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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan chen weiqiang chen Kangsheng Li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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Overview of current design and analysis of potential theories for automated fibre placement mechanisms

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Chinese Journal of Aeronautics 2022年第4期35卷 1-13页

作者： Wuxiang ZHANG Fei LIU Tao JIANG Minghui YI weiqiang chen Xilun DING School of Mechanical Engineering and Automation Beihang University37 Xueyucm RoadBeijing 100191China Ningbo Institute of Technology Beihang UniversityNingbo 315832China Beijing Weixing Manufacturing Plant Co. LtdBeijing 100191China

Automated fibre placement(AFP) systems have successfully intensified the demand for high-quality composite component manufacturing in both the military and civilian fields. One of the main elements of these systems is the AFP mechanism for accomplishing individual fibre delivery,clamp/cut/restart(CCR) and the consolidation process, and it consists of several functional submechanisms presenting strong coupling relationships and motion sequences. This review aims to summarize the development of AFP mechanisms and the associated research achievements and provide insight into the research challenges in promoting innovative design in such mechanisms. The systematic development of AFP systems is reviewed in detail, and subsequently, engineering tendency and the general principle of AFP mechanisms are introduced. Focusing on the mechanism design of AFP sub-mechanisms, including the creel assembly CCR and compaction mechanisms,the mechanical schemes as well as the AFP process parameter control are discussed. To improve system reliability and fully optimise AFP mechanisms, the essential theoretical foundation for AFP mechanisms are provided. It is believed that this attempt will help to change the design and optimisation of similar complete mechanisms. Based on the reviewed research, overall remarks and perspectives are presented to serve as a guide for exploring the possibility of novel easy-to-use and cost-effective integrated AFP applications.

关键词： Automated fibre placement systems Sub-mechanisms Structure design Layup performance Theoretical foundation

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Protective effects of ginkgo biloba leaves extract on peroxide-induced oxidative stress damage in PC12 cells

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Neural Regeneration Research 2007年第6期2卷 369-371页

作者： weiqiang chen Taiping Hu Ying Liu Department of Pathophysiology Guangdong Pharmaceutical College Guangzhou 510006 Guangdong Province China

BACKGROUND： Extracts of ginkgo biloba leaves （EGB） and its metabolites have been reported to enhance brain function and nerve behavior. It has also been hypothesized that they can protect neurons from oxidative stress. OBJECTIVE： To investigate protective effects of EGB on peroxide （H2O2）-induced oxidative stress damage in PC12 cells. DESIGN： Observational contrast study. SETTING： Department ofPathophysiology, Guangdong Pharmacological College. MATERIALS： EGB was provided by Xi＇an Fujie Biotechnological Development Company; 1640 culture medium, methylthiazolyl tetrazolium （MTT）, trypsin and dimathyl sulfoxide （DMSO） by Sigma Company; PC12 cell strain by Cell Center of Medical College of Zhongshan University; calf serum by Hangzhou Sijiqing Bioengineering Company; lactate dehydrogenase （LDH） kit by Nanjing Jiancheng Bioengineering Research Institute. METHODS： The experiment was carried out in Department of Cell Biology of Guangdong Pharmacological College from June to December 2005. ①Cell culture： PC12 cells were cultured in 1640 medium containing 200 g/L fetal calf serum. The cells were diluted to 1 × 10^7 L^-1 and washed every two days. Those cells were used to experiment until they grew in logarithm on solid wall. ② Grouping and intervention： PC12 cells （1 × 10^8L^-1） were plated in 96-well plates with the density of 200 μ L/hole and divided into three groups： normal control group （routinely adding media）, H2O2 group （treating with media and H2O2 for 20 hours） and EGB group （adding media, 100μmol/L EGB and 100 μmol/L H2O2）. ③ MTT assay： PC12 cells （1 × 10^8L^-1） were plated in 96-well plates and divided into three groups with 8 holes for each group. Under sterile condition, cells were added with 5 g/L MTT （100μL） and cultured for 4 hours. And then, 200 μ L DMSO fluid was added and shaken for 30 minutes until blue crystal products formed were dissolved soundly ④ Experimental evaluation： Absorbance （A） at 630 nm was measured and LDH activity was measured at the same

