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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang hua-Wei Zhang Xiao-Mei Song Yu-Ze Li wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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万家寨水库水量调度自适应模型研究

水利技术监督 2025年第1期 221-224,236页

作者：邢华孙超黄河万家寨水利枢纽有限公司山西太原030000

为增强水库水量调度对外部环境变化的适应性,提升流域水资源管理水平,基于水量调度中用水户与供水户的交互过程,文章建立万家寨水库水量调度自适应模型,并采用基于罚函数的分布式优化算法模拟供水决策机制。模型运行结果表明水库水量调... 详细信息

为增强水库水量调度对外部环境变化的适应性,提升流域水资源管理水平,基于水量调度中用水户与供水户的交互过程,文章建立万家寨水库水量调度自适应模型,并采用基于罚函数的分布式优化算法模拟供水决策机制。模型运行结果表明水库水量调度计划能根据社会经济发展和上游来水变化适应性生成,通过水库调水可有效满足区域城市、工业和生态用水需求,结果可为水库水量调度计划的编制和流域水资源管理提供依据。

关键词：水量调度水资源系统自适应模型利益偏好因子万家寨水库

Study on Evaluation Method of Failure Pressure for Pipeline with Axially Adjacent Defects

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China Ocean Engineering 2023年第4期37卷 598-612页

作者： sun Ming-ming FANG Hong-yuan DU Xue-ming WANG wen-hua LI Xin School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou 450001China National Local Joint Engineering Laboratory of Major Infrastructure Testing and Rehabilitation Technology Zhengzhou 450001China Collaborative Innovation Center of Water Conservancy and Transportation Infrastructure Safety Zhengzhou 450001China Yellow River Laboratory Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China School of Hydraulic Engineering Faculty of Infrastructure EngineeringDalian University of TechnologyDalian 116024China

The interaction between axially adjacent defects is more significant than that between circumferentially aligned ***,the existing failure pressure assessment methods cannot accurately predict the failure pressure of axial adjacent *** the paper,the finite element model is adopted to analyze the influence of defect size,distribution mode and spacing between adjacent defects on failure pressure.A new failure pressure evaluation method is proposed by establishing the effective depth calculation model of corrosion colony with different distribution *** burst test of X52 pipeline is carried out to verify the applicability of the *** shows that the results of new method are consistent with the test results of pipeline with various defects and steel grades.

关键词： steel pipeline effective depth axially adjacent defects burst test evaluation method

Temperature-pH Sensitive IPN Hydrogels Composed of Silk Sericin and Poly(N-isopropylacrylamide)

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Chinese Chemical Letters 2006年第3期17卷 403-406页

作者： wen WU wen Jing LI Li Qun WANG Ke hua TU Wei Lin sun Deparment of Polymer Science and Engineering Zhejiang University Hangzhou 310027 Ningbo Institute of Technology Zhejiang University Ningbo 315100

Interpenetrating polymer network （IPN） composed of silk sericin （SS） and poly（N-isopropylacrylamide）（PNIPAAm） was prepared. The morphology of the IPNs, in which the SS phase was stained with ammonium cuprate, was examined with TEM and a relative homogeneous distribution of the two polymers was exhibited. The swelling behavior of the IPN hydrogels showed both temperature and pH dependences.

关键词： Silk sericin poly(N-isopropylacrylamide) interpenetrating polymer network.

A novel flotation scheme: selective flotation of tungsten minerals from calcium minerals using Pb–BHA complexes in Shizhuyuan

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Rare Metals 2017年第6期36卷 533-540页

作者： Hai-Sheng Han wen-Li Liu Yue-hua Hu Wei sun Xiao-Dong Li School of Mineral Processing and Bioengineering Central South University Hu Nan Shizhuyuan Non-ferrous Metal Limited Liability Corporation

