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Drug-induced erythroderma in patients with acquired immunodeficiency syndrome

World Journal of Emergency Medicine 2021年第4期12卷 299-302页

作者： wei-fang zhu De-ren fang Hong fang Department of Dermatology the First Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310003China

BACKGROUND: To explore the clinical manifestations, diagnosis, and treatment of patients with acquired immunodeficiency syndrome(AIDS) complicated with drug-induced ***: The clinical data of 12 AIDS patients with drug-induced erythroderma in our hospital were retrospectively analyzed. The general information, offending medications, complications, modified severity-of-illness score for toxic epidermal necrolysis(SCORTEN) scores, and disease outcome spectrums were ***: Drug-induced erythroderma was mostly caused by antiviral drugs, antituberculosis drugs, antibiotics, traditional Chinese medicine, and immune checkpoint inhibitors. The spectrum of sensitizing drugs was broad, the clinical situation was complex, and infections were common. The affected areas were greater than 40% body surface area in all patients. The modified SCOTERN score averaged 3.01±0.99. All patients were treated with glucocorticoids, and nine patients were treated with intravenous immunoglobulin(IVIG) pulse therapy at the same time. The average time to effectiveness was 7.08±2.23 days, and the average hospital stay was 17.92±8.46 days. Eleven patients were cured, and one patient died of secondary multiple infections, who had a modified SCORTEN score of 5 points. The mortality rate in this study was 8.3%.CONCLUSIONS: The clinical situation of AIDS patients with drug-induced erythroderma in hospitalized patients is complex and the co-infection rate is high. The use of modified SCORTEN score may objectively and accurately assess the conditions, and the use of glucocorticoid combined with IVIG therapy may improve the prognosis.

关键词： Acquired immunodeficiency syndrome Drug eruption Erythroderma Modified severity-of-illness score for toxic epidermal necrolysis

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Survey on skin aging status and related influential factors in Southeast China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第1期10卷 57-66页

作者： Yi-na WANG Hong fang wei-fang zhu Department of Dermatology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate cutaneous aging patterns of residents in Hangzhou, Zhejiang, China, and their contributing factors. Methods： Eight hundred and forty-eight Hangzhou residents received the survey between March 2004 and September 2004. Results： Facial wrinkling first occurred at 21 years of age and skin elasticity began to lose at 22 years of age. In middle-aged and old people, facial wrinkling and looseness escalated with the increase of ultraviolet （UV）-exposure time, indicating the accelerating effect of a higher accumulative dose of UV radiation on skin aging. Only Fitzpatrick types Ⅱ, Ⅲ and Ⅳ were found in the skin phototypes of residents in Hangzhou area, and Fitzpatrick type Ⅱ seemed to be much more subject to severe wrinkling, elasticity destruction and skin tumors than types Ⅲ and Ⅳ. The oily skin was more protected against wrinkling and facial looseness than dry skin. However, as to concomitant cutaneous diseases, no difference was found among different skin types. Conclusion： Age, solar-exposure time, Fitzpatrick type and skin type are the associated forces in promoting skin aging, and emotional factor seems to be another independent risk factor. The age of 49 years and 2 h/d of solar-exposure time seem to be the turning points responsible for dramatic changes of cutaneous appearance in the process of skin aging in Southeast China.

关键词： Skin aging Influential factor Fitzpatrick type Solar exposure Skin type Concomitant facial disease

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Glucagonoma syndrome with necrolytic migratory erythema as initial manifestation

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 598-600页

作者： wei-fang zhu Shu-Sen Zheng Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Necrolytic migratory erythema(NME)is a group of cutaneous lesions characterized by periodic episodes of annular or figurative dark red plaques,which are typically accompanied by blisters,erosions,and *** is often associated with *** is an extremely rare neuroendocrine tumor that arises from pancreatic isletαcells and manifests as elevated glucagon,with an incidence of about 1 in 20 million per year[1,2].

关键词： erythema elevated islet

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Pancreatic panniculitis as the first presentation of pancreatic ductaladenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 106-108页

作者： wei-fang zhu Shan fang Jian-Jun Qiao Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Pancreatic panniculitis,also known as pancreatic fat necrosis or enzymatic panniculitis,is a rare type of panniculitis that occurs in 0.3%−3%of patients with pancreatic disease such as acute or chronic pancreatitis and pancreatic carcinoma,especially acinar cell carcinoma[1,2].The clinical manifestations are nonspecific erythema tender nodules.

