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国外中小学灾害教育的理念、实施及启示

外国中小学教育 2017年第10期 20-25页

作者：吴维屏上海师范大学教育学院

我国是世界上自然灾害最严重的少数国家之一,每年各种自然灾害造成的损失巨大,但我国自然灾害预防和应对突发性灾害的体制不完善,尤其是灾害教育严重滞后。本文主要从学校灾害教育的角度,对世界范围内灾害教育的文化理念以及一些国家的... 详细信息

我国是世界上自然灾害最严重的少数国家之一,每年各种自然灾害造成的损失巨大,但我国自然灾害预防和应对突发性灾害的体制不完善,尤其是灾害教育严重滞后。本文主要从学校灾害教育的角度,对世界范围内灾害教育的文化理念以及一些国家的实施从目标、内容和方法层面作了一定的分析梳理,并提出了"融合"为可借鉴的主要思想,以期对当前的中国学校灾害教育的落实起到一定的促进作用。

关键词：国外中小学灾害教育

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汉语教学中的语用点:由点到面的教学实践

世界汉语教学 2006年第1期20卷 91-96页

作者：吴伟平香港中文大学方树泉楼新雅中国语文研习所

本文以香港中文大学对外汉语教学中的口语教学探索为例，重点讨论三个问题：（1）语用点的结构与难度指数；（2）语用点与语言水平之间的关系；（3）如何以语用点为纲定出教学大纲及教学指标。作者认为，语言教学的总体设计以语用为纲... 详细信息

本文以香港中文大学对外汉语教学中的口语教学探索为例，重点讨论三个问题：（1）语用点的结构与难度指数；（2）语用点与语言水平之间的关系；（3）如何以语用点为纲定出教学大纲及教学指标。作者认为，语言教学的总体设计以语用为纲，不论在理论上或实践上都是一种可行的方法。在这个大框架下，本文探讨一种逆向设计的教学理念与实践：先根据主流学生的要求设计考试。再按测试的内容和形式决定教材编写和教学活动，由考试之点及教学之面。既然大部分学外语的学生都希望能在实际生活中运用语言，最后测试考的就应该是这种运用语言的能力。语用点是对语言运用能力的综合测量，也是贯穿测试、教学和教材编写各个重要环节的基本单位。

关键词：语用点语用学水平测试汉语教学教学大纲

德育课程厘定——以国外德育课程理论与实践为视角

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外国中小学教育 2018年第10期 76-80,54页

作者：吴维屏上海师范大学教育学院

本文以国外有关德育课程的理论和实践为视角,从德育课程设置的直接法和间接法之争引入,对德育课程的内涵,德育课程的呈现形态结合相关理论和实践作了一定的梳理,得出:没有必要也不可能对德育课程和非德育课程作截然的划分,德育课程所具... 详细信息

本文以国外有关德育课程的理论和实践为视角,从德育课程设置的直接法和间接法之争引入,对德育课程的内涵,德育课程的呈现形态结合相关理论和实践作了一定的梳理,得出:没有必要也不可能对德育课程和非德育课程作截然的划分,德育课程所具的各种形态正逐渐走向融合。

关键词：德育课程内涵形态融合

Post-collisional extensional and thrust-nappe structures in northern part of Dabie Mountains

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Chinese Science Bulletin 2003年第21期48卷 2378-2385页

作者： JIANG Laili, wu weiping, CHU Dongru, LIU Yican & ZHANG Yong Geological Survey of Anhui Province , Hefei 230001, China Correspondence should be addressed to Jiang Laili (e-mail: lailij@mail. ***) Geological Survey of Anhui Province Hefei China

