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激光微孔化猪脱细胞真皮基质的设计、制备及同步移植实验

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上海交通大学学报（医学版） 2012年第10期32卷 1307-1311页

作者：曾逃方罗旭辛国华万丽徐建军夏卫东毛葱王平林才宜春市人民医院烧伤科宜春336000 温州医学院附属第一医院烧伤科温州325000 南昌大学第一附属医院烧伤科南昌330006 温州医学院附属第一医院病理科温州325000 华南理工大学材料科学与工程学院广州510641 中科院上海技术物理研究所上海200083

目的构建一种新型真皮替代物——激光微孔化猪脱细胞真皮基质材料(LPADM)并验证其修复全层皮肤缺损的效果。方法取新鲜健康小白猪断层真皮,一部分经高钠-SDS法脱细胞获得脱细胞真皮基质(ADM),另一部分则先行激光打孔再经脱细胞获得LPADM... 详细信息

目的构建一种新型真皮替代物——激光微孔化猪脱细胞真皮基质材料(LPADM)并验证其修复全层皮肤缺损的效果。方法取新鲜健康小白猪断层真皮,一部分经高钠-SDS法脱细胞获得脱细胞真皮基质(ADM),另一部分则先行激光打孔再经脱细胞获得LPADM;检测LPADM的物理性状。在SD大鼠(n=30)背部制作2.0 cm×2.0 cm的全层皮肤缺损创面(n=4),分别采用LPADM自体中厚皮片(L组)和无孔ADM自体中厚皮片(A组)复合移植及自体全厚皮片(F组)和中厚皮片原位移植(C组)修复。分别于术后第3、5、7、10、14天,每组随机选取6只大鼠,观察创面皮片成活情况,处死动物后采集创面组织行组织学检查。结果制备的LPADM呈瓷白色,柔软有光泽;显微镜下观察未见细胞残留。移植术后第3天,组织学检查发现L组创面组织有内皮细胞围成的空腔样结构;术后第3、5、7、10天,L组和C组创面移植皮片成活良好,L组血管样结构中已可见红细胞;A组皮片起泡甚至发黑坏死;F组皮片部分起小泡,但泡皮下基底红润。术后第14天,L组真皮微孔中可见大量血管形成,L组、C组和F组移植皮片全部或基本存活,创面愈合率分别为(99.10±0.66)%、(99.25±0.23)%、(97.07±1.32)%,差异无统计学意义(P>0.05);A组皮片全部坏死脱落,创面愈合率为(27.46±2.05)%,显著低于其他各组(P<0.01)。结论构建的新型激光微孔化猪脱细胞真皮基质,同步复合自体皮移植,移植成功率高,较快实现早期血管化,为一种较理想的真皮替代物。

关键词：真皮替代物脱细胞真皮基质激光微孔移植

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针刺心经合穴对左手寸部脉图参数的影响

杭州师范学院学报（医学版） 2006年第2期26卷 90-92页

作者：宓云峰蔡飞王伟红傅可可劳维斯夏卫东杭州师范学院临床医学院浙江杭州310036

目的观测针刺心经合穴对左手寸部脉图参数的影响,根据三部九候脉诊法探讨左手寸部脉图与其所候脏腑是否有相关性。方法选择身体健康的在校大学生52例,随机配对分为两组,一组为心经合穴组,另一组为阑尾穴对照组。采用脉图仪对两组大学生... 详细信息

目的观测针刺心经合穴对左手寸部脉图参数的影响,根据三部九候脉诊法探讨左手寸部脉图与其所候脏腑是否有相关性。方法选择身体健康的在校大学生52例,随机配对分为两组,一组为心经合穴组,另一组为阑尾穴对照组。采用脉图仪对两组大学生的左手寸脉进行检测,分析针刺心经合穴前后左手寸脉脉图参数的变化。结果针刺少海穴后左手寸脉脉图主波波幅明显增高(P0.05);但脉搏周期延长(P<0.05),且以左心室舒张期延长明显(P<0.05)。结论针刺少海穴对左手寸脉有明显影响,即支持三部九候脉诊法中左手寸候心的理论。因此左手寸部脉象能反映心脏的生理及病理信息,在以后的中医临床诊断当中具有指导意义。

关键词：少海阑尾寸脉脉图三部九候

Liver transplantation for hepatocellular carcinoma beyond the Milan criteria: A review

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World Journal of Gastroenterology 2016年第12期22卷 3325-3334页

作者： dong-wei Xu Ping Wan Qiang xia Department of Liver Surgery Ren Ji Hospital School of Medicine Shanghai Jiao Tong University

