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A comparative study of CuO/TiO_2-SnO_2,CuO/TiO_2 and CuO/SnO_2 catalysts for low-temperature CO oxidation

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Journal of Natural Gas Chemistry 2009年第4期18卷 449-452页

作者： Kairong Li Yaojie Wang Shurong Wang Baolin Zhu Shoumin zhang weiping Huang Shihua Wu Department of Chemistry Nankai University Tianjin 300071 China

Nanometer SnO2 particles were synthesized by sol-gel dialytic processes and used as a support to prepare CuO supported catalysts via a deposition-precipitation method. The samples were characterized by means of TG-DTA, XRD, H2-TPR and XPS. The catalytic activity of the CuO/TiO2-SnO2 catalysts was markedly depended on the loading of CuO, and the optimum CuO loading was 8 wt.% （Tloo = 80 ℃）. The CuO/TiO2-SnO2 catalysts exhibited much higher catalytic activity than the CuO/TiO2 and CuO/SnO2 catalysts. H2-TPR result indicated that a large amount of CuO formed the active site for CO oxidation in 8 wt.% CuO/TiO2-SnO2 catalyst.

关键词： sol-gel dialytic processes CuO/TiO2-SnO2 catalyst low-temperature CO oxidation

Curcumin co-treatment ameliorates resistance to gefitinib in drug-resistant NCI-H1975 lung cancer cells

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Journal of Traditional Chinese Medicine 2017年第3期37卷 355-360页

作者： Jin Xin Wang Jue Shen Huifen Ran Ran Xu Kai Tong Xiangming zhang weiping Feng Li Institute of Hematology the First Affiliated Hospital of Medical School of Zhejiang University Department of Oncology the Third Affiliated Hospital of Zhejiang Chinese Medical University Institute of Hematology Zhejiang Provincial People's Hospital Traditional Chinese Medicine Department of National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

OBJECTIVE: To examine whether a combinative treatment with curcumin enhances the effects of the epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI) gefitinib on cell proliferation, clonogenic capacity and apoptosis in the drug-resistant lung cancer cell line NCI-H1975, and further investigate the molecular mechanisms ***: NCI-H1975 cells were treated with curcumin and gefitinib alone or in combination, and cell proliferation, clonogenic capacity and apoptosis were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay, clone forming experiments, and flow cytometry, respectively, while p38, extracellular regulated protein kinase(ERK)1/2, and protein kinase B(AKT)phosphorylation were examined using Western ***: Compared with the effects of either agent alone, the combination of curcumin and gefitinib had a stronger suppressive effect on proliferation and the clonogenic capacity(P < 0.05), and showed an increased ability to promote apoptosis(P < 0.05) and reduce p38, ERK1/2, and AKT phosphorylation(P < 0.05).CONCLUSION: Co-treatment of curcumin and gefitinib significantly improves the ability of gefitinib to inhibit cell proliferation, suppress the clonogenic capacity and enhance apoptosis in NCI-H1975 cells,and these effects are possibly mediated via a decrease in phosphorylation of proteins in downstream pathways of the epidermal growth factor receptor.

关键词： Lung neoplasms Cell line, tumor Cur-cumin Cell proliferation Apoptosis Receptor, epi-dermal growth factor Gefitinib

Capture the "Schr)dinger's cat" and future quantum technology

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Frontiers of Optoelectronics 2015年第4期 466-467页

作者： weiping zhang East China Normal University

The report will introduce the progress of the quantum physics and the achievement of construction and manipulation of the single quantum *** introducing the work of the Nobel Prize in physics of 2012,the report will interpret the advancement of future quantum technology including quantum telecommunication,quantum computer,atomic interferometer and gyroscope and quantum metrology.

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东乡族人群Duffy、Kidd、Diego血型系统等位基因频率多态性研究

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中国输血杂志 2024年第1期37卷 68-72页

作者：崔军张伟萍惠霞张晓萍李国英杨海燕临夏回族自治州中心血站甘肃临夏731100 甘肃省红十字血液中心甘肃省人民医院

目的了解甘肃省东乡族人群Duffy、Kidd、Diego血型系统等位基因频率多态性分布。方法2017年1—12月随机抽取甘肃省东乡族无血缘关系献血者100名,采用荧光PCR法检测献血者红细胞Duffy、Kidd、Diego血型系统等位基因。结果东乡族人群Duffy... 详细信息

