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Oncology Research 2024年第6期32卷 1093-1107页

作者： ZHILI ZHUO DONGNI zhang WENPING LU XIAOQING WU YONGJIA CUI weixuan zhang MENGFAN zhang Department of Oncology China Academy of Chinese Medical Sciences Guang’anmen HospitalBeijingChina

Breast cancer is the leading cause of cancer-related deaths in women worldwide,with Hormone Receptor(HR)+being the predominant ***(TAM)serves as the primary treatment for HR+breast ***,drug resistance often leads to recurrence,underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence ***(ART)has demonstrated efficacy in inhibiting the growth of drug-resistant cells,positioning art as a viable option for counteracting endocrine *** study explored the interaction between artemisinin and tamoxifen through a combined approach of bioinformatics analysis and experimental *** characterized genes(ar,cdkn1a,erbb2,esr1,hsp90aa1)and seven drug-disease crossover genes(cyp2e1,rorc,mapk10,glp1r,egfr,pgr,mgll)were identified using WGCNA crossover *** functional enrichment analyses were *** findings confirm a significant correlation between key cluster gene expression and immune cell infiltration in tamoxifen-resistant and-sensitized ***-seq analysis revealed high expression of key cluster genes in epithelial cells,suggesting artemisinin’s specific impact on tumor cells in estrogen receptor(ER)-positive BC *** target docking and in vitro experiments with artemisinin on LCC9 cells demonstrated a reversal effect in reducing migratory and drug resistance of drug-resistant cells by modulating relevant drug resistance *** results indicate that artemisinin could potentially reverse tamoxifen resistance in ER-positive breast cancer.

关键词： Artemisinin Tamoxifen resistance Breast cancer

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水载压力对管道超声导波信号的影响研究

仪器仪表学报 2024年第3期45卷 206-213页

作者：胡晓谍林霆威张维煊魏子麒王奕首厦门大学航空航天学院厦门361005 中国科学院自动化研究所北京110007

为了研究水载压力对管道超声导波信号的影响,利用半解析有限元的方法分析了管道导波的频散曲线和波结构,选择L(0,2)模态导波用于实验验证。设计了一个可承受30 MPa压力的防水卡箍,对管道上的压电传感器进行封装。将安装了防水耐压卡箍... 详细信息

为了研究水载压力对管道超声导波信号的影响,利用半解析有限元的方法分析了管道导波的频散曲线和波结构,选择L(0,2)模态导波用于实验验证。设计了一个可承受30 MPa压力的防水卡箍,对管道上的压电传感器进行封装。将安装了防水耐压卡箍的管道放入压力舱中进行打压循环测试,压力在0~30 MPa之间变化。打压过程中采集无损伤及5%损伤的管道超声导波信号,分析水载压力对导波信号的影响。实验结果表明,该防水卡箍具有良好的防水和耐压性能,水载压力对L(0,2)模态导波信号幅值没有显著影响。

关键词：管道超声导波水载压力半解析有限元

Simulation Analysis of Torsion Beam Hydroforming Based on the Fluid-Solid Coupling Method

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 139-156页

作者： Yu Huang Jian Li Jiachun Yang Yongdong Peng weixuan zhang Guangxi Key Laboratory of Automobile Components and Vehicle Technology Guangxi University of Science and TechnologyLiuzhou545006GuangxiChina

Hydroformed parts are widely used in industrial automotive parts because of their higher stiffness and fatigue strength and reduced weight relative to their corresponding cast and welded *** paper reports a hydraulicforming experimental platform for rectangular tube fittings that was constructed to conduct an experiment on the hydraulic forming of rectangular tube fittings.A finite element model was established on the basis of the fluid–solid coupling method and simulation *** correctness of the simulation analysis and the feasibility of the fluid–solid coupling method for hydraulic forming simulation analysis were verified by comparing the experimental results with the simulation *** the basis of the simulation analysis of the hydraulic process of the torsion beam using the fluid–solid coupling method,a sliding mold suitable for the hydroforming of torsion beams was designed for its structural *** effects of fluid characteristics,shaping pressure,axial feed rate,and friction coefficient on the wall thicknesses of torsions beams during formation were *** movement speed was related to tube *** pressure had a significant effect on rounded corners and straight *** axial feed speed was increased,and the uneven distribution of wall thicknesses was effectively *** the friction coefficient had a nonsignificant effect on the wall thickness of the ladder-shaped region,it had a significant influence on a large deformation of wall thickness in the V-shaped *** this paper,a method of fluid-solid coupling simulation analysis and sliding die is proposed to study the high pressure forming law in torsion beam.

