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马铃薯SRO家族全基因组鉴定及生物信息学分析

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分子植物育种 2024年第20期22卷 6644-6652页

作者：黄强郑敏刘小龙姜伟业舒婷欧阳满江西医学高等专科学校基础医学院上饶334000

SRO(Similar to radical-induced cell death 1)蛋白是植物特有的一类小蛋白家族转录因子,在植物抵御生物/非生物胁迫(盐害,干旱,高温,低温,水涝等)和生长发育中发挥着重要的作用。尽管SROs已在许多物种中进行了研究,但在马铃薯中仍缺... 详细信息

SRO(Similar to radical-induced cell death 1)蛋白是植物特有的一类小蛋白家族转录因子,在植物抵御生物/非生物胁迫(盐害,干旱,高温,低温,水涝等)和生长发育中发挥着重要的作用。尽管SROs已在许多物种中进行了研究,但在马铃薯中仍缺乏系统鉴定。基于马铃薯已公布的基因组数据对马铃薯SRO蛋白家族进行全基因组鉴定和生物信息学分析,共鉴定到9个St SROs家族成员,不均匀分布在5条染色体上,亚细胞定位预测该基因全部成员定位在细胞核上。启动子上游鉴定到了大量与生长发育、植物激素响应和生物/非生物胁迫有关的顺式作用元件,同时预测了调控该基因的miRNAs。该基因各成员对不同激素处理响应程度存在明显差异。上述结果为马铃薯St SROs潜在的分子功能提供了理论依据,表明该基因在马铃薯非生物胁迫方面可能具有重要意义。

关键词：马铃薯 SRO 基因家族生物信息学分析

Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells:detected by untargeted metabolomics and stable isotope tracing analysis

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Cancer Communications 2019年第1期39卷 161-173页

作者： Xin You weiye jiang Wenhua Lu Hui Zhang Tiantian Yu Jingyu Tian Shijun Wen Guillermo Garcia-Manero Peng Huang Yumin Hu Department of Experimental Therapeutics Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dong Feng East RoadGuangzhou 510060GuangdongP.R.China The First Department of Chemotherapy The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianP.R.China Metabolic Innovation Center Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of Leukemia The University of Texas M.D.Anderson Cancer CenterHoustonTX 77030USA

Background:Internal tandem duplications(ITD)within the juxtamembrane domain of FMS-like tyrosine kinase 3(FLT3)represent a poor prognostic indicator in acute myeloid leukemia(AML).Therapeutic benefits of tyrosine kinase inhibitors,such as sorafenib,are limited due to the emergence of drug *** investigations have been con-ducted to improve the understanding of the molecular mechanisms underlying the resistance to this FLT3 inhibitor,a profile of cell functioning at the metabolite level and crosstalk between metabolic pathways has yet to be *** study aimed to elucidate the alteration of metabolomic profile of leukemia cells resistant to the FLT3 ***:We established two sorafenib-resistant cell lines carrying FLT3/ITD mutations,namely the murine BaF3/ITD-R and the human MV4-11-R cell *** performed a global untargeted metabolomics and stable isotope-labe-ling mass spectrometry analysis to identify the metabolic alterations relevant to the therapeutic ***:The resistant cells displayed fundamentally rewired metabolic profiles,characterized by a higher demand for glucose,accompanied by a reduction in glucose flux into the pentose phosphate pathway(PPP);and by an increase in oxidative stress,accompanied by an enhanced glutathione *** demonstrated that the highest scoring network of altered metabolites in resistant cells was related to nucleotide degradation.A stable isotope tracing experiment was performed and the results indicated a decrease in the quantity of glucose entering the PPP in resistant *** experiment suggested that the inhibition of major enzymes in the PPP consist of glucose-6-phosphate dehydrogenase deficiency(G6PD)in the oxidative arm and transketolase(TKT)in the non-oxidative *** addition,we observed that chronic treatment with sorafenib resulted in an increased oxidative stress in FLT3/ITD-positive leu-kemia cells,which was accompanied by decreased cell proliferation and an enhanc

关键词： FLT3/ITD Metabolomics Glycolysis Antioxidants Resistance Sorafenib Acute myeloid leukemia Sorafenib Leukemia

ZIF-8 coated gold nanospheres: A multi-responsive drug delivery system promoting the killing effect of photothermal therapy against osteosarcoma cells

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Nano Research 2024年第3期17卷 1772-1784页