关键词： PC12 cell H2O2: extracts of ginkgo biloba leaves

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Effect of dry-wet cycles on dynamic properties and microstructures of sandstone:Experiments and modelling

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International Journal of Mining Science and Technology 2024年第5期34卷 655-679页

作者： Hai Pu Qingyu Yi Andrey P.Jivkov Zhengfu Bian weiqiang chen Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Earth Engineering China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China Department of Solids and Structures School of EngineeringUniversity of ManchesterManchester M139PLUK School of Environment Science and Spatial Informatics China University of Mining and TechnologyXuzhou 221116China Department of Civil and Environmental Engineering Rice UniversityHouston 77005USA State Key Laboratory of High Performance Civil Engineering Materials Jiangsu Research Institute of Building Science Co.Ltd.Nanjing 210008China Department of Materials University of OxfordOxford OX13PHUK

Underground pumped storage power plant(UPSP)is an innovative concept for space recycling of abandoned *** realization requires better understanding of the dynamic performance and durability of reservoir *** paper conducted ultrasonic detection,split Hopkinson pressure bar(SHPB)impact,mercury intrusion porosimetry(MIP),and backscatter electron observation(BSE)tests to investigate the dynamical behaviour and microstructure of sandstone with cyclical dry-wet damage.A coupling FEM-DEM model was constructed for reappearing mesoscopic structure *** results show that dry-wet cycles decrease the dynamic compressive strength(DCS)with a maximum reduction of 39.40%,the elastic limit strength is reduced from 41.75 to 25.62 *** sieved fragments obtain the highest crack growth rate during the 23rd dry-wet cycle with a predictable life of 25 cycles for each rock *** pore fractal features of the macropores and micro-meso pores show great differences between the early and late cycles,which verifies the computational statistics analysis of particle *** numerical results show that the failure patterns are governed by the strain in pre-peak stage and the shear cracks are *** dry-wet cycles reduce the energy transfer efficiency and lead to the discretization of force chain and crack fields.

关键词： Underground pumped storage power plant Dry-wet cycles Split Hopkinson pressure bar Macro and micro properties FEM-DEM coupling model Damage characterization

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1961-2020年赣江流域月尺度实际蒸发模拟及归因分析

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水土保持研究 2025年第1期32卷 195-202页

作者：姬广兴刘智培高红凯陈伟强黄珺嫦张亚丽郭宇龙陈轶楠河南农业大学资源与环境学院华东师范大学地理科学学院

[目的]探究赣江流域月时间尺度实际蒸发的变化规律和分配特征以及不同因素对实际蒸发量的贡献量，为生态环境保护和水资源高效利用提供理论依据。[方法]基于赣江流域外洲水文站1961—2020年径流量数据，结合Mann-Kendall突变检验法和Pet... 详细信息

[目的]探究赣江流域月时间尺度实际蒸发的变化规律和分配特征以及不同因素对实际蒸发量的贡献量，为生态环境保护和水资源高效利用提供理论依据。[方法]基于赣江流域外洲水文站1961—2020年径流量数据，结合Mann-Kendall突变检验法和Pettitt突变点检验法确定径流突变年份。其次利用ABCD水文模拟赣江流域基准期和突变期径流变化过程，计算得出月尺度实际蒸发量。然后利用去趋势预置白趋势检验法(TFPW-MK)分析实际蒸发的变化趋势和年内分布特征。最后采用月尺度Budyko模型对实际蒸发量变化进行归因分析。[结果](1)径流突变年份为1991年。(2)赣江流域2月、3月、4月、6月、9月的实际蒸发量呈现上升趋势，其余月份实际蒸发为下降趋势。其中2月、3月的实际蒸发量显著上升(p<0.05)。(3)赣江流域月尺度实际蒸发量呈现“单峰型”分布，在7月附近达到最大值。(4)气候变化会导致各月实际蒸发量的增加，人类活动会导致各月实际蒸发量减少。[结论]赣江流域实际蒸发量呈现先增大后减少的趋势，气候变化对实际蒸发量的贡献表现为正作用。人类活动对实际蒸发量变化表现为负作用。