Liver transplantation(LT) has been accepted as an effective therapy for hepatocellular carcinoma(HCC). The Milan criteria(MC) are widely used across the world to select LT candidates in HCC patients. However, the MC may be too strict because a substantial subset of patients who have HCC exceed the MC and who would benefit from LT may be unnecessarily excluded from the waiting list. In recent years, many extended criteria beyond the MC were raised, which were proved to be able to yield similar outcomes compared with those patients meeting the MC. Because the simple use of tumor size and number was insufficient to indicate HCC biological features and to predict the risk of tumor recurrence, some biological markers such as Alphafetoprotein, Des-Gamma-carboxy prothrombin and the neutrophil-to-lymphocyte ratio were useful in selecting LT candidates in HCC patients beyond the MC. For patients with advanced HCC, downstaging therapy is an effective way to reduce the tumor stage to fulfill the MC by using liver-directed therapy such as transarterial chemoembolization, radiofrequency ablation and percutaneous ethanol injection. This article reviews the recent advances in LT for HCC beyond the MC.

关键词： Liver transplantation Biological marker Milan criteria Hepatocellular carcinoma Downstaging therapy Adjuvant treatment

Temperature and electron density of soil plasma generated by LA-FPDPS

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Frontiers of physics 2012年第6期7卷 721-727页

作者： xia-Fen Li wei-dong Zhou Zhi-Feng Cui The Institute of Information Optics Zhejiang Normal UniversityJinhua 321004China Department of Physics Anhui Normal UniversityWuhu 241000China

Electron temperature and electron number density are important parameters in the characterization of plasma. In this paper the electron temperature and electron number density of soil plasma generated by laser ablation combined with nanosecond discharge spark at different discharge voltages have been studied. Saha-Boltzmann plot and Stark broadening are used to determine the temper- ature and electron number density. It is proved that local thermal equilibrium is fulfilled in the nanosecond spark enhanced plasma. The enhanced optical emission, signal to noise ratio and the stability in term of the relative standard deviation of signal intensity at different spark voltages were investigated in detail. A relative stable discharge process was observed with use of a 10 kV discharge voltage under the carried experimental configuration.

关键词： laser ablation fast pulse discharge plasma spectroscopy (LA-FPDPS) local thermodynamic equilibrium (LTE) electron temperature electron number density discharge voltage

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宁波市美洲斑潜蝇发生规律及防治技术研究

浙江万里学院学报 2001年第2期14卷 59-60页

作者：吴降星夏卫东姚炳初徐富康宁波市植物检疫站宁波315012 宁波市镇海区植物检疫站宁波315200 余姚市泗门镇农技站余姚315414

美洲斑潜蝇已成为宁波市主要的蔬菜害虫之一 ,反季节栽培的豆科 ,葫芦科和茄科蔬菜受害最为严重 .7月上旬初见幼虫为害 .全年可发生 7- 8代 .该虫最适生长发育温度为 2 5 - 30℃ ,蛹在 - 6℃时 1d ,- 5℃时 5d ,- 4℃时 7d才能被全部杀... 详细信息

美洲斑潜蝇已成为宁波市主要的蔬菜害虫之一 ,反季节栽培的豆科 ,葫芦科和茄科蔬菜受害最为严重 .7月上旬初见幼虫为害 .全年可发生 7- 8代 .该虫最适生长发育温度为 2 5 - 30℃ ,蛹在 - 6℃时 1d ,- 5℃时 5d ,- 4℃时 7d才能被全部杀死 ;幼虫可用 2 0 %灭扫利、10 %高效灭百可和 1%杀虫素等进行防治 .

关键词：美洲斑潜蝇发生规律防治

An improved deep dilated convolutional neural network for seismic facies interpretation

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Petroleum Science 2024年第3期21卷 1569-1583页

作者： Na-xia Yang Guo-Fa Li Ting-Hui Li dong-Feng Zhao wei-wei Gu State Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationChina University of Petroleum(Beijing)Beijing 102249China Dagang Branch Research InstituteBGPTianjin300280China

With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural *** intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic ***,the extensive demand for training data imposes limitations on their wider *** overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training ***,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader *** seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies *** analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image ***,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic *** approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.

关键词： Seismic facies interpretation Dilated convolution Spatial pyramid pooling Internal feature maps Compound loss function

An approach to determine coeffi cients of logarithmic velocity vertical profile in the bottom boundary layer

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Journal of Oceanology and Limnology 2021年第6期39卷 2144-2152页

作者： xiaowei wei Yiming ZHANG Changming dong Meibing JIN Changshui xia School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Southern Laboratory of Ocean Science and Engineering Zhuhai 519000China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266101China

Velocity vertical profiles in the bottom boundary layer are important to understand the oceanic *** logarithmic vertical profile,u=A ln z+B,is the universal profile for the horizontal velocity in the boundary layer,in which two coefficients(A and B)need to be *** two coefficients are the functions of the friction velocity(u_(*))and the roughness length(z_(0)),and they are calculated using u_(*)and z_(0).However,the measurement of u_(*)and z_(0) is a *** the present study,an approach is developed to estimate the two coefficients(A and B)by using a series of fl ume laboratory experiments with fl at boundary and regularly distributed cylinders as the rough *** acoustic doppler velocimeter(ADV)is used to measure the velocity vertical profiles of the steady *** the measured velocity data,the regressed logarithmic profiles are *** on the series of the A and B values,the mathematical formula for A and B are statistically established as the function of the cylinder height,inflow velocity,and the water depth,which avoids the measurement of the friction velocity and the roughness length.

