检索结果-南通市图书馆

NQO1 Mediates Lenvatinib Resistance by Regulating ROS-induced Apoptosis in Hepatocellular Carcinoma

Current Medical Science 2024年第1期44卷 168-179页

作者： wei XUE Ting WANG Wen-jing TIAN Si-qi PANG Hua-feng ZHANG wei-dong jia Department of General Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei 230601China The Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China

Objective Hepatocellular carcinoma(HCC)is the third leading cause of cancer-associated death *** a first-line drug for advanced HCC treatment,lenvatinib faces a significant hurdle due to the development of both intrinsic and acquired resistance among patients,and the underlying mechanism remains largely *** present study aims to identify the pivotal gene responsible for lenvatinib resistance in HCC,explore the potential molecular mechanism,and propose combinatorial therapeutic targets for HCC *** Cell viability and colony formation assays were conducted to evaluate the sensitivity of cells to lenvatinib and ***-Seq was used to determine the differences in transcriptome between parental cells and lenvatinib-resistant(LR)*** upregulated genes were analyzed by GO and KEGG ***,qPCR and Western blotting were employed to determine the relative gene expression ***,the intracellular reactive oxygen species(ROS)and apoptosis were detected by flow *** PLC-LR and Hep3B-LR were *** was a total of 116 significantly upregulated genes common to both LR cell *** GO and KEGG analyses indicated that these genes were involved in oxidoreductase and dehydrogenase activities,and reactive oxygen species ***,NAD(P)H:quinone oxidoreductase 1(NQO1)was highly expressed in LR cells,and was involved in the lenvatinib *** high expression of NQO1 decreased the production of ROS induced by lenvatinib,and subsequently suppressed the *** combination of lenvatinib and NQO1 inhibitor,dicoumarol,reversed the resistance of LR *** The high NQO1 expression in HCC cells impedes the lenvatinib-induced apoptosis by regulating the ROS levels,thereby promoting lenvatinib resistance in HCC cells.

关键词： hepatocellular carcinoma lenvatinib resistance NAD(P)H quinone oxidoreductase 1 reactive oxygen species apoptosis dicoumarol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computed tomography-based radiomics to predict early recurrence of hepatocellular carcinoma post-hepatectomy in patients background on cirrhosis

引用

World Journal of Gastroenterology 2024年第15期30卷 2128-2142页

作者： Gui-Xiang Qian Zi-Ling Xu Yong-Hai Li jian-Lin Lu Xiang-Yi Bu Ming-Tong wei wei-dong jia Department of Hepatic Surgery Anhui Provincial HospitalThe First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Hepatic Surgery Anhui Provincial Hospital Affiliated to Anhui Medical UniversityAnhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Anorectal Surgery the First People’s Hospital of HefeiHefei 230001Anhui ProvinceChina

BACKGROUND The prognosis for hepatocellular carcinoma(HCC)in the presence of cirrhosis is unfavourable,primarily attributable to the high incidence of *** To develop a machine learning model for predicting early recurrence(ER)of posthepatectomy HCC in patients with cirrhosis and to stratify patients’overall survival(OS)based on the predicted risk of *** In this retrospective study,214 HCC patients with cirrhosis who underwent curative hepatectomy were *** feature selection was conducted using the least absolute shrinkage and selection operator and recursive feature elimination ***-radiologic features were selected through univariate and multivariate logistic regression *** machine learning methods were used for model comparison,aiming to identify the optimal *** model’s performance was evaluated using the receiver operating characteristic curve[area under the curve(AUC)],calibration,and decision curve ***,the Kaplan-Meier(K-M)curve was used to evaluate the stratification effect of the model on patient *** Within this study,the most effective predictive performance for ER of post-hepatectomy HCC in the background of cirrhosis was demonstrated by a model that integrated radiomics features and clinical-radiologic *** the training cohort,this model attained an AUC of 0.844,while in the validation cohort,it achieved a value of *** K-M curves illustrated that the combined model not only facilitated risk stratification but also exhibited significant discriminatory ability concerning patients’*** The combined model,integrating both radiomics and clinical-radiologic characteristics,exhibited excellent performance in HCC with *** K-M curves assessing OS revealed statistically significant differences.

