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Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin(Heart)-Pi(Spleen)Deficiency Syndrome:A Multi-centre Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 299-307页

作者： chen Xu chen Jiu-xi HAN Xue-yan ZHAO Yang CAO Jing jiao Xiu-zhen LIU Hong-mei GUO Chun-li MENG Shuo LIANG Shuai QI Jiang-xia chen Dong LI Ming-xia jiao Yun-xia WANG Ting-ting HONG Xia Xiyuan Clinical Medical College Beijing University of Chinese MedicineBeijing 100091China Department of Encephalopathy Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China First College of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Encephalopathy Botou Traditional Chinese Medicine Hospital of Hebei ProvinceBotou 062150China Institute of Basic Medicine Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Nephrology Pinggu HospitalBeijing Hospital of Traditional Chinese MedicineBeijing 101299China

Objective:To evaluate the efficacy and safety of Jianpi Jieyu Decoction(JJD)for treating patients with mild-to-moderate depression of Xin(Heart)-Pi(Spleen)deficiency(XPD)***:In this multi-center,randomized,controlled study,140 patients with mild-to-moderate depression of XPD syndrome were included from Xiyuan Hospital of China Academy of Chinese Medical Sciences and Botou Hospital of Traditional Chinese Medicine from December 2017 to December *** were randomly divided into JJD group and paroxetine group by using a random number table,with 70 cases in each *** patients in the JJD group were given JJD one dose per day(twice daily at morning and evening,100 m L each time),and the patients in the paroxetine group were given paroxetine(10 mg/d in week 1;20 mg/d in weeks 2-6),both orally administration for a total of 6 *** primary outcome was the change of 17-item Hamilton Depression Rating Scale(HAMD-17)score at week 6 from *** secondary outcomes included the Hamilton Anxiety Scale(HAMA)score,Traditional Chinese Medicine Symptom Scale(TCMSS),and Clinlcal Global Impression(CGI)scores at the 2nd,4th,and 6th weekends of treatment,HAMD-17 response(defined as a reduction in score of>50%)and HAMD-17 remission(defined as a score of 7)at the end of the 6th week of *** events(AEs)were also ***:From baseline to week 6,the HAMD-17 scores decreased 10.2±4.0 and 9.1±4.9 points in the JJD and paroxetine groups,respectively(P=0.689).The HAMD-17 response occurred in 60%of patients in the JJD group and in 50%of those in the paroxetine group(P=0.292);HAMD-17 remission occurred in 45.7%and 30%of patients,respectively(P=0.128).The differences of CGI scores at the 6th week were not statistically significant(P>0.05).There were significant differences in HAMD-17 scores between the two groups at 2nd and 4th week(P=0.001 and P=0.014).The HAMA scores declined 8.1±3.0 and 6.9±4.3 points from baseline to week 6 in the JJD and paroxe

关键词： depression Xin(Heart)-Pi(Spleen)deficiency syndrome Chinese medicine Jianpi Jieyu Decoction depression efficacy safety

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超声扫查路线图对颈椎超声初学者学习效果的影响

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基础医学与临床 2024年第4期44卷 572-576页

作者：陈思张娇张越伦崔旭蕾谭刚中国医学科学院、北京协和医学院、北京协和医院麻醉科北京100730 中国医学科学院、北京协和医学院、北京协和医院医学科学研究中心北京100730

目的利用团队近期研究成果“颈椎超声扫查路线图”作为教学工具,评价该工具对颈椎超声初学者学习效果、学习信心的影响。方法本研究为自身前-后对照研究。纳入北京协和医院麻醉科40名临床一线医生,完成评估问卷1。问卷设计为:3个关于... 详细信息