The similar floatabilities of calcium minerals and the huge difference between scheelite and wolframite have resulted in difficulties during their separation by flotation in Shizhuyuan Mine. In this study, novel collectors, lead complexes of benzohydroxamic acid（Pb-BHA）,were introduced to modify the surface properties of scheelite and wolframite, thereby effectively and selectively improving floatability. The Pb-BHA complexes are found to be selective for the separation of scheelite and calcium minerals with little use of depressants and enable the synchronous flotation of scheelite and ***, a novel flotation process was developed for the recovery of tungsten minerals. The process is simplified greatly, and the recovery is improved by almost 10%.Removing or decreasing the amount of water glass contributes to the improvement of tungsten and fluorite recovery and the circulation of water and reagents, which benefits the environment.

关键词： Tungsten minerals Flotation Calciumminerals Benzohydroxamic acid complexes Water glass

High-Order Extended Kalman Filter Design for a Class of Complex Dynamic Systems with Polynomial Nonlinearities

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Chinese Journal of Electronics 2021年第3期30卷 508-515页

作者： sun Xiaohui wen Chenglin wen Tao School of Automation Hangzhou Dianzi University School of Automation Guangdong University of Petrochemical Technology School of Electronic and Information Engineering Beijing Jiaotong University

A novel High-order extended Kalman Filter(HEKF) is designed for a class of complex dynamic systems with polynomial nonlinearities. The state and measurement models are represented by multidimensional high-order polynomials, respectively. All highorder polynomials in the state model are defined as implicit variables. By combining original variables with implicit variables, the state model is equivalently formulated to be a pseudo-linear form. By modeling dynamic relationship between implicit variables and combining original variables with all implicit variables, a new linear augmented state model is established correspondingly. The measurement model can be equivalently formulated as a linear form. On the basis of the new linear state and linear measurement models, the HEKF is designed and derived in *** results demonstrate the effectiveness of the proposed estimator.

关键词： state estimation implicit variables linear form state model modeling dynamic relationship measurement model nonlinear filters Kalman Filter design polynomials HEKF high-order polynomials combining original variables Kalman filters polynomial nonlinearities measurement models linear state complex dynamic systems pseudolinear form

Electrochemical performance of Al_2O_3 pre-coated spinel LiMn_2O_4

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Rare Metals 2019年第2期38卷 128-135页

作者： Hong-Ming Zhou Yu-hua Zhu Jian Li wen-Jiao sun Zhong-Zhong Liu School of Materials Science and Engineering Central South University Hunan Zhengyuan Institute for Energy Storage Materials and Devices

Al_2O_3-coated spinel LiMn_2O_4 cathode materials, presintered LiMn_2O_4(P-LMO), and calcined LiMn_2O_4(C-LMO) were synthesized by chemical deposition and thermal treating method using presintered and calcined LiMn_2O_4 as precursors. The crystal structure, morphology,the thickness of the coating layer, and particle size of prepared samples were investigated by X-ray diffraction(XRD), scanning electron microscopy(SEM), high-resolution transmission electron microscopy(HRTEM), and Malvern instruments. The average particle size of P-LMO with like-spheres(0.3 μm) is much smaller than that of C-LMO(0.5 μm). The Al_2O_3 layer of P-LMO can effectively reduce the charge transfer resistance and inhibit the Mn dissolution. The electrochemical performance of P-LMO is better than that of C-LMO. It is found that the LiMn_2O_4 cathode materials have excellent electrochemical cyclability by coated 2 mol% Al_2O_3 at the surface of presintered material. The initial discharge capacity of the material with 2 mol% Al_2O_3-coated is 114.0 m Ah·g^(-1) at 0.1 C rate and 55 ℃, and the capacity retention is 87.3 % at 0.5 C rate.

