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BiVO_(4)/GO纳米复合材料制备及其光催化性能研究

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钢铁钒钛 2024年第2期45卷 51-57页

作者：王丽师兆忠崔伟娜周华占桂荣刘进开封大学材料与化学工程学院河南开封475004 河南省先进材料与绿色过程工程技术研究中心河南开封475004 河南省先进碳化硅材料重点实验室河南开封475004 开封大学功能材料研究中心河南开封475004

钒酸铋(BiVO_(4))因其便宜易得、制备条件温和简单、窄带隙(~2.4 eV)、突出的光响应能力和优异的稳定性而在光催化领域受到广泛关注。以硝酸铋和偏钒酸铵为原料,采用水热法成功制备了鱼骨状钒酸铋/石墨烯(BiVO_(4)/GO)复合光催化材料,通... 详细信息

钒酸铋(BiVO_(4))因其便宜易得、制备条件温和简单、窄带隙(~2.4 eV)、突出的光响应能力和优异的稳定性而在光催化领域受到广泛关注。以硝酸铋和偏钒酸铵为原料,采用水热法成功制备了鱼骨状钒酸铋/石墨烯(BiVO_(4)/GO)复合光催化材料,通过X射线粉末衍射、扫描电镜、透射电镜对复合光催化材料结构和形貌进行表征,并考察其模拟太阳光下对阿昔洛韦(AC)的降解活性。扫描电镜和透射电镜照片显示,钒酸铋(BiVO_(4))为独特的鱼骨状结构,GO片层穿插其间,将BiVO_(4)纳米结构很好地连接起来。GO的加入改变了BiVO_(4)原有的纯单斜白钨矿结构。BiVO_(4)/GO(BG-3)对AC的降解效率高达97.23%,循环使用5次后降解效率还可以达到87.15%,说明该催化剂具有良好的循环使用活性。采用Langmuir-Hinshelwood(L-H)一级动力学模型方程拟合催化降解过程,相关系数R2均大于0.99,说明L-H一级动力学模型方程非常适合于拟合该催化动力学过程。

关键词： BiVO_(4) GO 纳米复合材料光催化阿昔洛韦

Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages

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Food Science and Human Wellness 2023年第6期12卷 2252-2262页

作者： Shanshan Tie Lijuan Zhang Bin Li Shanghua Xing Haitao Wang Yannan Chen weina cui Shaobin Gu Mingqian Tan Academy of Food Interdisciplinary Science School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China College of Food and Bioengineering Henan University of Science and TechnologyLuoyang 471023China College of Food Science Shenyang Agricultural UniversityNational R&D Professional Center for Berry ProcessingShenyang 110866China

Inflammation plays an important role in the occurrence and development of many inflammatory *** purpose of this study was to evaluate the anti-inflammatory effect and metabolic behavior of the dual targeting procyanidins(PC)nanoparticles on lipopolysaccharide(LPS)-stimulated inflammatory macrophages by metabolomics *** double-targeting PC nanoparticles could specifi cally target both the CD44 receptor and mitochondria,while the single targeting PC-loaded nanoparticles that could target the CD44 receptor on the surface of *** double-targeting PC nanoparticles had better inhibitory effect than single-targeting PC nanoparticles on the leakage of lactate dehydrogenase and reactive oxygen species overexpression induced by *** acid metabolism,energy metabolism and purine metabolism were disordered in LPS-treated group,and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS *** changes of these potential biomarkers and their corresponding pathways are helpful to further understand the mechanism of PC nanoparticles in alleviating inflammation,and promote their application in nutrition intervention.

关键词： Procyanidins nanoparticles Metabolomics Inflammation Macrophages Lipopolysaccharide

推广应用建筑保温与结构一体化材料助力建筑业高质量低碳发展探析

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建设科技 2024年第17期 80-83页

作者：张敬琦呼斯乐徐国伟王婷崔炜娜曹萨出茹拉内蒙古自治区住房和城乡建设绿色研究发展中心呼和浩特010000

本文研究探讨了一种建筑保温与结构一体化技术体系。与传统的外墙外保温技术相比,该技术不仅能有效解决保温体系与建筑主体同寿命问题,而且在确保建筑节能工程质量与消防安全等方面也得到了加强,并能从根本上减少外保温工程后期维护成... 详细信息

