检索结果-南通市图书馆

皮肤针治疗肝肾不足型雄激素性脱发的疗效观察

在线全文

学校读者我要写书评

暂无评论

上海针灸杂志 2024年第6期43卷 669-674页

作者：肖鑫冉陈唯依余安胜云南中医药大学第一附属医院昆明650021 上海市气功研究所上海200030 上海中医药大学附属曙光医院上海201203

目的观察皮肤针治疗肝肾不足型雄激素性脱发的临床疗效。方法将64例肝肾不足型雄激素性脱发患者随机分为对照组和治疗组,每组32例。治疗组用皮肤针局部叩刺治疗,对照组用常规针刺治疗。分别观察两组患者治疗前、治疗4周后、治疗后的临... 详细信息

目的观察皮肤针治疗肝肾不足型雄激素性脱发的临床疗效。方法将64例肝肾不足型雄激素性脱发患者随机分为对照组和治疗组,每组32例。治疗组用皮肤针局部叩刺治疗,对照组用常规针刺治疗。分别观察两组患者治疗前、治疗4周后、治疗后的临床症状评分、中医证候积分和头皮温度的变化。比较两组临床疗效。结果治疗4周后和治疗后,两组临床症状评分均低于治疗前(P0.05),治疗组临床症状评分的治疗前后差值大于对照组(P0.05)。治疗组头皮温度升高程度较对照组更为明显(P0.05);两组治疗后的总有效率均高于同组治疗4周后(P<0.05)。结论皮肤针治疗肝肾不足型雄激素性脱发的临床疗效与常规针刺治疗相当,在改善临床症状和升高头皮温度方面优于常规针刺,可能通过改善头皮微循环而减轻临床症状。

关键词：针刺疗法皮肤针疗法梅花针疗法脱发雄激素肝肾不足

在线全文

学校读者我要写书评

暂无评论

宏观压痕测量血管壁力学性能方法的研究

生物医学工程学杂志 2024年第3期41卷 469-475页

作者：曹祎凡高志鹏石怡柯李芬宋辉张倩倩赵雅威陈凌峰李晓娜陈维毅太原理工大学生物医学工程学院太原030024 太原理工大学机械与运载工程学院太原030024 太原理工大学应用力学研究所太原030024

在动脉疾病的诊断和治疗中,有效评估血管壁局部生物力学特性至关重要。压痕测量可用于评估动脉局部力学性能,但压头的几何结构和分析理论对测量结果的影响尚不清楚。本文采用4种压头对猪的肺动脉、胸主动脉近心端和胸主动脉远心端进行测... 详细信息

在动脉疾病的诊断和治疗中,有效评估血管壁局部生物力学特性至关重要。压痕测量可用于评估动脉局部力学性能,但压头的几何结构和分析理论对测量结果的影响尚不清楚。本文采用4种压头对猪的肺动脉、胸主动脉近心端和胸主动脉远心端进行测量,并通过斯内登(Sneddon)和瑟尔吉(Sirghi)理论计算动脉弹性模量,探究压头几何结构和分析理论对弹性模量测量值的影响。结果显示,圆柱形压头测量的动脉弹性模量值低于球形压头测量值;其次,与Sirghi理论计算结果相比,通过不考虑黏附力的Sneddon理论获得的动脉弹性模量值略大。综上,本研究可为毫米级压痕技术有效测量动脉局部力学特性提供参数支持。

关键词：生物力学动脉压痕实验

基底硬度介导IL-1β调控软骨细胞炎症响应

在线全文

学校读者我要写书评

暂无评论

太原理工大学学报 2024年第2期55卷 384-389页

作者：孟楠王笑笑张艳君陈维毅卫小春张全有太原理工大学生物医学工程学院山西晋中030600 山西医科大学第二医院骨与软骨组织损伤修复山西省重点实验室太原030001

【目的】基质力学微环境异常是导致骨性关节炎(osteoarthritis,OA)的关键因素之一。然而,软骨细胞在基质力学微环境发生变化过程中的炎症响应目前尚不清楚。【方法】利用聚二甲基硅氧烷(polydimethylsiloxane,PDMS)模拟正常和OA软骨细... 详细信息