关键词： Cathode materials Lithium manganese oxide Pre-coated Aluminum oxide Cycling stability

Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase

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Chinese Journal of Cancer 2015年第4期34卷 166-176页

作者： Peng Wang Yi-Chen sun wen-hua Lu Peng huang Yumin Hu sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Institute of Cardiopulmonary Cerebral Resuscitation Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center

Introduction:Oncogenic aaivation of the K-ras gene occurs in >90%of pancreatic ductal carcinoma and plays a critical role in the pathogenesis of this *** of reactive oxygen species(ROS) has also been observed in a wide spectrum of *** study aimed to investigate the mechanistic association between K-ras-induced transformation and increased ROS stress and its therapeutic implications in pancreatic ***:ROS level,NADPH oxidase(NOX) aaivity and expression,and cell invasion were examined in human pancreatic dua epithelial E6E7 cells transfeaed with K-ras^(G12V) compared with parental E6E7 *** cytotoxic effea and antitumor effect of capsaicin,a NOX inhibitor,were also tested in vitro and in ***:K-ras transfeaion caused activation of the membrane-associated redox enzyme NOX and elevated ROS generation through the phosphatidylinositol 3'-kinase(PI3K) ***,capsaicin preferentially inhibited the enzyme aaivity of NOX and induced severe ROS accumulation in K-ras-transformed cells compared with parental E6E7 ***,capsaicin effeaively inhibited cell proliferation,prevented invasiveness of /(-ras-transformed pancreatic cancer cells,and caused minimum toxicity to parental E6E7 *** vivo,capsaicin exhibited antitumor aaivity against pancreatic cancer and showed oxidative damage to the xenograft tumor ***:K-ras oncogenic signaling causes increased ROS stress through NOX,and abnormal ROS stress can selectively kill tumor cells by using NOX *** study provides a basis for developing a novel therapeutic strategy to effectively kill K-ras-transformed cells through a redox-mediated mechanism.

关键词： NAD(P)H氧化酶基因转化癌细胞胰腺癌 NADPH氧化酶氧化还原酶抗肿瘤活性杀伤

Combination of cataract surgery with intravitreal injection of dexamethasone intravitreal implant(Ozurdex)for uveitis-induced cataract

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 361-366页

作者： Jin Deng wen-Tao sun hua Ai Li-Ping Wang Xi’an People’s Hospital(Xi’an Fouth Hospital) Shaanxi Eye HospitalAffiliated People’s Hospital of Northwest UniversityXi’an 710004Shaanxi ProvinceChina

AIM:To evaluate the long-term results of patients with chronic uveitis-induced cataract by phacoemulsification with IOL implantation and intravitreal injection of dexamethasone(DEX)intravitreal implant(Ozurdex).METHODS:The study included 32 eyes of 26 patients treated with DEX implant due to chronic uveitis-induced cataract and followed up for at least a ***-corrected visual acuity(BCVA),intraocular pressure(IOP),anterior chamber reaction,central macular thickness(CMT),intraoperative and postoperative complications and uveitis recurrence were analyzed ***:A successful surgery was performed in all *** average follow-up period was *** female/male ratio was 13/*** age was 45.65±3.83y(range 26 to 65y).Etiologically,rheumatic arthritis occurred in 6 patients(18.75%),ankylosing spondylitis in 4(12.50%),HLA-B27 associated uveitis in 3(9.38%),Vogt-KoyanagiHarada-associated uveitis in 4(12.50%),Behcet’s disease in 2(6.25%),and 7(21.88%)suffered from unknown *** 32 eyes had varying degrees of improvement at 12mo after surgery,with 2 eyes showing BCVA of 0.1 or below(6.25%),6 having 0.1-0.5(18.75%),18 of 0.5-1.0(56.25%),and 6 of 1.0 or above(18.75%).No cases with increased IOP were *** values of mean CMT was increased at day 1,decreased at 1,3mo after surgery and increased at 6,12mo after *** severe uveitis reactions,such as fibrinous exudates in the anterior chamber and exudative membrane formation on the anterior surface of the IOL,were observed after ***:The present studies show that intravitreal injection of Ozudex during cataract operation can provide a new option for the clinical treatment of uveitis-induced cataract.

关键词： uveitis-induced cataract dexamethasone implant intravitreal injection