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Research Progress in Astragalus Membranaceus and Its Active Components on Immune Responses in Liver Fibrosis

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Chinese Journal of Integrative Medicine 2020年第10期26卷 794-800页

作者： LIU Yu-tong LV wen-liang Shaanxi University of Traditional Chinese Medicine Xianyang(712046)Shaanxi ProvinceChina Department of Infection Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China

The interaction between immune cells and hepatic stellate cells(HSCs)can modulate the development of hepatic *** can also regulate hepatic fibrosis and liver cirrhosis caused by excessive deposition of extracellular matrix(ECM).This article reviews the action mechanism of immune cells on liver fibrosis and the effect of Astragalus membranaeus and its active components on immune ***-depth study of interaction between immune cells and HSCs on the pathogenesis of liver fibrosis,and the regulatory effect of Astragalus membranaeus and its active components on immune mechanism will provide new insights in the treatment of liver fibrosis.

关键词： liver fibrosis immune cell Astragalus membranaceus review

Effect of heavy metals on soil nematode communities in the vicinity of a metallurgical factory

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Journal of Environmental Sciences 2006年第2期18卷 323-328页

作者： LI Qi JIANG Yong liang wen-ju Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

The influence of Cu and Zn on soil nematode communities was examined along a pollution gradient with increasing distance from a metallurgical factory. Total and available heavy metal contents were used to study the effects of heavy metals on nematode abundance, trophic groups and ecological indices. The results demonstrated significant correlations between the number of total nematodes, bacterivores, plant-parasites and the total and available heavy metals. Bacterivores and plant-parasites were the dominant trophic groups. Significant differences in different sampling sites were found only in the number of bacterivores（P〈0.01）. The Shannon-Weaver diversity index（W）, trophic diversity index（TD）, evenness index（J＇） and dominance index（λ） were found to be sensitive to soil pH and C/N ratios. Significant correlations were found between the total nematodes （TNEM）, some genera （A crobeloides, Aphelenchoides, Cephalobus, Ditylenchus, Mesorhabditis, Tetylenchus and Tylenchus） and distance from the factory.

关键词： soil nematodes trophic groups ecological indices heavy metals metallurgical factory

Dependence of low redshift Type Ia Supernovae luminosities on host galaxies

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Research in Astronomy and Astrophysics 2013年第9期13卷 1087-1096页

作者： wen-Ke liang Jian-Cheng Wang National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences University of Chinese Academy of Sciences

We study the relation between Type Ia Supernovae （SNe Ia） and properties of their host galaxies using a large sample with low redshift. By examining the Hubble residuals of the entire sample from the best-fit cosmology, we show that SNe Ia in passive hosts are brighter than those in star-forming hosts after light curve correction at the 2. 1σ confidence level. We find that SNe Ia in high luminosity hosts are brighter after light-curve correction at the 〉 3σ confidence level. We also find that SNe Ia in large galaxies are brighter after light-curve correction at the ≥2σ confidence level. We demonstrate that the residuals depend linearly on host luminosity at a confidence of 4or or host size at a confidence of 3.3σ.

关键词： supernovae: general -- distance scale -- galaxies: classification

The Unconventional Influence of a Nearby Molecule onto Transport of Single C60 Molecule Transistor

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Chinese Physics Letters 2019年第12期36卷 62-66页

作者： Xiao Guo wen-jie liang Beijing National Center for Condensed Matter Physics Bejjing Key Laboratory for Nanomaterials and NanodevicesInstitute of PhysicsChinese Academy of SciencesBeijing 100190 CAS Center of Excellence in Topological Quantum Computation and School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190 Songshan Lake Materials Laboratory Dongguan 523808

We study the transport property of single C60 molecular transistors with special focus on the situation that other molecules are in *** devices are prepared using electromigration and thermal deposition *** single C60 molecule transistors show typical coulomb blockade behavior at low *** we increase the coverage of molecules slightly by extending the deposition time,the transport spectrum of devices displays a switching behavior in the general coulomb blockade *** attribute this unconventional phenomenon to the influence from a nearby C60 *** analyzing this transport behavior quantitatively based on the parallel-double-quantum-dot model,the interaction from the nearby molecule is proved to be of capacity and tunneling *** stimulation is also applied to the device to investigate the effect of local charging environment variation on intermolecular interaction.

关键词： transport behavior tunneling

Designing reduced beacon trajectory for sensor localization

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1971-1982页

作者： HUANG wen-liang LI Shi-jian LIU Duo School of Computer Science Zhejiang University Hangzhou 310027 China Graduate School Zhejiang University Hangzhou 310027 China

Localization is one of the substantial issues in wireless sensor networks. The key problem for the mobile beacon localization is how to choose the appropriate beacon trajectory. However, little research has been done on it. In this paper, firstly, we deduce the number of positions for a beacon to send a packet according to the acreage of ROI (region of interest); and next we present a novel method based on virtual force to arrange the positions in arbitrary ROI; then we apply TSP (travelling salesman problem) algorithm to the positions sequence to obtain the optimal touring path, i.e. the reduced beacon trajectory. When a mobile beacon moves along the touring path, sending RF signals at every position, the sensors in ROI can work out their position with trilateration. Experimental results demonstrate that the localization method, based on the beacon reduced path, is efficient and has flexible accuracy.

