the XRD measure ments on the microstructures of seven hot-rolled medium-Mn steels. Finally, the densities ot seven steels were calculated merely from compositions and compared with the measured ones. The differ ence between them is no more than 1 %, suggesting that the presented model should be of good value in designing the low density steels.

关键词： Density Medium Mn steel Retained austenite fraction Volume expansion Transformation

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On Scheduling a Deteriorating Rate-Modifying Activity to Minimize the Number of Tardy Jobs

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Journal of the Operations Research Society of China 2020年第1期8卷 165-175页

作者： wen-Chang luo Faculty of Science Ningbo UniversityNingbo 315211ZhejiangChina

We investigate a single-machine scheduling problem,where a deteriorating rate-modifying activity can be performed on the machine to reduce the processing times of *** objective is to minimize the number of tardy *** the assumption that the duration of the rate-modifying activity is a nonnegative and nondecreasing function on its starting time,we propose an optimal polynomial time algorithm running in O(n^(3))time.

关键词： Scheduling Rate-modifying activity Due date Polynomial time algorithm

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Synchronous primary cancers of trachea and esophagus and ventricular tachycardia

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Chinese Journal of Cancer Research 2014年第3期26卷 345-350页

作者： wen luo Guomin luo Youling Gong Jin Wang Oncology Center West China HospitalSichuan University

The incidence of multiple primary cancers involving trachea is rare. We present a case of synchronous double primary cancer of trachea and esophagus in a 70-year-old woman, with a special symptom of ventricular tachycardia and no/a/story of smoking and alcohol drinking. Biopsies （tom multiple loci demonstrated the patient had primary small cell cancer of trachea and squamous cell carcinoma in situ of esophagus. The patient was successfully treated with four cycles of chemotherapy consisting of etoposide and earboplatin （EC） followed by thoracic radiotherapy （60 Gy in 30 fractions, in 6 weeks）, and was evaluated to have complete response of tumor. To our knowledge, there is no synchronous cancer of trachea and esophagus has been reported in English literature, and our experience showed sequential EC chemotherapy and radiotherapy provided an effective treatment to control both cancers.

关键词： Synchronous cancer trachea small cell cancer esophagus carcinoma tachycardia radiotherapy ehemotherapy

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The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 312-323页

作者： wen-Juan luo wen-Fang Zhang Department of Ophthalmology Lanzhou University Second Hospital

AIM: To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume(MPV), platelet distribution width(PDW), neutrophil to lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR), and the presence and severity of diabetic retinopathy(DR). METHODS: We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to December 13, 2017. Standardized mean difference(SMD) calculated with confidence interval(CI) of 95% was used to estimate the values of those indices. RESULTS: A total of 31 studies were included in the present Meta-analysis. As compared with type 2 diabetes mellitus(T2 DM) patients without DR, the values of MPV, PDW, NLR, and PLR were higher in patients with DR(SMD=0.67; 95%CI: 0.36 to 0.98; SMD=0.51; 95%CI: 0.27 to 0.75; SMD=0.77; 95%CI: 0.49 to 1.05 and SMD=1.18; 95%CI: 0.07 to 2.28). Additionally, it was also observed that MPV was closely correlated with the severity of DR. CONCLUSION: MPV, PDW, NLR, and PLR could be recommended as diagnostic biomarkers for DR, and MPV could be applied to assess the severity of DR.

关键词： mean platelet volume platelet distribution width neutrophil to lymphocyte ratio platelet-lymphocyte ratio diabetic retinopathy

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Progress on statistical models of evaluating inclusions in clean steels

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Journal of Iron and Steel Research International 2022年第8期29卷 1153-1163页

作者： Zheng Wang Yue-hui Guan Hai-wen luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Jiang Yin Xing Cheng Alloy Material Co. Ltd.Jiangyin 214432JiangsuChina

Non-metallic inclusions are critical for the fatigue failure of clean steels in service;especially,the large and hard inclusions are *** it is not possible to measure all the inclusions in the large-volume clean steels,statistical models have been developed to evaluate inclusions,aiming at predicting the maximum inclusion size in the large volume from the data of inclusions,which are derived from the limited observations on small-volume *** statistical models were reviewed together with their supporting *** particular,the block maxima and the threshold types of models were discussed through a thorough comparison as they are both widely used and based on the extreme value *** predicted results not only are used to distinguish the different cleanliness levels of steels,but also help to estimate fatigue ***,future research is proposed to focus on tackling the present difficulties encountered by statistical models,including the sufficient credibility of obtained results and the robustness of models for applications.

关键词： Clean steel Maximum inclusion prediction Statistical model Extreme value theory Fatigue failure

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Numerical simulation of flow and heat transfer of n-decane in sub-millimeter spiral tube at supercritical pressure

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Chinese Journal of Chemical Engineering 2023年第8期60卷 173-185页

作者： Jiahao Xing Huaizhi Han Ruitian Yu wen luo School of Chemical Engineering Sichuan UniversityChengdu 610065China Engineering Research Center of Combustion and Cooling for Aerospace Power Ministry of EducationSichuan UniversityChengdu 610065China

The flow and heat transfer characteristics of n-decane in the sub-millimeter spiral tube(SMST) at supercritical pressure(p = 3 MPa) are studied by the RNG k-ε numerical model in this paper. The effects of various Reynolds numbers(Re) and structural parameters pitch(s) and spiral diameter(D) are *** indicate that the average Nusselt numberNu and friction factorNu increase with an increase in Re, and decrease with an increase in D/d(tube diameter). In terms of the structural parameter s/d, it is found that as s/d increases, the Nu first increase, and then decrease. and the critical structural parameter is s/d = 4. Compared with the straight tube, the SMST can improve Nu by 34.8% at best, while it can improve Nu by 102.1% at most. In addition, a comprehensive heat transfer coefficient is applied to analyze the thermodynamic properties of SMST. With the optimal structural parameters of D/d = 6 and s/d = 4, the comprehensive heat transfer factor of supercritical pressure hydrocarbon fuel in the SMST can reach 1.074. At last, correlations of the average Nusselt number and friction factor are developed to predict the flow and heat transfer of n-decane at supercritical pressure.

关键词： Sub-millimeter spiral tube Supercritical pressure Numerical simulation Heat transfer performance

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