关键词： Machine learning Radiomics Hepatocellular carcinoma Cirrhosis Early recurrence Overall survival Computed tomography Prognosis Risk factor Delta-radiomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于双重约束的光伏逆变器无功调控策略

引用

电力电子技术 2024年第3期58卷 75-77,107页

作者：李炜王朋董伟佳李云飞中国石油化工股份有限公司胜利油田分公司技术检测中心山东东营257000 中国石油大学(华东) 新能源学院山东青岛266580

针对光伏并网逆变器在应用中存在无功调节范围小、动态响应速度慢,导致逆变器效率低的问题,结合光伏逆变器的结构特点,提出了一种基于最大功率点追踪(MPPT)与并网点电压双重约束的逆变器无功调控策略。该策略在d-q解耦控制的基础上,通... 详细信息

针对光伏并网逆变器在应用中存在无功调节范围小、动态响应速度慢,导致逆变器效率低的问题,结合光伏逆变器的结构特点,提出了一种基于最大功率点追踪(MPPT)与并网点电压双重约束的逆变器无功调控策略。该策略在d-q解耦控制的基础上,通过分析光伏逆变器不同工作状态下的无功调节能力,推导出光伏逆变器最大输出无功约束条件,最大限度将逆变器冗余容量作为备用无功功率输送到配电网进行无功补偿,提高了光伏逆变器无功调节范围和光照强度不足时的利用率。最后搭建Simulink仿真模型和实验平台进行验证。结果表明,在无功功率约束条件下,光伏逆变器可以大范围调节输出无功,验证了所提策略的可行性。

关键词：光伏逆变器功率约束无功补偿

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Changes in Spring Snow Cover over the Eastern and Western Tibetan Plateau and Their Associated Mechanism

引用

Advances in Atmospheric Sciences 2024年第5期41卷 959-973页

作者： Fangchi LIU Xiaojing jia wei dong Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhouZhejiang 310058China

The spring snow cover(SC)over the western Tibetan Plateau(TP)(TPSC)(W_TPSC)and eastern TPSC(E_TPSC)have displayed remarkable decreasing and increasing trends,respectively,during 1985–*** current work investigates the possible mechanisms accounting for these distinct TPSC *** results indicate that the decrease in W_TPSC is primarily attributed to rising temperatures,while the increase in E_TPSC is closely linked to enhanced *** circulation analysis shows that the essential system responsible for the TPSC changes is a significant anticyclonic system centered over the northwestern *** anomalous descending motion and adiabatic heating linked to this anticyclone leads to warmer temperatures and consequent snowmelt over the western ***,anomalous easterly winds along the southern flank of this anticyclone serve to transport additional moisture from the North Pacific,leading to an increase in snowfall over the eastern *** analysis reveals that the anomalous anticyclone is associated with an atmospheric wave pattern that originates from upstream *** warming of the subtropical North Atlantic(NA)sea surface temperature(SST)induces an atmospheric pattern resembling a wave train that travels eastward across the Eurasian continent before reaching the ***,the decline in winter sea ice(SIC)over the Barents Sea exerts a persistent warming influence on the atmosphere,inducing an anomalous atmospheric circulation that propagates southeastward and strengthens the northwest TP anticyclone in ***,an enhancement of subtropical stationary waves has resulted in significant increases in easterly moisture fluxes over the coastal areas of East Asia,which further promotes more snowfall over eastern TP.

关键词： snow cover Tibetan Plateau long-term changes spring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An approximate analytical model for unconventional reservoir considering variable matrix blocks and simultaneous matrix depletion

引用

Petroleum Science 2024年第1期21卷 352-365页

作者： Kai-Xuan Qiu jia Li dong Feng Shi-Ming wei Gang Lei jiangmen Laboratory of Carbon Science and Technology Jiangmen529100GuangdongChina The Hong Kong University of Science and Technology(Guangzhou) Guangzhou511400GuangdongChina China University of Geosciences(Beijing) Beijing100083China China University of Petroleum(Beijing) Beijing102249China China University of Geosciences(Wuhan) Wuhan430074HubeiChina Shenzhen Research Institute China University of GeosciencesShenzhen518063GuangdongChina

In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture *** has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture *** addition,most of the existing models are solved analytically based on Laplace transform and numerical ***,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix *** simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the ***,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by ***,a relationship between oil rate and production time in real-time space is *** new model is verified against classical analytical *** the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,***,the new model also has an excellent agreement with the numerical *** model is then applied to two actual tight oil wells completed in western Canada sedimentary *** identifying the flow regime,the solution suitably matches the field production data,and the model parameters are *** these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.

