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头孢菌素类抗生素的活性及其临床应用

国外医药(抗生素分册) 1982年第1期 34-43页

作者： Allan j.weinstein 刘孟雄

自从六十年代初头孢菌素类抗生素首次运用于临床以来,这类抗生素已在现代治疗细菌感染方面起着重要的作用。大量具有各种不同微生物学性质、药理学性质和毒性的头孢菌素已经问世。本文旨在综述一下头孢菌素类抗生素的重要特性和临床应... 详细信息

自从六十年代初头孢菌素类抗生素首次运用于临床以来,这类抗生素已在现代治疗细菌感染方面起着重要的作用。大量具有各种不同微生物学性质、药理学性质和毒性的头孢菌素已经问世。本文旨在综述一下头孢菌素类抗生素的重要特性和临床应用。头孢菌素类抗生素最初是从顶头孢霉菌(Cephalosporium acremonuim)中衍生出来的。从这种真菌中分离出三种化合物,即头孢菌素C、头孢菌素N和头孢菌素P。头孢菌素P具有中等强度的抗链球菌、棒状杆菌和梭状芽胞杆菌的活性,但是细菌对这一化合

关键词：头抱菌素环己烯四氢化苯环烯烃变形杆菌链球菌嗜血杆菌属流感嗜血杆菌流感杆菌临床应用

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最新的捕获细胞图片的方式横空出世

张江科技评论 2019年第5期 78-79页

作者： weinstein j a REGEV A ZHANG F

利用标记的核酸堆叠DNA碱基,采用计算机算法解析碱基堆叠信号,直接观测基因组信息创新点从光学显微镜、电子显微镜、荧光显微镜、光片显微镜到近年来发展火热的用于观察蛋白质三维立体结构的冷冻电镜,显微镜的使用性能逐级在提升,标志... 详细信息

利用标记的核酸堆叠DNA碱基,采用计算机算法解析碱基堆叠信号,直接观测基因组信息创新点从光学显微镜、电子显微镜、荧光显微镜、光片显微镜到近年来发展火热的用于观察蛋白质三维立体结构的冷冻电镜,显微镜的使用性能逐级在提升,标志着显微技术

关键词：光学显微镜基因组信息

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第二代及第三代头孢菌素:作用与临床应用

国外医药(抗生素分册) 1981年第1期 102-105+101页

作者： weinstein.A.j. 段民江

作者系统的综述了头孢菌素的来源、作用机制及不良反应,对17种头孢菌素的抗菌活性、药理、临床应用以及付作用等作了概述。其中目前国外临床广泛应用的或正在试用的新品种列表如下,本文摘介第二代及第三代头孢菌素。

关键词：头抱菌素环己烯大肠杆菌第一代本品四氢化苯环烯烃大肠埃希氏菌埃希氏杆菌属变形菌属肠杆菌科变形杆菌属流感杆菌嗜血杆菌属流感嗜血杆菌抗菌活性肠杆菌属临床应用第二代

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消声室中的拖曳试验(英文)

消声室中的拖曳试验(英文)

第十届全国噪声与振动控制工程学术会议

作者： j.weinstein V.Clemente Industrial Acoustics Company Bronx.NY Industrial Acoustics Company Bronx.NY

在汽车工业和其它工业中应用消声室,目的是适当地模拟无反射的室外环境。也就是说,在消声室中,点声源的声压级随传声器至声源距离加倍而减少6dB。所谓拖曳试验,即用同步电动机拖动传声器匀速地增加至声源距离,同时对声压级进行记录的试...

在汽车工业和其它工业中应用消声室,目的是适当地模拟无反射的室外环境。也就是说,在消声室中,点声源的声压级随传声器至声源距离加倍而减少6dB。所谓拖曳试验,即用同步电动机拖动传声器匀速地增加至声源距离,同时对声压级进行记录的试验。本文采用纯音及宽带噪声源在全消声室和半消声室中得出拖曳试验结果,并与理论分析预报作了比较。

关键词：

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小单孢菌产生的抗生素

国外医药(抗生素分册) 1982年第1期 5-9页

作者： G.H.Wagman M.j.weinstein 姜成林

引言小单孢菌属最初是1923年Φrskov描述的,1932年由jensen扩大成四个种。1941年Erikson研究了20株小单孢菌,它们在儿丁质上都生长良好。1942年Welsch报道了小单孢菌产生的第一个抗生素。在Waksman等人的研究中,发现这类微生物在葡萄糖... 详细信息

引言小单孢菌属最初是1923年Φrskov描述的,1932年由jensen扩大成四个种。1941年Erikson研究了20株小单孢菌,它们在儿丁质上都生长良好。1942年Welsch报道了小单孢菌产生的第一个抗生素。在Waksman等人的研究中,发现这类微生物在葡萄糖-淀粉琼脂上生长良好。Fisher等人(1951年)在合成培养基内发酵小单孢菌生产放线菌素。Taira等(1952年)曾用淀粉胨发酵小单孢菌生产小菌素A和B。1957年由青铜色小单孢菌进行甾体转化的专利转让给CharlesPfizer公司。

