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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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A Server Placement Algorithm for Reducing Risk and Improving Power Utilization in Data Centers

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Tsinghua Science and Technology 2024年第1期29卷 158-173页

作者： Rui Chen Huikang Huang Xiaoxuan Luo weiwei lin School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China Peng Cheng Laboratory Shenzhen 518066China

As the power demand in data centers is increasing,the power capacity of the power supply system has become an essential resource to be *** many data centers use power oversubscription to make full use of the power capacity,there are unavoidable power supply risks associated with ***,how to improve the data center power capacity utilization while ensuring power supply security has become an important *** solve this problem,we first define it and propose a risk evaluation metric called Weighted Power Supply Risk(WPSRisk).Then,a method,named Hybrid Genetic Algorithm with Ant Colony System(HGAACS),is proposed to improve power capacity utilization and reduce power supply risks by optimizing the server placement in the power supply *** uses historical power data of each server to find a better placement solution by population *** possesses not only the remarkable local search ability of Ant Colony System(ACS),but also enhances the global search capability by incorporating genetic operators from Genetic Algorithm(GA).To verify the performance of HGAACS,we experimentally compare it with five other placement *** experimental results show that HGAACS can perform better than other algorithms in both improving power utilization and reducing the riskof powersupply system.

关键词： server placement power utilization power supply risk swarm intelligence algorithm

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Effect of Residual Stress on Corrosion Sensitivity of Carbon Steel Studied by SECM

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Chemical Research in Chinese Universities 2014年第6期30卷 1022-1027页

作者： WANG Yujie HAN Xiaoping LIU Yu ZHANG weiwei NIU lin Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China

The effect of compressive residual stress on the reactivity of carbon steel in a neutral chloride solution was investigated by means of potentiodynamic polarization and local electrochemical measurement with scanning electrochemical microscope（SECM）. Meanwhile, X-ray diffraction, as a nondestructive technique, was employed to determine the levels of residual stress in near-surface layers of carbon steel specimen. The results show that the resi- dual stress existed in the specimen fell into the category of compressive residual stress which was inversely propor- tional to the corrosion sensitivity of carbon steel specimen. By using I/I3 couple as a redox mediator in the current feedback mode of SECM measurements, the Faradaic current on Pt tip, which was relevant to the rate of the I3- ion reduction, fell with the increase of compressive residual stress. The correlation between compressive residual stress and heterogeneous electron transfer rate has been proposed based on the inference of the localized electrochemical reactions occurred on the specimen surface,

关键词： rCarbon steel Corrosion sensitivity Residual stress Scanning electrochemical microscope(SECM)

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Multi-factor combined biomarker screening strategy to rapidly diagnose Alzheimer's disease and evaluate drug effect based on a rat model

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Journal of Pharmaceutical Analysis 2022年第4期12卷 627-636页

作者： Yanmeng Liu Xinyue Zhang weiwei lin Nurmuhammat Kehriman Wen Kuang Xiaomei ling The State Key Laboratory of Natural and Biomimetic Drugs and Department of Pharmaceutical Analysis School of Pharmaceutical SciencesPeking UniversityBeijing100191China

Alzheimer's disease(AD)represents the main form of dementia;however,valid diagnosis and treatment measures are *** discovery of valuable biomarkers through omics technologies can help solve this *** this reason,metabolomic analysis using ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS)was carried out on plasma,hippocampus,and cortex samples of an AD rat *** on the metabolomic data,we report a multi-factor combined biomarker screening strategy to rapidly and accurately identify potential *** with the usual procedure,our strategy can identify fewer biomarkers with higher diagnostic specificity and *** addition to diagnosis,the potential biomarkers identified using our strategy were also beneficial for drug ***-factor combined biomarker screening strategy was used to identify differential metabolites from a rat model of amyloid beta peptide 1e40(Aβ_(1-40))plus ibotenic acid-induced AD(compared with the controls)for the first time;lysophosphatidylcholine(LysoPC)and intermediates of sphingolipid metabolism were screened as potential ***,the effects of donepezil and pine nut were successfully reflected by regulating the levels of the abovementioned biomarkers and metabolic profile distribution in partial least squaresdiscriminant analysis(PLS-DA).This novel biomarker screening strategy can be used to analyze other metabolomic data to simultaneously enable disease diagnosis and drug evaluation.