目的了解甘肃省东乡族人群Duffy、Kidd、Diego血型系统等位基因频率多态性分布。方法2017年1—12月随机抽取甘肃省东乡族无血缘关系献血者100名,采用荧光PCR法检测献血者红细胞Duffy、Kidd、Diego血型系统等位基因。结果东乡族人群Duffy、Kidd、Diego血型系统等位基因频率为:Fy^(*)01为0.835、Fy^(*)02为0.165;Jk^(*)01为0.570、Jk^(*)02为0.430;DI^(*)01为0.020、DI^(*)02为0.980。未发现Fy(a-b-)、Jk(a-b-)、Di(a+b-)稀有表型。Duffy、Kidd、Diego血型系统等位基因对偶抗原Fya/Fy^(b)、Jk^(a)/Jk^(b)、Di^(a)/Di^(b)的不配合率分别为:23.76%、37.01%、3.84%。结论甘肃省东乡族人群Duffy、Kidd、Diego血型系统等位基因呈多态性分布,具有独特的民族分布特征。

关键词：红细胞血型等位基因频率基因多态性东乡族

疏调平衡针刺法对高血压脑出血术后患者运动功能、焦虑、抑郁及神经功能缺损程度的影响

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河南中医 2024年第5期44卷 759-763页

作者：张卫平赵扣玲范雪娇邢焕民商丘市立医院河南商丘476100

目的:观察疏调平衡针刺法对高血压脑出血(hypertensive cerebral hemorrhage,HICH)术后患者运动功能、焦虑、抑郁及神经功能缺损程度的影响。方法:选取2022年3月至2023年6月商丘市立医院治疗的HICH术后患者96例,随机分为对照组和观察组... 详细信息

目的:观察疏调平衡针刺法对高血压脑出血(hypertensive cerebral hemorrhage,HICH)术后患者运动功能、焦虑、抑郁及神经功能缺损程度的影响。方法:选取2022年3月至2023年6月商丘市立医院治疗的HICH术后患者96例,随机分为对照组和观察组,每组48例。对照组给予常规术后康复治疗,观察组在对照组治疗的基础上给予疏调平衡针刺法治疗。观察两组治疗前后Fugl-Meyer运动量表(Fugl-Meyer assessment,FMA)评分、中国脑卒中患者临床神经功能缺损程度评分量表(china stroke scale,CSS)评分、焦虑自评量表(self-rating anxiety Scale,SAS)评分、抑郁自评量表(self-rating depression scale,SDS)评分、超氧化物歧化酶(superoxide Dismutase,SOD)、白细胞介素(interleukin,IL)-6、肿瘤坏死因子(tumor necrosis factor,TNF)-α、C反应蛋白(C reactive protein,CRP)、丙二醛(malondialdehyde,MDA)、一氧化氮(nitric oxide,NO)变化情况及临床疗效。结果:对照组有效率为77.08%,观察组有效率为95.84%,观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后FMA评分高于对照组,CSS评分、SDS评分、SAS评分低于对照组,差异有统计学意义(P<0.05);观察组治疗后IL-6、TNF-α、CRP和MDA水平低于对照组,SOD、NO水平高于对照组,差异有统计学意义(P<0.05)。结论:疏调平衡针刺法可有效缓解HICH术后患者焦虑抑郁情绪,改善运动功能、神经功能。

关键词：高血压脑出血术后疏调平衡针刺法运动功能焦虑抑郁神经功能缺损程度

Route selection for opportunity-sensing and prediction of waterlogging

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Frontiers of Computer Science 2024年第4期18卷 147-159页

作者： Jingbin WANG Weijie zhang Zhiyong YU Fangwan HUANG weiping ZHU Longbiao CHEN College of Computer and Data Science Fuzhou UniversityFuzhou 350108China Department of Computer Science and Technology Xiamen UniversityXiamen 361005China

Accurate monitoring of urban waterlogging contributes to the city’s normal operation and the safety of residents’daily ***,due to feedback delays or high costs,existing methods make large-scale,fine-grained waterlogging monitoring impossible.A common method is to forecast the city’s global waterlogging status using its partial waterlogging *** method has two challenges:first,existing predictive algorithms are either driven by knowledge or data alone;and second,the partial waterlogging data is not collected selectively,resulting in poor *** overcome the aforementioned challenges,this paper proposes a framework for large-scale and fine-grained spatiotemporal waterlogging monitoring based on the opportunistic sensing of limited bus *** framework follows the Sparse Crowdsensing and mainly comprises a pair of iterative predictor and *** predictor uses the collected waterlogging status and the predicted status of the uncollected area to train the graph convolutional neural *** combines both knowledge-driven and data-driven approaches and can be used to forecast waterlogging status in all regions for the upcoming *** selector consists of a two-stage selection procedure that can select valuable bus routes while satisfying budget *** experimental results on real waterlogging and bus routes in Shenzhen show that the proposed framework could easily perform urban waterlogging monitoring with low cost,high accuracy,wide coverage,and fine granularity.

