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Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han Yan-Ting liu wei Huang Qi Wang Xin Xiong Ying Zhang Jian-Guo Zhao Shi-Hua li Xiao-Jiang li wei-li yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

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Italian Domination of Strong Product of Two Paths

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Chinese Quarterly Journal of Mathematics 2024年第3期39卷 221-234页

作者： wei li-yang li Feng Computer College Qinghai Normal UniversityXining 810000China

The domination problem of graphs is an important issue in the field of graph *** paper mainly considers the Italian domination number of the strong product between two *** constructing recursive Italian dominating functions,the upper bound of its Italian domination number is obtained,and then a partition method is proposed to prove its lower ***,this paper yields a sharp bound for the Italian domination number of the strong product of paths.

关键词： Partitioning approach Roman domination Italian domination Strong product

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Effects of ammonium exchange and Si/Al ratio on the conversion of methanol to propylene over a novel and large partical size ZSM-5

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Journal of Natural Gas Chemistry 2011年第3期20卷 261-265页

作者： Ruchao wei Chunyi li Chaohe yang Honghong Shan State Key Laboratory of Heavy Oil Processing China University of Petroleum Qingdao 266555 Shandong China

One type of ZSM-5 zeolite with large partical size was prepared and characterized by XRD, SEM, N2 adsorption-desorption, XRF, Py-IR and NH3-TPD techniques. Effects of ammonium exchange and SiO2/Al2O3 molar ratios on the reaction of methanol to propylene （MTP） over Na-ZSM-5 and H-ZSM-5 zeolites have been studied in a fixed-bed flow reactor under the operating conditions of T = 500 °C, P = 1 atm, and WHSV = 6 h-1. Ammonium exchange led to a rapid decrease in Na content for Na-ZSM-5 zeolite. The reaction results indicated that Na-ZSM-5 and H-ZSM-5 with different SiO2/Al2O3 molar ratios all exhibited high activity for methanol conversion. Ammonium exchange and the decreased SiO2/Al2O3 molar ratio of ZSM-5 zeolite led to an increase both in strong acid sites and weak acid sites. Na-ZSM-5 with high SiO2/Al2O3 molar ratio was favorable for the formation of propylene. The highest propylene selectivity （45.9%） was obtained over Na-ZSM-5 zeolite catalyst with SiO2/Al2O3 molar ratio of 220.

关键词： ZSM-5 MTP propylene ammonium exchange acidity

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Effect of Alloying on the Microstructure and Fracture Toughness of Nb-Mo-Si Alloys

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稀有金属材料与工程 2009年第A3期38卷 58-61页

作者： wei Qiang li yang Zheng lijing Ma Chaoli li Huanxi Beijing University of Aeronautics and Astronautics Beijing 100083 China

It was found that typical Nbss /Nb5Si3 eutectic lamellar structure formed in the Nb-Mo-Si alloy. The interface between Nbss and Nb5Si3 phases was so strong that the alloy fractured mainly in the cleavage mode. In this paper, the fourth element was added with the aim of modifying interface structure. The microstructural characterization and the fracture toughness of Nb-17Si-10Mo ternary alloy doped with Ga, In, Zn and V, respectively, were investigated. It was revealed that the lamellar structure maintained with the addition of Ga and In, whereas it changed slightly with Zn and V additions. Moreover, a little increase in fracture toughness of Nb-17Si-10Mo ternary alloy was obtained through the addition of Ga and Zn.

关键词：共晶层状结构铌钼硅合金物理性能结构分析

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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1357-1368页

作者： Miao-Miao Zhao wei-li yang Fang-Yuan yang li Zhang wei-Jin Huang wei Hou Chang-Fa Fan Rong-Hua Jin Ying-Mei Feng You-Chun Wang Jin-Kui yang Department of Endocrinology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Division of HIV/AIDS and Sex-Transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)BeijingChina Department of Science and Technology Beijing Youan HospitalCapital Medical UniversityBeijingChina Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijingChina

To discover new drugs to combat COVID-19,an understanding of the molecular basis of SARS-CoV-2 infection is urgently ***,for the first time,we report the crucial role of cathepsin L(CTSL)in patients with *** circulating level of CTSL was elevated after SARS-CoV-2 infection and was positively correlated with disease course and ***,SARS-CoV-2 pseudovirus infection increased CTSL expression in human cells in vitro and human ACE2 transgenic mice in vivo,while CTSL overexpression,in turn,enhanced pseudovirus infection in human *** functionally cleaved the SARS-CoV-2 spike protein and enhanced virus entry,as evidenced by CTSL overexpression and knockdown in vitro and application of CTSL inhibitor drugs in ***,amantadine,a licensed anti-influenza drug,significantly inhibited CTSL activity after SARS-CoV-2 pseudovirus infection and prevented infection both in vitro and in ***,CTSL is a promising target for new anti-COVID-19 drug development.