作者： Miao Lei weiye Cai Luetao Zou Bin Yu Lin Chen Yang Cao Shanlin Xiang Chao Song Jiandu Lei Wei jiang Zhenming Hu Department of Orthopedics Orthopedic Laboratory of Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou 646699China Department of Orthopedics The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China Department of Orthopedics Chongqing University Three Gorges HospitalChongqing 404000China Department of Geriatrics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550025China Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and TechnologyBeijing Forestry UniversityBeijing 100083China

Photothermal therapy(PTT)has been widely used in the treatment of tumors,but its efficacy is greatly limited by the inability of precise drug delivery and the increase of heat shock proteins(HSPs)caused by high *** article describes a therapeutic strategy to enhance PTT with starvation therapy in conjunction with ferroptosis mechanism.A nanoparticle platform ZIF-8@GA was constructed by wrapping together glucose oxidase(GOX)and gold nanospheres(AuNPs)loaded with dihydroartemisinin(DHA)with zeolitic imidazolate framework-8(ZIF-8).This platform can take advantage of the micro-environment of osteosarcoma(OS)cells,featuring low pH and high reactive oxygen species(ROS),for precision drug *** can effectively catalyze glucose to produce gluconic acid and H_(2)O_(2),and DHA can also induce ROS production in OS *** produced by GOX and DHA can further generate lipid peroxidation(LPO)and lead to ferroptosis of OS *** the same time,ROS and LPO produced can inhibit the expression of HSPs,thereby increasing the therapeutic effect of *** vitro experiments show that the nanoparticles are pH and ROS responsive.1μg/mL GOX combined with 0.2μg/mL DHA promotes ferroptosis of OS cells,and increases the killing effect of near-infrared(NIR)on OS *** in vivo experiments showed that the nano drug-delivery platform combined with PTT can effectively inhibit the growth of OS ***,this study provides a new idea for the treatment of OS with biomaterials combined with various treatment methods.

关键词： zeolitic imidazolate framework-8(ZIF-8) gold nanospheres(AuNPs) photothermal therapy(PTT) starvation therapy ferroptosis

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基于深度图的人体动作分类自适应算法

郑州大学学报（理学版） 2021年第1期53卷 16-21页

作者：蒋韦晔刘成明郑州大学软件学院河南郑州450002

由于深度相机成本的降低,越来越多的研究人员使用RGB-D(red,green,blue and depth)视频进行人类动作识别(human activity recognition,HAR)。使用深度运动图的局部二值模式进行特征提取,利用自适应差分进化极限学习机(self-adaptive dif... 详细信息

由于深度相机成本的降低,越来越多的研究人员使用RGB-D(red,green,blue and depth)视频进行人类动作识别(human activity recognition,HAR)。使用深度运动图的局部二值模式进行特征提取,利用自适应差分进化极限学习机(self-adaptive differential evolution extreme learning machine,SaDE-ELM)用于动作分类,其中隐藏节点的学习参数通过自适应差分进化的方法进行修改。为了验证所提出方法的有效性,用3个公共数据集(MSR Action3D,MSRDaily Activity3D,MSRGesture3D)进行了实验。仿真结果表明,该方法优于基于内核的极限学习机(kernel extreme learning machine,KELM)的方法。

关键词：人类动作识别深度运动图差分进化自适应差分进化极限学习机

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大鼠眼球的生物光子检测及其生物学意义

中山大学学报：自然科学版 2014年第5期53卷 112-117页

作者：姜伟业杨钊赵季平西北大学生命科学学院

生物超弱发光(Ultra-weak Photon Emissions or Ultraweak Bioluminescence,UPEs)又简称为生物光子(Biophotons),被证明在植物、微生物和一些动物细胞之间起到信息传递的作用,是否在神经回路和视觉通路中起到信号传递的作用仍然不清楚... 详细信息

生物超弱发光(Ultra-weak Photon Emissions or Ultraweak Bioluminescence,UPEs)又简称为生物光子(Biophotons),被证明在植物、微生物和一些动物细胞之间起到信息传递的作用,是否在神经回路和视觉通路中起到信号传递的作用仍然不清楚。利用EM-CCD为基础,构建生物光子检测系统,对新分离的大鼠全眼、晶状体、玻璃体以及视网膜样品自发的生物光子和可见光诱导产生的生物光子进行检测。结果显示大鼠眼球中视网膜等部分可以自发和在光诱导情况下辐射出生物光子。

关键词：生物光子电子倍增CCD 负后像离散暗噪音

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学前游戏理论在儿童游戏家具设计中的应用

家具 2021年第1期42卷 44-47页

作者：江唯烨苗艳凤南京林业大学家居与工业设计学院南京210037

儿童家具市场需求随着儿童数量的增长而不断扩大,在此大背景下家长对儿童家具质的追求也逐渐提升,设计以理论研究成果支撑成为大势所趋。以学前儿童游戏理论研究成果为基础,对游戏的定义、游戏分类、游戏发展目标、游戏行为特征、游戏... 详细信息