本文研究探讨了一种建筑保温与结构一体化技术体系。与传统的外墙外保温技术相比,该技术不仅能有效解决保温体系与建筑主体同寿命问题,而且在确保建筑节能工程质量与消防安全等方面也得到了加强,并能从根本上减少外保温工程后期维护成本和大量建筑垃圾的产生,同时也提高了建筑装配率,是建筑工业化转型升级、提升建筑经济效益的必然选择。

关键词：外墙外保温一体化推广应用

A Method to Improve the Up-Conversion Fluorescence of Polymer Modified NaYF<sub>4</sub>:Yb,Er(Tm) Nanocomposites

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World Journal of Nano Science and Engineering 2012年第2期2卷 41-46页

作者： weina cui Siyu Ni Shunan Shan Xingping Zhou College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai China College of Life and Environment Shanghai Normal University Shanghai China

The modification of NaYF4:Yb,Er(Tm) nanoparticles synthesized in the presence of an ionic surfactant is critical to their application in biological fields for better solubility and biocompatibility. In this work, NaYF4:Yb,Er(Tm) was transformed from insoluble, inactive to hydrophilic, biocompatible via ligand exchange modification with polyacrylic acid (PAA). Ligand exchange was carried out at room temperature when a colloidal solution of NaYF4:Yb,Er(Tm) in tetrahydrofuran (THF) was treated with excess PAA. The PAA modified NaYF4:Yb,Er(Tm) nanoparticles got better surface properties but with declined inner up-conversion fluorescence. Generally, coating an analogous layer of material outside the core nanoparticles can improve the optical properties of the core. Accordingly, NaYF4:Yb,Er(Tm)/NaYF4 nanoparticles were synthesized before PAA modification to avoid the optical intensity decaying. The result of fluorescence test proved that the water soluble NaYF4:Yb,Er(Tm)/NaYF4/PAA nanocomposites had a sound up-conversion property compared with that of NaYF4:Yb,Er(Tm)/PAA. Furthermore, the up-conversion fluorescence property of the nanocomposite varied with the doping ratio of Er(Tm) to Yb and the possible mechanism for this change was also discussed.

关键词： Doping Ratio Fluorescence Ligand Exchange Polyacrylic Acid Sodium Yttrium Fluoride Surface Modification

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特发性颅内高压的临床表现与诊治策略

中华耳鼻咽喉头颈外科杂志 2023年第4期58卷 384-388页

作者：李熙星崔卫娜河北医科大学第二医院耳鼻咽喉头颈外科石家庄050000

特发性颅内高压(idiopathic intracranial hypertension,IIH)是一种以病因不明的颅内压升高为特征的综合征,缺乏颅内病理的临床和放射学证据。IIH被认为与肥胖有关,随着肥胖症的流行,IIH的发病率也在增加。IIH通常在神经科和眼科实践中... 详细信息

特发性颅内高压(idiopathic intracranial hypertension,IIH)是一种以病因不明的颅内压升高为特征的综合征,缺乏颅内病理的临床和放射学证据。IIH被认为与肥胖有关,随着肥胖症的流行,IIH的发病率也在增加。IIH通常在神经科和眼科实践中遇到,头痛、视力障碍和视乳头水肿是该病的特征,但一些患者可能会出现搏动性耳鸣、头晕、睡眠呼吸暂停和自发性脑脊液漏等而就诊于耳鼻咽喉头颈外科。本文综述IIH常见的临床表现、当前诊断标准及治疗策略,促进对早期疾病的识别和管理,并讨论了耳鼻咽喉头颈外科医生在管理IIH及相关疾病中发挥的潜在作用。

关键词：耳鼻咽喉头颈外科颅内高压睡眠呼吸暂停搏动性耳鸣脑脊液漏诊治策略诊断标准潜在作用

Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects

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Science China Life Sciences 2024年第10期67卷 2132-2148页

作者： Mengting Wang Liping Wang Yanxin Huang Zhibin Qiao Shanru Yi weina Zhang Jing Wang Guang Yang Xinyu cui Xiaochen Kou Yanhong Zhao Hong Wang Cizhong Jiang Shaorong Gao Jiayu Chen Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital Shanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cell Research Tongji University Shanghai Tenth People's Hospital School of MedicineTongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of the Ministry of Education Orthopaedic Department of Tongji HospitalTongji University Shanghai Institute of Stem Cell Research and Clinical Translation

