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A systematic review of treating Helicobacter pylori infection with Traditional Chinese Medicine

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World Journal of Gastroenterology 2009年第37期15卷 4715-4719页

作者： Jiang lin wei-Wen huang Department of Gastroenterology Shuguang Hospital Shanghai University of Traditional ChineseMedicine Shanghai 200021 China

AIM: To evaluate the efficacy and safety of Traditional Chinese Medicine (TCM) in the treatment of Helicobacter pylori (H pylori) infection. METHODS: We electronically and manually searched electronic databases, references lists and conferences compilations, and included all randomized clinical trials comparing the treatment of H pylori using TCM with proton pump inhibitor or colloidal bismuth subcitratebased triple therapy as controls. The Jadad score was used to assess trial quality, H pylori eradication rate and the incidence of side effects were taken as outcome measurements, and heterogeneity analysis, meta-analysis and funnel plot analysis were conducted. RESULTS: Sixteen trials were included. The Jadad scores of all the trials were not more than 2. Clinical heterogeneity and substantial statistical heterogeneity existed among the trials (P = 0.001, I 2 = 59%) and meta-analysis was not conducted. The average eradication rates following TCM and triple therapy were 72% and 78% and the incidence of side effects were 2% and 29%, respectively. The funnel plot was obviously asymmetric. CONCLUSION: Available evidence is not convincing enough to show that TCM has the same efficacy as triple therapy in H pylori treatment. TCM may be safer than triple therapy. TCM should not be recommended as monotherapy in H pylori infection.

关键词： Drug toxicity Helicobacter pylori Traditional Chinese Medicine Treatment efficacy

Temperature effect on the kinetics of persulfate oxidation of p-chloroaniline

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Chinese Chemical Letters 2011年第3期22卷 358-361页

作者： Yong Qing Zhang Xiao Zhe Du wei lin huang College of Environmental Science and Engineering South China University of Technology Guangzhou 510006 China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of Education Guangzhou 510006 China Department of Environmental Sciences Rutgers. The State University of New Jersey New Brunswick NJ 08901 USA

The kinetics of heat-facilitated persulfate oxidation of p-chloroaniline（PCA） in aqueous solutions was measured at five different temperature conditions and at four different oxidant *** PCA degradation was found to follow a pseudo-first-order decay model when the persulfate was *** pseudo-first-order rate constants of PCA degradation by persulfate（50 mmol/ L） at pH 7.0 are 0.12×10^-4,0.28×10^-4,0.43×10^-4,0.83×10^-4,1.32×10^-4 s^-1 at 10,20,30,40 and 50℃,respectively. Under the above reaction conditions,the reaction has activation energy of 49.97 kJ/*** observed rate was found to be function of temperature and oxidant *** temperature and increasing persulfate concentration can significantly accelerate the PCA degradation.

关键词： Persulfate p-Chloroaniline Kinetics In situ chemical oxidation Temperature

A deep learning network for estimation of seismic local slopes

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Petroleum Science 2021年第1期18卷 92-105页

作者： wei-lin huang Fei Gao Jian-Ping Liao Xiao-Yu Chuai State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BeijingBeijing 102249China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology-BeijingBeijig 100083China Hunan Provincial Key Laboratory of Shale Gas Resource Utilization Hunan University of Science and TechnologyXiangtan 411201China Hebei Coal Research Institute Co. LtdJizhong Energy GroupXingtai 054000China

The local slopes contain rich information of the reflection geometry,which can be used to facilitate many subsequent procedures such as seismic velocities picking,normal move out correction,time-domain imaging and structural *** the slope estimation is achieved by manually picking or scanning the seismic profile along various *** present here a deep learning-based technique to automatically estimate the local slope map from the seismic *** the presented technique,three convolution layers are used to extract structural features in a local window and three fully connected layers serve as a classifier to predict the slope of the central point of the local window based on the extracted *** deep learning network is trained using only synthetic seismic data,it can however accurately estimate local slopes within real seismic *** examine its feasibility using simulated and real-seismic *** estimated local slope maps demonstrate the succes sful performance of the synthetically-trained network.

关键词： Deep learning Neural network Seismic data Local slopes

In situ chemical oxidation of aniline by persulfate with iron(Ⅱ) activation at ambient temperature

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Chinese Chemical Letters 2010年第8期21卷 911-913页

作者： Yong Qing Zhang wei lin huang Donna E.Fennell College of Environmental Science and Engineering South China University of TechnologyGuangzhou 510006China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou 510006China Department of Environmental Sciences RutgersThe State University of New JerseyNew BrunswickNJ 08901USA

The kinetics of aniline degradation by persulfate processes with iron（Ⅱ） activation at ambient temperature was investigated in this *** iron（Ⅱ） as initiator,the oxidation reactions were found to follow a biphasic rate phenomenon：a rapid transformation followed by a slow but sustained oxidation *** the first 30 s,the reaction mainly relies on the persulfate-Fe^（2＋） reaction in which aniline is oxidized *** 30 s,the aniline was still oxidized but the rate of reaction tended to be slower and the rates were clearly *** the initial fast oxidation,the reactions appeared to follow a pseudo-first-order model.

