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Botrytis cinerea-induced F-box protein 1 enhances disease resistance by inhibiting JAO/JOX-mediated jasmonic acid catabolism in Arabidopsis

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Molecular Plant 2024年第2期17卷 297-311页

作者： Min Zhang weiwei li Tingyu Zhang Yueyan liu lijing liu The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China

Jasmonic acid(JA)is a crucial phytohormone that regulates plant *** endogenous JA level is determined by the rates of its biosynthesis and catabolism in *** activation of JA biosynthesis has been well documented;however,how plants repress JA catabolism upon pathogen infection remains *** this study,we identified and characterized Botrytis cinerea-induced F-box protein 1(BFP1)in *** expression of BFP1 was induced by *** in a JA signaling-dependent manner,and BFP1 protein was critical for plant defense against *** and plant response to *** addition,BFP1 overexpression increased plant defenses against broad-spectrum pathogens without fitness *** experiments demonstrated that BFP1 interacts with and mediates the ubiquitination and degrada-tion of jasmonic acid oxidases(JAOs,also known as jasmonate-induced oxygenases,JoXs),the enzymes that hydroxylate JA to *** with this,BFP1 affects the accumulation of JA and 12OH-JA during *** ***,mutation of JAo2 complemented the phenotypes of the bfp1 ***,our results unveil a new mechanism used by plants to activate immune responses upon path-ogeninfection:suppressing JA catabolism.

关键词： plant immunity BFP1 JAO/JOXs JA catabolism ubiquitination-mediated degradation

ASTSDL:predicting the functionality of incomplete programming code via an AST-sequence-based deep learning model

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Science China(Information Sciences) 2024年第1期67卷 86-104页

作者： Yaoshen YU Zhiqiu HUANG Guohua SHEN weiwei li Yichao SHAO College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Collaborative Innovation Center of Novel Software Technology and Industrialization Key Laboratory of Safety-Critical Software Ministry of Industry and Information Technology

Code recommendation systems have been widely used in helping developers implement unfamiliar programming *** existing code recommenders or code search engines can retrieve relevant code rapidly with high accuracy,however,they cannot recommend any code outside similar *** propose an approach to predict the functionality of incomplete programming code by using syntactical information,and providing a list of potential functionalities to guess what the developers want,in order to increase the diversity of *** this paper,we propose a deep learning model called ASTSDL,which uses a sequencebased representation of source code to predict *** extract syntactical information from the abstract syntax tree(AST) of the source code,apply a deep learning model to capture the syntactic and sequential information,and predict the functionality of the source code *** experimental results demonstrate that ASTSDL can effectively predict the functionality of incomplete code with an accuracy above 84% in the top-10 list,even if there is only half of the complete code.

关键词： functionality prediction incomplete programming code syntactical information code representation model deep learning algorithm

Near-infrared double-cable conjugated polymers based on alkyl linkers with tunable length for single-component organic solar cells

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Chinese Chemical Letters 2024年第4期35卷 452-456页

作者： Yikun Wang Qiaomei Chen Shijie liang Dongdong Xia Chaowei Zhao Christopher R.McNeill weiwei li Beijing Advanced Innovation Center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang 330096China Department of Materials Science and Engineering Monash UniversityWellington RoadClaytonVictoria 3800Australia

The photovoltaic properties of double-cable conjugated polymers are significantly influenced by the length of the alkyl linkers that connect donor backbones and acceptor side units. In this study, a series of 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile(IC)-based double-cable polymers with alkyl linkers ranging from C_8H_(16)to C_(16)H_(32)(Px, x = 8, 10, 12, 14, 16) were synthesized for single-component organic solar cells(SCOSCs). Among these, the linker length x = 12(P12) is found to optimize the power conversion efficiencies(PCEs) in SCOSCs. Specifically, PCEs increase from P8 to P12 and then decline from P12to P16. Detailed investigations of optical absorption, charge transport, and morphology provide insights into the underlying factors contributing to these PCE variations. The findings indicate that the exceptional photovoltaic properties observed in P12 can be attributed to three key factors: A delicate balance between enhanced charge separation facilitated by the increased spacer length and reduced crystallinity resulting from longer spacers, higher charge mobilities, and well-balanced hole/electron transport characteristics. This study highlights the critical role of linker length in determining the photovoltaic properties of double-cable conjugated polymer-based SCOSCs and offers valuable guidance for the design of novel double-cable conjugated polymers.

