检索结果-南通市图书馆

Stathmin siRNA对EC9706细胞紫杉醇化疗敏感性的影响

在线全文

学校读者我要写书评

暂无评论

郑州大学学报（医学版） 2013年第3期48卷 300-303页

作者：王峰轩小燕罗亚辉翟文龙马望秦艳茹张伟杰路太英宗红王留兴郑州大学第一附属医院肿瘤科郑州450052 郑州大学基础医学院微生物学与免疫学教研室郑州450001 郑州大学护理学院郑州450052

目的:探讨Stathmin表达下调的EC9076细胞对紫杉醇(PTX)化疗敏感性的变化。方法:将EC9706细胞分为PTX组、pSUPER+PTX组和pSUPER-S2+PTX组3组,MTT法检测pSUPER-S2+PTX对EC9706细胞存活率的影响;流式细胞术检测其对EC9076细胞周期的影响;采用AnnexinV-FITC/PI合染流式细胞仪、原位酶标记法和DNALadder检测其对EC9076细胞凋亡的影响。结果:MTT结果显示,pSUPER-S2+PTX组EC9706细胞存活率低于PTX组和pSUPER+PTX组(F组间=7.324,P=0.022;F时间=6.471,P=0.027)。与PTX组和pSUPER+PTX组相比,pSUPER-S2+PTX能明显增加G2/M期细胞、减少G0/G1期细胞(F=75.360,10.938,P<0.001);流式细胞仪和TUNEL法检测早期细胞凋亡率均显示pSUPER-S2+PTX可促进细胞凋亡(F=36.827和15.091,F<0.001)。DNALadder实验显示pSUPER-S2+PTX组凋亡条带明显增多。讨论:抑制Stathmin的表达能增加EC9706细胞对PTX的化疗敏感性。

关键词： Stathmin 紫杉醇 EC9076细胞食管鳞状细胞癌

在线全文

学校读者我要写书评

暂无评论

利用脉冲激光对木制品表面抛光技术的研究

机械工程师 2014年第7期 27-28页

作者：翟文贺王晓楠薛树成吴哲邓涛袁伟杰吴辉东北林业大学哈尔滨150040

介绍了木制品表面的毛刺现象以及去除木制品表面毛刺使木制品表面抛光的重要性。利用脉冲激光对木制品表面进行抛光的技术,最后对脉冲激光使木制品表面抛光技术的发展趋势进行展望。

关键词：脉冲激光木制品毛刺现象表面抛光

^(131)I治疗Graves甲亢伴粒细胞减少症的效果研究

在线全文

学校读者我要写书评

暂无评论

标记免疫分析与临床 2023年第8期30卷 1347-1350,1372页

作者：张伟杰巴竺飞于雅巍翟宁于鹏訾媛李琳梅华北理工大学附属医院核医学科河北唐山063000 华北理工大学附属医院放射科河北唐山063000

目的探究合并粒细胞减少症对^(131)I治疗Graves甲亢的影响以及粒细胞减少症的治疗效果与甲亢的关系。方法选取2016年7月至2021年7月于我科行^(131)I治疗的180例Graves甲亢患者为研究对象,根据有无粒细胞减少症分为两组,其中伴有粒细胞... 详细信息

目的探究合并粒细胞减少症对^(131)I治疗Graves甲亢的影响以及粒细胞减少症的治疗效果与甲亢的关系。方法选取2016年7月至2021年7月于我科行^(131)I治疗的180例Graves甲亢患者为研究对象,根据有无粒细胞减少症分为两组,其中伴有粒细胞减少组患者80例,无粒细胞减少组患者100例。比较两组患者^(131)I治疗甲亢的效果,分析粒细胞减少症的疗效与甲亢的关系。结果(1)^(131)I治疗前对两组患者的基线资料进行比较,粒细胞减少组的白细胞计数、中性粒细胞绝对值均低于粒细胞正常组,两者之间差异有统计学意义,但在性别、年龄、甲状腺质量、最高摄碘率、治疗剂量、甲状腺激素水平以及TRAb方面差异均无统计学意义,两组具有可比性。(2)^(131)I治疗后随访12月,复查甲功发现,两组患者FT_(3)、FT4均明显减低,TSH升高,甲状腺功能逐渐恢复至正常,粒细胞减少组与粒细胞正常组的甲亢治愈例数分别为66例、87例,差异无统计学意义(P>0.05),合并粒细胞减少症并不会影响^(131)I对Graves甲亢的治疗效果。(3)根据甲亢治愈情况,将Graves甲亢伴粒细胞减少症患者分为甲亢治愈组和未愈组,比较粒细胞减少症的治疗情况,甲亢治愈组的粒细胞减少症治愈率为91.3%,显著高于甲亢未愈组的58.8%,粒细胞减少症的疗效与甲亢有关。结论^(131)I对Graves甲亢伴粒细胞减少症患者同样具有很好的治疗效果,随着甲亢的治愈,粒细胞减少症的治愈率也会提高。

