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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Endowing rotation invariance for 3D finger shape and vein verification

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Frontiers of Computer Science 2022年第5期16卷 115-130页

作者： Hongbin XU weili yang Qiuxia WU Wenxiong KANG School of Software Engineering South China University of TechnologyGuangzhou 510006China School of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China

Finger vein biometrics have been extensively studied for the capability to detect aliveness,and the high security as intrinsic ***,vein pattern distortion caused by finger rotation degrades the performance of CNN in 2D finger vein recognition,especially in a contactless *** address the finger posture variation problem,we propose a 3D finger vein verification system extracting axial rotation invariant *** efficient 3D finger vein reconstruction optimization model is proposed and several accelerating strategies are adopted to achieve real-time 3D reconstruction on an embedded *** main contribution in this paper is that we are the first to propose a novel 3D point-cloud-based endto-end neural network to extract deep axial rotation invariant feature,namely *** the network,the rotation problem is transformed to a permutation problem with the help of specially designed rotation ***,to validate the performance of the proposed network more rigorously and enrich the database resources for the finger vein recognition community,we built the largest publicly available 3D finger vein dataset with different degrees of finger rotation,namely the Large-scale Finger Multi-Biometric Database-3D Pose Varied Finger Vein(SCUT LFMB-3DPVFV)*** results on 3D finger vein datasets show that our 3DFVSNet holds strong robustness against axial rotation compared to other approaches.

关键词： 3D finger-vein biometrics point-cloud CNN

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New pathogenic insights from large animal models of neurodegenerative diseases

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Protein & Cell 2022年第10期13卷 707-720页

作者： Peng Yin Shihua Li Xiao-Jiang Li weili yang Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hongkong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510632China

Animal models are essential for investigating the pathogenesis and developing the treatment of human *** of genetic mutations responsible for neurodegenerative diseases has enabled the creation of a large number of small animal models that mimic genetic defects found in the affected *** the current animal models,rodents with genetic modifications are the most commonly used animal models and provided important insights into ***,most of genetically modified rodent models lack overt neurodegeneration,imposing challenges and obstacles in utilizing them to rigorously test the therapeutic effects on *** studies that used CRISPR/Cas9-targeted large animal(pigs and monkeys)have uncovered important pathological events that resemble neurodegeneration in the patient’s brain but could not be produced in small animal *** we highlight the unique nature of large animals to model neurodegenerative diseases as well as the limitations and challenges in establishing large animal models of neurodegenerative diseases,with focus on Huntington disease,Amyotrophic lateral sclerosis,and Parkinson *** also discuss how to use the important pathogenic insights from large animal models to make rodent models more capable of recapitulating important pathological features of neurodegenerative diseases.

关键词： large animal models neurodegenerative diseases CRISPR/Cas9

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Research progress on the development mechanism and exploratory protection of the scaling off on earthen sites in NW China

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Science China(Technological Sciences) 2023年第8期66卷 2183-2196页

作者： DU YuMin DONG WenQiang CUI Kai CHEN WenWu yang weili Institute of Culture and Heritage Northwestern Polytechnical UniversityXi’an 710072China Western Center for Disaster Mitigation in Civil Engineering of Ministry of Education of China School of Civil EngineeringLanzhou University of TechnologyLanzhou 730050China Key Scientific Research Base of the State Administration of Cultural Heritage for the Conservation and Restoration of Murals and Material Science Research Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Mechanics on Disaster and Environment in Western China College of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an 710072China