目的利用团队近期研究成果“颈椎超声扫查路线图”作为教学工具,评价该工具对颈椎超声初学者学习效果、学习信心的影响。方法本研究为自身前-后对照研究。纳入北京协和医院麻醉科40名临床一线医生,完成评估问卷1。问卷设计为:3个关于颈椎超声理论知识的自我评估问题,3个关于颈椎超声实践技能的自我评估问题和1个关于未来使用颈椎超声的意愿问题。在不涉及路线图的传统教学后,再次完成相同内容的问卷2。休息20 min后,教师介绍并解释路线图,随后学员完成问卷3。问卷3增加了4个学习满意度相关问题。所有问题的答案使用1到10分制评估。主要结果为综合学习得分,计算为(理论知识自评总分+实践技能自评总分+未来使用颈椎超声的意愿得分)/7。结果 40位学员在学习前、传统学习后、路线图学习后三个时间点的综合学习得分为2.9±1.3、4.8±1.8、5.7±1.8,F(2,22)=52.11,P<0.001,偏η2=0.83。向学员介绍路线图后,与介绍前的传统培训结果相比,综合学习得分增加了1.0 (95%CI:0.46~1.49)(P<0.001)。结论 “颈椎超声扫查路线图”可以显著提高颈椎超声初学者的学习效果及学习信心,可作为常规培训工具应用于颈椎超声教学。

关键词：疼痛脊柱超声颈椎教学

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Numerical evaluation of overestimation of the interface thickness around ellipsoidal particle

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Theoretical & Applied Mechanics Letters 2013年第5期3卷 39-41页

作者： wenxiang Xu Huisu chen wen chen Institute of Soft Matter Mechanics College of Mechanics and Materials Hohai University Jiangsu Key Laboratory of Construction Materials College of Materials Science and EngineeringSoutheast University

Abstract When interfacial layers are viewed as a separate phase, the interface thickness plays an essential role in assessing physico-mechanical properties of particulate materials. However, the interface thickness from sectional analysis is often overestimated, due to the irregularity of surface textures of grains in opaque materials that gives rise to the normal of a cross-sectional plane non-perpendicular to the surface of grains. Hence, the determination of the overestimation degree is very critical to precisely obtain the interface thickness. This article develops a numerical model for the overestimation degree of the interface thickness around an ellipsoidal grain with an arbitrary aspect ratio, by applying an accurate sectional analysis algorithm, and quantitative stereology and geometrical probability theories. Furthermore, on the basis of the developed numerical model, the influence of ellipsoidal particle shape on the overestimation degree is quantitatively charac-terized.

关键词： multiphase materials interface thickness ellipsoidal particle overestimation model

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A Combined Countermeasure Against Side-Channel and Fault Attack with Threshold Implementation Technique

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Chinese Journal of Electronics 2023年第2期32卷 199-208页

作者： jiao Zhipeng chen Hua FENG Jingyi KUANG Xiaoyun YANG Yiwei LI Haoyuan FAN Limin Trusted Computing and Information Assurance Laboratory Institute of SoftwareChinese Academy of Sciences University of Chinese Academy of Sciences Electric Power Research Institute China Southern Power Grid

Side-channel attack(SCA) and fault attack(FA) are two classical physical attacks against cryptographic implementation. In order to resist them, we present a combined countermeasure scheme which can resist both SCA and FA. The scheme combines threshold implementation and duplication-based exchange techniques. The exchange technique can confuse the fault propagation path and randomize the faulty values. The threshold implementation technique can ensure a provable security against SCA. Moreover, it can also help to resist the FA by its incomplete property and random numbers. Compared with other methods, the proposed scheme has simple structure, which can be easily implemented in hardware and result in a low implementation cost. Finally, we present a detailed design for the block cipher light encryption device(LED) and implement *** hardware cost evaluation shows our scheme has the minimum overhead factor.

关键词： Resistance Ciphers Costs Resists Side-channel attacks Light emitting diodes Hardware

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板结构水下爆炸下的空化特性

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火炸药学报 2024年第8期47卷 714-729,I0003页

作者：陈钰帆黄锡堤赖志超秦健孟祥尧文彦博黄瑞源福州大学土木工程学院福建福州350100 海军研究院北京100161

针对水下爆炸过程中产生的空化效应会对舰船板结构产生二次加载作用,对结构的毁伤不可忽略,并且空化特性与爆炸的方位角和板的曲率等情况显著相关。采用实验与数值模拟相结合的方法,研究了不同爆炸方位角和不同板曲率对空化特性以及板... 详细信息