关键词： Fluid-solid coupling Hydraulic expansion Rectangular tube Torsional beam Wall thickness distribution

Superchiral fields generated by nanostructures and their applications for chiral sensing

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Chinese Physics B 2021年第11期30卷 32-48页

作者： Huizhen zhang weixuan zhang Saisai Hou Rongyao Wang Xiangdong zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China

Chirality is ubiquitous in natural *** with similar physical and chemical properties,chiral enantiomers could play different roles in biochemical *** of chiral enantiomers is extremely important in biochemical,analytical chemistry,and pharmaceutical *** chiroptical spectroscopic methods are disadvantageous at a limited detection sensitivity because of the weak signals of natural chiral ***,superchiral fields were proposed to effectively enhance the interaction between light and molecules,allowing for ultrasensitive chiral *** theoretical and experimental works have been devoted to generation of superchiral fields based on artificial nanostructures and their application in ultrasensitive chiral *** this review,we present a survey on these *** begin with the introduction of chiral properties of electromagnetic ***,the optical chirality enhancement and ultrasensitive chiral detection based on chiral and achiral nanostructures are discussed ***,we give a short summary and a perspective for the future ultrasensitive chiral sensing.

关键词： superchiral fields chiral detection chiral nanostructures achiral nanostructures

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中医全程管理卵巢癌思路探析

中国中医药信息杂志 2024年第5期31卷 157-161页

作者：张炜玄姜奕慈卢雯平宋清雅中国中医科学院广安门医院北京100053 北京核工业医院北京100045

卵巢癌的中医全程管理从未病先防、既病防变2个角度出发。预防方面审病求因、把握摄生,避寒、畅情志、调整生活方式;急病阶段从围手术期与化疗期不同的不良反应入手,急治其标以改善症状、减毒增效;维持治疗阶段治病求本,辨证论治,以提... 详细信息

卵巢癌的中医全程管理从未病先防、既病防变2个角度出发。预防方面审病求因、把握摄生,避寒、畅情志、调整生活方式;急病阶段从围手术期与化疗期不同的不良反应入手,急治其标以改善症状、减毒增效;维持治疗阶段治病求本,辨证论治,以提高患者生存质量,延长生存期。本文分阶段探讨中医全程管理卵巢癌思路,并附验案一则。

关键词：卵巢癌中医药全程管理

新疆某小型水泥生产企业职业健康风险现况调查

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职业与健康 2024年第5期40卷 697-700页

作者：张伟轩张娜李月飞刘红梅胡晓远新疆恒泰职业环境检测评价有限公司外采检测组新疆乌鲁木齐830000 新疆维吾尔自治区疾病预防控制中心职业健康与辐射防护所新疆乌鲁木齐830000 新疆医科大学公共卫生学院新疆量乌鲁木齐830011

目的了解新疆小型水泥生产企业的职业健康风险及防护现状,为改善新疆水泥行业职业卫生工作提供依据。方法2021年12月,以新疆某小型水泥生产企业为调查对象,对14项职业卫生危险因素13个关键岗位职业危害暴露水平现场检测评估及企业职业... 详细信息

目的了解新疆小型水泥生产企业的职业健康风险及防护现状,为改善新疆水泥行业职业卫生工作提供依据。方法2021年12月,以新疆某小型水泥生产企业为调查对象,对14项职业卫生危险因素13个关键岗位职业危害暴露水平现场检测评估及企业职业防护措施及个人防护用品的调查,结合职业卫生相关标准对企业职业卫生现状做出综合评价。结果新疆某水泥生产企业存在的主要职业危害因素为噪声、高温、工频电场、矽尘、石灰石粉尘、石膏粉尘、煤尘、水泥粉尘、一氧化碳、二氧化氮和二氧化硫。本研究职业危害因素检测80个检测点,其中79个检测点合格,1个噪声检测点不合格,整体合格率为98.7%。熟料烧成单元噪声[90.84 dB(A)]明显高于其他各单元,中控楼噪声[51.65 dB(A)]明显低于其他单元,各评价单元噪声差异有统计学意义(F=7.63,P<0.01)。破碎工段接触粉尘浓度(6.93 mg/m^(3))显著高于制粉工段(1.18mg/m^(3))和包装工段(1.39 mg/m^(3)),且破碎工段总尘与呼尘均高于其他2个工段,不同工段接触粉尘浓度差异有统计学意义(F=14.73,P<0.01)。结论新疆小型水泥生产企业主要职业病危害因素为噪声和粉尘,企业防护措施对粉尘的控制效果较明显,降噪需进一步改善生产设备。