The scaling off is among the most pervasive and severe deterioration *** scaling off developed on earthen sites in Northwest China has a special and complex binary structure composed of crusted and loose *** the synergistic functions of external environmental elements such as rainfall,temperature,and wind,and rammed earth properties,this deterioration has gradually created the crust on the site’s surface,and has then evolved into exfoliation and finally fallen off,leading to the reciprocating progressive destruction of earthen ***,determining the development mechanism of scaling off and implementing targeted protection measures for the scientific conservation of earthen sites has become *** this review study,the properties of the building material causing the binary structure and the coupling effects of water,temperature,salt,and wind on the development of scaling off were determined,and the quantitative evaluation system for this deterioration development was *** interpreting the reasons for the development of the scaling off,protective measures including chemical grouting,electro-osmosis grouting,and overlay applications were *** study also pointed out the research hotspots and shortage in the study process on the scaling *** hotspots generally focused on the development mechanism of binary structure,quantitative assessment of the degree of development,and related scientific consolidation *** shortcomings around the above directions include less attention to the development characteristics and mechanism of scaling off on earthen sites under special environment types,optimization and applicability of quantitative evaluation models,and the development and feasibility of reinforcement slurries and *** study can be beneficial in providing theoretical support for the scientific conservation and engineering practice of the scaling off on the earthen sites.

关键词： scaling off earthen sites binary structure development mechanism quantitative evaluation protection

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Extraction of Submerged Topographic Line in B-Scan Ultrasonic Image

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Wuhan University Journal of Natural Sciences 2015年第4期20卷 350-354页

作者： SONG Huan ZOU Xianjian yang weili Electronic Information School Wuhan University College of Science Guizhou Minzu University

The analysis of underwater topography ultrasonic image, which can be obtained by using B-scan ultrasound imaging technique, is the basis and important work in topography study. In this paper, we present a novel self-adapted method for the extraction of submerged topographic line. Since the distribution of gray values in the image has a mutation process, this feature is used to appropriately track the topographic line of imaging band, and wavelet denoising method is applied to denoise the obtained lines. The described method also takes the continuity of topography into consideration during tracking procedure. The results show that the extraction error is within 2-pixel width（approximate 1 mm）. This method is suitable for the extraction of current model topographic lines with the advantages of good self-adaption, high speed and high resolution.

关键词： ultrasonic image submerged topography wavelet denoising method self-adapted tracking

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Identification and Analysis of Human Sex-biased MicroRNAs

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 200-211页

作者： Chunmei Cui weili yang Jiangcheng Shi Yong Zhou Jichun yang Qinghua Cui Yuan Zhou Department of Biomedical Informatics Department of Physiology and Pathophysiology Center for Noncoding RNA Medicine MOE Key Laboratory of Cardiovascular Sciences School of Basic Medical Sciences Peking University Department of Physiology and Pathophysiology Center for Noncoding RNA Medicine School of Basic Medical SciencesPeking University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University

Sex differences are widely observed under various circumstances ranging from physiolog- ical processes to therapeutic responses, and a myriad of sex-biased genes have been identified. In recent years, transcriptomic datasets of microRNAs （miRNAs）, an important class of non-coding RNAs, become increasingly accessible. However, comprehensive analysis of sex difference in miRNA expression has not been performed. Here, we identified the differentially-expressed miR- NAs between males and females by examining the transcriptomic datasets available in public data- bases and conducted a systemic analysis of their biological characteristics. Consequently, we identified 73 female-biased miRNAs （FmiRs） and 163 male-biased miRNAs （MmiRs） across four tissues including brain, colorectal mucosa, peripheral blood, and cord blood. Our results suggest that compared to FmiRs, MmiRs tend to be clustered in the human genome and exhibit higher evolutionary rate, higher expression tissue specificity, and lower disease spectrum width. In *** enrichment analysis of miRNAs show that FmiR genes are significantly associated with metabolism process and cell cycle process, whereas MmiR genes tend to be enriched for functions like histone modification and circadian rhythm. In all, the identification and analysis of sex-biased miRNAs together could provide new insights into the biological differences between females and males and facilitate the exploration of sex-biased disease susceptibility and therapy.