关键词： ^(131)I Graves甲亢粒细胞减少症甲亢并发症

Recent Progress on Two-Dimensional Materials

在线全文

学校读者我要写书评

暂无评论

物理化学学报 2022年

作者： Cheng Chang Wei Chen Ye Chen Yonghua Chen Yu Chen Feng Ding Chunhai Fan Hongjin Fan Zhanxi Fan Cheng Gong Yongji Gong Qiyuan He Xun Hong Sheng Hu Weida Hu Wei Huang Yuan Huang Wei Ji Dehui Li Lain-Jong Li Qiang Li Li Lin Chongyi Ling Minghua Liu Nan Liu Zhuang Liu Kian Ping Loh Jianmin Ma Feng Miao Hailin Peng Mingfei Shao Li Song Shao Su Shuo Sun Chaoliang Tan Zhiyong Tang Dingsheng Wang Huan Wang Jinlan Wang Xin Wang Xinran Wang Andrew T. S. Wee Zhongming Wei Yuen Wu Zhongshuai Wu Jie Xiong Qihua Xiong Weigao Xu Peng Yin Haibo Zeng Zhiyuan Zeng Tianyou zhai Han Zhang Hui Zhang Qichun Zhang Tierui Zhang Xiang Zhang Lidong Zhao Meiting Zhao weijie Zhao Yunxuan Zhao Kaige Zhou Xing Zhou Yu Zhou Hongwei Zhu Hua Zhang Zhongfan Liu Department of Electrical and Computer Engineering and Quantum Technology Center， University of Maryland， College Park School of Materials Science and Engineering， Beihang University Department of Materials Science and Engineering， City University of Hong Kong Center of Advanced Nanocatalysis (CAN)， Hefei National Laboratory for Physical Sciences at the Microscale， Department of Applied Chemistry， University of Science and Technology of China College of Chemistry and Chemical Engineering， State Key Laboratory of Physical Chemistry of Solid Surfaces， Collaborative Innovation Center of Chemistry for Energy Materials (iChEM)， Xiamen University State Key Laboratory of Infrared Physics， Shanghai Institute of Technical Physics， Chinese Academy of Sciences Advanced Research Institute of Multidisciplinary Science， Beijing Institute of Technology Beijing Key Laboratory of Optoelectronic Functional Materials & Micro-Nano Devices， Department of Physics， Renmin University of China School of Optical and Electronic Information， Wuhan National Laboratory for Optoelectronics， Huazhong University of Science and Technology Department of Mechanical Engineering， The University of Hong Kong Institute of Science and Technology Austria School of Physics， Southeast University Department of Materials Science and Engineering， National University of Singapore CAS Key Laboratory of Colloid， Interface and Chemical Thermodynamics， Institute of Chemistry， Chinese Academy of Sciences College of Chemistry， Beijing Normal University Institute of Functional Nano & Soft Materials (FUNSOM)， Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices， Soochow University School of Materials and Energy， University of Electronic Science and Technology of China School of Physics， Nanjing University Center for Nanochemistry (CNC)， Beijing National Laboratory for Molecular Sciences， College of Chemistry and Molecular Engineering， Beijing Graphene Institute (BGI)， Peking University State Key Laboratory of Chemical Resource Engineering， Beijing

Research on two-dimensional (2D) materials has been explosively increasing in last seventeen years in varying subjects including condensed matter physics， electronic engineering， materials science， and chemistry since the mechanical exfoliation of graphene in 2004. Starting from graphene， 2D materials now have become a big family with numerous members and diverse categories. The unique structural features and physicochemical properties of 2D materials make them one class of the most appealing candidates for a wide range of potential applications. In particular， we have seen some major breakthroughs made in the field of 2D materials in last five years not only in developing novel synthetic methods and exploring new structures/properties but also in identifying innovative applications and pushing forward commercialisation. In this review， we provide a critical summary on the recent progress made in the field of 2D materials with a particular focus on last five years. After a brief background introduction， we first discuss the major synthetic methods for 2D materials， including the mechanical exfoliation， liquid exfoliation， vapor phase deposition， and wet-chemical synthesis as well as phase engineering of 2D materials belonging to the field of phase engineering of nanomaterials (PEN). We then introduce the superconducting/optical/magnetic properties and chirality of 2D materials along with newly emerging magic angle 2D superlattices. Following that， the promising applications of 2D materials in electronics， optoelectronics， catalysis， energy storage， solar cells， biomedicine， sensors， environments， etc. are described sequentially. Thereafter， we present the theoretic calculations and simulations of 2D materials. Finally， after concluding the current progress， we provide some personal discussions on the existing challenges and future outlooks in this rapidly developing field.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

