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Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin chen Shui-Dan Xu Min-Hua Deng Shi-Hui Hao jie-wei chen Xiao-Dan Ma wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

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Clinical characteristics and risk factors of post-operative intestinal flora disorder following laparoscopic colonic surgery:A propensityscore-matching analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1259-1270页

作者： Gan-Bin Li chen-Tong Wang Xiao Zhang Xiao-Yuan Qiu wei-jie chen Jun-Yang Lu Lai Xu Bin Wu YiXiao Guo-Le Lin Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China

BACKGROUND Intestinal flora disorder(IFD)poses a significant challenge after laparoscopic colonic surgery,and no standard criteria exists for its diagnosis and *** To analyze the clinical features and risk factors of *** Patients with colon cancer receiving laparoscopic surgery were included using propensity-score-matching(PSM)*** on the occurrence of IFD,patients were categorized into IFD and non-IFD *** clinical characteristics and treatment approaches for patients with IFD were *** regression analysis was performed to identify the risk factors of *** The IFD incidence after laparoscopic surgery was 9.0%(97 of 1073 patients).After PSM,97 and 194 patients were identified in the IFD and non-IFD groups,*** most common symptoms of IFD were diarrhea and abdominal,typically occurring on post-operative days 3 and *** patients were managed conservatively,including modulation of the intestinal flora(90.7%),oral/intravenous application of vancomycin(74.2%),and insertion of a gastric/ileus tube for decompression(23.7%).Multivariate regression analysis identified that preoperative intestinal obstruction[odds ratio(OR)=2.79,95%CI:1.04–7.47,P=0.041]and post-operative antibiotics(OR=8.57,95%CI:3.31–23.49,P<0.001)were independent risk factors for IFD,whereas pre-operative parenteral nutrition(OR=0.12,95%CI:0.06–0.26,P<0.001)emerged as a protective *** A stepwise approach of probiotics,vancomycin,and decompression could be an alternative treatment for *** attention is warranted post-operatively for patients with pre-operative obstruction or early use of antibiotics.

关键词： Colon cancer,Laparoscopy Intestinal flora disorder Clinical characteristics Risk factors

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Uncertainty of temperature rise under nationally determined contributions and carbon neutral policies

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气候变化研究进展:英文版 2023年第4期14卷 580-586页

作者： jie-wei chen Hui-Juan CUI Nan chen Guo-Qiang QIAN Key Laboratory of Land Surface Pattern and Simulation Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Sino Carbon Innovation&Investment Co. Ltd.Beijing 100007China

Nationally determined contributions raised by Paris Agreement aim to control the temperature rise below 2°C or even 1.5°C at the end of the 21st century,compared to pre-industrial ***,the climate response of the Nationally Determined Contributions(NDCs)remains uncertain due to unstable policies and their *** this study,we calculated the uncertainty of global temperature rise caused by uncertain NDCs and carbon-neutral policies and discussed the difficulty of policy *** results show that there will be 8 GtC uncertainty in emission at the end of the 21st century,responsible for the temperature rise of 0.37°C(1.73–2.10°C).A delayed policy in emission reduction by major emitters would result in a temperature rise of over 2°C,while under non-delay policy,the 2°C target will be possibly ***,low-emission countries would introduce a 30 GtC cumulative emission uncertainty at the end of the 21st century if there are no restrictions,leading to a 0.3°C global warming *** countries need more substantial reductions in carbon intensity to achieve their climate policies while developing countries are under less *** reduction of carbon intensity requires the strengthening of technical and economic *** study provides a reference for the realization of emission policies and temperature rise targets.

关键词： Uncertainty Temperature rise Nationally determined contribution Carbon neutrality Carbon emission intensity

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Controlled Microstructure and Photochromism of Inorganic-organic Thin Films by Ultrasound

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Journal of Materials Science & Technology 2007年第4期23卷 477-480页

作者： Yanhua PANG wei FENG jie chen Yan LIU weimin CAI College of Environmental Science and Engineering Dalian Maritime University Dalian 116026 China