The TET family is well known for active DNA demethylation and plays important roles in regulating transcription, the epigenome and development. Nevertheless, previous studies using knockdown（KD） or knockout（KO） models to investigate the function of TET have faced challenges in distinguishing its enzymatic and nonenzymatic roles, as well as compensatory effects among TET family members, which has made the understanding of the enzymatic role of TET not accurate enough. To solve this problem, we successfully generated mice catalytically inactive for specific Tet members(Tetm/m). We observed that, compared with the reported KO mice, mutant mice exhibited distinct developmental defects, including growth retardation, sex imbalance, infertility, and perinatal lethality. Notably, Tetm/mmouse embryonic stem cells（mESCs） were successfully established but entered an impaired developmental program, demonstrating extended pluripotency and defects in ectodermal differentiation caused by abnormal DNA methylation. Intriguingly, Tet3, traditionally considered less critical for m ESCs due to its lower expression level, had a significant impact on the global hydroxymethylation, gene expression, and differentiation potential of mESCs. Notably, there were common regulatory regions between Tet1 and Tet3 in pluripotency regulation. In summary, our study provides a more accurate reference for the functional mechanism of Tet hydroxymethylase activity in mouse development and ESC pluripotency regulation.

关键词： Tet hydroxymethylase activity mESCs DNA demethylation 5hmC

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性激素对前庭疾病的影响最新研究进展

中华耳科学杂志 2023年第5期21卷 691-695页

作者：李熙星崔卫娜河北医科大学第二医院耳鼻咽喉头颈外科石家庄050000

许多前庭疾病在女性中的发病率明显高于男性。最近的流行病学研究进一步支持了这一观点。尽管在这一领域的研究有所增加,但这种不平衡背后的机制尚不清楚。性激素波动(如青春期、月经周期、怀孕和绝经期)已被发现在众多前庭疾病中发挥... 详细信息

许多前庭疾病在女性中的发病率明显高于男性。最近的流行病学研究进一步支持了这一观点。尽管在这一领域的研究有所增加,但这种不平衡背后的机制尚不清楚。性激素波动(如青春期、月经周期、怀孕和绝经期)已被发现在众多前庭疾病中发挥重要作用。本文综述了近年来该领域的研究进展,简要讨论了性激素对几种常见的前庭疾病的影响,并阐述了其中的潜在机制。

关键词：雌激素孕激素前庭障碍特异性突触

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基于纳米载体的内耳药物递送最新研究进展

中华耳鼻咽喉头颈外科杂志 2021年第11期56卷 1215-1219页

作者：李熙星张光远崔卫娜河北医科大学第二医院耳鼻咽喉头颈外科石家庄050000

内耳疾病导致的听力及平衡障碍十分普遍。传统的给药方式,由于各种限制很难在内耳达到有效的药物浓度及治疗效果。纳米技术作为21世纪的关键技术之一,对医学、生物工程和药学的渗透与影响是显而易见的。近年来基于纳米载体的内耳药物递... 详细信息

内耳疾病导致的听力及平衡障碍十分普遍。传统的给药方式,由于各种限制很难在内耳达到有效的药物浓度及治疗效果。纳米技术作为21世纪的关键技术之一,对医学、生物工程和药学的渗透与影响是显而易见的。近年来基于纳米载体的内耳药物递送研究相继展开并取得了一定成果,本文就当前内耳药物传输所面临的困难和纳米载体在内耳药物递送方面(包括给药途径、药物渗透、药物靶向、药物控释等)的最新进展做一综述。

关键词：药物递送内耳疾病药物靶向纳米载体药物传输给药途径纳米技术药物渗透

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耳硬化症的病因及发病机制研究进展

中华耳鼻咽喉头颈外科杂志 2020年第4期55卷 413-417页

作者：李熙星陈雨濛崔卫娜邵永良河北医科大学第二医院耳鼻咽喉头颈外科石家庄050000

耳硬化症是影响听软骨囊内稳态的主要疾病,是导致获得性听力损失的最常见原因之一。其病因复杂,目前多认为由遗传和环境因素共同引起。研究表明遗传因素在耳硬化症的发生及发展过程中起着重要的作用,涉及多种分子途径,包括骨重塑、免疫... 详细信息

耳硬化症是影响听软骨囊内稳态的主要疾病,是导致获得性听力损失的最常见原因之一。其病因复杂,目前多认为由遗传和环境因素共同引起。研究表明遗传因素在耳硬化症的发生及发展过程中起着重要的作用,涉及多种分子途径,包括骨重塑、免疫途径、炎症及内分泌与代谢途径。本文回顾目前对耳硬化症病因及发病机制的认识,并总结一些已被证明有助于耳硬化症发展的环境和遗传因素。

关键词：耳硬化症遗传因素听力损失免疫途径内稳态代谢途径内分泌