【目的】基质力学微环境异常是导致骨性关节炎(osteoarthritis,OA)的关键因素之一。然而,软骨细胞在基质力学微环境发生变化过程中的炎症响应目前尚不清楚。【方法】利用聚二甲基硅氧烷(polydimethylsiloxane,PDMS)模拟正常和OA软骨细胞周基质(pericellular matrix,PCM)硬度,制备不同硬度的细胞培养基底,定量分析基底硬度和炎症因子白细胞介素-1β(interleukin-1β,IL-1β)协同作用对软骨细胞形态、炎症介质和基质重塑蛋白表达的影响。首先,定量分析了不同基底硬度和IL-1β对软骨细胞前列腺素E2(prostaglandin,PGE2)和一氧化氮(NO)分泌水平的影响;其次,采用免疫荧光技术分析了IL-1β对不同硬度基底上软骨细胞铺展面积和核面积的影响;最后,采用Western blot分析了不同硬度基底上软骨细胞Ⅱ型胶原(typeⅡcollagen,COLⅡ)和基质金属蛋白酶13(matrix metalloproteinase-13,MMP13)蛋白水平的表达。【结果】实验结果表明,基底硬度介导软骨细胞对炎症信号IL-1β的响应。软基底显著增强PGE2和NO释放量(P<0.0001)及MMP-13的蛋白表达水平(P<0.05),而IL-1β能进一步增强这一调控作用;硬基底能显著促进软骨细胞铺展面积、核面积(P<0.0001)和Ⅱ型胶原蛋白表达水平(P<0.01),IL-1β加入后同样能进一步增强这种调控作用。【结论】有助于揭示软骨细胞感受基质力学微环境的力学生物学调控机制,同时也为优化细胞诱导性生物材料的设计提供了参考。

关键词：软骨细胞基底硬度白细胞介素1β 细胞周基质 Ⅱ型胶原基质金属蛋白酶13

维普期刊数据库博看期刊

Boosted photoreduction of diluted CO_(2) through oxygen vacancy engineering in NiO nanoplatelets

在线全文

学校读者我要写书评

暂无评论

Nano Research 2021年第3期14卷 730-737页

作者： weiyi chen Xueming Liu Bin Han Shujie Liang Hong Deng Zhang Lin School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Resource RecyclingSouth China University of TechnologyGuangzhou510006China Guangdong Engineering and Technology Research Center for Environmental Nanomaterials Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters(Ministry of Education)South China University of TechnologyGuangzhou510006China

Converting carbon dioxide(CO_(2))to diverse value-added products through photocatalysis can validly alleviate the critical issues of greenhouse effect and energy shortages *** particular,based on practical considerations,exploring novel catalysts to achieve efficient photoreduction of diluted CO_(2) is necessary and ***,this process is extremely challenging owing to the disturbance of competitive adsorption at low CO_(2) ***,we delicately synthesize oxygen vacancy-laden NiO nanoplatelets(r-NiO)via calcination under Ar protection to reduce diluted CO_(2) through visible light irradiation(>400 nm)assisted by a Ru-based *** from the strongly CO_(2) adsorption energy of oxygen vacancies,which was confirmed by density functional calculations,the r-NiO catalysts exhibit higher activity and selectivity(6.28×10^(3)µmol·h^(−1)·g^(−1);82.11%)for diluted CO_(2)-to-CO conversion than that of the normal NiO(3.94×10^(3)µmol·h^(−1)·g^(−1);65.26%).Besides,the presence of oxygen vacancies can also promote the separation of electron-hole *** research demonstrates that oxygen vacancies could act as promising candidates for photocatalytic CO_(2) reduction,offering fundamental guidance for the actual photoreduction of diluted CO_(2) in the future.

关键词： diluted CO_(2) photocatalytic reduction oxygen vacancies NiO nanoplatelets adsorption

Piezo1介导基底硬度调控软骨细胞初级纤毛形态

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川大学学报（医学版） 2024年第1期55卷 67-73页

作者：郭华庆兰敏华张强刘艳丽张艳君张全有陈维毅太原理工大学生物医学工程学院太原030024 山西医科大学第二医院骨与软骨组织损伤修复山西省重点实验室太原030009

目的研究基底硬度如何调控软骨细胞初级纤毛的形态,并进一步探究Piezo1如何介导基底硬度调控初级纤毛的形态。方法将聚二甲基硅氧烷(polydimethylsiloxane,PDMS)固化剂和主剂分别以1∶10(硬)、1∶50(中硬度)和1∶70(软)的比例混合,制成... 详细信息