Thrust-nappe structures and extensional struc-tures simultaneously occur in the northern part of the Dabie Mountains. The systematic structural study reveals that extensional structures along the Mozitan-Xiaotian fault and thrust-nappe structures that take the Jinzhai-Shucheng fault as their frontal thrust share the same shear sense, and display a transitional relationship from the ductile exten- sional structure of deep level in the south to the ductile-brit- tle and brittle thrust-nappe structure of shallow level in the north. The extensional and thrust-nappe structures in the region are explained to result from post-collisional processes by the continuous subduction of the Yangtze continental block and the extension induced by the uplifting of the core part of the Dabie Mountains, which are components of the extensional structures produced in the exhumation process of the ultrahigh pressure metamorphic rocks in the Dabie Mountains. Because of the frontal blocking in the process of the north-westward spreading, the extension and detachment of the low-grade metamorphic rocks along the Mozi-tan-Xiaotian fault was transformed into the northwestward thrusting, resulting in the thrust-nappe structures. They de-veloped in the period of 200 170 Ma, maybe last till the late Jurassic.

关键词：大别山中国变质岩张性构造

Effect of Batroxobin on Neuronal Apoptosis During Focal Cerebral Ischemia and Reperfusion in Rats

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Journal of Traditional Chinese Medicine 2001年第2期21卷 136-140页

作者：吴卫平匡培根李振洲 Neurotransmitter Research Laboratory Department of NeurologyChinese PLA General HospitalPostgraduate Military Medical SchoolBeijing100853

We have found that Batroxobin plays a protective role in ischemic brain injury, which attracted us to investigate the effect of Batroxobin on apoptosis of neurons during cerebral ischemia and reperfusion. The apoptotic cells in ischemic rat brains at different reperfusion intervals were tested with method of TdT-mediated dUTP-DIG nick end labeling (TUNEL) and the effect of Batroxobin on the apoptosis of neurons was studied in left middle cerebral artery (LMCA) occlusion and reperfusion in rat models (n = 18). The results showed that few scattered apoptosis cells were observed in right cerebral hemispheres after LMCA occlusion and reperfusion, and that a lot of apoptosis cells were found in left ischemic cortex and caudoputamen at 12 h reperfusion, and they reached peak at 24 h-48 h reperfusion. However, in the rats pretreated with Batroxobin, the number of apoptosis cells in left cerebral cortex and caudoputamen reduced significantly and the neuronal damage was much milder at 24 h reperfusion than that of saline-treated rats. The results indicate that administration of Batroxobin may reduce the apoptosis of neurons induced by cerebral ischemia and reperfusion and afford significant cerebroprotection in the model of focal cerebral ischemia and reperfusion.

关键词： Animals Apoptosis Batroxobin Brain Ischemia Male Neurons Neuroprotective Agents Random Allocation Rats Rats, Sprague-Dawley Reperfusion Injury

Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells

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Cellular & Molecular Immunology 2008年第5期5卷 373-378页

作者： Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun Mengchao wu weiping Zhou The 3rd Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Chemokines are involved in human hepatocellular carcinoma （HCC） carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 （CXCR4） and chemokine ligand 12 （CXCL12） in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ±1.13, 2.34 ±1.16 and 1.63 ±1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96± 0.32 and 1.86 ±0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes （CI） of 3.9 ±1.1 and 4.1± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells.

关键词： CXCR4 CXCL12 hepatocellular carcinoma migration metastasis

Inefficient or even Deleterious effect of Interferon beta-1a on Neuromyelitis optica

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Inefficient or even Deleterious effect of Interferon beta-1a...

Syntheses and structures of two copper（Ⅱ） metal-organic frameworks with 1D channels based on 5,5’-（pyridine-3,5-diyl）diisophthalic acid

中华医学会第十七次全国神经病学学术会议

作者： Qian wu JiaWei Wang weiping wu Yining Huang Feng Gao 北京同仁医院中国人民解放军总医院北京大学第一附属医院

Objective To evaluate effects of Interferon beta-1a(IFNB-1a)and Natalizumab on Neuromyelitis optica(NMO).Methods We retrospectively analyzed four NMO patients treated with Interferon beta-1a(IFNβ-1a).One of them followed by *** number of relapse was compared before and after IFNB-1a *** patients had cerebral and spinal MRI on

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Syntheses and structures of two copper（Ⅱ） metal-organic f...

