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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo Bin Feng Min liu Fan Zheng Shuang Huang Yanpeng fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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米糠蛋白提取、改性及在食品加工中的应用

食品与发酵工业 2025年第1期51卷 363-372页

作者：刘芳韩伟郭超张颖张维清刘玉春王超上海理工大学健康科学与工程学院上海200093 国家粮食和物资储备局科学研究院北京100037

米糠是稻谷加工过程中的主要副产物之一,产量大、营养价值丰富,蛋白质含量高出普通精米的一倍,是一种极具开发潜力的高附加值资源。从中提取的蛋白质含氨基酸种类齐全、过敏性低、生物效价高且具有多种生理活性,是优质的植物性蛋白,可... 详细信息

米糠是稻谷加工过程中的主要副产物之一,产量大、营养价值丰富,蛋白质含量高出普通精米的一倍,是一种极具开发潜力的高附加值资源。从中提取的蛋白质含氨基酸种类齐全、过敏性低、生物效价高且具有多种生理活性,是优质的植物性蛋白,可用来弥补蛋白质资源的缺乏。但目前米糠蛋白的提取效率低、成本高,导致加工利用水平不高。该文综述了米糠蛋白的提取和改性技术,比较了不同提取方法对米糠蛋白含量和提取率的影响以及不同改性方法对米糠蛋白乳化性、起泡性、溶解性等功能特性的影响,简述了米糠蛋白在食品加工行业的应用情况,展望了生物发酵法、组合法高效提取并改性米糠蛋白的研究前景以及米糠蛋白在食品、药品领域的应用前景,旨在提高米糠的综合利用率,为米糠蛋白的生产、加工提供一些思路和参考。

关键词：米糠蛋白发酵改性应用食品加工

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A self-adaptive inorganic in-situ separator by particle crosslinking for nonflammable lithium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 469-480页

作者： Jiarui Yang Jiuzhou liu Wenrui Cai Ziyu Zhao Shan Wang Lu He Shanshan Lv Zhiwei Zhu Zhongfeng Ji Guojiang Wen Hua Li Yuanming Zhai Xuewei Fu wei Yang Yu Wang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University

All-safe liquid-state lithium-ion batteries(ASLS-LIBs) is of great interest as they can potentially combine the safety of all-solid-state batteries with the high performance and low manufacturing cost of traditional liquid-state LIBs. However, the practical success of ASLS-LIBs is bottlenecked by the lack of advanced separator technology that can simultaneously realize high performances in puncturing-tolerability,fire-resistance, and importantly, wetting-capability with non-flammable liquid-electrolytes. Here, we propose a concept of inorganic in-situ separator(IISS) by hybrid-sol physical crosslinking directly onto the electrode surface to address the above challenges. Particularly, the hybrid-sol is designed with silica nanoparticles as the building block and poly(vinylidene difluoride) nanoparticles as the crosslinking agent. The critical factors for controlling the IISS microstructures and properties have been systematically investigated. The advantages of the IISS have been confirmed by its fast wetting with various fireresistant liquid-electrolytes, customizable thickness and porous structures, robust interface with planar or three-dimensional(3D)-structured electrodes, and importantly, unexpected self-adaptability against puncturing. Enabled by the above merits, a fire-resistant ASLS-LIB is successfully assembled and demonstrated with stable electrochemical performance. This sol-crosslinked IISS may open an avenue for the studies on the next-generation separator technology, cell assembling, solid electrolyte processing as well as non-flammable secondary batteries.

关键词： Silica nanoparticles

Engineering N3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2025年

作者： Yina Nie weijie Yang Xin Wang Xiang Li Lele wei Xiaolin Bai Lin liu Feng Fu Jun Wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3N4（M1U3CN） photocatalyst with bridged N3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3Cvacancies and abundant micromeso-macroporous distribution in M1U3CN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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北京奶牛产业链利润分配机制研究

中国畜牧杂志 2016年第20期52卷 6-11页

作者：陈吉铭王琛何忠伟刘芳何向育北京农学院经济管理学院北京102206

本文立足北京市奶牛产业链发展情况,通过走访和追踪调研,从北京市奶牛产业链运行涉及的奶牛养殖、乳制品加工和乳制品销售3个重要环节,对北京市奶牛产业链利润分配现状进行分析研究,并提出优化北京市奶牛产业链利润分配机制的对策建议,... 详细信息