针对水下爆炸过程中产生的空化效应会对舰船板结构产生二次加载作用,对结构的毁伤不可忽略,并且空化特性与爆炸的方位角和板的曲率等情况显著相关。采用实验与数值模拟相结合的方法,研究了不同爆炸方位角和不同板曲率对空化特性以及板的动态响应的影响;通过对比不同爆距下的气泡和空化演化过程,验证了数值方法的准确性。结果表明,爆炸方位角在0°~90°之间时,空化区域的体积随方位角的增大先减小后增大,气泡和射流的方向受板的影响向板偏移;气泡脉动水射流和空化的耦合作用对板的动态响应占主导作用,方位角等于60°时可达总应变的73.15%;爆炸方位角会影响板的动态响应,临界方位角在45°附近,此时板的位移和等效塑性应变最大;板的曲率会显著影响空化现象,曲率越大空化现象越难发生,空化区域体积越小,板的动态响应随曲率的增大而减小,且减小率也随之减小。

关键词：爆炸力学水下爆炸空化效应爆炸方位角曲率动态响应

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人造板定制橱柜产品完整BOM结构树解决方案探讨

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中国人造板 2024年第10期31卷 26-30页

作者：谢结玲陈立航温子娴陈国梁索菲亚家居股份有限公司广州511358

针对定制家居产业中,人造板定制橱柜产品BOM(Bill of Materials)结构树层级不完整、重要信息版块缺失等问题,探讨了构建橱柜产品完整BOM结构树的解决思路,以期为定制家居行业大规模生产的数据管理提供参考。

关键词：产品BOM结构树定制橱柜数据管理

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琼东南盆地宝岛21-1区陵水组沉积特征及其油气地质意义

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地质科技通报 2024年第5期43卷 31-44页

作者：江汝锋曹立成邓孝亮何云龙焦垚祺陈子归李韬张祺中海石油(中国)有限公司海南分公司海口570311 中国地质大学(武汉)海洋地质资源湖北省重点实验室武汉430074

近期在琼东南盆地宝岛21-1区发现了我国首个深水深层大气田,对南海深水区深层油气勘探研究具有重要意义。基于宝岛21-1区最新获得的钻井和地震资料,分析了上渐新统陵水组三段的沉积特征及其油气地质意义。结果表明,陵三段沉积时期以双... 详细信息

近期在琼东南盆地宝岛21-1区发现了我国首个深水深层大气田,对南海深水区深层油气勘探研究具有重要意义。基于宝岛21-1区最新获得的钻井和地震资料,分析了上渐新统陵水组三段的沉积特征及其油气地质意义。结果表明,陵三段沉积时期以双向物源为主,早期扇三角洲沉积发育于邻近高地,晚期辫状河三角洲沉积受NW向海南隆起物源和NE向神狐隆起物源的控制。此外,陡坡和缓坡的沉积物搬运通道表现出较大差异。陵三段沉积演化可分为3个阶段:由早期扇三角洲沉积、中期扇三角洲-辫状河三角洲沉积发展至晚期辫状河三角洲沉积,物源区也从早期邻近高地的单向供源、中期邻近高地-神狐隆起的双向供源演化至晚期海南隆起-神狐隆起的双向供源。研究区邻近崖城组烃源岩,发育12-1号断裂及伴生断裂,形成构造-岩性圈闭,成藏地质条件优越。宝岛21-1区气田的发现是我国深水油气勘探领域的重大突破,指明了海相盆地中断裂转换带是未来深水勘探的关键区域。

关键词：琼东南盆地宝岛21-1区陵水组沉积特征油气勘探

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Association of VDR Polymorphisms and Gene-obesity Interaction with Type 2 Diabetes:A Case-control Study among Chinese Rural Population

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Biomedical and Environmental Sciences 2022年第11期35卷 1074-1078页

作者： XU Ze ZHANG Dong Dong LIU Ya Ping ZHANG Yu Jing XUE Yuan GAO jiao jiao ZHAO Tong HUANG Hao Yue LI wen Jie LI Xing Department of Nutrition and Food Hygiene College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina

In recent years,the prevalence of type 2 diabetes(T2D)has increased at an alarming rate,and the epidemic of T2D mellitus and its complications poses a major global health ***,the International Diabetes Federation esti... 详细信息

关键词： Diabetes obesity mellitus

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广东省潮州市2022年非伤寒沙门菌病原学特征

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中国热带医学 2024年第6期24卷 714-720页

作者：文金洲李柏生唐少煌曾树权周涵谢钒陈少雄潮州市疾病预防控制中心广东潮州521000 广东省疾病预防控制中心广东广州510000 潮州市中心医院广东潮州521000

