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布南色林对女性精神分裂症患者短期内泌乳素水平及月经的影响研究

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药品评价 2024年第1期21卷 60-63页

作者：胡春华李味味孙蔚华刘旺林赣州市第三人民医院江西赣州341000

目的探讨女性精神分裂症患者采用布南色林的疗效及对泌乳素水平和月经的影响。方法采用随机数字表法将2021年1月至2022年1月赣州市第三人民医院收治的女性精神分裂症患者120例分为三组,各40例。对照1组采用奥氮平治疗,对照2组采用利培... 详细信息

目的探讨女性精神分裂症患者采用布南色林的疗效及对泌乳素水平和月经的影响。方法采用随机数字表法将2021年1月至2022年1月赣州市第三人民医院收治的女性精神分裂症患者120例分为三组,各40例。对照1组采用奥氮平治疗,对照2组采用利培酮治疗,观察组采用布南色林治疗,均治疗8周。比较三组治疗效果、性激素、月经情况及不良反应。结果三组治疗总有效率比较,差异无统计学意义(P>0.05)。治疗后,对照1组、对照2组泌卵泡生成激素(FSH)、黄体生成激素(LH)及雌二醇(E2)水平均比治疗前低,泌乳素(PRL)、睾酮(T)水平均比治疗前高,差异有统计学意义(P0.05);观察组月经延迟发生率比对照1组、对照2组低,差异有统计学意义(P0.05)。观察组不良反应发生率比对照1组、对照2组低,差异有统计学意义(P<0.05)。结论女性精神分裂症患者采用布南色林治疗效果满意,对PRL及月经影响小,并可减少不良反应发生。

关键词：精神分裂症布南色林泌乳素月经

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李伟伟论治小儿秋季咳嗽临床经验

江西中医药大学学报 2024年第2期36卷 33-35,38页

作者：霍诗琦李伟伟陈仕王上福广西中医药大学南宁530001 广西中医药大学第一附属医院南宁530023

秋季咳嗽以燥邪犯肺为主,导致肺失宣发肃降之功,气机失调,肺气上逆发为咳嗽,治疗上应清肺润燥,宣降相宜。因小儿脾常不足,运化功能不全,加之秋季长夏湿土之气未尽,脾湿与肺燥并存;肝常有余,木火刑金,致肺气更虚,故小儿秋季咳嗽缠绵难愈... 详细信息

秋季咳嗽以燥邪犯肺为主,导致肺失宣发肃降之功,气机失调,肺气上逆发为咳嗽,治疗上应清肺润燥,宣降相宜。因小儿脾常不足,运化功能不全,加之秋季长夏湿土之气未尽,脾湿与肺燥并存;肝常有余,木火刑金,致肺气更虚,故小儿秋季咳嗽缠绵难愈,临床上除宣肺润燥止咳外,还应健脾消食,除湿化痰,抑木扶土,用自拟方“桑杏石甘汤”加减,临床取得较好疗效。

关键词：秋季咳嗽桑杏石甘汤儿科燥湿并存临床经验

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元素成像技术在安检领域的研究进展

中国无机分析化学 2024年第6期14卷 758-771页

作者：胡晓光周君霞白李薇薇徐灏寓黄子旭胡保发秦沛中国人民公安大学北京100083

元素成像作为一种快速、直观的无损检测技术,在核工业、航空航天、新能源、地质、考古、先进制造等多个领域得到广泛应用。其中X射线凭借较强穿透物体的能力,在安检领域已得到广泛应用。太赫兹和毫米波凭借对人体无接触、几乎无损害的特... 详细信息

元素成像作为一种快速、直观的无损检测技术,在核工业、航空航天、新能源、地质、考古、先进制造等多个领域得到广泛应用。其中X射线凭借较强穿透物体的能力,在安检领域已得到广泛应用。太赫兹和毫米波凭借对人体无接触、几乎无损害的特点,在安检领域崭露头角。对这三种元素成像技术的原理、成像过程、安检图像数据集和近几年的图像增强和智能处理技术进行了总结和归纳。未来,随着应用的深入发掘和技术的不断进步,元素成像和人工智能的结合必将进一步深入,不断提高分析的质量和速度,从而以高水平安全保障社会经济的高质量发展。

关键词：元素成像安检 X射线太赫兹毫米波

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PHM技术在HXN3型高原机车中的应用

铁道机车与动车 2024年第2期 19-22,25,I0001,I0002页

作者：苏宇婷吴嘉舜段訾义李伟伟中车大连机车车辆有限公司辽宁大连116022

为推进我国轨道交通产业关键技术研发及产业数字化,在HXN3型高原内燃机车上开展PHM研究和系统应用,从需求分析、总体架构、物理架构、功能架构、逻辑架构等方面总结归纳了内燃机车PHM体系及关键技术。PHM系统的应用,能有效提高机车运行... 详细信息