老年发病的运动神经元病临床特点及诊治:15例病例系列分析

中国化学会第九届全国无机化学学术会议

作者： Yunlong wu weiping wu Guo-Ping Yang Yao-Yu Wang College of Chemistry ＆ Materials Science Northwest University

The engineering of MOFs tends to be the most rapidly investigated area not only due to their intriguing architectures but also because that a great number of MOFs have been proven to be potential functional materials in diverse areas[1].The main efforts are centered on the design of suitable organic ligands for constructing coordination *** tetracarboxyl compounds containing di-isophthalate moieties have been widely used to assemble diverse porous architectures because of the rotation of phenyl and carboxylate groups and the versatile coordination modes of carboxylate groups,which prefer to form SBUs such as paddle-wheel-like Cu2（COO）4;More importantly,the incorporation of isophthalates subunits with diverse aromatic backbones can lead to twisted conformations when it reacts with metal salts,which have high potential to lead to great structural diversity[2].Herein,a new metal-organic frameworks with 1D open channels based on 5,5’-（pyridine-3,5-diyl）diisophthalic acid（H4pdda）,[H2N（Me）2]2[Cu3（pdda）2（H2O）]·x G（1）（G=guest molecules）,has been synthesized under solvothermal conditions and characterized by single crystal X-ray *** 1exhibits 3D 3-nodal（4,5,6）-connected anionic network with{44.62}{46.64}2{48.66.8}topology,in which mononuclear copper units act as 4-connected nodes,paddle-wheel Cu2（CO2）4 serve as 6-connected nodes and the ligands can be simplified as 5-connected *** are two type 1D open channels with different sizes in *** channels are occupied by（H2N（Me）2）+cations formed in situ from DMF under solvothermal conditions and guest solvent *** solvent accessible void space of the framework is 54.7%after removal of the coordinated aqua.

关键词： 5 5’-(Pyridine-3 5-diyl)diisophthalic Acid Metal-Organic Frameworks 1D open channels

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解放军医学院学报 2024年第7期45卷 758-761页

作者：刘艳张法军刘丹柏秀娟平荣宇张善春邢建丽蔡晓平吴卫平解放军总医院第二医学中心神经内科国家老年疾病临床研究中心北京100853 解放军总医院第二医学中心保健七科北京100853 解放军总医院第七医学中心老年医学科北京100700

背景运动神经元病(motor neuron disease,MND)是一种神经系统变性疾病,预后不佳,多为中年起病,目前国内缺乏对老年起病的MND的研究。目的探讨60岁以上发病的MND的临床特点及预后。方法收集2008年9—2023年9月在解放军总医院第七医学中... 详细信息

背景运动神经元病(motor neuron disease,MND)是一种神经系统变性疾病,预后不佳,多为中年起病,目前国内缺乏对老年起病的MND的研究。目的探讨60岁以上发病的MND的临床特点及预后。方法收集2008年9—2023年9月在解放军总医院第七医学中心住院的老年起病的MND患者的临床资料,分析其临床特征、诊治及结局。结果共收集15例老年起病的MND患者,男性10例,女5例,平均年龄(66.2±5.71)岁,发病年龄为60~79岁。延髓起病4例,单侧上肢起病6例,单侧下肢起病3例,双下肢起病1例,四肢起病1例。7例患者在起病18个月内出现了延髓症状,呼吸肌受累3例。临床分型方面,肌萎缩侧索硬化9例,进行性脊肌萎缩症4例,进行性延髓麻痹2例。6例在发病初期被误诊,误诊率达40%。5例放弃治疗,其余治疗效果也不佳。结论老年起病的MND男性多于女性,多为单侧起病,延髓起病的比例高,以肢体起病的患者更易、也更早出现延髓症状,呼吸肌受累比例较高。提示老年起病的MND可能生存期更短,共患病多,误诊率高,弃疗率高。

关键词：运动神经元病老年临床特征肌萎缩侧索硬化进行性延髓麻痹