关键词： Sensor network Sensor localization Mobile beacon Virtual force

Relationship between Indian Ocean dipole and ENSO and their connection with the onset of South China Sea summer monsoon

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Acta Oceanologica Sinica 2006年第6期25卷 22-32页

作者： liang Zhaoning wen Zhiping liang Jieyi WU Liji WU Naigeng Research Center for Monsoon and Environment/Department of Atmospheric Sciences Sun Yat-sen University Guangzhou 510275 China

Using Reynolds and Smith 1950 - 1998 re-constructed monthly-mean SST to discuss the relationship between the ENSO and Indian Ocean dipole （IOD） and their possible connection with the onset of South China Sea summer monsoon（ SCSSM）, the results are obtained as follows ： Most of IOD events have a closely positive relation to simultaneous ENSO events in summer and autumn. IOD events in autumn （ mature phase） are also closely related to ENSO events in winter （ mature phase）. When these two kinds of events happen in phase, i.e. , positive （negative） IOD events are coupled with E1 Nifío （La Nifía） events, they are always followed by late （ or early） onsets of SCSSM. On the contrary, when these two kinds of events happen out of phase, i.e. positive （negative） IOD events are coupled with La Nifia （ E1 Nifío） events, they are followed by normal onsets of SCSSM. In addition, single IOD events or single ENSO events cannot correspond well to the abnormal onset of SCSSM.

关键词： Indian Ocean dipole ENSO South China Sea summer monsoon early or late onset

Purification of AS-CMP effluent by combined photosynthetic bacteria and coagulation treatment

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Journal of Environmental Sciences 2000年第1期12卷 83-87页

作者： Wu, Shu-Bin liang, wen-Zhi State Key Lab. Pulp and Paper Eng. South China University of Technology Guangzhou 510641 China

The effluent from the pulping of E. urophylla by alkali sodium sulfite chemi mechanical process(AS-CMP) was characterized for its biodegradability by photosynthetic bacteria (PSB). Chemical coagulation post treatment of biotreated wastewater was also studied. One month continuous treatment in the laboratory indicated that the COD Cr , BOD 5 and SS removals in biotreatment stages reached 56%, 83% and 89% respectively, and the CH 2Cl 2 extractives decreased from 10.7 mg/L to 7.7 mg/L. In chemical coagulation post treatment stage, the effects of process conditions, such as coagulant dosage, pH value and the coordinated coagulation flocculation treatment of three kinds of coagulants on coagulation effectiveness were discussed. The optimum operating conditions were given.

关键词： wastewater treatment AS CMP E. urophylla photosynthetic bacteria(PSB) flocculation coagulation CLC number: X703 Document code: A

pH-responsive Polymersome Based on PMCP-b-PDPA as a Drug Delivery System to Enhance Cellular Internalization and Intracellular Drug Release

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Chinese Journal of Polymer Science 2017年第11期35卷 1352-1362页

作者： wen-liang Wang 马晓晶于喜飞 The Polymer Composites Engineering Laboratory Changchun Institute of Applied ChemistryChinese Academy of Sciences University of Science and Technology of China

Choline phosphate （CP） as a novel zwitterion possesses specific and excellent properties compared with phosphorylcholine （PC）, as well as its polymer, such as poly（2-（methacryloyloxy）ethyl choline phosphate）（PMCP）, has been studied extensively due to its unique characteristics of rapid cellular internalization via the special quadrupole interactions with the cell membrane. Recently, we reported a novel PMCP-based drug delivery system to enhance the cellular internalization where the drug was conjugated to the polymer via reversible acylhydrazone bond. Herein, to make full use of this feature of PMCP, we synthesized the diblock copolymer poly（2-（methacryloyloxy）ethyl choline phosphate）-b-poly（2- （diisopropylamino）ethyl methacrylate）（PMCP-b-PDPA）, which could self-assemble into polymersomes with hydrophilic PMCP corona and hydrophobic membrane wall in mild conditions when the pH value is 〉 6.4. It has been found that these polymersomes can be successfully used to load anticancer drug Dox with the loading content of about 11.30 wt%. After the polymersome is rapidly internalized by the cell with the aid of PMCP, the loaded drug can be burst-released in endosomes since PDPA segment is protonated at low pH environment, which renders PDPA to transfer from hydrophobic to hydrophilic, and the subsequent polymersomes collapse thoroughly. Ultimately, the ＂proton sponge＂ effect of PDPA chain can further accelerate the Dox to escape from endosome to cytoplasm to exert cytostatic effects. Meanwhile, the cell viability assays showed that the Dox-loaded polymersomes exhibited significant inhibitory effect on tumor cells, indicating its great potential as a targeted intracellular delivery system with high efficiency.

关键词： Drug delivery Choline phosphate Polymersome PDPA Enhanced cellular internalization

Effect of the amplification factor on seismic stability of expanded municipal solid waste landfills using the pseudo-dynamic method

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第10期14卷 731-738页

作者： Xiao-bo RUAN Shu-lin SUN wen-liang LIU College of Civil and Transportation Engineering Hohai University College of Earth Sciences and Engineering Hohai University

The evaluation of the seismic stability of an expanded municipal solid waste(MSW) landfill is very important in seismic prone *** this paper,the pseudo-dynamic method was used to calculate the average safety factor for the expanded landfill with a trapezoidal berm based on under-berm failure ***,the effects of the variation of parameters such as the amplification factor,seismic coefficient,height of berm,angle of back slope of berm,and depth of waste mass at the back slope on the seismic stability of the landfill were *** results indicated that the influences of the vertical seismic coefficient,height of berm,and angle of the back slope of the berm on the seismic stability of the landfill are weakened as the amplification factor increases,but the influence of the horizontal seismic coefficient on the seismic stability of the landfill is *** the other hand,a certain ratio of the height of the waste mass above the back slope to the depth of waste mass at the back slope,or the reasonable consideration of the magnitude of the amplification factor will be conducive to the seismic design of the *** addition,the results obtained by the pseudo-static and pseudo-dynamic methods were compared.

关键词： Seismic stability Expanded landfill Under-berm failure Pseudo-dynamic method Amplification factor