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Anti-oxidant and anti-inflammatory effects of hydrogenrich water alleviate ethanol-induced fatty liver in mice

World Journal of Gastroenterology 2017年第27期23卷 4920-4934页

作者： Ching-Pin Lin wen-chen Chuang Fung-Jou Lu Chih-Yen chen Institute of Biochemistry Microbiology and ImmunologyChung Shan Medical University Division of Gastroenterology Department of Internal MedicineChung Shan Medical University Hospital Institute of Medicine Chung Shan Medical University Division of Gastroenterology and Hepatology Department of MedicineTaipei Veterans General Hospital Faculty of Medicine National Yang-Ming University School of Medicine

AIM To investigate the effects of hydrogen-rich water(HRW) treatment on prevention of ethanol(Et OH)-induced early fatty liver in *** In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control,Et OH,Et OH + silymarin,Et OH + HRW and Et OH + silymarin + HRW. Each group was fed a Lieber-De Carli liquid diet containing Et OH or isocaloric maltose dextrin(control diet). Silymarin was used as a positive control to compare HRW efficacy against chronic Et OH-induced hepatotoxicity. HRW was freshly prepared and given at a dosage of 1.2 m L/mouse trice daily. Blood and liver tissue were collected after chronic-binge liquid-diet feeding for 12 *** The in vitro study showed that HRW directly scavenged hydrogen peroxide. The in vivo study showed that HRW increased expression of acyl ghrelin,which was correlated with food intake. HRW treatment significantly reduced Et OH-induced increases in serum alanine aminotransferase,aspartate aminotransferase,triglycerol and total cholesterol levels,hepatic lipid accumulation and inflammatory cytokines,including tumor necrosis factor-alpha(TNF-α) and interleukin(IL)-6. HRW attenuated malondialdehyde level,restored glutathione depletion and increased superoxide dismutase,glutathione peroxidase and catalase activities in the liver. Moreover,HRW reduced TNF-α and IL-6 levels but increased IL-10 and IL-22 *** HRW protects against chronic Et OH-induced liver injury,possibly by inducing acyl ghrelin to suppress the pro-inflammatory cytokines TNF-α and IL-6 and induce IL-10 and IL-22,thus activating antioxidant enzymes against oxidative stress.

关键词： Hydrogen Chronic plus binge Et OH feeding Antioxidant Protective cytokine Acyl ghrelin Female mice

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Machine learning-based identification for the main influencing factors of alluvial fan development in the Lhasa River Basin,Qinghai-Tibet Plateau

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Journal of Geographical Sciences 2022年第8期32卷 1557-1580页

作者： chen Tongde WEI Wei jiao Juying ZHANG Ziqi LI Jianjun State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationNorthwest A&F UniversityYangling 712100ShaanxiChina School of Automation Northwestern Polytechnical UniversityXi'an 710072China Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYangling 712100ShaanxiChina

Alluvial fans are an important land resource in the Qinghai-Tibet Plateau with the expansion of human activities. However, the factors of alluvial fan development are poorly understood. According to our previous investigation and research, approximately 826 alluvial fans exist in the Lhasa River Basin(LRB). The main purpose of this work is to identify the main influencing factors by using machine learning. A development index(Di) of alluvial fan was created by combining its area, perimeter, height and gradient. The 72% of data, including Di, 11 types of environmental parameters of the matching catchment of alluvial fan and 10 commonly used machine learning algorithms were used to train and build *** 18% of data were used to validate models. The remaining 10% of data were used to test the model accuracy. The feature importance of the model was used to illustrate the significance of the 11 types of environmental parameters to Di. The primary modelling results showed that the accuracy of the ensemble models, including Gradient Boost Decision Tree,Random Forest and XGBoost, are not less than 0.5(R^(2)). The accuracy of the Gradient Boost Decision Tree and XGBoost improved after grid research, and their R^(2) values are 0.782 and 0.870, respectively. The XGBoost was selected as the final model due to its optimal accuracy and generalisation ability at the sites closest to the LRB. Morphology parameters are the main factors in alluvial fan development, with a cumulative value of relative feature importance of 74.60% in XGBoost. The final model will have better accuracy and generalisation ability after adding training samples in other regions.