本文立足北京市奶牛产业链发展情况,通过走访和追踪调研,从北京市奶牛产业链运行涉及的奶牛养殖、乳制品加工和乳制品销售3个重要环节,对北京市奶牛产业链利润分配现状进行分析研究,并提出优化北京市奶牛产业链利润分配机制的对策建议,以期增强北京市奶牛产业链的稳定性,更好地保障首都乳制品的高质量供给,推动北京市乳制品产业的健康持续发展。

关键词：奶牛产业链利润分配机制

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Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

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Science China Chemistry 2025年

作者： Xinyu Xu Yuan Ma Hui Cao Li Xu Haoming Chen Sulai liu wei Sun Guosheng Song Xiaobing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Department of Hepatobiliary Surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University Shenzhen Research Institute of Hunan University

Atherosclerosis(AS) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with AS is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

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第二次国际印度洋科学考察计划(IIOE-2)介绍

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海洋科学进展 2017年第1期35卷 1-7页

作者：于卫东方越刘琳王永刚周磊邱云杜岩国家海洋局第一海洋研究所山东青岛266061 青岛海洋科学与技术国家实验室区域海洋动力学与数值模拟功能实验室山东青岛266061 国家海洋局第二海洋研究所浙江杭州310012 国家海洋局第三海洋研究所福建厦门361005 中国科学院南海海洋研究所广东广州510301 热带海洋环境国家重点实验室广东广州510301

为纪念首次国际印度洋科学考察计划(International Indian Ocean Expedition,IIOE)成功实施50周年,进一步推动印度洋多学科交叉的新认识,政府间海洋学委员会(Intergovernmental Oceanographic Commission,IOC)、国际海洋研究科学委员会(Scientific Committee on Oceanic Research,SCOR)和印度洋全球海洋观测系统计划(Indian Ocean Global Ocean Observing System,IOGOOS)在2015年联合启动了第二次国际印度洋科学考察计划(Second International Indian Ocean Expedition,IIOE-2,2015—2020年)。本文简要回顾了首次IIOE的发起、实施和主要成果,介绍了IIOE-2的主要内容和我国的优先参与方向,呼吁我国科学家将IIOE-2与我国"一带一路"倡议相结合,更加积极地参与IIOE-2国际合作,推动在印度洋环流与气候、海洋生态系统与可持续发展、地球生物化学循环、海底科学等领域取得新的科学进展。

关键词：印度洋国际合作考察学科交叉

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu wei Jia-wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Ni-catalyzed cross-electrophile alkyl-alkyl coupling reactions

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Science China Chemistry 2025年

作者： Li-Xu You Lan Tian Chun-Ling Guo Shun-Xi Li Yu-Cheng liu Yu-Long Li wei Shu College of Chemistry and Environmental Engineering Key Laboratory of Green Catalysis of Higher Education Institutes of Sichuan Sichuan University of Science and Engineering Guangming Advanced Research Institute Shenzhen Grubbs Institute Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology

Introducing saturated carbon-carbon bonds into organic molecules significantly increases the three-dimensional configuration,thus altering the physical and chemical properties as well as the functions of molecules. Transition-metal-catalyzed carboncarbon cross-couplings represent one of the most straightforward, efficient and modular alternatives to build saturation in a single step. However, the efficient construction of alkyl-alkyl bonds remains a formidable challenge due to the precise manipulation of multiple alkyl metallic intermediates as well as associated competitive side reactions and selectivity control. Over the past years, Ni-catalyzed cross-coupling under reductive conditions has gained more and more attention for alkyl-alkyl crosscoupling partially attributing to the low-valent state of metal centers under reducing conditions, which suppresses the competitive β-hydride elimination process, thus facilitating the formation of alkyl-alkyl bonds. In this review, the initiative and progress of Ni-catalyzed cross-electrophile alkyl-alkyl cross-coupling, including the efforts in racemic and enantioselective formation of alkyl-alkyl bonds, have been summarized and discussed. Moreover, the challenges and further opportunities in this area have also been discussed.

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