关键词： Single-component organic solar cells Double-cable conjugated polymers Photovoltaic properties Alkyl linkers

Superior Latent Heat Eutectic Salt Na_(2)CO_(3)-li_(2)CO_(3)-liF for Thermal Energy Storage:Preparation and Performance Investigation

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Journal of Thermal Science 2024年第2期33卷 501-508页

作者： li weiwei MIAO Qi ZHANG Yelong DING Hongliang YANG Sa LAI Yuan FENG Daili DING Yulong JIN Yi TAN linghua School of Chemistry and Chemical Engineering Nanjing University of Science&TechnologyNanjing210094China National Special Superfine Powder Engineering Research Center Nanjing University of Science and TechnologyNanjing210094China Nanjing Jinhe Energy Material Co. LtdNanjing210047China School of Chemical Engineering University of BirminghamBirminghamB152TTUK School of Energy&Environmental Engineering University of Science and Technology BeijingBeijing100083China

In this paper,a novel ternary eutectic salt Na_(2)CO_(3)-li_(2)CO_(3)-liF was designed and investigated for concentrated solar power(CSP).The FactSage software was used to predict the composition and eutectic point of Na_(2)CO_(3)-li_(2)CO_(3)-*** microstructure,thermophysical properties,and thermal stability of eutectic salts were experimentally measured using various analytical *** a mass ratio of 57%:32%:11%,the eutectic salt exhibited excellent thermal storage properties with a fusion enthalpy of 413 J/g and a melting point of 426.8℃.The excellent thermal stability of the eutectic salt was reflected by a weight loss of only 0.8% at 600℃.

关键词： phase change materials ternary eutectic salt latent heat thermal stability

Organic-inorganic hybrid piezotronic bipolar junction transistor for pressure sensing

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Microsystems & Nanoengineering 2024年第3期10卷 229-244页

作者： Emad Iranmanesh Zihao liang weiwei li Congwei liao Shunyu Jin Chuan liu Kai Wang Shengdong Zhang Charalampos Doumanidis Gehan A.J.Amaratunga Hang Zhou Guangdong Provincial Key Laboratory of In-Memory Computing Chips School of Electronic and Computer EngineeringPeking University Shenzhen Graduate SchoolShenzhen 518055P.R.China School of Mechanical Engineering Guangdong Technion-Israel Institute of TechnologyShantou 515063P.R.China State Key Laboratory of Microelectronics Device and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029P.R.China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 23000PR China School of Electronics and Information Technology Sun Yat-sen UniversityNo.132 East Waihuan RoadGuangzhou 510006P.R.China Department of Mechanical Aerospaceand Biomedical EngineeringUniversity of South AlabamaShelby Hall3128MobileAL 36688USA Electrical Engineering Division Department of EngineeringUniversity of Cambridge9 JJ Thomson AvenueCambridge CB30FAUnited Kingdom Zhejiang University International CampusHainingChina

With the rapid development of the Internet of Things(IoTs),wearable sensors are playing an increasingly important role in daily monitoring of personal health and *** signal-to-noise-ratio has become the most critical performance factor to *** enhance it,on the one hand,good sensing materials/devices have been employed;on the other hand,signal amplification and noise reduction circuits have been ***,most of these devices and circuits work in an active sampling mode,requiring frequent data acquisition and hence,entailing high-power *** this scenario,a flexible and wearable event-triggered sensor with embedded signal amplification without an external power supply is of great ***,we report a flexible two-terminal piezotronic n-p-n bipolar junction transistor(PBJT)that acts as an autonomous and highly sensitive,current-and/or voltage-mediated pressure *** PBJT is formed by two back-to-back piezotronic diodes which are defined as emitter-base and collectorbase *** force exertion on the emitter side,as a result of the piezoelectric effect,the emitter-base diode is forward biased while the collector-base diode is reverse *** to the inherent BJT amplification effect,the PBJT achieves record-high sensitivities of 139.7 kPa^(-1)(current-based)and 88.66 kPa^(-1)(voltage-based)in sensing *** PBJT also has a fast response time ofli ranging from a flying butterfly to a gentle finger ***,the PBJT advances the state of the art not only in terms of sensitivity but also in regard to being self-driven and autonomous,making it promising for pressure sensing and other IoT applications.

关键词： bipolar transistor IoT

Community Incidence Estimates of Five Pathogens Based on Foodborne Diseases Active Surveillance—China,2023

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China CDC weekly 2024年第24期6卷 574-579,I0002页

作者： Penghui Fan Haihong Han Jikai liu Xiaochen Ma Ronghua Zhang Hong liu Yijing Zhou Zunhua Chu Jian Wen li lin weiwei li Yunchang Guo NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Shanghai Center for Disease Control and Prevention ShanghaiChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Province Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Guangdong Province Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Sichuan Province Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina

What is already known about this topic?Foodborne diseases,representing significant food safety and public health challenges globally,are not welldocumented in terms of incidence,particularly for cases characterized by acute gastroenteritis(AGI)in *** is added by this report?This study developed a pyramid model to estimate the incidence of five pathogens,stratified by gender and *** estimated incidences per 100,000 people with 95%uncertainty intervals(UI)are as follows:Norovirus,3,188.28(95%UI:2,518.03,7,296.96);Salmonella spp.,1,295.59(95%UI:1,002.62,1,573.11);diarrheagenic ***(DEC),782.62(95%UI:651.19,932.05);Vibrio parahaemolyticus,404.06(95%UI:342.19,468.93);and Shigella spp.,26.73(95%UI:21.05,33.46).What are the implications for public health practice?This study elucidates the incidence rates across various gender and age groups,thereby identifying priority populations for targeted preventive interventions aimed at reducing disease *** insights are crucial for the development of public health policies and management of food safety risks.