为推进我国轨道交通产业关键技术研发及产业数字化,在HXN3型高原内燃机车上开展PHM研究和系统应用,从需求分析、总体架构、物理架构、功能架构、逻辑架构等方面总结归纳了内燃机车PHM体系及关键技术。PHM系统的应用,能有效提高机车运行保障能力,推动国家铁路装备向运维智能化、全寿命周期成本最优化的高质量发展。

关键词： PHM HXN3型高原机车故障诊断

A temperature-activated nanocomposite metamaterial absorber with a wide tunability

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Nano Research 2018年第7期11卷 3931-3942页

作者： weiwei li lingyu Zhao Zhaohe Dai Hao Jin Feng Duan Junchao liu Zhihui Zeng Jun Zhao Zhong Zhang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China University of Chinese Academy of Sciences Beijing 100149 China

Novel thin and flexible broadband electromagnetic microwave absorbers are realized with nanocomposites and achieve a wide frequency tunability （from 10 to 17.2 GHz） by actively adjusting the resistance. The proposed absorbers are fabricated by scalable screen printing of optimized nanoparticle ink onto the flexible dielectric composite substrates. Based on the shape memory effects of the substrate and piezoresistive effect of the nanocomposite frequency selective surface, a controllable sheet resistance, and thereby tunable wave absorption performance, can be realized in a temperature-activated and dynamically stable manner. The results provide new dimensions for the design of active electromagnetic devices by utilizing previously underestimated intrinsic properties of the artificial materials and the smart behavior of polymer-based nanocomposites.

关键词： composite materials flexible electronics metamaterials polymeric materials shape memory polymers

Inhibitory Effect of Arsenic Trioxide on Growth and Telomerase Activity of SMMC-7721 and BEL-7402 Hepatocarcinoma Cells and Determination of their GSH Content

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Chinese Journal of Clinical Oncology 2006年第3期3卷 207-211页

作者： weiwei Ren Hong li Yuan Zhang Department of Pathophysiology and Institute of Hematology Medical College of Jinan University Guangzhou 510632China.

OBJECTIVE To explore the inhibitory effect of arsenic trioxide on growth and telomerase activity of BEL-7402 and SMMC-7721 hepatocarcinoma cells, and to measure their GSH level. METHODS Cell culture and trypan blue exclusion were used to examine the inhibitory effect of arsenic trioxide on BEL-7402 and SMMC-7721 hepatocarcinoma lines. A GSH kit and telomerase kit were used to mearsure the GSH content in cells and telomerase activity. RESULTS The growth of BEL-7402 cells was significantly inhibited at a level of 0.50μmol/L of arsenic trioxide by 24 h. The inhibitory effect increased with time and concetration of arsenic trioxide. The telomerase activity of BEL-7402 cells was also significantly inhibited at a level of 0.50μmol/L of arsenic trioxide by 24 h, after which the inhibitory effect increased with time. On the other hand, at 24 h of incubation a level of 2.00 μmol/L of arsenic trioxide was required to significantly inhibit growth of SMMC-7721 cells, and only after 48 h with 2.00μmol/L of arsenic trioxide did telomerase activity significantly decline. The GSH content of the BEL-7402 and SMMC-7721 cells was 18.7±1.4 and 50.8±5.2 nmol/mg protein respectively, a significant difference. CONCLUSION Different concentrations of arsenic trioxide are required to inhibit growth and telomerase activity of SMMC-7721 and BEL-7402 cells. Perhaps BEL-7402 cells are more sensitive to arsenic trioxide because of their low level of GSH content, which results in a low capacity for oxidation-reduction and poorer detoxification mechanisms in BEL-7402 cells.

关键词： arsenic trioxide growth telomerase hepatocarcinoma.

Subsurface banding of blended controlled-release urea can optimize rice yields while minimizing yield-scaled greenhouse gas emissions

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The Crop Journal 2023年第3期11卷 914-921页

作者： weiwei li Sajjad Ahmad Dun liu Shen Gao Yuhui Wang Weike Tao lin Chen Zhenghui liu Yu Jiang Ganghua li Yanfeng Ding National Engineering and Technology Center for Information Agriculture/Key Laboratory of Crop Physiology and Ecology in Southern China/Jiangsu Collaborative Innovation Center for Modern Crop Production Nanjing Agricultural UniversityNanjing 210095JiangsuChina