关键词：实际蒸发量变化气候变化人类活动 ABCD模型月尺度Budyko模型

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Influence of flavone extract from cultivated saussurea on learning and memory in a mouse model of Alzheimer's disease A comparison with estradiol benzoate

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Neural Regeneration Research 2011年第30期6卷 2332-2336页

作者： weiqiang chen Shuiming Gong Yan Li Ming Li Zemin Yang Lirong Zhanf Department of Pathophysiology School of Basic Courses Guangdong Pharmaceutical University Guangzhou 510006 Guangdong Province China Key Laboratory of Bioactive Substances of Guangdong Province Guangdong Pharmaceutical University Guangzhou 510006 Guangdong Province China Out-patient Department Guangdong Pharmaceutical University Guangzhou 510006 Guangdong Province China Department of Microbiology and Parasitology School of Basic Medical Science Guangzhou University of Chinese Medicine Guangzhou 510006 Guangdong Province China

The present study established a mouse model of Alzheimer＇s disease, and investigated the effects of treatment with flavone extract from artificially cultivated saussurea. A positive control group was treated with estradiol benzoate, and learning and memory ability were examined in the 8-arm radial maze. The learning and recognition ability of mice with Alzheimer＇s disease treated with flavone extract was significantly improved and the number of hippocampal neurons was significantly increased in the flavone-treated and positive control groups compared with the model group. The results indicate that flavone extract from artificially cultivated saussurea can improve learning and memory deficits in mice with Alzheimer＇s disease, exerting effects similar to those of estradiol benzoate.

关键词： flavone extract from saussurea Alzheimer's disease mouse estrogen neurodegenerative disease neural regeneration

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Molecular mechanism of fly ash affecting the performance of cemented backfill material

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International Journal of Minerals,Metallurgy and Materials 2023年第8期30卷 1560-1572页

作者： Shuo Yang Jiangyu Wu Hongwen Jing Xinguo Zhang weiqiang chen Yiming Wang Qian Yin Dan Ma State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China Shandong Key Laboratory of Mining Disaster Prevention and Control Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of High Performance Civil Engineering Materials Jiangsu Research Institute of Building Science Co.Ltd.Nanjing 210008China Department of Materials University of OxfordParks RdOxfordOX13PHUnited Kingdom Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringThe University of ManchesterManchester M139PLUnited Kingdom School of Mines China University of Mining and TechnologyXuzhou 221116China

The great challenge of cemented tailings backfill(CTB)is difficult simultaneously maintaining its excellent mechanical properties and low *** ash(FA)can potentially address this problem and further replace cement in favor of low carbon ***,its mechanism on CTB with low cement dosage and low Ca system remains ***,this study conducted uniaxial compression,Xray diffraction(XRD),and scanning electron microscopy(SEM)-energy dispersive spectrometer(EDS)tests to investigate the effect of FA dosage on the mechanical property and microstructure of CTB.A molecular model of FA-CSH was constructed to reproduce the molecular structure evolution of CTB with FA based on the test *** influences of FA dosage and calcium/silica molar ratio(Ca/Si ratio)on the matrix strength and failure model were analyzed to reveal the mechanism of FA on calcium silicate hydrated(C-S-H).The results show that the strength of CTB increases initially and then decreases with FA dosage,and the FA supplement leads to a decrease in Ca(OH)_(2) diffraction intensity and Ca/Si ratio around the FA *** and SEM-EDS findings show that the Ca/Si ratio of C-S-H decreases with the progression of *** FA-CSH model indicates that FA can reinforce the silica chain of C-S-H to increase the matrix ***,this enhancement is weakened by supplementing excessive FA *** addition,the hydrogen bonds among water molecules deteriorate,reducing the matrix strength.A low Ca/Si ratio results in an increase in water molecules and a decrease in the ionic bonds combined with Ca^(2+).The hydrogen bonds among water molecules cannot withstand high stresses,resulting in a reduction in *** water absorption of the FA-CSH model is negatively correlated with the FA dosage and Ca/Si *** use of optimal FA dosage and Ca/Si ratio leads to suitable water absorption,which further affects the failure mode of FA-CSH.