液相色谱-串联质谱应用研究进展

计量科学与技术 2021年第2期65卷 7-15,6页

作者：易可可谢洁龚晓云翟睿彭涛曾伟杰刘梅英黄泽建江游时国庆戴新华方向中国计量科学研究院北京100029 北京科技大学北京100083

液相色谱-串联质谱(Liquid chromatography-tandem mass spectrometry,LC-MS/MS)是由具有高效分离能力的液相色谱和具有高准确分析能力的质谱串联,实现化合物鉴定和定量的重要分析技术。随着先进仪器的研发和相关技术的发展,使得LC-MS/M... 详细信息

液相色谱-串联质谱(Liquid chromatography-tandem mass spectrometry,LC-MS/MS)是由具有高效分离能力的液相色谱和具有高准确分析能力的质谱串联,实现化合物鉴定和定量的重要分析技术。随着先进仪器的研发和相关技术的发展,使得LC-MS/MS的分离分析能力更加强大。简单介绍了质谱仪的发展历史以及工作原理,对LC-MS/MS在食品安全、临床诊断、环境监测、生命科学和医学制药等领域的应用研究进展进行了综述,并对其发展趋势和应用前景进行了展望,以期为相关领域技术人员提供参考。

关键词：液相色谱-串联质谱应用研究综述

在线全文

学校读者我要写书评

暂无评论

二维材料最新研究进展

物理化学学报 2021年第12期37卷 1-151页

作者：常诚陈伟陈也陈永华陈雨丁峰樊春海范红金范战西龚成宫勇吉何其远洪勋胡晟胡伟达黄维黄元季威李德慧李连忠李强林立凌崇益刘鸣华刘楠刘庄 Kian Ping Loh 马建民缪峰彭海琳邵明飞宋礼苏邵孙硕谭超良唐智勇王定胜王欢王金兰王欣王欣然 Andrew T.S.Wee 魏钟鸣吴宇恩吴忠帅熊杰熊启华徐伟高尹鹏曾海波曾志远翟天佑张晗张辉张其春张铁锐张翔赵立东赵美廷赵伟杰赵运宣周凯歌周兴周喻朱宏伟张华刘忠范 Institute of Science and Technology Austria Am Campus 13400 KlosterneuburgAustria Department of Chemistry National University of Singapore3 Science Drive 3117543Singapore Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong KongChina Key Laboratory of Flexible Electronics and Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China School of Life Sciences Shanghai UniversityShanghai 200444China Centre for Multidimensional Carbon Materials Institute for Basic ScienceUlsan 44919Korea School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Department of Chemistry City University of Hong KongKowloonHong KongChina Department of Electrical and Computer Engineering and Quantum Technology Center University of MarylandCollege ParkMaryland 20742USA School of Materials Science and Engineering Beihang UniversityBeijing 100191China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina Center of Advanced Nanocatalysis(CAN) Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China College of Chemistry and Chemical Engineering State Key Laboratory of Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy Materials(iChEM)Xiamen UniversityXiamen361005Fujian ProvinceChina State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China School of Optical and Electronic Information Wuhan National Laboratory

Research on two-dimensional(2D) materials has been explosively increasing in last seventeen years in varying subjects including condensed matter physics, electronic engineering, materials science, and chemistry since the mechanical exfoliation of graphene in 2004. Starting from graphene, 2D materials now have become a big family with numerous members and diverse categories. The unique structural features and physicochemical properties of 2D materials make them one class of the most appealing candidates for a wide range of potential applications. In particular, we have seen some major breakthroughs made in the field of 2D materials in last five years not only in developing novel synthetic methods and exploring new structures/properties but also in identifying innovative applications and pushing forward commercialisation. In this review, we provide a critical summary on the recent progress made in the field of 2D materials with a particular focus on last five years. After a brief backgroundintroduction, we first discuss the major synthetic methods for 2D materials, including the mechanical exfoliation, liquid exfoliation, vapor phase deposition, and wet-chemical synthesis as well as phase engineering of 2D materials belonging to the field of phase engineering of nanomaterials(PEN). We then introduce the superconducting/optical/magnetic properties and chirality of 2D materials along with newly emerging magic angle 2D superlattices. Following that, the promising applications of 2D materials in electronics, optoelectronics, catalysis, energy storage, solar cells, biomedicine, sensors, environments, etc. are described sequentially. Thereafter, we present the theoretic calculations and simulations of 2D materials. Finally, after concluding the current progress, we provide some personal discussions on the existing challenges and future outlooks in this rapidly developing field.

关键词： Two-dimensional materials Transition metal dichalcogenides Phase engineering of nanomaterials Electronics Optoelectronics Catalysis Energy storage and conversion