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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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高表达hSSAT基因A549人肺癌细胞系的构建和筛选

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中国药理通讯 2010年第4期27卷 34-35页

作者： Liu wei Cai Fu-qiang han Yu WangYan-lin 中国三峡大学医学院分子生物学研究所

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin han Lanxin Luo Caiyan wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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Characteristics of the OH （X~2П） Photofragment from the Photodissociation of the Methyl nitrite at 266nm

Characteristics of the OH （X~2П） Photofragment from the P...

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第九届全国化学动力学会议

作者： Yue Xianfang,Sun Julong,Liu Zhenfeng,wei qiang,han Keli State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences,Dalian 116023,China

＜正＞The 266 nm photodissociation of methyl nitrite （CH3ONO） in the S2 state has been investigated in the bulk conditions. The dominant decay channel was assigned to CH3ONO→CH3O（X2E） + NO（X2П）.Energetic considerations indicate that the CH3O（X2E） products are unstable, a few of which decay further to CH2（X1A1） + OH（X2П）. The

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覆膜与降雨类型对土壤水分及NO_3^--N淋失的影响

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环境科学学报 2017年第11期37卷 4352-4359页

作者：任瑞于兴修徐苗苗张家鹏胡砚霞王伟汉强湖北大学资源环境学院区域开发与环境响应湖北省重点实验室武汉430062

在丹江口库区青塘河五龙池小流域,以黄棕壤横垄种植玉米为例,设置覆膜与无覆膜两种处理,采用田间小区实验研究覆膜与降雨类型对0~30 cm土壤水分和NO-3-N淋失的影响.结果表明:两处理土壤含水量均随土层加深而增加,与无覆膜相比覆膜可降低... 详细信息

在丹江口库区青塘河五龙池小流域,以黄棕壤横垄种植玉米为例,设置覆膜与无覆膜两种处理,采用田间小区实验研究覆膜与降雨类型对0~30 cm土壤水分和NO-3-N淋失的影响.结果表明:两处理土壤含水量均随土层加深而增加,与无覆膜相比覆膜可降低0~10、10~20、20~30cm土层中的含水量.不同降雨类型对覆膜土壤含水量的影响有区别,小雨时3层土壤间差异显著,含水量随土层加深急剧增加;中雨时10~20cm比0~10 cm、20~30 cm比10~20 cm分别高50.80%、6.62%,0~10 cm土壤含水量显著低于10~20 cm和20~30 cm;暴雨时含水量随土层加深增幅变小;覆膜土壤土层越深土壤含水量受降雨的影响越小.覆膜可降低0~10、10~20 cm土层中的NO-3-N淋失量,分别降低40.74%、24.48%,但会增加20~30 cm的淋失;两处理土壤NO-3-N淋失量均随土层加深而增加.不同降雨类型对覆膜土壤NO-3-N淋失的影响也有区别,小雨时随土壤深度的增加淋失量增多;中雨时,0~10、20~30 cm NO-3-N淋失量分别为10~20 cm的1.75、8.41倍;暴雨时,0~10、20~30 cm分别比10~20 cm低18.97%和60.69%.土壤中NO-3-N淋失受土壤含水量的影响,且随土层加深含水量对NO-3-N淋失的影响减弱.

关键词：覆膜降雨类型土壤含水量 NO3^--N淋失丹江口库区

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： wei Wang Zi-Qing Chen Yong-Qi Li Yu-Long Wang Mei-Chen Liu Yun-Bo Ruan Yang Zhang Shu-Juan Liu qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

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On the General and Resonant Solutions of Atoms Reflected by an Evanescent Laser Wave

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Chinese Physics Letters 1996年第8期13卷 587-589页

作者： TAN wei-han LI qiang-ning Department of Physics Shanghai UniversityShanghai 200072 and Shanghai Institute of Optics and fine Mechanics Chinese Academy of SciencesShanghai 201800

Usually the reflection of two level atoms by a detuning evanescent laser wave was studied in past few years.1-3 In previous paper we have presented an exact solution for this model based on the matrix Laplace transformation technique,and proceeded the numerical calculations for a given set of parameters.4 However in the special case of resonance interaction considered in this paper,the solution for Schrödinger wave equation and reflectivity calculation can be greatly simplified;besides,the resonant solution provides a check to the numerical data based on the general solution of the previous paper.

关键词： parameters wave simplified

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子午流注穴位按摩对改善甲状腺术后患者头痛症状和睡眠质量的临床研究

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临床与病理杂志 2017年第2期37卷 301-307页

作者：钱艳周春姣何为傅强韩玲广东省中医院大学城医院外三科广州510006

目的:探讨子午流注穴位按摩对甲状腺术后患者的头痛及睡眠质量的临床效果。方法:将97名甲状腺术后患者随机分为对照组(49例)和观察组(48例),观察组实施子午流注穴位按摩,对照组实施常规护理干预;收集并比较两组患者在术后第1,3,5,7天的... 详细信息

目的:探讨子午流注穴位按摩对甲状腺术后患者的头痛及睡眠质量的临床效果。方法:将97名甲状腺术后患者随机分为对照组(49例)和观察组(48例),观察组实施子午流注穴位按摩,对照组实施常规护理干预;收集并比较两组患者在术后第1,3,5,7天的头痛症状评分(Headache Symptom Scores,HSS)和匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)。结果:重复测量方差结果显示,两组患者在第1、3、5、7天的VAS得分变化的组间效应、时间效应以及交互效应差异均具有统计学意义(P<0.001);除催眠药物以外,两组在各时间点PSQI值及各维度变化的组间效应、时间效应以及交互效应均具有统计学意义(P<0.001)。结论:子午流注穴位按摩能有效减轻甲状腺术后患者的头痛情况,提高睡眠质量,且随时间的增加改善效果越明显。

关键词：甲状腺手术头痛睡眠障碍子午流注穴位按摩

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An enhanced treatment of boundary conditions in implicit smoothed particle hydrodynamics

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Acta Mechanica Sinica 2014年第1期30卷 37-49页

作者： Ya-wei han Hong-Fu qiang Hu Liu wei-Ran Gao Xi’an Research Inst.of Hi-Tech.

In this work, an enhanced treatment of the solid boundaries is proposed for smoothed particle hydrodynamics with implicit time integration scheme （Implicit SPH）. Three types of virtual particles, i.e., boundary particles, image particles and mirror particles, are used to impose boundary conditions. Boundary particles are fixed on the solid boundary, and each boundary particle is associated with two fixed image particles inside the fluid domain and two fixed mirror particles outside the fluid domain. The image particles take the flow properties through fluid particles with moving least squares （MLS） interpolation and the properties of mirror particles can be obtained by the corresponding image particles. A repulsive force is also applied for boundary particles to prevent fluid particles from unphysical penetra- tion through solid boundaries. The new boundary treatment method has been validated with five numerical examples. All the numerical results show that Implicit SPH with this new boundary-treatment method can obtain accurate results for non-Newtonian fluids as well as Newtonian fluids, and this method is suitable for complex solid boundaries and can be easily extended to 3D problems.

关键词： Implicit SPH. Boundary conditions. Power-law model Repulsive force MLS interpolation

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