A series of inorganic-organic thin films based on uniformly dispersed nanoparticles of polyoxometalates （POM）entrapped in polyacrylamide （PAM） matrix were prepared by ultrasonic method with different irradiation *** microstructure, photochromic behavior and mechanism of the films were studied by transmission electron microscopy （TEM）, ultraviolet-visible spectra （UV-VIS） and Fourier transform-infrared spectroscopy （FT-IR）.The microstructure and photochromic properties of the hybrid thin films could be controlled by *** image revealed that the average size of phosphotungstic acid （PWA） nanoparticles decreased from 20 to 10 nm with the ultrasound irradiation time from 30 to 60 min. After irradiated with ultraviolet light,the transparent films changed from colorless to blue and showed reversible photochromism. The hybrid film, with ultrasound irradiation for 60 min had higher photochromic efficiency and faster bleaching reaction than the one with ultrasound irradiation for 30 min. FT-IR spectra showed that the Keggin geometry of heteropolyoxometalate was still preserved inside the composites, and the interactions between polyanions and polymer matrix increased as the ultrasound time prolonged. It is suggested that the mechanism of the different photochromic properties for the inorganic-organic thin films is the variation of the microstructure and interfacial interactions induced by ultrasound.

关键词： Inorganic-organic Thin Films sonochemical controlled microstruture photochromism

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Analysis of the Cellular Localization of Herpes Simplex Virus 1 Immediate-early Protein ICP22

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Virologica Sinica 2010年第3期25卷 158-167页

作者： wei CUN jie chen Ying ZHANG Long-ding LIU Qi-han LI Institute of Medical Biology Chinese Academy of Medical Sciences Peking Union Medical College Kunming 650118 China

Nuclear proteins often form punctiform structures, but the precise mechanism for this process is unknown. As a preliminary study, we investigated the aggregation of an HSV-1 immediate-early protein, infected-cell protein 22 （ICP22）, in the nucleus by observing the localization of ICP22-EGFP fusion protein Results showed that, in high-level expression conditions, ICP22-EGFP gradually concentrates in the nucleus, persists throughout the cell cycle without disaggregation even in the cell division phase, and is finally distributed to daughter cells. We subsequently constructed a mammalian cell expression system, which had tetracycline- dependent transcriptional regulators. Consequently, the location of ICP22-EGFP in the nucleus changed with distinct induction conditions. This suggests that the cellular location of ICP22 is also influenced by promoter regulation, in addition to its own structure. Our findings provide new clues for the investigation of transcriptional regulation of viral genes. In addition, the non-protease reporter system we constructed could be utilized to evaluate the role of intemal ribosome entry sites （IRES） on transcriptional regulation.

关键词： Herpes Simplex Virus 1 (HSV-1) ICP22 Transcriptional regulation Cellular localization Nuclear functional domain

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Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

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BIOCELL 2024年第7期48卷 1105-1113页

作者： CHUNLING LIANG JING chen XIAOjie chen wei YAN jie YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of Cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy ***ﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac ***:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁ***:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HCFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁ*** the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(ChIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was ***:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HCFs upon Ang II ***5B bound to the TREM1 promoter and upregulated its transcriptional ***,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 ***:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁ***ﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： Cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation

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JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1043-1045页

作者： Shu-Man Li Li-Ru He jie-wei chen jie Zhou Run-Cong Nie Xiao-Han Jin Xin Wang Jian-Hua Fu Feng-wei Wang Dan Xie State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouPR China Department of Medical Oncology Henan Cancer Hospitalthe Affiliated Cancer Hospital of Zhengzhou UniversityHenanPR China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouPR China Guangdong Esophageal Cancer Institute GuangzhouPR China

Dear Editor,Esophageal squamous cell carcinoma(ESCC)is a common cancer worldwide with a 5-year survival rate less than 25%.Reliable molecular markers that could serve as predictors for diagnosis and treatment for ESCC patients are greatly *** dysregulation of epigenetic control is one of the common features in ***3 is a histone demethylase specific for H3K27me3/me2 that switches a gene from its repressive state to an active form.1 The dysregulation of JMJD3 is reported to play key roles in many cancer ***,JMJD3 was reported to be overexpressed in ESCC,2 but the potential mechanism of JMJD3 in ESCC remains poorly understood.