目的分析2022年潮州市非伤寒沙门菌血清型、耐药性及分子流行病学特征,为有效防控食源性疾病的发生提供病原学支持。方法2022年通过广东省潮州市哨点监测和食品风险监测,分离人源非伤寒沙门菌和食品来源非伤寒沙门菌,并对菌株开展血清... 详细信息

目的分析2022年潮州市非伤寒沙门菌血清型、耐药性及分子流行病学特征,为有效防控食源性疾病的发生提供病原学支持。方法2022年通过广东省潮州市哨点监测和食品风险监测,分离人源非伤寒沙门菌和食品来源非伤寒沙门菌,并对菌株开展血清学分型、药敏试验和全基因组测序分析。结果2022年潮州市腹泻监测粪便标本共采集1257份,检出非伤寒沙门菌58株,分离率4.61%;116份食品标本中检出非伤寒沙门菌2株,分离率1.72%。幼儿期为感染的主要年龄段(14/144,9.72%)。6月份检出率最高(12/123,9.76%)。58株人源非伤寒沙门菌可分成12种血清型,其中鼠伤寒沙门菌检出率最高(44/58,75.86%)。药敏结果示,55株存在耐药,耐药率91.67%,其中氨苄西林、四环素、氯霉素和链霉素的耐药率较高,分别为76.67%、70.00%、67.67%和60.00%;49株具有多重耐药性,多重耐药率占81.67%。分子特征示,通过多位点序列分型(multilocus sequence typing,MLST)60株沙门菌菌株可分成14个序列分型(sequence typing,ST),鼠伤寒沙门菌ST34占主导优势,全基因组单核苷酸多态性(whole genome single nucleotide polymorphism,wg-SNP)进化分析示,本研究菌株间表现为较高的遗传异质性,鼠伤寒沙门菌聚类分布,临床样本肠炎沙门菌进化关系较为接近。结论2022年潮州市人源非伤寒沙门菌血清型多样,其中鼠伤寒沙门菌占优势,多重耐药情况严重,分子分型呈现进化多样性特点。

关键词：非伤寒沙门菌血清分型药敏试验全基因组测序

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High ratio of illegitimate visitation by small bees severely weakens the potential function of heteranthery

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Journal of Plant Ecology 2015年第2期8卷 213-223页

作者： jiao-Kun Li Yun-Peng Song Hui Xu Yan-wen Zhang Jian-Yu Zhu Lu-Lu Tang School of Minerals Processing and Bioengineering Central South UniversityNo.932South lushan RoadChangsha 410083China School of Metallurgy and Environment Central South UniversityNo.932South lushan RoadChangsha 410083China School of Life Sciences Central South UniversityNo.172Tongzipo RoadChangsha 410013China Department of Biology Changchun Normal UniversityNo.3291North Changji RoadChangchun 130032China

Aims in heterantherous plants,‘division of labor’among structurally dif-ferent stamens,*** and feeding functions,has been thought to reduce the evolutionary conflict of relying on pollen both as the carrier of male gametes and as the food for *** key to successful division of labor among different sets of stamens is the size match between stamens and legitimate pollinators,which results in the precise deposition of pollen onto specific locations on pollinator’s body and facilitates cross ***,the potential impact of small illegitimate insects that are ubiquitous dur-ing the pollination process on the plant reproduction in heteranth-erous species has been largely neglected in previous studies and never been demonstrated *** Here,we investigated the functions of three different types of sta-mens in Commelina *** pollinator visitation,pollen removal and deposition were compared among flowers with dif-ferent types of anthers emasculated at two natural ***,the mating systems of *** in wild populations were estimated using microsatellite *** Findingsour data showed that the main floral visitors for *** at the two studied populations were small illegitimate bees rather than legitimate pollinators,accounting for 77.5 and 92.2%of total flower visits,*** manipulations in *** demon-strated that the two types of brightly yellow stamens separately func-tioned as‘deceptive attraction’and‘feeding’*** the brown inconspicuous stamens of *** with the largest amount of fertile pollen had the potential function in offering pollen for cross pollination,the high ratio of illegitimate visitation by small bees significantly affected the dispersal and deposition of pollen from the pollinating anthers,and subsequently decreased the levels of outcrossing(tm=0.23-0.32)in wild *** work further confirmed that the size match betwe

关键词： Commelina communis division of labor heteranthery illegitimate visitation mating system

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