目的研究基底硬度如何调控软骨细胞初级纤毛的形态,并进一步探究Piezo1如何介导基底硬度调控初级纤毛的形态。方法将聚二甲基硅氧烷(polydimethylsiloxane,PDMS)固化剂和主剂分别以1∶10(硬)、1∶50(中硬度)和1∶70(软)的比例混合,制成厚度为1 mm且具有不同硬度的基底膜:硬基底(2.21±0.12)MPa、中硬度基底(54.47±6.06)kPa和软基底(2.13±0.10)kPa。利用3种不同硬度基底培养软骨细胞;再分别用Tubastatin A(Tub A)抑制组蛋白脱乙酰酶6(histone deacetylase 6,HDAC6)、Piezo1激活剂Yoda1和抑制剂GsMTx4处理细胞,基于免疫荧光技术分析HDAC6、Yoda1和GsMTx4对软骨细胞形态和初级纤毛长度的影响。结果硬基底会增加软骨细胞铺展面积,免疫荧光显示与中等基底和软基底相比在硬基底上细胞骨架和细胞核面积显著增加(P<0.05),并且初级纤毛显著伸长(P<0.05),但是并不影响初级纤毛的出现率。软骨细胞HDAC6的活性随着基底硬度变软依次升高,抑制软骨细胞HDAC6的活性后,细胞骨架面积和细胞核面积以及初级纤毛长度在硬基底上增加更为显著(P<0.05)。经测试,加入Piezo1激活剂和抑制剂可以调控软骨细胞HDAC6的活性,并且初级纤毛的长度在加入激活剂Yoda1后显著增加(P<0.05),而在经抑制剂GsMTx4处理后,初级纤毛长度在硬基底上显著缩短(P<0.05)。结论培养皿基底硬度和Piezo1可能都通过调控HDAC6活性进而影响软骨细胞初级纤毛形态。

关键词：软骨细胞基底硬度初级纤毛细胞骨架 HDAC6 Piezo1

Analysis of specific lipid metabolites in cord blood of patients with gestational diabetes mellitus

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2022年第6期46卷 1565-1573页

作者： YANQIU LI chenJUN HAO weiyi chen QINGJU MENG Obstetrics Department Maternal and Child Health Hospital of PanYu DistrictGuangzhou511483China

This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus(GDM),the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of *** 2019–2020,21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital,Panyu District,*** general information such as weight,height,age,body mass index(BMI)before pregnancy were ***-targeted metabonomic detection and analysis were performed in umbilical cord plasma using LCMS *** age,BMI,delivery methods,and infant weight were different between GDM and *** were 167 lipid metabolites in umbilical cord blood associated with *** them,158 upregulated and 9 downregulated in *** were 13 dysregulated metabolites with C<30,including Lyso-phosphatidyl-colines LPC 16:0,18:2,18:1,18:0,20:4 and 22:6,glycerophosphocholines PC O-16:1,oleoylcarnitine CAR 18:2 and 18:1,dihexosylceramides Hex2Cer 13:0;2O,phosphatidylethanolamine PE O-22:6_2:0 and PE O-22:6_3:0 and sphingomyelin SM 8:0;2O/11:*** metabolites were associated with glycerophospholipid metabolism and sphingolipid ***,Lyso-phosphatidyl-colines,glycerophosphocholines,oleoylcarnitine,dihexosylceramides,phosphatidylethanolamine,and sphingomyelin were main lipid metabolites of GDM,which might be used for diagnosis and treatment of GDM.

关键词： Lipid Metabolite Gestational diabetes mellitus Pregnancy Infant

Phosphine production in anaerobic wastewater treatment under tetracycline antibiotic pressure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第7期30卷 239-250页

作者： Meiqing Lu Xiaojun Niu weiyi chen Zhu Liang Sheng You Xiaohong Gu School of Environment and Energy South China University of Technology Guangzhou 510006 China State Key Laboratory of Lake Science and Environment Nanjing 210008 China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen Key Laboratory of Soil and Groundwater Pollution Control Shenzhen 518055 China Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control Guangzhou 510640 China China Water Resources Pearl River Planning Surveying & Designing Co. Ltd. Guangzhou 510640 China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSouth China University of Technology Guangzhou Higher Education Mega Centre Guangzhou 510006 China