关键词： velocity vertical logarithmic distribution bottom boundary layer the friction velocity

Hollow cubic MnS-CoS_(2)-NC@NC designed by two kinds of nitrogen-doped carbon strategy for sodium ion batteries with ultraordinary rate and cycling performance

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Nano Research 2022年第4期15卷 3273-3282页

作者： Ruipeng wei Yutao dong Yingying Zhang Xiyang Kang xia Sheng Jianmin Zhang College of Science Henan Agricultural UniversityZhengzhou 450002China College of Chemistry Zhengzhou UniversityZhengzhou 450001China

In order to obtain an advanced anode material that exhibits excellent electrochemical performance in sodium ion batteries,a hollow nanocube MnS-CoS_(2)-NC@NC(NC=nitrogen-doped carbon)with two kinds of nitrogen-doped carbon was synthesized by simple one-step *** of the two kinds of nitrogen-doped carbon comes from the organic ligands in the precursor being mixed in the sulfide after calcination,and the other comes from the calcination of the coated polydopamine(PDA)to form a carbon shell wrapped outside the *** characteristic nanostructure with two kinds of nitrogen-doped carbon can not only improve the overall conductivity of the electrode material,which is obviously beneficial to the rapid transmission of sodium ions and thus outstanding rate performance,but also can alleviate volume expansion to maintain battery cycle *** the half-cell,the MnS-CoS_(2)-NC@NC electrode not only provides an ultra-high specific capacity of 608.5 mA·h·g^(-1)at 0.2 A·g^(-1)for 100 cycles,but also shows an outstanding rate performance of 560.5 mA·h·g^(-1)at 5.0 A·g^(-1)for 1,100 *** in a full-cell composed with Na3V2(PO4)3 as the positive material,it can still maintain a capacity of 436.7 mA·h·g^(-1)after 900 cycles at 1.0 A·g^(-1).In order to explore its sodium storage mechanism,in-situ and ex-situ X-ray diffraction(XRD)tests were carried out to prove that CoS_(2)and MnS were reduced to produce metallic Co and metallic Mn during the discharging process,respectively,and reversibly returned during the charging process.

关键词： MnS CoS_(2) hollow nanocube nitrogen-doped carbon sodium ion battery

活性猪脱细胞真皮基质复合自体刃厚皮片移植修复SD大鼠皮肤缺损

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中华医学美学美容杂志 2012年第3期18卷 197-199页

作者：林才罗旭万丽夏卫东毛葱温州医学院附属第一医院烧伤科 325000 温州医学院华南理工大学材料科学与工程学院

目的构建具活性细胞成分的激光微孔化猪脱细胞真皮基质（LPADM），并通过I期复合白体刃厚皮片移植观察其在修复SD大鼠全层皮肤缺损中的效果。方法设LPADM组与无孔PADM组，将同种异体成纤维细胞（fibroblast，FB）种植于LPADM上培养，另... 详细信息

目的构建具活性细胞成分的激光微孔化猪脱细胞真皮基质（LPADM），并通过I期复合白体刃厚皮片移植观察其在修复SD大鼠全层皮肤缺损中的效果。方法设LPADM组与无孔PADM组，将同种异体成纤维细胞（fibroblast，FB）种植于LPADM上培养，另设仅用FB培养液培养的FB为对照纰，采用双抗体夹心ABC—ELISA法测定各组FB细胞活性因子自细胞介素-10（IL-10）、白细胞介素-6（II-6）、p1转化生长因子（TGF—β1）、层粘连蛋白（I。N）、血管内皮细胞生长因子（VEGF）的表达。制作SI）大鼠全层皮肤缺损伤口模型，将具活性的LPADM复合自体刃厚皮片I期移植，记录其生长情况，定期活检，并进行组织学观察。结果LPADM组、PADM组、对照组各组各时相点各指标吸光度值比较．差异均无统计学意义（F为0．050～1．763，P〉0．05）。移植的LPADM中可见生长良好的FB。移植术后3周，创面愈合良好，未见明显排斥反应。术后1个月，创面瘢痕轻，复合皮肤可提捏。结论用活性LPADM复合自休刃厚皮片I期移植修复SD大鼠全层皮肤缺损，可有效修复创面，并具有较高的生物安全性。

关键词：脱细胞真皮基质成纤维细胞复合皮移植