关键词： infection drugs ACE2

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Cold Simulation of Oxygen Transfer Rate in BOF

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Journal of Iron and Steel Research International 2010年第9期17卷 7-13页

作者： WU wei yang li-bin ZHENG Cong-jie liU liu Central Iron and Steel Research Institute Beijing 100081 China

By measuring the mass transfer coefficient of benzoic acid between water and oil, the oxygen transfer rate in BOF bath was researched, and the influence of top and bottom blowing gas flow rate on the mass transfer between metal and slag was discussed. The results show that with increasing the bottom blowing gas flow rate under the conditions of fixed top blowing, the mass transfer rate evidently increases, and the influence of fixed top blowing on the mass transfer is 10% of bottom blowing. The stirring intensity was determined as a function of top blowing gas flow rate, bottom blowing gas flow rate, and lance height. The equation of the mass transfer coefficient between metal and slag was established. The relationship between the emulsification ratio of oil to water and the bottom blowing gas flow rate under the conditions of top and bottom blowing was obtained. The result shows that with the increase in the bottom blowing gas flow rate, the emulsification ratio increases linearly, which increases the mass transfer rate of benzoic acid between water and oil.

关键词： oxygen transfer rate slag-metal reaction cold simulation stirring intensity

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Metallurgical performance evaluation of space-weathered Chang’e-5 lunar soil

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1241-1248页

作者： Chen li Wenhui Ma yang li Kuixian wei Center for Lunar and Planetary Sciences Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China

Space metallurgy is an interdisciplinary field that combines planetary space science and metallurgical *** involves systematic and theoretical engineering technology for utilizing planetary resources in ***,space metallurgy on the Moon is challenging because the lunar surface has experienced space weathering due to the lack of atmosphere and magnetic field,making the mi-crostructure of lunar soil differ from that of minerals on the *** this study,scanning electron microscopy and transmission electron microscopy analyses were performed on Chang’e-5 powder lunar soil *** microstructural characteristics of the lunar soil may drastically change its metallurgical *** main special structure of lunar soil minerals include the nanophase iron formed by the impact of micrometeorites,the amorphous layer caused by solar wind injection,and radiation tracks modified by high-energy particle rays inside mineral *** nanophase iron presents a wide distribution,which may have a great impact on the electromagnetic prop-erties of lunar *** ions injected by solar wind may promote the hydrogen reduction *** widely distributed amorph-ous layer and impact glass can promote the melting and diffusion process of lunar ***,although high-energy events on the lun-ar surface transform the lunar soil,they also increase the chemical activity of the lunar *** is a property that earth samples and tradi-tional simulated lunar soil *** application of space metallurgy requires comprehensive consideration of the unique physical and chemical properties of lunar soil.

关键词： space metallurgy Chang’e-5 lunar soil space weathering metallurgical performance

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Nonlinear dynamic analysis of a rotor/bearing/seal system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第1期12卷 46-55页

作者： wei li Yi yang De-ren SHENG Jian-hong CHEN Yong-qiang CHE Department of Energy Engineering Zhejiang University Hangzhou 310027 China

In this study a new dynamic model of a rotor system is established based on the Hamilton principle and the finite element method (FEM). We analyze the dynamic behavior of the rotor system with the coupled effects of the nonlinear oil film force, the nonlinear seal force, and the mass eccentricity of the disk. The equations of the motion are solved effectively using the fourth order Runge-Kutta method in MATLAB. The dynamic behavior of the system is illustrated by bifurcation diagrams, largest Lyapunov exponents, phase trajectory diagrams, and Poincaré maps. The numerical results show that the rotational speed of the rotor, the pressure drop in the seal, the seal length, the seal clearance, and the mass eccentricity of the disk are the key parameters that significantly affect the dynamic characteristics of the rotor system. The motion of the rotor system exhibits complex types of periodic, quasi-periodic, double-periodic, multi-periodic, and chaotic vibrations. This analysis can be used to guide the design of seal parameters and to diagnose the vibration of rotor/bearing/seal systems.

关键词： Nonlinear Rotor system Hamilton principle Dynamic Finite element method (FEM)

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Preparation and Characterization of Microcapsules for Self-healing Materials

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Chemical Research in Chinese Universities 2010年第3期26卷 496-500页

作者： liAO Le-ping ZHANG wei ZHAO yang li Wu-Jun National Key Laboratory for Remanufacturing Academy of Armored Force Engineering Beijing 100072 P. R. China

The urea-formaldehyde（UF） capsules filled with a healing agent, a mixture of epoxy resins（epoxy 711 and E-51） as core material, were produced by means of one step in-situ polymerization. The characteristics of these microcapsules were studied via scanning electron microscopy（SEM）, particle size analysis, FTIR and DSC/TGA. The results show that the dispersed and integrated microcapsules of 5 μm in shell thickness were synthesized successfully. The capsules were produced with diameters ranging from 10 to 250 μm via controlling agitation rate. Young＇s modulus of the capsule was a little lower than those of the epoxy resins, but the microcapsules having such a shell thickness were robust enough to survive handling during manufacturing self-healing composites. When damage occurred in the epoxy matrix, the crack could rupture the microcapsule to make the repairing agent release.

关键词： Urea-formaldehyde Microcapsule Epoxy resin Self-healing

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Pd/C-catalyzed selective reduction of aromatic azides with Hantzsch 1,4-dihydropyridine

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Chinese Chemical Letters 2008年第8期19卷 885-888页

作者： Zhen Gang liu Xiu Qin Niu wei Yu li yang Zhong li liu State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

The reagent combination of Hantzsch 1,4-dihydropyridine and Pd/C was found to be an efficient reducing system for the selective reduction of aromatic azides.

关键词： Reduction Hantzsch 1,4-dihydropyridine Pd/C Aromatic azides

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