关键词： JMJD3 squamous epigenetic

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Efficacy of scleral-fixated 3-looped haptics intraocular lens implantation for surgical management of microspherophakia

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1944-1950页

作者： Xue-Wen Yu Xian Ge wei-jie chen Shuang Ni Xue-Qi Lin Si-Ting Sheng Dan chen Wen Xu Eye Center of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Ophthalmology the First People’s Hospital of Xiaoshan DistrictXiaoshan Affiliated Hospital of Wenzhou Medical UniversityHangzhou 311200Zhejiang ProvinceChina Jianyang Eye Hospital of Jianhu County Yancheng 224700Jiangsu ProvinceChina

AIM:To evaluate the safety and efficacy of scleral-fixated 3-looped haptics intraocular lens(IOL)implantation for surgical management of ***:A retrospective case series include 10 microspherophakic patients(15 eyes)who underwent lens removal plus a modified surgical treatment of scleral-fixated 3-looped haptics IOL *** primary outcomes involved visual acuity,intraocular pressure(IOP).Secondary outcomes were spherical equivalent(SE),anterior chamber depth(ACD),corneal endothelial cell density and postoperative ***:After a postoperative follow-up of 17.60±15.44mo,improved visual outcomes can be *** uncorrected distance visual acuity(UCVA)log MAR improved from 1.54±0.59 preoperatively to 0.51±0.35 postoperatively(P=0.001),and best corrected visual acuity(BCVA)log MAR improved from 0.97±0.91 preoperatively to 0.24±0.23 postoperatively(P=0.003).Moreover,the SE decreased from-9.58±7.47D preoperatively to-0.65±2.21 D postoperatively(P<0.001).In terms of safety profile,the average IOP decreased from 21.10±12.94 mm Hg preoperatively to 14.03±3.57 mm Hg postoperatively(P=0.044),and the previously elevated IOP of three eyes decreased to the normal *** ACD increased from 2.25±1.45 mm preoperatively to 3.35±0.39 mm postoperatively(P=0.017).The density of corneal endothelial cells did not change significantly after surgery(P=0.140).The posterior chamber IOLs were well centered and no severe complications were ***:Lens removal plus the modified surgical treatment of scleral-fixated 3-looped haptics IOL implantation can help in improvement of visual acuity,which can be regarded as a relative safe method for the surgical management of microspherophakia.

关键词： microspherophakia transscleral suture fixation 3-looped haptics intraocular lens

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Texture and Se vacancy optimization induces high thermoelectric performance in Bi_(2)Se_(3) flexible thin films

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Rare Metals 2024年第6期43卷 2796-2804页

作者： Dong-wei Ao wei-Di Liu Yue-Xing chen Fan Ma Yi-jie Gu Zhuang-Hao Zheng School of Machinery and Automation Weifang UniversityWeifang 261061China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbane 4072Australia Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China

Bi_(2)Se_(3)-based flexible thin film with high thermoelectric performance is promising for the waste heat recovery *** this work,a novel post-selenization method is employed to prepare n-type Bi_(2)Se_(3)flexible thin films with highly textured *** strengthened texture and Se vacancy optimization can be simultaneously achieved by optimizing the selenization *** highly oriented texture leads to the increased carrier mobility and results in a high electric conductivity of~290.47 S·cm^(-1)at 623 ***,a high Seebeck coefficient(>110μW·K-1)is obtained due to the reduced carrier concentration,induced by optimizing vacancy ***,a high power factor of 3.49μW·cm^(-1)·K^(-2)at 623 K has been achieved in asprepared highly-bendable Bi_(2)Se_(3)flexible thin films selenized at 783 *** study introduces an effective post-selenization method to tune the texture structure and vacancies of Bi_(2)Se_(3)flexible thin films,and correspondingly achieves high thermoelectric performance.

关键词： Thermoelectric Bi_(2)Se_(3) Flexible thin film Post-selenization

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A robust genomic-based prognostic model for the assessment ofcancer stemness and survival for patients with hepatocellularcarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 97-102页

作者： cheng-Li Du Shen-Yu wei Yun-Hao chen Kang-jie chen Division of Thoracic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang University School of Medicine Hangzhou 310003China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Hepatocellular carcinoma(HCC)is an aggressive malignancy with poor long-term prognosis[1].Liver cancer stem cell(CSC)can drive the metastasis,drug resistance,and recurrence of HCC[2].The regulatory mechanisms about liver cancer stemness have been investigated,which encouraged the identification and characterization of novel prognostic and therapeutic strategies for HCC[3].

关键词： cancer prognosis Liver

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