关键词： Persulfate Aniline In situ chemical oxidation

Automatic microseismic events detection using morphological multiscale top-hat transformation

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Petroleum Science 2022年第5期19卷 2027-2045页

作者： Guo-Jun Shang wei-lin huang Li-Kun Yuan Jin-Song Shen Fei Gao Li-Song Zhao State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BeijingBeijing102249China Department of Automation China University of Petroleum-BeijingBeijing102249China Hebei Coal Research Institute Company Ltd. Jizhong Energy GroupXingtaiHebei 054000China

The occurrence of microseismic is not random but is related to the physical properties of the underground *** to the low intensity and the influence of noise,microseismic eventually lead to poor signal-to-noise *** proposed a method for automatic detection of microseismic events by adoption of multiscale top-hat *** method is based on the difference between the signal and noise in the multiscale top-hat transform section and achieves the detection on a specific *** microseismic data are decomposed into different scales by multiscale morphology top-hat transformation *** the potential microseismic events could be detected by picking up the peak value in the multiscale top-hat section,and the characteristic profile obtains the start point with a specific threshold ***,the synthetic data experiences demonstrate the advantages of this method under strong and weak noisy conditions,and the filed data example also shows its reliability and adaptability.

关键词： Microseismic events detection Multiscale morphology Top-hat transformation

Local Hybrid linear State Estimation for Electric Power Systems Using Stream Processing

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1259-1268页

作者： Kang Sun Manyun huang Zhinong wei Yuzhang lin Guoqiang Sun College of Energy and Electrical Engineering Hohai UniversityNanjing 210098China Department of Department of Electrical and Computer Engineering University of Massachusetts LowellLowell MA 01854USA IEEE

The increasing penetration of renewable energy resources with highly fluctuating outputs has placed increasing concern on the accuracy and timeliness of electric power system state estimation(SE).Meanwhile,we note that only a fraction of system states fluctuate at the millisecond level and require to be *** such,refreshing only those states with significant variation would enhance the computational efficiency of SE and make fast-continuous update of states ***,this is difficult to achieve with conventional SE methods,which generally refresh states of the entire system every 4–5 *** this context,we propose a local hybrid linear SE framework using stream processing,in which synchronized measurements received from phasor measurement units(PMUs),and trigger/timingmode measurements received from remote terminal units(RTUs)are used to update the associated local ***,the measurement update process efficiency and timeliness are enhanced by proposing a trigger measurement-based fast dynamic partitioning algorithm for determining the areas of the system with states requiring *** particular,non-iterative hybrid linear formulations with both RTUs and PMUs are employed to solve the local SE *** timeliness,accuracy,and computational efficiency of the proposed method are demonstrated by extensive simulations based on IEEE 118-,300-,and 2383-bus systems.

关键词： Fast dynamic partitioning local hybrid linear state estimation phasor measurement units stream processing timeliness trigger/timing-mode measurements

Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying Xia Ming Sun Hai huang wei-lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

Aerodynamic/stealth design of S-duct inlet based on discrete adjoint method

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 725-746页

作者： Jun DENG Ke ZHAO lin ZHOU wei ZHANG Bowen SHU Jiangtao huang Zhenghong GAO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Aerospace Technology Institute of China Aerodynamic Research and Development CenterMianyang 621000Sichuan ProvinceChina

It is a major challenge for the airframe-inlet design of modern combat aircrafts,as the flow and electromagnetic wave propagation in the inlet of stealth aircraft are very *** this study,an aerodynamic/stealth optimization design method for an S-duct inlet is *** upwind scheme is introduced to the aerodynamic adjoint equation to resolve the shock wave and flow *** multilevel fast multipole algorithm(MLFMA)is utilized for the stealth adjoint equation.A dorsal S-duct inlet of flying wing layout is optimized to improve the aerodynamic and stealth *** the aerodynamic and stealth characteristics of the inlet are effectively ***,the optimization results are analyzed,and it shows that the main contradiction between aerodynamic characteristics and stealth characteristics is the centerline and crosssectional *** S-duct is smoothed,and the cross-sectional area is increased to improve the aerodynamic characteristics,while it is completely opposite for the stealth *** radar cross section(RCS)is reduced by phase cancelation for low frequency *** method is suitable for the aerodynamic/stealth design of the aircraft airframe-inlet system.

关键词： S-duct inlet aerodynamic/stealth optimization design discrete adjoint upwind scheme multilevel fast multipole algorithm(MLFMA)