关键词： Sex bias MicroRNAs Conservation Disease association Personalized medicine

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Sedimentation Rate Rhythms:Evidence from Filling of the Tarim Basin,Northwest China

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Acta Geologica Sinica(English Edition) 2015年第4期89卷 1264-1275页

作者： CHEN Shuping JIN Zhijun WANG Yi ZHOU Ziyong LI Jingchang yang weili State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum Petroleum Exploration and Production Research Institute SINOPEC

Variations of sedimentation rate within a basin over geologic time are a time series that can be filtered into several cyclic wave curves. Based on back-stripping and the empirical mode decomposition method, the cores from 14 wells in the Tarim Basin were selected to do filtering analysis. Four cycles or quasi-cycles （33 Ma, 64.4 Ma, 103.6 Ma, and 224 Ma） were obtained. Among these, the 33 Ma period, which was related to the internal earth activity, an external force, or a combination of the two, was the most obvious. The 64.4 Ma period corresponded to the solar system crossing the galaxy plane or the periodic melting of inner-earth material. The 103.6 Ma period was related with plate collisional tectonism around the Tarim Plate. The 224 Ma period was related to one galaxy year and may also be related to the aesthenospherical convection cycle.

关键词： geological rhythm basin filling back-stripping wave analysis wave mechanism

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The DrugPattern tool for drug set enrichment analysis and its prediction for beneficial effects of oxLDL on type 2 diabetes

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Journal of Genetics and Genomics 2018年第7期45卷 389-397页

作者： Chuanbo Huang weili yang Junpei wang Yuan Zhou Bin Geng Georgios Kararigas Jichun yang Qinghua Cui Department of Biomedical Informatics Department of Physiology and Pathophysiology MOE Key Lab of Cardiovascular Sciences School of Basic Medical Sciences Center for Non-Coding RNA Medicine Peking UniversityBeijing 100191China School of Mathematics Sciences Huaqiao University Quanzhou 362021 China Hypertension Center Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Beijing 100037 China Charit-Universitatsmedizin Berlin. Corporate Member of Freie Universitat Berlin Humboldt-Universitat zu Berlin Berlin Institute of Health Institute of Gender in Medicine and Center for Cardiovascular Research. DZHK (German Centre for Cardiovascular Research) 10115 Berlin Germany Center of Bioinformatics Key Laboratory for Neuro-lnformation of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China

Enrichment analysis methods, e.g., gene set enrichment analysis, represent one class of important bio- informatical resources for mining patterns in biomedical datasets. However, tools for inferring patterns and rules of a list of drugs are limited. In this study, we developed a web-based tool, DrugPattern, for drug set enrichment analysis. We first collected and curated 7019 drug sets, including indications, adverse reactions, targets, pathways, etc. from public databases. For a list of interested drugs, DrugPat- tern then evaluates the significance of the enrichment of these drugs in each of the 7019 drug sets. To validate DrugPattern, we employed it for the prediction of the effects of oxidized low-density lipoprotein （oxLDL）, a factor expected to be deleterious. We predicted that oxLDL has beneficial effects on some diseases, most of which were supported by evidence in the literature. Because DrugPattern predicted the potential beneficial effects of oxLDL in type 2 diabetes （T2D）, animal experiments were then performed to further verify this prediction. As a result, the experimental evidences validated the DrugPattern prediction that oxLDL indeed has beneficial effects on T2D in the case of energy restriction. These data confirmed the prediction accuracy of our approach and revealed unexpected protective roles for oxLDL in various diseases. This study provides a tool to infer patterns and rules in biomedical datasets based on drug set enrichment analysis.

