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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu wei-zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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DNA Damage Response in Hematopoietic Stem Cell Ageing

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 147-154页

作者： Tangliang Li zhong-wei zhou Zhenyu Ju Zhao-Qi Wang Institute of Aging Research School of MedicineHangzhou Normal UniversityHangzhou 311121China Leibniz Institute on Aging-Fritz Lipmann Institute(FLI) Jena D-07745Germany Faculty of Biology and Pharmacy Friedrich-Schiller University of JenaJena D-07745Germany

Maintenance of tissue-specific stem cells is vital for organ homeostasis and organismal *** stem cells（HSCs） are the most primitive cell type in the hematopoietic *** divide asymmetrically and give rise to daughter cells with HSC identity（selfrenewal） and progenitor progenies（differentiation）,which further proliferate and differentiate into full hematopoietic *** ageing process is accompanied with abnormalities in the HSC self-renewal and *** changes and epigenetic modulations have been implicated as the key regulators in HSC ageing *** DNA damage response（DDR）in the cells involves an orchestrated signaling pathway,consisting of cell cycle regulation,cell death and senescence,transcriptional regulation,as well as chromatin *** studies employing DNA repair-deficient mouse models indicate that DDR could intrinsically and extrinsically regulate HSC maintenance and play important roles in tissue homeostasis of the hematopoietic *** this review,we summarize the current understanding of how the DDR determines the HSC fates and finally contributes to organismal ageing.

关键词： Hematopoietic stem cells DNA damage response Epigenetics Ageing P53

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A numerical local orthogonal transform method forstratified waveguides

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第12期11卷 998-1008页

作者： Peng LI wei-zhou zhong Guo-sheng LI Zhi-hua CHEN School of Economies and Finance Xi'an Jiaotong University Xi'an 710061 China Department of Mathematics North China University of Water Conservancy and Electric Power Zhengzhou 450045 China Department of Mathematics Zhongyuan University of Technology Zhengzhou 450007 China Science Department Zhijiang College of Zhejiang University of Technology Hangzhou 310027 China

Flattening of the interfaces is necessary in computing wave propagation along strati?ed waveguides in large range step sizes while using marching methods. When the supposition that there exists one horizontal straight line in two adjacent interfaces does not hold, the previously suggested local orthogonal transform method with an analytical formulation is not feasible. This paper presents a numerical coordinate transform and an equation transform to perform the transforms numerically for waveguides without satisfying the supposition. The boundary value problem is then reduced to an initial value problem by one-way reformulation based on the Dirichlet-to-Neumann (DtN) map. This method is applicable in solving long-range wave propagation problems in slowly varying waveguides with a multilayered medium structure.

关键词： Helmholtz equation Local orthogonal transform Dirichlet-to-Neumann (DtN) reformulation Marching method Internal interface

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Electronic Structure and Catalysis on (001) Polar Surface of Cubic Zirconia

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Chemical Research in Chinese Universities 2010年第3期26卷 460-464页

作者： SHEN Pei-jun DING wei-zhong zhou Yu-ding HUANG Shao-qing Department of Materials Science and Engineering Shanghai University Shanghai 200072 P. R. China

The electronic structure of （001） polar surface of cubic zirconia was studied by GGA（WC） approximation. We found the cubic lattice near （001） surface showed an intensive tendency to transfer to tetragonal lattice. The metallic state appeared on both the terminations. For O-termination, some O2p states were vacated and hole carriers concentrated on surface oxygen-ions. For Zr-termination, some Zr4d states became partial occupied for the loss of O2p states. We observed the hole states were mainly localized at the corresponding ions on surface for both the terminations, while the charge states on Zr-termination were dispersed on surface.

关键词： Polar surface Electronic structure Hole/charge distribution Cataylsis Article

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Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model

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Journal of Genetics and Genomics 2024年第4期51卷 419-432页

作者： Qing Yang Qiang Cao Yue Yu Xianxin Lai Jiahao Feng Xinjie Li Yinan Jiang Yazhou Sun zhong-wei zhou Xin Li School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous *** methylation and hydroxymethylation play important roles in regulating cerebral cortex ***,it remains unclear whether abnormal cerebral cortex development,such as microcephaly,could rescale the epigenetic landscape,potentially contributing to dysregulated gene expression during brain *** this study,we characterize and compare the DNA methylome/hydroxymethylome and transcriptome profiles of the cerebral cortex across several developmental stages in wild-type(WT)mice and Mcph1 knockout(Mcph1-del)mice with severe ***,we discover a global reduction of 5′-hydroxymethylcytosine(5hmC)level,primarily in TET1-binding regions,in Mcph1-del mice compared to WT mice during juvenile and adult ***,genes exhibiting diminished 5hmC levels and concurrently decreased expression are essential for neurodevelopment and brain ***,genes displaying a delayed accumulation of 5hmC in Mcph1-del mice are significantly associated with the establishment and maintenance of the nervous system during the adult *** findings reveal that aberrant cerebral cortex development in the early stages profoundly alters the epigenetic regulation program,which provides unique insights into the molecular mechanisms underpinning diseases related to cerebral cortex development.