关键词： alluvial fan machine learning feature importance XGBoost Lhasa River Basin

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超声扫查路线图对颈椎超声初学者学习效果的影响

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基础医学与临床 2024年第4期44卷 572-576页

作者：陈思张娇张越伦崔旭蕾谭刚中国医学科学院、北京协和医学院、北京协和医院麻醉科北京100730 中国医学科学院、北京协和医学院、北京协和医院医学科学研究中心北京100730

目的利用团队近期研究成果“颈椎超声扫查路线图”作为教学工具,评价该工具对颈椎超声初学者学习效果、学习信心的影响。方法本研究为自身前-后对照研究。纳入北京协和医院麻醉科40名临床一线医生,完成评估问卷1。问卷设计为:3个关于... 详细信息

目的利用团队近期研究成果“颈椎超声扫查路线图”作为教学工具,评价该工具对颈椎超声初学者学习效果、学习信心的影响。方法本研究为自身前-后对照研究。纳入北京协和医院麻醉科40名临床一线医生,完成评估问卷1。问卷设计为:3个关于颈椎超声理论知识的自我评估问题,3个关于颈椎超声实践技能的自我评估问题和1个关于未来使用颈椎超声的意愿问题。在不涉及路线图的传统教学后,再次完成相同内容的问卷2。休息20 min后,教师介绍并解释路线图,随后学员完成问卷3。问卷3增加了4个学习满意度相关问题。所有问题的答案使用1到10分制评估。主要结果为综合学习得分,计算为(理论知识自评总分+实践技能自评总分+未来使用颈椎超声的意愿得分)/7。结果 40位学员在学习前、传统学习后、路线图学习后三个时间点的综合学习得分为2.9±1.3、4.8±1.8、5.7±1.8,F(2,22)=52.11,P<0.001,偏η2=0.83。向学员介绍路线图后,与介绍前的传统培训结果相比,综合学习得分增加了1.0 (95%CI:0.46~1.49)(P<0.001)。结论 “颈椎超声扫查路线图”可以显著提高颈椎超声初学者的学习效果及学习信心,可作为常规培训工具应用于颈椎超声教学。

关键词：疼痛脊柱超声颈椎教学

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一起阀控保护动作事件分析

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青海电力 2024年第2期43卷 69-72页

作者：朱国超马海峰崔国良陈姣青海省电力公司超高压公司青海西宁810000

通过对青海某750 kV变电站750 kV甲乙Ⅱ线阀控保护装置动作跳开断路器事件的分析,找出750kV甲乙Ⅱ线阀控保护装置动作原因,研究解决阀控保护误动作的方法。通过优化阀控保护装置SV采样数据解析机制,最终解决此问题,并对日后安全稳定运... 详细信息

通过对青海某750 kV变电站750 kV甲乙Ⅱ线阀控保护装置动作跳开断路器事件的分析,找出750kV甲乙Ⅱ线阀控保护装置动作原因,研究解决阀控保护误动作的方法。通过优化阀控保护装置SV采样数据解析机制,最终解决此问题,并对日后安全稳定运行提出相应建议。

关键词：高压电抗器控制保护合并单元报文机制

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Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin(Heart)-Pi(Spleen)Deficiency Syndrome:A Multi-centre Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 299-307页

作者： chen Xu chen Jiu-xi HAN Xue-yan ZHAO Yang CAO Jing jiao Xiu-zhen LIU Hong-mei GUO Chun-li MENG Shuo LIANG Shuai QI Jiang-xia chen Dong LI Ming-xia jiao Yun-xia WANG Ting-ting HONG Xia Xiyuan Clinical Medical College Beijing University of Chinese MedicineBeijing 100091China Department of Encephalopathy Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China First College of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Encephalopathy Botou Traditional Chinese Medicine Hospital of Hebei ProvinceBotou 062150China Institute of Basic Medicine Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Nephrology Pinggu HospitalBeijing Hospital of Traditional Chinese MedicineBeijing 101299China