关键词：抗生素微生物利福霉素抗结核抗菌素革兰氏阳性细菌

Short range correlations in nuclei

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Chinese Physics C 2010年第9期34卷 1224-1228页

作者： L.B.weinstein Physics Department Old Dominion University

Studying nucleon-nucleon （NN） correlated pairs will teach us a great deal about the high momentum part of the nuclear wave function,the short range part of the NN interaction,and the nature of cold dense nuclear *** correlations are similar in all nuclei,differing only in *** momentum nucleons,p 〉p fermi,all have a correlated partner with approximately equal and opposite *** pair relative momenta of 300 〈prel 〈500 MeV/c,these correlated pairs are dominated by tensor *** is shown by the dominance of pn over pp pairs at pair total momentum and by the parity of pn to pp pairs at large pair total momentum.

关键词： correlations nucleon momentum distributions tensor correlations

A new direction for Alzheimer's research

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Neural Regeneration Research 2018年第2期13卷 190-193页

作者： james D.weinstein Marshall University School of Medicine Medical Center

Despite decades of research, at present there is no curative therapy for Alzheimer＇s disease. Changes in the way new drugs are tested appear to be necessary. Three changes are presented here and will be discussed. The first change is that Alzheimer＇s disease must be considered a disease of four major pathological processes, not one. The four processes are： 1） vascular hy- poperfusion of the brain with associated mitochondrial dysfunction, 2） destructive protein inclusions, 3） uncontrolled oxidative stress, and 4） proinflammatory immune processes second- ary to microglial and astrocytic dysfunction in the brain. The second change recommended is to alter the standard cognitive measurement tools used to quantify mental decline in test patients. Specifically the Dementia Severity Rating Scale （DSRS） should supersede Mini-Mental State Examination （MMSE） and other popular tests, and a measurement scale developed in research should be used to produce a linear and non-irregular baseline. Finally, accepting the concept that four etiologies cause Alzheimer＇s disease leads to the last necessary change, that new thera- pies must be employed directed against all four causes, likely as a combination. There are drugs ready to be employed in such a combinations which are available and used clinically for other purposes so can be used ＂offlabel＂ and one such combination is suggested.

关键词： Alzheimer's disease etiologies combination therapy cognitive testing failed research off-label use Dementia Severity Rating Scale

皮质盲:可逆性后大脑白质病综合征的临床及放射学特征——病例报道及文献回顾

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 47-47页

作者： Kahana A. Rowley H.A. weinstein j.M. 陈立军 Dept. of Ophthalmol. and Vis. Sci. University of Wisconsin School of Medicine 600 Highland Avenue MadisonWI53705United States

Purpose: To alert ophthalmologists to the recognition of cortical visual loss as the presenting feature in patients with reversible posterior leukoencephalopathy syndrome (RPLES). Unique radiologic findings are paramount to the diagnosis. Design: Interventional case report. Methods: A patient was seen with perioperative bilateral cerebral visual loss that was misinterpreted initially as an irreversible ischemic event. Further detailed analysis of the radiologic findings and clinical history led to the correct diagnosis. Main Outcome Measures: Visual acuity and magnetic resonance imaging (MRI) of the brain. Results: Recognition of the correct diagnosis of RPLES led to the institution of antihypertensive therapy and recovery of normal vision. Conclusions: The diagnosis of RPLES should be considered in all patients with acute cerebral visual loss, especially in the setting of recent surgery, blood transfusion, chemotherapy, immunosuppressant use, hypertension, eclampsia, or seizures. Prompt diagnosis requires close collaboration with a radiologist and an emergent MRI study, which ideally should include diffusion- weighted imaging with calculation of an apparent diffusion coefficient map. Differentiation from acute cerebral ischemia is important in order to avoid permanent visual loss by prompt and vigorous treatment of exacerbating factors such as intermittent hypertension. Prompt diagnosis will also help to avoid potentially dangerous invasive procedures such as thrombolytic therapy.

关键词：脑白质病皮质盲文献回顾缺血性病变急性脑缺血临床病史弥散加权成像围手术期患者干预性表观弥散系数

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer cell line

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 482-489页

作者： jacqueline CONCHA Caroline weinstein Maria Elvira ZUNIGA Department of Biochemistry Pharmacy School Universidad de Valparaiso Gran Bretafia 1093 Playa Ancha Valparaiso Chile School of Biochemistry Engineering Pontificia Universidad Catolica de Valparaiso General Cruz 34 Valparaiso Chile Creas Conicyt-Regional Gore Region de Valparaiso R12C1001 Blanco 1623 of 1402 Valparaiso Chile

In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps： lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions： 50℃, pH 4.0, 2% enzyme/substrate （E/S） ratio, 15 h, and a solid to liquid ratio of 1 ： 10. The pectic extract showed a degree of polymerization （DP） profile of 55.8% with DP≥7; 4.9% with DP6; 5.8% between DP2 and DP6 ; 4.7% with DP2; and 28.8% with DP1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5-25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen （4- OHT）, a classical anticancer drug, which killed 56.5% of the cells.

关键词： pectic extracts antiproliferative activity,breast cancer enzymatic treatment