关键词： Pancreatic acute adenocarcinoma

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RBBP4 promotes colon cancer malignant progression via regulating Wnt/β-catenin pathway

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World Journal of Gastroenterology 2020年第35期26卷 5328-5342页

作者： Yan-Dong Li Zhen Lv wei-fang zhu Division of Colon and Rectal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Surgery Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Division of Dermatology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Our previous study demonstrated that RBBP4 was upregulated in colon cancer and correlated with poor prognosis of colon cancer and hepatic ***,the potential biological function of RBBP4 in colon cancer is still *** To investigate the biological role and the potential mechanisms of RBBP4 in colon cancer *** Real-time polymerase chain reaction and western blot analysis were used to detect the expression of RBBP4 in colon cancer cell *** cell proliferation and viability of SW620 and HCT116 cells with RBBP4 knockdown was detected by Cell Counting Kit-8 and 5-ethynyl-2’-deoxyuridine *** transwell assay was used to detect the invasion and migration capabilities of colon cancer cells with RBBP4 *** cytometry apoptosis assay was used to detect the apoptosis of colon cancer *** blotting analysis was used to detect the expression of epithelial-mesenchymal transition and apoptosis related markers in colon *** nuclear translocation ofβ-catenin was examined by Western blotting analysis in colon cancer cells with RBBP4 *** TOPFlash luciferase assay was used to detect the effect of RBBP4 on Wnt/β-catenin *** rescue experiments were performed in colon cancer cells treated with Wnt/β-catenin activator LiCl and RBBP4 *** We found that RBBP4 was highly expressed in colon cancer cell *** 5-ethynyl-2’-deoxyuridine assay showed that knockdown of RBBP4 significantly inhibited cell ***4 inhibition reduced cell invasion and migration via regulating proteins related to epithelial-mesenchymal *** of RBBP4 significantly inhibited survivin-mediated ***,the TOPFlash assay showed that RBBP4 knockdown increased activity of the Wnt/β-catenin ***,RBBP4 knockdown suppressed nuclear translocation ofβ-*** Wnt/β-catenin activator,rescue experiments suggested that the role of RBBP4 in colon cancer

关键词： Colon cancer Wnt/β-catenin RBBP4 Epithelial-mesenchymal transition Apoptosis Invasion

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Correlation between invasive microbiota in margin-surrounding mucosa and anastomotic healing in patients with colorectal cancer

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 717-728页

作者： Yan-Dong Li Kang-Xin He wei-fang zhu Division of Colon and Rectal Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Division of Dermatology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Impaired anastomotic healing is one of the major complications resulting from radical resection in colorectal cancer(CRC).Accumulating evidence suggests that intestinal microbiota is correlated with anastomotic *** To explore the microbiota structural shift in margin-surrounding mucosa and evaluate the predictive ability of selected bacterial taxa for impaired anastomotic *** Margin-surrounding mucosa samples derived from 37 patients were collected to characterize the microbial community structure by 16 s r RNA gene *** patients were divided into two groups according to the healing status of anastomoses:well-healing group(n=30)and impaired-healing group(n=7).Statistic differences in bacteria taxa were compared by Wilcoxon test and chisquared *** predictive ability of the selected bacterial taxa for the healing status of anastomoses was evaluated by the area under the receiver operator characteristic *** Community structure shifts were observed in the impaired-healing group andwell-healing *** bacterial species were found to be significantly correlated with anastomotic healing,and among these species,Alistipes shahii,Dialister pneumosintes,and Corynebacterium suicordis were considered as the predictive *** the known risk factor age into consideration,Alistipes shahii,Dialister pneumosintes,and Corynebacterium suicordis improved predictive ability for the healing status of *** These data show that Alistipes shahii,Dialister pneumosintes,and Corynebacterium suicordis could be considered as supplementary factors in the prediction of anastomosis healing status in patients after CRC radical resection.

关键词： Intestinal microbiota 16s rRNA gene sequencing Anastomotic healing Predictive ability Colorectal cancer Radical resection

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Monkeypox presenting as a chancre-like rash:A case report

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World Journal of Clinical Cases 2023年第25期11卷 6025-6030页

作者： wei-fang zhu Shu-Juan Song Lin-wei wei Jian-Jun Qiao Division of Dermatology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Hangzhou Center of Disease Control and Prevention Hangzhou Center of Disease Control and PreventionHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Since May 2022,outbreaks of monkeypox have occurred in many countries around the world,and several cases have been reported in *** SUMMARY A 38-year-old man presented with a small,painless,shallow ulcer on the coronary groove for 8 *** day after the rash appeared,the patient developed inguinal lymphadenopathy with *** patient had a history of male-male sexual activity and denied a recent history of travel *** virus was detected by quantitative polymerase chain reaction from the rash site and throat *** on the epidemiological history,clinical manifestations and nucleic acid test results,the patient was diagnosed with *** Monkeypox is an emerging infectious disease in *** presenting as a chancre-like rash is easily *** can be made based on exposure history,clinical manifestations and nucleic acid test results.