关键词： waterlogging prediction sparse crowdsensing active learning route selection graph convolutional network

Thermoelastic Dissipation in Diamond Micro Hemispherical Shell Resonators

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Journal of Shanghai Jiaotong university(Science) 2020年第3期25卷 281-287页

作者： FENG Jun zhang weiping LIU Zhaoyang GU Liutao CHENG Yuxiang National Key Laboratory of Science and Technology on Micro/Nano Fabrication Shanghai Jiao Tong UniversityShanghai 200240China Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Aerospace Control Technology Institute Shanghai 200233China

Maximizing quality factor (Q) is essential to improve the performance of micro hemispherical shell resonators (μHSRs) which can be used in microelectromechanical system (MEMS) gyroscopes to measure angular *** energy dissipation mechanisms limit Q,where thermoelastic dissipation (TED) is the major one and studied in this *** coupled thermo-mechanical equations for calculating TED are formulated,and then temperature distribution in a deformed μHSR and its quality factor related to TED (QTED) are obtained by solving the equations through a finite-element method (FEM).It has been found that different fabrication process conditions can obtain various geometrical parameters in our previous *** order to provide guidelines for the design and fabrication of μHSRs,the effects of their geometry on resonant frequency (f0) and QTED are *** change of anchor height and small enough anchor radius have no effect on both f0 and QTED,but the shell size including its radius,thickness and height has significant impact on f0 and *** is found that whether a μHSR has lower f0 and higher QTED or higher f0 and higher QTED can be achieved by changing these geometrical *** results presented in this paper can also be applied to other similar resonators.

关键词： microelectromechanical system(MEMS) diamond hemispherical shell resonators quality factor thermoelastic dissipation(TED)

ISG60 Negatively Regulates Cell Antiviral Responses by Disrupting the VISA-Associated Complexes

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Wuhan University Journal of Natural Sciences 2012年第1期17卷 1-6页

作者： LI Chao zhang weiping LI Ying GUO Lin SHU Hongbing LIU Yu College of Life Sciences Wuhan UniversityWuhan 430072HubeiChina

Viral infection activates the transcription factors NF-KB and interferon regulatory factor 3 （IRF3）, which collaborate to induce type I interferons （IFNs） and initiate host innate antiviral response. IFN-stimulated gene 56 （ISG56） induced by type I IFNs is a negative regulator of cellular antiviral response. In this study, we identified ISG60 as an ISG56-associated protein by biochemical purification and mass spectrometry analysis. Overex- pression of ISG60 inhibited Sendai virus-induced activation of NF-KB and IRF3. Coimmunoprecipitation assays indicated that ISG60 interacted with MDA5 and VISA, two important signaling proteins participating in virus-triggered production of type I IFNs. Furthermore, ISG60 disrupted the interaction of VISA with MDA5 or RIG-I. These results indicate that ISG60 is a negative regulator of virus-triggered type I IFNs induction.

关键词： interferon antiviral response negative regulation

GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation

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Journal of Genetics and Genomics 2022年第3期49卷 208-216页

作者： Zixin Cai Fen Liu Yan Yang Dandan Li Shanbiao Hu Lei Song Shaojie Yu Ting Li Bilian Liu Hairong Luo weiping zhang Zhiguang Zhou Jingjing zhang National Clinical Research Center for Metabolic Diseases Metabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of EducationAnd Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011 China Department of Urological Organ Transplantation The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Liver Organ Transplantation The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Pathophysiology Naval Medical UniversityShanghai 200433China

Decreased functional β-cell mass is the hallmark of diabetes, but the cause of this metabolic defect remains elusive. Here, we show that the levels of the growth factor receptor-bound protein 10(GRB10), a negative regulator of insulin and m TORC1 signaling, are markedly induced in islets of diabetic mice and high glucose-treated insulinoma cell line INS-1 cells. β-cell-specific knockout of Grb10 in mice increased β-cell mass and improved β-cell function. Grb10-deficient β-cells exhibit enhanced m TORC1 signaling and reduced β-cell dedifferentiation, which could be blocked by rapamycin. On the contrary, Grb10 overexpression induced β-cell dedifferentiation in MIN6 cells. Our study identifies GRB10 as a critical regulator of β-cell dedifferentiation and β-cell mass, which exerts its effect by inhibiting m TORC1 signaling.

关键词： Grb10 β-cell mass mTORC1 Dedifferentiation