关键词： Biomarker discovery Metabolomics Multi-factor combined biomarker screening strategy Disease diagnosis Drug evaluation

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Pedestrian and Vehicle Detection Based on Pruning YOLOv4 with Cloud-Edge Collaboration

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Computer Modeling in Engineering & Sciences 2023年第11期137卷 2025-2047页

作者： Huabin Wang Ruichao Mo Yuping Chen weiwei lin Minxian Xu Bo Liu School of Computer Science and Engineering Huizhou UniversityHuizhou516007China School of Computer Science and Engineering South China University of TechnologyGuangzhou510006China School of Computer Science and Technology South China Normal UniversityGuangzhou510631China Department of New Network Technologies Peng Cheng LaboratoryShenzhen518066China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen518055China

Nowadays,the rapid development of edge computing has driven an increasing number of deep learning applications deployed at the edge of the network,such as pedestrian and vehicle detection,to provide efficient intelligent services to mobile ***,as the accuracy requirements continue to increase,the components of deep learning models for pedestrian and vehicle detection,such as YOLOv4,become more sophisticated and the computing resources required for model training are increasing dramatically,which in turn leads to significant challenges in achieving effective deployment on resource-constrained edge devices while ensuring the high accuracy *** addressing this challenge,a cloud-edge collaboration-based pedestrian and vehicle detection framework is proposed in this paper,which enables sufficient training of models by utilizing the abundant computing resources in the cloud,and then deploying the well-trained models on edge devices,thus reducing the computing resource requirements for model training on edge ***,to reduce the size of the model deployed on edge devices,an automatic pruning method combines the convolution layer and BN layer is proposed to compress the pedestrian and vehicle detection model *** results show that the framework proposed in this paper is able to deploy the pruned model on a real edge device,Jetson TX2,with 6.72 times higher ***,the channel pruning reduces the volume and the number of parameters to 96.77%for the model,and the computing amount is reduced to 81.37%.

关键词： Pedestrian and vehicle detection YOLOv4 channel pruning cloud-edge collaboration

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Induced neuronal differentiation of neural stem cells by a combination of cytokines One-step versus two-step methods

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Neural Regeneration Research 2009年第11期4卷 814-821页

作者： Xiaoli Sun Xue Chen Tianyi Zhang Zhenglin Jiang weiwei lin Ying Yuan XiaodongWang Department of Histology and Embryology Medical School of Nantong University Nantong 226001 Jiangsu Province China Affiliated Hospital of Nantong University Nantong 226001 Jiangsu Province China Jiangsu Province Key Laboratory of Neuroregeneration Nantong 226001 Jiangsu Province China

BACKGROUND： A combination of basic fibroblast growth factor （bFGF）, platelet-derived growth factor （PDGF）, human heregulin-beta-1, beta-mercaptoethanol retinoic acid and forskolin has been reported to induce the differentiation of rat bone marrow stromal cells into myelinating Schwann-like cells. OBJECTIVE： To investigate the inducing effects of a combination of bFGF, PDGF, human heregulin-beta-1, beta-mercaptoethanol retinoic acid and forskolin on neural stem cell differentiation by one- and two-step methods. DESIGN, TIME AND SETTING： A cytobiology experiment was performed at the Department of Histology and Embryology, Medical School of Nantong University, and Jiangsu Province Key Laboratory of Neuroregeneration, China, between August 2005 and January 2007. MATERIALS： A total of 30 healthy Sprague Dawley rat embryos at gestational days 14-16 were selected, bFGF, PDGF, human heregulin-beta-t, beta-mercaptoethanol, retinoic acid, and forskolin were purchased from Sigma, USA. METHODS： Passage 3 rat neural stem cells were cultured by a one-step method in serum-free medium plus 10 ng/m/bFGF, 5 ng/mL PDGF, 200 ng/mL heregulin-beta-1,35 ng/mL all-trans retinoic acid, and 5 pmol/L forskolin or by a two-step method in serum-free medium plus 35 ng/m/ all-trans retinoic acid for 72 hours, followed by serum-free medium plus 10 ng/mL bFGF, 5 ng/mL PDGF, 200 ng/mL heregulin-beta-t and 5 μmol/L forskolin. The control condition consisted of 10% fetal bovine serum alone or 20 ng/mL bFGF alone. MAIN OUTCOME MEASURES： Differentiated cells were identified by immunocytochemical staining for microtubule associate protein-2 （MAP2） and St 00 protein. Geometric parameters and sodium ion currents of the differentiated cells were measured by image analysis and whole-cell patch-clamp techniques, respectively. RESULTS： Compared with the two-step culture method, neuronal-like cells exhibited longer processes and a similar appearance to mature neurons using the one-step method. The percentage of

关键词： neural stem cells differentiation neuron cytokines whole-cell patch-clamp

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Study on green power supply modes for heavy load in Remote Areas

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Global Energy Interconnection 2024年第4期7卷 475-485页