关键词： acute diseases stratified

KIF5B-mediated internalization of FMDV promotes virus infection

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Virologica Sinica 2024年第3期39卷 378-389页

作者： Wei Zhang Fan Yang Yang Yang Weijun Cao Wenhua Shao Jiali Wang Mengyao Huang Zhitong Chen Xiaoyi Zhao weiwei li Zixiang Zhu Haixue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou 730046China

Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV internalization after infection remains *** this study,we found that kinesin family member 5B(KIF5B)plays a vital role during FMDV ***,we confirmed the interaction between KIF5B and FMDV structural protein VP1 by co-immunoprecipitation(Co-IP)and co-localization in FMDV-infected *** particular,the stalk[amino acids(aa)413–678]domain of KIF5B was indispensable for KIF5B-VP1 ***,overexpression of KIF5B dramatically enhanced FMDV replication;consistently,knockdown or knockout of KIF5B suppressed FMDV ***,we also demonstrated that KIF5B promotes the internalization of FMDV via regulating clathrin ***5B also promotes the transmission of viral particles to early and late endosomes during the early stages of *** conclusion,our results demonstrate that KIF5B promotes the internalization of FMDV via regulating clathrin uncoating and intracellular *** study may provide a new therapeutic target for developing FMDV antiviral drugs.

关键词： FMDV VP1 protein KIF5B Endosome Clathrin

Alkyl-thiophene-alkyl linkers to construct double-cable conjugated polymers for single-component organic solar cells

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Chinese Chemical Letters 2024年第1期35卷 542-546页

作者： Wenbin Lai Safakath Karuthedath Chengyi Xiao Lei Meng Frédéric Laquai weiwei li Yongfang li Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Beijing Advanced Innovation Center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China King Abdullah University of Science and Technology(KAUST) KAUST Solar Center(KSC)Physical Sciences and Engineering Division(PSE)Material Science and Engineering Program(MSE)Thuwal 23955-6900Kingdom of Saudi Arabia University of Chinese Academy of Sciences Beijing 100049China Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

In this work,semirigid linkers of the alkyl-thiophene-alkyl structure are developed to construct double-cable *** alkyl units,propyl(C3H6),hexyl(C6H12),and dodecyl(C12H24),are applied as semirigid linkers,yielding three double-cable polymers:PBC6-T,PBC12-T,and PBC24-T,***12-T which uses C6H12-thiophene-C6H12 linkers is found to exhibit the best device efficiency of 5.56%,while PBC6-T and PBC24-T with shorter or longer linkers yield device efficiencies of only 2.65%and 1.09%in single-component organic solar cells(SCOSCs).Further studies reveal that PBC12-T exhibits higher crystallinity and improved charge transport,resulting in better *** work provides an approach to construct double-cable conjugated polymers with long alkyl linkers,and it shows the importance of the linker length for the photovoltaic performance of SCOSCs.

关键词： Double-cable conjugated polymer Single-component organic solar cell Crystallinity Semirigid linkers Alkyl-thiophene-alkyl

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

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Bone Research 2024年第2期12卷 334-348页

作者： Ziqian Xiang Pengfei Zhang Chunwang Jia Rongkun Xu Dingren Cao Zhaoning Xu Tingting Lu Jingwei liu Xiaoxiong Wang Cheng Qiu Wenyang Fu weiwei li Lei Cheng Qiang Yang Shiqing Feng lianlei Wang Yunpeng Zhao Xinyu liu Department of Orthopaedics Qilu Hospital of Shandong UniversityJinan 250012China University of Health and Rehabilitation Sciences Qingdao 226000China Xiangya School of Medicine Central South UniversityChangsha 410013China School of Nursing and Rehabilitation Shandong UniversityJinan 250012China Department of Pediatrics Cangzhou Central HospitalCangzhou 061011China Department of Pediatric Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Pathology Qilu Hospital of Shandong UniversityJinan 250012China Department of Spine Surgery Tianjin HospitalTianjin UniversityTianjin 30021China The Second Hospital of Shandong University Cheeloo College of MedicineShandong UniversityJinan 250012China

To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be ***,Piezo1 channel was identified as a key iron transporter in response to mechanical ***1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron ***,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical ***,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.

关键词： stress overload channel