关键词： Enrichment analysis Drug Data mining oxLDL Type 2 diabetes

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A nonmulberry silk fibroin-based robust mandruka for rapid hemostasis treatment

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Frontiers of Materials Science 2023年第4期17卷 147-157页

作者： Hao Zhang Siyuan Luo weili yang Qisheng Luo Perumal Ramesh Kannan Yao Li Xiangdong Kong Institute of Smart Biomedical Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

Uncontrolled hemorrhage resulting from traumas causes severe health *** is an urgent need for expeditious hemostatic materials to treat bleeding ***,we developed a natural protein-based hemostatic sponge extracted from nonmulberry cocoons that exhibited rapid coagulation and effective *** first built a degumming and dissolution system suitable for the Dictyoploca japonica cocoons to obtain regenerated silk fibroin(DSF).The DSF was then combined with carboxymethyl chitosan(CMCS)by glutaraldehyde(GA)crosslinking to ensure the structural stability of *** resulting DSF–CMCS–GA exhibited remarkable hemostatic properties,displaying the highest absorption *** also demonstrated comparable efficacy to commercial hemostatic *** blood-clotting index and hemolysis test showed that the prepared sponge possessed hemostatic activity and good *** with mulberry silk fibroin hemostatic sponges(SF–CMCS–GA),DSF–CMCS–GA showed slightly better effects,making them a potential alternative to mulberry *** conclusion,our study introduces the use of Dictyoploca japonica silk fibroin for hemostasis,highlighting the exploitation of wild silkworm resources and providing an excellent silk fibroin-based hemostatic sealant for acute accident wounds and biomedical applications involving massive hemorrhage.

关键词： nonmulberry silk fibroin Dictyoploca japonica regenerated silk fibroin hemostatic sponge

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Reservoir Characteristics and Controlling Factors of Silurian Lower Kepingtage Formation in Tahe Area, Tarim Basin, NW China

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Journal of Earth Science 2017年第6期28卷 1135-1144页

作者： Ruohan Liu Zaixing Jiang Ming Wang weili yang Jingxiang Guo Minghao Wu Yi Gao Shanyazi Wei Zhihong Nie Hong He School of Energy Resources China University of Geosciences Beijing 100083 China Institute of Earth Sciences China University of Geosciences Beijing 100083 China Exploration and Production Research Institute SINOPEC Beijing 100083 China Geophysical-China Oilfield Services Limited Tianjin 300451 China PetroChina Coalbed Methane Company Limited Beijing 100028 China

With the breakthrough of exploration in Well TP16-1, the lower Kepingtage Formation becomes a key target for petroleum exploration of deep clastic reservoir in Tahe area. In this paper we focused on the research of the reservoir characteristics and its controlling factors in two sub-member formations（S1k11 and S1k13）. Based on X-ray diffraction, conventional physical properties data（porosity and permeability） and reservoir storage space data（casting thin section and scanning electron microscope）, we determined that the S1k1 Formation belongs to extra-low porosity and permeability reservoir, although the upper S1k13 Formation shows relative better physical characteristic than the lower S1k11 Formation. The development of storage space in the study area is controlled by sedimentary microfacies, diagenesis process. Reservoirs in S1k1 Formation are mainly located in channel（S1k11 sandstones） and sand flat（S1k13 sandstones）. The sand flat sediments with a more coarse grain size compared with the channel. In diagenesis, compaction is the major controlling factor for reducing the porosity, followed by cementation. Dissolution of diagenesis is the major controlling factor in enhancing the reservoir porosities. Compared with channel（S1k11） sandstones, sand flat sandstones（S1k13） have better reservoir quality for its weaker compaction, cementation and stronger dissolution. On the basis of sedimentary characteristics（grain size and subfacies）, physical property（porosity and permeability） and reservoir storage space, we divide the S1k1 reservoir into three categories（I, II and III）. Type I reservoir is high quality reservoir. It is mainly distributed in the south area of S1k11 and S1k13 reservoir. Type II is moderate reservoir. It is located in the middle of S1k11 reservoir and in the north of S1k13 reservoir. Type III is the poor reservoir. It is only located in the north of S1k11 reservoir.

关键词： reservoir characteristics controlling factors reservoir assessment lower Kepingtage Formation Tahe area Tarim Basin

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