Objective:To evaluate the efficacy and safety of Jianpi Jieyu Decoction(JJD)for treating patients with mild-to-moderate depression of Xin(Heart)-Pi(Spleen)deficiency(XPD)***:In this multi-center,randomized,controlled study,140 patients with mild-to-moderate depression of XPD syndrome were included from Xiyuan Hospital of China Academy of Chinese Medical Sciences and Botou Hospital of Traditional Chinese Medicine from December 2017 to December *** were randomly divided into JJD group and paroxetine group by using a random number table,with 70 cases in each *** patients in the JJD group were given JJD one dose per day(twice daily at morning and evening,100 m L each time),and the patients in the paroxetine group were given paroxetine(10 mg/d in week 1;20 mg/d in weeks 2-6),both orally administration for a total of 6 *** primary outcome was the change of 17-item Hamilton Depression Rating Scale(HAMD-17)score at week 6 from *** secondary outcomes included the Hamilton Anxiety Scale(HAMA)score,Traditional Chinese Medicine Symptom Scale(TCMSS),and Clinlcal Global Impression(CGI)scores at the 2nd,4th,and 6th weekends of treatment,HAMD-17 response(defined as a reduction in score of>50%)and HAMD-17 remission(defined as a score of 7)at the end of the 6th week of *** events(AEs)were also ***:From baseline to week 6,the HAMD-17 scores decreased 10.2±4.0 and 9.1±4.9 points in the JJD and paroxetine groups,respectively(P=0.689).The HAMD-17 response occurred in 60%of patients in the JJD group and in 50%of those in the paroxetine group(P=0.292);HAMD-17 remission occurred in 45.7%and 30%of patients,respectively(P=0.128).The differences of CGI scores at the 6th week were not statistically significant(P>0.05).There were significant differences in HAMD-17 scores between the two groups at 2nd and 4th week(P=0.001 and P=0.014).The HAMA scores declined 8.1±3.0 and 6.9±4.3 points from baseline to week 6 in the JJD and paroxe

关键词： depression Xin(Heart)-Pi(Spleen)deficiency syndrome Chinese medicine Jianpi Jieyu Decoction depression efficacy safety

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枫杨总黄酮通过抑制中性粒细胞胞外陷阱网的释放减轻大鼠类风湿关节炎

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南方医科大学学报 2024年第9期44卷 1645-1652页

作者：杨锐舒翊秦文晖杰蔡熹王震张棽向阳吴昊湖北恩施学院医学部湖北恩施445000 湖北恩施学院风湿性疾病发生与干预湖北省重点实验室湖北恩施445000

目的探讨枫杨总黄酮(PHSTF)干预类风湿关节炎(RA)的机制,为治疗类风湿关节炎提供新的理论基础。方法将25只雄性SD大鼠随机分为正常组、模型组(CIA组)、枫杨总黄酮低剂量组[CIA+PHSTF(45 mg/kg)]、枫杨总黄酮高剂量组[CIA+PHSTF(90 mg/k... 详细信息