关键词：水泥职业健康风险分析

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先进飞行器结构与机构健康管理技术研究进展

强度与环境 2024年第4期51卷 17-24页

作者：吴迪姚宇地张维烜尹进王奕首北京宇航系统工程研究所北京100076 厦门大学航空航天学院厦门361005

先进飞行器健康管理技术是实现其全寿命周期的安全服役和视情维护的关键技术。本文聚焦于先进飞行器结构和机构两个重要系统,分析了飞行器结构和机构健康监测的必要性与急迫性,总结近十几年内健康监测技术在先进飞行器结构机构损伤监测... 详细信息

先进飞行器健康管理技术是实现其全寿命周期的安全服役和视情维护的关键技术。本文聚焦于先进飞行器结构和机构两个重要系统,分析了飞行器结构和机构健康监测的必要性与急迫性,总结近十几年内健康监测技术在先进飞行器结构机构损伤监测与载荷识别上的典型案例与相关进展,讨论飞行器健康管理技术面临的挑战,并展望技术发展趋势。

关键词：先进飞行器复合材料结构机构健康监测与管理

Low-threshold topological nanolasers based on the second-order corner state

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Light(Science & Applications) 2020年第1期9卷 968-973页

作者： weixuan zhang Xin Xie Huiming Hao Jianchen Dang Shan Xiao Shushu Shi Haiqiao Ni Zhichuan Niu Can Wang Kuijuan Jin Xiangdong zhang Xiulai Xu Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education School of PhysicsBeijing Institute of Technology100081 BeijingChina Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systems Micro-nano CenterSchool of PhysicsBeijing Institute of Technology100081 BeijingChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation and School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Superlattices and Microstructures Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Songshan Lake Materials Laboratory DongguanGuangdong 523808China

Topological lasers are immune to imperfections and *** have been recently demonstrated based on many kinds of robust edge states,which are mostly at the *** realization of 2D on-chip topological nanolasers with a small footprint,a low threshold and high energy efficiency has yet to be ***,we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab.A topological nanocavity is formed utilizing the Wannier-type 0D corner *** behaviour with a low threshold of approximately 1μW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active *** performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal *** experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes.

关键词： quantum utilizing realization

Topologically protected long-range coherent energy transfer

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Photonics Research 2020年第11期8卷 I0050-I0057页

作者： Yujing Wang Jun Ren weixuan zhang Lu He Xiangdong zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education School of PhysicsBeijing Institute of TechnologyBeijing 100081China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China

The realization of robust coherent energy transfer with a long range from a donor to an acceptor has many important applications in the field of quantum ***,it is hard to be realized using conventional ***,we demonstrate theoretically that robust energy transfer can be achieved using a photonic crystal platform,which includes the topologically protected edge state and zero-dimensional topological corner *** the donor and the acceptor are put into a pair of separated topological cavities,the energy transfer between them can be fulfilled with the assistance of the topologically protected interface *** an energy transfer is robust against various kinds of defects,and can also occur over very long distances,which is very beneficial for biological detections,sensors,quantum information science,and so on.

关键词： protected topological transfer

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纳米硒缓解油菜高盐胁迫的机理研究

新疆农机化 2024年第5期 20-22页

作者：张玮烜韩猛王富全张小涵邱士芬布素爽李强临沂大学农林科学学院山东临沂276000 枣庄市市中区乡村振兴服务中心山东枣庄277100 蒙阴县农业农村发展服务中心山东临沂276000 临沂市蒙阴县农业农村局山东临沂276000

本文以硒源与不同盐浓度的纳米硒为测试对象,探究不同处理对油菜根长、株高、生物量、叶绿素、活性氧和CAT酶的影响。结果证实硒的喷施对高盐胁迫下油菜的生理生长具有一定的促进作用,能够显著提升油菜的根长、株高和生物量,纳米硒的喷... 详细信息

本文以硒源与不同盐浓度的纳米硒为测试对象,探究不同处理对油菜根长、株高、生物量、叶绿素、活性氧和CAT酶的影响。结果证实硒的喷施对高盐胁迫下油菜的生理生长具有一定的促进作用,能够显著提升油菜的根长、株高和生物量,纳米硒的喷施对油菜生理生长的促进作用更为明显。含硒组活性氧的含量明显低于无硒组,说明硒具有清除活性氧的作用。含硒组CAT酶含量高于无硒组,说明硒能够提高CAT酶的活性,增强油菜抗逆性。本研究能够为作物抗逆提供理论基础与技术支持。

关键词：纳米硒盐胁迫生理指标活性氧 CAT酶