关键词： Microcephaly Epigeneticmodification Tet1 Cerebral cortexdevelopment DNA hydroxymethylome Transcriptome

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Placement of ^(125)I seed strands and stents for a type Ⅳ Klatskin tumor

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World Journal of Gastroenterology 2015年第1期21卷 373-376页

作者： Wen Zhang Zheng-Qiang Yang Hai-Bin Shi Shen Liu wei-zhong zhou Lin-Bo Zhao Department of Interventional Radiology First Affiliate Hospital of Nanjing Medical University

Herein,we report a new technique that consists of placing two 125 I seed strands and two stents in the right and left intrahepatic bile ducts for the treatment of hilar cholangiocarcinoma.A 75-year-old man presented with jaundice and was diagnosed with Bismuth type Ⅳ Klatskin *** computed tomography(CT) showed intrahepatic and extrahepatic bile ductdilatation and a soft tissue mass in the hepatic *** curative surgical resection was not possible,we placed 125 I seed strands and stents in the right and left intrahepatic bile *** months later,abdominal CT showed less intrahepatic and extrahepatic bile duct dilatation than before the *** technique was feasible and could be considered for the treatment of patients with Bismuth type Ⅳ tumors.

关键词： Cholangiocarcinoma Klatskin tumor 125I seed strand

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Transarterial embolization for massive gastrointestinal hemorrhage following abdominal surgery

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World Journal of Gastroenterology 2013年第40期19卷 6869-6875页

作者： Chun-Gao zhou Hai-Bin Shi Sheng Liu Zheng-Qiang Yang Lin-Bo Zhao Jin-Guo Xia wei-zhong zhou Lin-Sun Li Department of Interventional Radiology the First Affiliated Hospital of Nanjing Medical University

AIM:To evaluate the clinical results of angiography and embolization for massive gastrointestinal hemorrhage after abdominal ***:This retrospective study included 26 patients with postoperative hemorrhage after abdominal surgery. All patients underwent emergency transarterial angiography,and 21 patients underwent emergency embolization. We retrospectively analyzed the angiographic features and the clinical outcomes of transcatheter arterial ***:Angiography showed that a discrete bleeding focus was detected in 21(81%) of 26 *** angiographic findings included extravasations of contrast medium(n = 9),pseudoaneurysms(n =9),and fusiform aneurysms(n = 3). Transarterial embolization was technically successful in 21(95%) of 22patients. Clinical success was achieved in 18(82%) of 22 patients. No postembolization complications were observed. Three patients died of ***:The positive rate of angiographic findings in 26 patients with postoperative gastrointestinal hemorrhage was 81%. Transcatheter arterial embolization seems to be an effective and safe method in the management of postoperative gastrointestinal hemorrhage.

关键词： Transcatheter arterial embolization Postoperative hemorrhage Complications Surgery

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企业集团与一体化经济组织

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中国软科学 2000年第8期 53-56页

作者：仲伟周西安交通大学管理学院陕西西安710049

运用经济学的基本方法 ,通过对企业集团与一体化经济组织 (企业 )的性质与功能进行充分比较分析 ,揭示了企业集团与经济一体化组织 (企业 )在配置资源方面的异同 ,并依次对我国经济实践中的企业集团构建及其运作提出了自己的政策建议。

关键词：企业集团一体化经济组织比较分析实证研究中国企业

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中国区域全要素碳排放绩效及影响因素研究

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商业经济与管理 2012年第1期 85-96页

作者：仲云云仲伟周西安交通大学经济与金融学院陕西西安710061

文章运用线性数据转换函数法对生产过程中的非期望产出——二氧化碳排放进行处理;利用BC2-DEA模型和Malmquist指数法,分别从静态和动态角度计算了中国29个省份1995-2009年的全要素碳排放绩效,并分析了其影响因素,结果表明:中国全要素碳... 详细信息

文章运用线性数据转换函数法对生产过程中的非期望产出——二氧化碳排放进行处理;利用BC2-DEA模型和Malmquist指数法,分别从静态和动态角度计算了中国29个省份1995-2009年的全要素碳排放绩效,并分析了其影响因素,结果表明:中国全要素碳排放绩效近些年呈现下降趋势,并表现为明显的区域特征。文章还进一步分析了全要素碳排放绩效的影响因素,进一步揭示各影响因素对碳排放效率和曼奎斯特碳排放绩效指数的影响方向和影响程度,并提出了现阶段的节能减排政策建议。

关键词：全要素碳排放绩效碳排放效率非期望产出 BC2-DEA模型 Malmquist指数

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寡头市场下价格时变产品的最优交货时间策略

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系统工程理论与实践 2014年第10期34卷 2515-2525页

作者：刘聪粉仲伟周宋长青西安交通大学经济与金融学院西安710061 华侨大学工商管理学院泉州362021

针对需求对价格和交货时间的敏感性,价格与交货时间呈线性关系,构建了寡头市场下按单生产(make to order(MTO))企业的产品最优交货时间的决策模型,关注产品之间的替代性以及面临的不同市场竞争环境,使模型更贴近现实情况.首先对模型的... 详细信息

针对需求对价格和交货时间的敏感性,价格与交货时间呈线性关系,构建了寡头市场下按单生产(make to order(MTO))企业的产品最优交货时间的决策模型,关注产品之间的替代性以及面临的不同市场竞争环境,使模型更贴近现实情况.首先对模型的最优性进行分析,其次通过数值算例,探讨了顾客偏好系数和替代率对最优决策的影响,以及寡头企业在竞争与合作机制下的最优选择.结果表明顾客的不同偏好将带来不同的决策结果,企业应根据顾客类型进行市场细分并采取不同的决策;在两企业之间存在替代性的情况下,缺乏合作的动机,竞争普遍存在.但如果两企业想保持稳定的交货时间和价格,应采用合作机制.相关结论可以为企业科学进行市场竞争提供有益的指导.

关键词：寡头市场价格时变最优交货时间策略替代率

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