作者： Yu Li Yixi Cuomu Yiming Gao Guoqin Lv weiwei lin Sirui Li Changchun Zhou State Grid Xizang Electric Power Co. Ltd.Lhasa 850010Tibet Autonomous RegionP.R.China Global Energy Interconnection Development and Cooperation Organization Beijing 100031P.R.China State Grid Fujian Power Economic Research Institute Fuzhou 350012P.R.China Eindhoven University of Technology Eindhoven.5621 AENetherlands

In this study,the present situation and characteristics of power supply in remote areas are *** studying the cases of power supply projects in remote areas,the experience is analyzed and described,and the applicability of related technologies,such as grid-forming storage and power load management,is studied,including grid-connection technologies,such as grid-forming converters and power load *** this basis,three power-supply modes were *** application scenarios and advantages of the three modes were compared and *** on the local development situation,the temporal sequences of the three schemes are described,and a case study was *** study of the heavy-load power supply mode in remote areas contributes to solving the problem of heavy-load green power consumption in remote areas and promoting the further development of renewable energy.

关键词： Remote area Renewable energy Grid-forming storage Power load management Power supply mode

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A novel Tb^(3+) and Eu^(3+) co-doped dual-emitting phosphate K_(3)SrBi(P_(2)O_(7))_(2) phosphor for application in FIR thermometers

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Journal of Rare Earths 2024年第3期42卷 455-463,I0001页

作者： Baochen Wang Shifeng Sun Zeqi Li Zongwang Li weiwei lin Chao Zeng Yan-gai Liu Ruiyu Mi School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu241000China State-Province Joint Engineering Laboratory of Zeolite Membrane Materials Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationInstitute of Advanced MaterialsCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of GeosciencesBeijing100083China

Rare earth co-doped phosphor for fluorescence intensity ratio(FIR) thermometer has gained increasing attention in recent years. Herein, the novel Tb^(3+)and Eu^(3+)co-doped K_(3)SrBi(P_(2)O_(7))_(2)(KSBP) phosphate phosphors were reported. The crystal structure of the title phosphor was determined using Rietveld refinement and proved to have a three-dimensional structure. The time-resolved spectroscopy reveals that there is almost no energy transfer between Tb^(3+)and Eu^(3+). More importantly, Tb^(3+)and Eu^(3+)emissions show different thermal quenching behaviors, which claims the potential of this material for application in optical thermometer. The FIR of the typical KSBP:0.02Tb^(3+),0.04Eu^(3+)sample demonstrates a polynomial relationship as a function of temperature and the absolute and relative sensitivity are0.025 K^(-1) and 0.59%/K, respectively. In general, our study reports a novel and potential KSBP:Tb^(3+),Eu^(3+)phosphate phosphor that is promising for use in high-sensitive FIR thermometers.

关键词： Phosphor Thermometer Fluorescence intensity ratio Thermal stability Rare earths

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Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications

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Regenerative Biomaterials 2017年第2期4卷 69-79页

作者： Hongye Hao Ya Deng Yingke Wu Siyuan Liu weiwei lin Jiehua Li Feng Luo College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard *** obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering *** phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell *** addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity *** interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing ***,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing.

关键词： phosphatidylcholine polyurethane soft tissue engineering macrophage

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Reductive amination of 1,6-hexanediol with Ru/Al2O3 catalyst in supercritical ammonia

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Science China Chemistry 2017年第7期60卷 920-926页

作者： Yan Li Haiyang Cheng Chao Zhang Bin Zhang Tong Liu Qifan Wu Xinluona Su weiwei lin Fengyu Zhao State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Laboratory of Green Chemistry and Process Changchun Institute of Applied ChemistryChinese Academy of Sciences Changchun 130022China Department of Environmental Science and Engineering Heilongfiang UniversityHarbin 150080China

Hexamethylenediamine(HMDA) is an important reagent for the synthesis of Nylon-6,6, and it is usually produced by the hydrogenation of adiponitrile using a toxic reagent of hydrocyanic acid. Herein, we developed an environmental friendly route to produce HMDA via catalytic reductive amination of 1,6-hexanediol(HDO) in the presence of hydrogen. The activities of several heterogeneous metal catalysts such as supported Ni, Co, Ru, Pt, Pd catalysts were screened for the present reaction in supercritical ammonia without any additives. Among the catalysts examined, Ru/Al_2O_3 presented a high catalytic activity and highest selectivity for the desired product of HMDA. The high performance of Ru/Al_2O_3 was discussed based on the Ru dispersion and the surface properties like the acid-basicity. In addition, the reaction parameters such as reaction temperature,time, H_2 and NH_3 pressure were examined, and the reaction processes were discussed in detail.

关键词： 1 6-hexanediol hexamethylenediamine supercritical ammonia reductive amination Ru/Al2O3

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