目的探讨枫杨总黄酮(PHSTF)干预类风湿关节炎(RA)的机制,为治疗类风湿关节炎提供新的理论基础。方法将25只雄性SD大鼠随机分为正常组、模型组(CIA组)、枫杨总黄酮低剂量组[CIA+PHSTF(45 mg/kg)]、枫杨总黄酮高剂量组[CIA+PHSTF(90 mg/kg)]、雷公藤多苷片组[CIA+TPG(10 mg/kg)],5只/组。除正常组外,对其余大鼠采用二次免疫法建立CIA大鼠模型。二次免疫结束后,枫杨总黄酮组和雷公藤多苷片组按相应剂量灌胃给药,1次/d,连续4周。采用ELISA检测血清中细胞因子(TNF-α、IL-1β)的水平;HE染色检测踝关节组织损伤情况;免疫组化(IHC)检测踝关节中性粒细胞胞外陷阱网(NETs)标志物瓜氨酸化组蛋白3(Cit-H3)的表达水平。建立细胞模型,设立枫杨总黄酮不同剂量组(0、12.5、25、50、100、200μg/mL),利用CCK-8探索PHSTF用药浓度,采用迪夫快速染色法观察中性粒细胞的形态;设立对照组(Control),佛波酯(PMA)刺激中性粒细胞模拟NETs形成建立模型组(PMA),枫杨总黄酮低剂量组[CIA+PHSTF(100μg/mL)],枫杨总黄酮高剂量组[CIA+PHSTF(200μg/mL)]。Western blotting检测枫杨总黄酮干预后NETs标志性蛋白Cit-H3,肽酰基精氨酸脱亚胺酶4(PADI4),中性粒细胞弹性蛋白酶(NE)以及髓过氧化物酶(MPO)的表达,免疫荧光检测Cit-H3的表达观察NETs形成。结果体内实验中,与模型组相比较枫杨总黄酮可明显改善CIA大鼠踝关节的肿胀程度(P<0.05),降低血清中炎症因子水平(P<0.05),显著改善踝关节组织病理程度,降低血清以及踝关节软骨中性粒细胞胞外诱捕网浓度,抑制中性粒细胞胞外诱捕网的释放(P<0.05)。体外实验中,枫杨总黄酮并未对中性粒细胞活性有明显影响(P<0.01),此外枫杨总黄酮显著抑制PMA诱导的中性粒细胞胞外诱捕网的释放(P<0.05)。结论枫杨总黄酮可以通过抑制NETs的产生,达到干预类风湿关节炎的目的。

关键词：枫杨总黄酮中性粒细胞胞外陷阱网类风湿关节炎

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Numerical evaluation of overestimation of the interface thickness around ellipsoidal particle

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Theoretical & Applied Mechanics Letters 2013年第5期3卷 39-41页

作者： wenxiang Xu Huisu chen wen chen Institute of Soft Matter Mechanics College of Mechanics and Materials Hohai University Jiangsu Key Laboratory of Construction Materials College of Materials Science and EngineeringSoutheast University

Abstract When interfacial layers are viewed as a separate phase, the interface thickness plays an essential role in assessing physico-mechanical properties of particulate materials. However, the interface thickness from sectional analysis is often overestimated, due to the irregularity of surface textures of grains in opaque materials that gives rise to the normal of a cross-sectional plane non-perpendicular to the surface of grains. Hence, the determination of the overestimation degree is very critical to precisely obtain the interface thickness. This article develops a numerical model for the overestimation degree of the interface thickness around an ellipsoidal grain with an arbitrary aspect ratio, by applying an accurate sectional analysis algorithm, and quantitative stereology and geometrical probability theories. Furthermore, on the basis of the developed numerical model, the influence of ellipsoidal particle shape on the overestimation degree is quantitatively charac-terized.

关键词： multiphase materials interface thickness ellipsoidal particle overestimation model

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Association of VDR Polymorphisms and Gene-obesity Interaction with Type 2 Diabetes:A Case-control Study among Chinese Rural Population

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Biomedical and Environmental Sciences 2022年第11期35卷 1074-1078页

作者： XU Ze ZHANG Dong Dong LIU Ya Ping ZHANG Yu Jing XUE Yuan GAO jiao jiao ZHAO Tong HUANG Hao Yue LI wen Jie LI Xing Department of Nutrition and Food Hygiene College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina

In recent years,the prevalence of type 2 diabetes(T2D)has increased at an alarming rate,and the epidemic of T2D mellitus and its complications poses a major global health ***,the International Diabetes Federation esti... 详细信息

关键词： Diabetes obesity mellitus

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World Federation of Acupuncture-Moxibustion Societies(WFAS)Clinical Practice Guideline on Acupuncture and Moxibustion:Migraine recommendation summaries

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World Journal of Acupuncture-Moxibustion 2024年第3期34卷 204-212页