关键词： fly ash cemented tailings backfill calcium/silica ratio microstructure molecular dynamics simulation

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Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis

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Horticulture Research 2023年第9期10卷 306-320页

作者： Ziyan Xie Yaolei Mi Lingzhe Kong Maolun Gao Shanshan chen weiqiang chen Xiangxiao Meng Wei Sun Shilin chen Zhichao Xu Key Laboratory of Saline-alkali Vegetation Ecology Restoration(Northeast Forestry University) Ministry of EducationHarbin 150040China College of Life Science Northeast Forestry UniversityHarbin 150040China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China

Is Cannabis a boon or bane?Cannabis sativa has long been a versatile crop for fiber extraction(industrial hemp),traditional Chinese medicine(hemp seeds),and recreational drugs(marijuana).Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of △^(9)-tetrahydrocannabinol;however,recently,the perspective has changed with the recognition of additional therapeutic values,particularly the pharmacological potential of cannabidiol.A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis ***,we comprehensively review the historical usage of Cannabis,biosynthesis of trichome-specific cannabinoids,regulatory network of trichome development,and synthetic biology of *** review provides valuable insights into the efficient biosynthesis and green production of cannabinoids,and the development and utilization of novel Cannabis varieties.

关键词： comprehensive versatile globally

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Numerical study on the combustion process in a gas turbine combustor with different reference velocities

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Advances in Aerodynamics 2023年第1期5卷 497-517页

作者： cheng Gong Shufan Zhao weiqiang chen Wenyu Li Yu Zhou Ming Qiu Aerospace Technology Institute China Aerodynamics Research and Development CenterMianyang 621000China

The mixing and combustion processes under different reference velocities in a gas turbine combustor were numerically investigated using the Flamelet Generated Manifold(FGM)model based on the Reynolds Averaged Navier-Stokes(RANS)*** flow and combustion fields show strong self-similarity except on the slow auto-ignition in the mixing layer between fuel-rich product and fresh air upstream of the flame stabilization *** time-scale analysis was carried out to understand the combustion modes inside the *** general,the residence time of the fuel-mixture is much longer than both the chemical time scale and the mixing time ***,the combustion properties in each sub-zone were dominated by the mean flow ***,the combustion process exhibits a mixing-controlled feature in ***,partially premixed combustion still appears on the flame *** of the fuel was found to be oxidized in the primary zone and the intermediate zone;however,the slow oxidization reactions also play a non-negligible role on the whole combustion ***,a sketch map on the space of mixture fraction and combustion efficiency was proposed to understand the mixing and oxidization experiences of the fuel mixture.

关键词： Gas turbine combustor Swirling flame FGM Combustion mode Time-scale analysis

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A justice and innovative way ahead of consumption-based emission accounting approach

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Science China Earth Sciences 2024年第10期67卷 2999-3010页

作者： Qun SHEN Hongbo DUAN Yun TANG Linbing TANG Li SHANG Xinyu DOU Wei WEI weiqiang chen Zhu LIU State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization CAS Key Laboratory of Low-Carbon Conversion Science&EngineeringShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China School of Economics&Management University of Chinese Academy of SciencesBeijing 100190China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Department of Earth System Science Tsinghua UnivesityBeijing 100084China

Carbon emission accounting is an important basis for global climate *** on the consumption-based accounting(CBA)method,the characteristics of carbon flow between national,regional,and product processes could be more clearly ***,CBA is more conducive to clarifying the attribution of responsibilities between producers and consumers,with the principles of fairness and *** accounting for carbon emissions in typical countries from 1990 to 2019,we found that the CBA emissions are higher than the production-based accounting(PBA)emissions in major developed countries,while the results are reversed for developing *** the past 30 years,the CBA emissions in targeted developed countries generally have shown a downward trend,while in developing countries,they have shown an upward *** emissions in China have shown a continuous growth trend from 1990 to 2019,but the pace has slowed down significantly over the last ***,the embodied carbon intensity of China’s exports continues to decline,indicating that China is providing more green and low-carbon products to the *** the PV industry as an example,this study further reveals the contribution of specific product industries to the country’s carbon transfer through product carbon footprint *** order to provide a scientific basis for global mitigation and climate governance,it is urgent to innovate a scientific,practical,and standardized CBA technology system.

关键词： Consumption-based accounting Production-based accounting Carbon transfer Carbon footprint

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