儿童家具市场需求随着儿童数量的增长而不断扩大,在此大背景下家长对儿童家具质的追求也逐渐提升,设计以理论研究成果支撑成为大势所趋。以学前儿童游戏理论研究成果为基础,对游戏的定义、游戏分类、游戏发展目标、游戏行为特征、游戏年龄差异等能够为儿童游戏家具设计提供指导意义的研究以及儿童行为观察结论进行梳理总结,以此提出3项儿童游戏家具的设计准则,为促进儿童游戏家具科学化设计发展提供新思路。

关键词：学前儿童游戏理论游戏行为儿童年龄儿童家具

可见光光学相干层析成像技术发展综述(特邀)

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中国激光 2024年第15期51卷 1-14页

作者：宋维业姚政开吴付旺户凯旋姜显春山东大学机械工程学院山东济南250061 山东大学高效洁净机械制造教育部重点实验室山东济南250061

光学相干层析成像技术是一种高分辨率、高信噪比的非接触式三维成像技术,在视网膜成像等领域具有重要的应用价值与意义。可见光光学相干层析成像技术采用波长更短的光源,相比于采用传统的近红外波段光源具有独特的成像优势——可以达到... 详细信息

光学相干层析成像技术是一种高分辨率、高信噪比的非接触式三维成像技术,在视网膜成像等领域具有重要的应用价值与意义。可见光光学相干层析成像技术采用波长更短的光源,相比于采用传统的近红外波段光源具有独特的成像优势——可以达到亚微米级的轴向分辨率,具有更高的视网膜层间对比度,可以检测视网膜血管的血氧饱和度——对多种疾病的早期诊断、治疗和深入研究具有重要意义。本文简述了光学相干层析成像技术的发展现状,并对可见光光学相干层析成像技术在系统结构优化、动物成像应用和临床应用方面的代表性工作进行了综述。

关键词：光学相干层析成像可见光成像系统视网膜成像血氧饱和度检测

The Tianma 65 m radio telescope at Shanghai

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Astronomical Techniques and Instruments 2024年第5期1卷 239-246页

作者： Qinghui Liu Zhiqiang Shen Xiaoyu Hong Qian Ye Bin Li Jinqing Wang Rongbing Zhao Li Fu weiye Zhong Lingling Wang Juan Li Zhen Yan Wu jiang Bo Xia Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

The Shanghai Tianma 65 m radio telescope(TMRT)is a large,fully rotatable radio telescope with multiple scientific *** main body of the telescope and four low-frequency receiving systems,including L,C,and S/X bands,were completed between 2008 and *** 2013 to 2017,four high-frequency receiving systems,including Ku,K,Ka,and Q bands,were constructed and their performance was comprehensively *** are three main innovations.(1)A fully movable large radio telescope system with advanced performance and complete functions has been built.(2)An advanced,reliable main reflector adjustment system has been completed,overcoming gravity deformation and creating a large antenna with a main reflective surface accuracy of 0.28 mm(root mean square)for any elevation.(3)Five innovative technologies have been developed to achieve high-precision pointing in any direction within 3″.The TMRT has made a crucial contribution to the orbital measurement and positioning of China’s lunar and deep space *** enhancing China's ability to participate in international VLBI observations and radio astronomy,this has facilitated a series of achievements in observational radio astronomical research,in areas such as VLBI,spectral lines,and pulsars.

关键词： Radio telescope Tianma Large antenna Receiving system Surface accuracy

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白玉豆的营养成分分析与评价

现代食品 2021年第20期6卷 164-166页

作者：郑敏王钏姜伟业舒婷江西医学高等专科学校江西上饶334000

采用国家标准检测方法对白玉豆的氨基酸、矿物质元素、脂肪、淀粉和膳食纤维等营养成分测定与分析,结果表明白玉豆蛋白质营养价值高,是植物性优质蛋白的良好来源;白玉豆富含膳食纤维和淀粉、日常膳食中可作为主食部分替代品;脂肪含量低... 详细信息

采用国家标准检测方法对白玉豆的氨基酸、矿物质元素、脂肪、淀粉和膳食纤维等营养成分测定与分析,结果表明白玉豆蛋白质营养价值高,是植物性优质蛋白的良好来源;白玉豆富含膳食纤维和淀粉、日常膳食中可作为主食部分替代品;脂肪含量低,适合高血脂人群食用;有丰富的矿物质元素,能为人体提供多种重要的营养素。

关键词：白玉豆营养成分分析评价