The influence of tetracycline（TC） antibiotics on phosphine（PH3） production in the anaerobic wastewater treatment was studied. A lab-scale anaerobic baffled reactor with three compartments was employed to simulate this process. The reactor was operated in a TC-absence wastewater and 250 μg/L TC-presence wastewater for three months after a start-up period,respectively. The responses of p H, oxidation–reduction potential（ORP）, chemical oxygen demand（COD）, total phosphorus（TP）, enzymes activity（dehydrogenase and acid phosphatase）,and microbial community were investigated to reveal the effect of TC on PH3 *** suggested that the dehydrogenase（DH） activity, acid phosphatase（ACP） activity and COD have positive relationship with PH3 production, while p H, ORP level and the TP in liquid phase have negative relationship with PH3 production. With prolonged TC exposure, decrease in p H and increase in DH activity are beneficial to PH3 production, while decrease in COD and ACP activity are not the limiting factors for PH3 production.

关键词： Tetracycline antibiotic Anaerobic Wastewater treatment Phosphine production

The effects of Haversian fluid pressure and harmonic axial loading on the poroelastic behaviors of a single osteon

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2012年第9期55卷 1646-1656页

作者： WU XiaoGang chen weiyi GAO ZhiPeng GUO HongMei WANG LiLi Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology Taiyuan 030024 China

In order to well understand the mechanism of the mechanotransduction in bone, we propose a new model of transverse iso- tropic and poroelastic osteon cylinder considering Haversian fluid pressure. The analytical pore pressure and velocity solutions are obtained to examine the fluid transport behavior and pressure distribution in a loaded osteon on two different exterior sur- face cases. Case I is stress free and fully permeable and case I1 is impermeable. The following are the results obtained. （i） The Haversian fluid may not be ignored because it can enlarge the whole osteonal fluid pressure field, and it bears the external loads together with the solid skeleton. （ii） The increase of both axial strain amplitude and frequency can result in the increase of fluid pressure and velocity amplitudes, while in case II, the frequency has little effect on the fluid pressure amplitude. （iii） Under the same loading conditions, the pressure amplitude in case II is larger than that in case I, while the velocity amplitude is smaller than that in case I. This model permits the linking of the external loads to the osteonal fluid pressure and velocity, which may be a stimulus to the mechanotransduction of bone remodeling signals.

关键词： osteon poroelasticity transverse isotropic bone fluid flow intraosseous pressure

在线全文

学校读者我要写书评

暂无评论

莲藕对鱼糜凝胶品质的影响

食品科技 2024年第3期49卷 120-125页

作者：黄彩芸谢媛媛陈尉怡郑如依陈训俭付裕含王蔚新黄冈师范学院生物与农业资源学院大别山特色资源开发协同创新中心湖北省经济林种质资源改良与资源综合利用重点实验室湖北黄冈438000

鱼糜制品是一种以鱼肉为原料加工制成的食品,其蛋白质含量高、脂肪含量低、易于消化吸收,且来源丰富,因此深受广大消费者喜爱。莲藕营养成分丰富,淀粉含量较高。文章探讨莲藕添加量对鱼糜凝胶品质的影响,以期为莲藕在鱼糜制品中的应用... 详细信息

鱼糜制品是一种以鱼肉为原料加工制成的食品,其蛋白质含量高、脂肪含量低、易于消化吸收,且来源丰富,因此深受广大消费者喜爱。莲藕营养成分丰富,淀粉含量较高。文章探讨莲藕添加量对鱼糜凝胶品质的影响,以期为莲藕在鱼糜制品中的应用提供一定的理论支持。结果表明,随着莲藕添加量的增加,鱼糜凝胶的白度以及感官评分中的色泽以及组织状态与空白组相比,有轻微浮动,整体影响不显著(P>0.05)。鱼糜凝胶的蒸煮损失率、质构和感官评分中的滋味、气味以及总分呈现出先上升后下降的趋势。当莲藕添加量达到20%时,各项指标均达到最大值。该方法旨在探究不同莲藕添加量对鱼糜凝胶品质的影响,以求为莲藕产品的开发和利用提供一定的理论基础。

关键词：鱼糜凝胶质构莲藕影响