关键词： Monkeypox Chancre-Like rash China Case report

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Application of 4% formaldehyde under electronic colonoscope as a minimally invasive treatment of chronic hemorrhagic radiation proctitis

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World Journal of Emergency Medicine 2019年第4期10卷 228-231页

作者： Yan-dong Li Jia-he Xu Jian-jiang Lin wei-fang zhu Division of Colon&Rectal Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

BACKGROUND: To investigate the effectiveness of topical application of 4% formaldehyde as a minimally invasive treatment of rectal bleeding due to chronic radiation proctitis(CRP) under direct vision of electronic ***: The clinical data of 13 CRP patients complicated with ≥ grade Ⅱ bleeding admitted to our hospital between January 2003 and December 2018 were retrospectively analyzed. Under the guidance of electronic colonoscope,4% formaldehyde combined with 5-aminosalicylic acid(5-ASA) suppositories was topically applied. Patients were followed up for two months after treatment,and the therapeutic effectiveness was observed and ***: The rectal bleeding due to CRP was markedly reduced after topical application of 4% formaldehyde under colonoscope in all 13 patients. The bleeding stopped after one treatment session in 11 patients and after the second session in 2 patients. 5-ASA was also applied along with the use of 4% formaldehyde. The therapeutic effectiveness was satisfactory during the 1-and 2-month follow-up ***: Topical application of 4% formaldehyde under the direct vision of colonoscope as a minimally invasive treatment for CRB-induced bleeding is a simple,effective,affordable,and repeatable technique without obvious complications,which deserves further exploration and promotion.

关键词： Radiation proctitis Rectal bleeding Formaldehyde

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Excisional hemorrhoidal surgery and its effect on anal continence

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World Journal of Gastroenterology 2012年第30期18卷 4059-4063页

作者： Yan-Dong Li Jia-He Xu Jian-Jiang Lin wei-fang zhu Department of Surgery School of Medicine First Affiliated Hospital Zhejiang University Hangzhou 310003 Zhejiang Province China Department of Infectious Disease School of Medicine First Affiliated Hospital Zhejiang University Hangzhou 310003 Zhejiang Province China

AIM:To investigate the role of anal cushions in hemorrhoidectomy and its effect on anal continence of the ***:Seventy-six consecutive patients(33 men and 43 women) with a mean age of 44 years were *** underwent Milligan-Morgan hemorrhoidectomy because of symptomatic third-and fourth-degree hemorrhoids and failure in conservative treatment for *** score was recorded and liquid continence test was performed for each patient before and two months after operation using the techniques described in our previous *** speed-constant rectal lavage apparatus was prepared in our *** device could output a pulsed and speed-constant saline stream with a high pressure,which is capable of overcoming any rectal resistance *** patients were divided into three groups,group A( 1200 mL) according to the results of the preoperative liquid continence ***:All the patients completed the *** average number of hemorrhoidal masses excised was *** patients presented with hemorrhoidal symptoms for more than one year,including a mean duration of incontinence of 5.2 *** most common symptoms before surgery were anal bleeding(n = 55),prolapsed lesion(n = 34),anal pain(n = 12) and constipation(n = 17).There were grade Ⅲ hemorrhoids in 39(51.3%) patients,and grade Ⅳ in 37(48.7%) patients according to Goligher *** patients had experienced hemorrhoid surgery at least *** with postoperative results,the retained volume in the preoperative liquid continence test was higher in 40 patients,lower in 27 patients,and similar in the other 9 *** overall preoperative retained volume in the liquid continence test was 1130.61 ± 78.35 mL,and postoperative volume was slightly decreased(991.27 ± 42.77 mL),but there was no significant difference(P = 0.057).Difference was significant in the test value before and after hemorrhoidectomy in group A(858.24 ± 32.01 mL v

关键词： Anal cushion Anal incontinence Liquids continence test Wexner score Hemorrhoidectomy

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Safety and efficacy of omalizumab for antihistamine-resistant chronic urticaria in children:a case series and literature review

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World Journal of Pediatrics 2024年第3期20卷 294-298页

作者： wei-fang zhu Chen Wang Jian-Jun Qiao Lan-Juan Li Department of Dermatology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Chronic urticaria(CU)is a common skin disease characterized by the occurrence of wheals,with or without angioedema,lasting more than 6 *** prevalence of CU is about 0.7%[1],but higher in children,with an incidence of 1.38%[1].The occurrence of severe pruritus and unpredictable wheals may severely impact patients'quality of life,cause psychological problems,including sleep disorders and depression,and lead to economic burden due to limitation on daily life and work[2,3].

关键词： edema prevalence children

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