作者： wen-qian MA Shuo CUI Jing HU Zhong-jie chen Jin HUO Ya-ping LIU Xiao-yu WANG Zi-wei SONG Qi GAO Shu-hua MA Yi ZHANG Zhong-chao WU Ji-ping ZHAO Xiang-hong JING Xiao-dong WU Yu-tong FEI Bin XU Shao-zong chen cheng QIAN Chun-gui YANG Dong-qing ZHANG Ling ZHAO Bin LI Filomena Petti Aldo Liguori Carlos Llopis Claudia Skopalik Zhao DONG Jian YIN Zhen HUA Dong-sheng WANG Gerd Lutterjohann Yue jiao Jing-jing WANG Institute of Acupuncture and moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Experimental Research Center China Academy of Chinese Medical SciencesBejing100700China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100007China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100105China Key Laboratory of the Ministry of Education for the Integration of Needle and Medicine Nanjing University of Chinese MedicineNanjing 210023China School of Acupuncture-moxibustion and Tuina Mossage Shandong University of Traditional Chinese MedicineJinan 250355China Shenzhou Open University of Traditional Chinese medicine Noord-Holland 671011 EKNetherlands Chinese Medicine Society Sweden Stockholm 10653Sweden School of Acupuncture-moxibustion and Tuina Mossage Chengdu University of Traditional Chinese MedicineChengdu 610075China Acupuncture-moxibustion Department of Beijing Hospital of Traditional Chinese Mediane Bejing 100010China Istituto Paracelso Rome 00153Italy European Foundation of Traditional Chinese Medicine Madrid 28000Spain Department of Neurology First Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Neurology of Beijing Hospital Beijing 100853China Anesthesiology Department and pain diagnosis and treatment center Beijing HospitalBejing 100853China Division of Psychology of Beijing Normal University Beijing 100091China German Medical Association for Acupuncture(DAGfA) Munich 80801Germany Tsinghua University Hospital Bejing 100084China

Clinical Practice Guideline on Acupuncture and Moxibustion:Migraine(WFAS 007.9-2023)is a clinical practice guideline officially released by the World Federation of Acupuncture-Moxibustion Societies(WFAS)on October 9,2023,and is the first international guideline on the treatment of migraine with *** international standard was developed under the guidance of rigorous evidence-based methodology,and it contains guideline purpose,scope,applicable population,applicable settings,overview of acupuncture for migraine,guideline development process and *** promoting the understanding and application of this guideline,this article summarizes a total of 18 recommendations in order to assist clinical decisions for migraine with acupuncture.

关键词： Acupuncture acupuncture Moxibustion

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板结构水下爆炸下的空化特性

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火炸药学报 2024年第8期47卷 714-729,I0003页

作者：陈钰帆黄锡堤赖志超秦健孟祥尧文彦博黄瑞源福州大学土木工程学院福建福州350100 海军研究院北京100161

针对水下爆炸过程中产生的空化效应会对舰船板结构产生二次加载作用,对结构的毁伤不可忽略,并且空化特性与爆炸的方位角和板的曲率等情况显著相关。采用实验与数值模拟相结合的方法,研究了不同爆炸方位角和不同板曲率对空化特性以及板... 详细信息

针对水下爆炸过程中产生的空化效应会对舰船板结构产生二次加载作用,对结构的毁伤不可忽略,并且空化特性与爆炸的方位角和板的曲率等情况显著相关。采用实验与数值模拟相结合的方法,研究了不同爆炸方位角和不同板曲率对空化特性以及板的动态响应的影响;通过对比不同爆距下的气泡和空化演化过程,验证了数值方法的准确性。结果表明,爆炸方位角在0°~90°之间时,空化区域的体积随方位角的增大先减小后增大,气泡和射流的方向受板的影响向板偏移;气泡脉动水射流和空化的耦合作用对板的动态响应占主导作用,方位角等于60°时可达总应变的73.15%;爆炸方位角会影响板的动态响应,临界方位角在45°附近,此时板的位移和等效塑性应变最大;板的曲率会显著影响空化现象,曲率越大空化现象越难发生,空化区域体积越小,板的动态响应随曲率的增大而减小,且减小率也随之减小。

关键词：爆炸力学水下爆炸空化效应爆炸方位角曲率动态响应

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