Controlled-release urea(CRU)is widely reported to supply crop nitrogen(N)demand with one basal application,thus effectively replacing split applications of urea without diminishing grain yield and N use efficiency(NUE).However,its use for replacement for high-yield split applications of urea(CK)for rice is *** addition,the degree to which greenhouse gas(GHG)emissions in rice systems are affected when CRU is substituted for CK remains *** 2017 and 2018,we sampled plant growth and gas emissions in a rice paddy field treated with three CRU types(sulfur-coated urea[SCU],polymer-coated urea[PCU],and bulk blended CRU[BBU])applied via two methods(surface broadcasting on the soil and subsurface banding at 5 cm depth),with CK as a *** three CRUs led to different soil NH_(4)^(+)-N dynamics,and the N supply pattern under BBU was more beneficial for rice seedling establishment than under SCU and PCU,resulting in grain yield and NUE comparable to those under *** type showed no significant effect on either CH_(4) emissions or N_(2)O emissions,and broadcast CRUs exhibited significantly higher total GHG emissions than ***,banded CRUs significantly reduced the total GHG emissions in comparison with broadcast CRUs,by 9.2%averaged across the two *** CH_(4) emissions,particularly during the period prior to the middle drainage,contributed largely to the GHG *** comparably high grain yield and low total GHG emissions,banded BBU showed a low yield-scaled GHG(GHG emissions divided by grain yield)comparable to that under CK in both ***,our study suggested that N management synchronized with rice demand and contributing to a high NUE tended to minimize yield-scaled *** CRU can hardly substitute for CK in terms of either grain yield or GHG emissions,but banded BBU is a promising N management strategy for sustaining rice production while minimizing environmental impacts.

关键词： Controlled-release fertilizer N subsurface placement CH_(4) N_(2)O Yield

SWG: an architecture for sparse weight gradient computation

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Science China(Information Sciences) 2024年第2期67卷 302-321页

作者： weiwei WU Fengbin TU Xiangyu li Shaojun WEI Shouyi YIN School of Integrated Circuits Tsinghua University Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology

On-device training for deep neural networks(DNN) has become a trend due to various user preferences and scenarios. The DNN training process consists of three phases, feedforward(FF), backpropagation(BP), and weight gradient(WG) update. WG takes about one-third of the computation in the whole training process. Current training accelerators usually ignore the special computation property of WG and process it in a way similar to FF/BP. Besides, the extensive data sparsity existing in WG, which brings opportunities to save computation, is not well explored. Nevertheless, exploiting the optimization opportunities would meet three underutilization problems, which are caused by(1) the mismatch between WG data dimensions and hardware parallelism,(2) the full sparsity, i.e., the sparsity of feature map(Fmap),error map(Emap), and gradient, and(3) the workload imbalance resulting from irregular sparsity. In this paper, we propose a specific architecture for sparse weight gradient(SWG) computation. The architecture is designed based on hierarchical unrolling and sparsity-aware(HUSA) dataflow to exploit the optimization opportunities of the special computation property and full data sparsity. In HUSA dataflow, the data dimensions are unrolled hierarchically on the hardware architecture. A valid-data trace(VDT) mechanism is embedded in the dataflow to avoid the underutilization caused by the two-sided input sparsity. The gradient is unrolled in PE to alleviate the underutilization induced by output sparsity while maintaining the data reuse opportunities. Besides, we design an intra-and inter-column balancer(IIBLC) to dynamically tackle the workload imbalance problem resulting from the irregular sparsity. Experimental results show that with HUSA dataflow exploiting the full sparsity, SWG achieves a speedup of 12.23× over state-of-the-art gradient computation architecture, Train Ware. SWG helps to improve the energy efficiency of the state-of-the-art training accelerator LNPU from

关键词： CNN training gradient computation sparsity architecture

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中医热证动物模型构建及评价方式现状研究

中国中医药图书情报杂志 2024年第3期48卷 11-16页

作者：曹明慧张学智叶晖郭浩黎巍威北京大学第一医院北京大学中西医结合研究所北京100034 中国中医科学院西苑医院基础医学研究所北京100091

辨证论治是中医的主要特色,“证”体现的是疾病发生发展进程中不同阶段病理的本质。建立对应疾病的证候模型对挖掘证候的本质,探索中医药研究的规范化、客观化、科学化均具有重要价值。“热证”是中医辨证中极具代表性的基础证型,其病... 详细信息

辨证论治是中医的主要特色,“证”体现的是疾病发生发展进程中不同阶段病理的本质。建立对应疾病的证候模型对挖掘证候的本质,探索中医药研究的规范化、客观化、科学化均具有重要价值。“热证”是中医辨证中极具代表性的基础证型,其病证结合动物模型的制备和研发对于药理实验研究、寒热证实质研究及中医病证结合动物模型的研发尤为重要。本文从模型制备方法、客观指标评价等方面对中医热证动物模型的制备现状及研究进展进行相关述评。

关键词：热证动物模型病证结合述评