关键词： Analytical solution Unconventional reservoir Variable matrix Simultaneous flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quality assessment of friction-stir-welded aluminum alloy welds via three-dimensional force signals

引用

Advances in Manufacturing 2024年第1期12卷 61-75页

作者： Ji-Hong dong Yi-Ming Huang jia-Lei Zhu wei Guan Xu-Kai Ren Huan-wei Yu Lei Cui Beijing Institute of Petrochemical Technology Beijing102617People’s Republic of China Beijing Academy of Safety Engineering and Technology Beijing102617People’s Republic of China AVIC Manufacturing Technology Institute Beijing100024People’s Republic of China Tianjin Key Laboratory of Advanced Joining Technology School of Materials Science and EngineeringTianjin UniversityTianjin300350People’s Republic of China Shaoxing Special Equipment Testing Institute Shaoxing Key Laboratory of Special Equipment Intelligent Testing and EvaluationShaoxing312071ZhejiangPeople’s Republic of China

An online detection technology must be developed for realizing the real-time control of friction stir *** this study,the three-dimensional force exerted on a material during friction stir welding was collected synchronously and the relationship between the forces and welding quality was *** results indicated that the fluctuation period of the traverse force was equal to that of the lateral force during the stable welding *** phase difference between two horizontal forces wasπ/*** values of the horizontal forces increased with welding speed,whereas their amplitudes remained the *** proposed force model showed that the traverse and lateral forces conformed to an elliptical curve,and this result was consistent with the behavior of the measured *** variational mode decomposition was used to process the plunge *** intrinsic mode function that represented the real fluctuation in the plunge force varied at the same frequency as the spindle rotational *** tunnel defects occurred,the fluctuation period features were consistent with those obtained during normal welding,whereas the ratio parameter defined in this study increased significantly.

关键词： Friction stir welding(FSW) Three-dimensional force model Variational mode decomposition Tunnel defect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Abnormal Traffic Detection for Internet of Things Based on an Improved Residual Network

引用

Computers, Materials & Continua 2024年第6期79卷 4433-4448页

作者： Tingting Su jia Wang wei Hu Gaoqiang dong Jeon Gwanggil School of Computer Science and Technology Xinjiang UniversityUrumqi830046China School of Cyber Science and Engineering Jinling Institute of Technology CityNanjing210000China College of Information Technology Incheon National UniversityIncheon22012Korea

Along with the progression of Internet of Things(IoT)technology,network terminals are becoming continuously more *** has been widely applied in various scenarios,including urban infrastructure,transportation,industry,personal life,and other socio-economic *** introduction of deep learning has brought new security challenges,like an increment in abnormal traffic,which threatens network *** feature extraction leads to less accurate classification *** abnormal traffic detection,the data of network traffic is high-dimensional and *** data not only increases the computational burden of model training but also makes information extraction more *** address these issues,this paper proposes an MD-MRD-ResNeXt model for abnormal network traffic *** fully utilize the multi-scale information in network traffic,a Multi-scale Dilated feature extraction(MD)block is *** module can effectively understand and process information at various scales and uses dilated convolution technology to significantly broaden the model’s receptive *** proposed Max-feature-map Residual with Dual-channel pooling(MRD)block integrates the maximum feature map with the residual *** module ensures the model focuses on key information,thereby optimizing computational efficiency and reducing unnecessary information *** results show that compared to the latest methods,the proposed abnormal traffic detection model improves accuracy by about 2%.

关键词： Abnormal network traffic deep learning residual network multi-scale feature extraction max-feature-map

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metal-based inorganic nanocrystals for biological sonodynamic therapy applications:recent progress and perspectives

引用

Rare Metals 2024年第2期43卷 413-430页

作者： dong Wang jia-Tao Zhang Institute of Medical-Industrial Integration Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green ApplicationsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their *** therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue *** soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of ***,many sonosensitizers are studied and applied to SDT-based ***-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band *** representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is ***-gistic effects of SDT in combination with other therapeutic modalities are mainly *** the same time,the critical and potential issues and future perspectives are addressed.

关键词： Metal-based inorganic nanocrystals Sonodynamic therapy(SDT) Tumor treatment Antibacteria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase

引用

Science China Chemistry 2024年第7期67卷 2382-2391页

作者： Ke-wei Chen jia-Nan Chen Jun Zhang Chao Wang Tian-Yu Sun Yun-dong Wu Key Laboratory of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicSchool of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Changping Laboratory Beijing 102200China

Fluoroacetate dehalogenases(FAcD),a homodimeric enzyme,catalyzes the conversion of fluoroacetic acid to glycolic acid(GoA).It has been proved that the enzyme has a half-of-the-site ***,its catalytic(C)subunit converts the first substrate to a covalent intermediate;then,the non-catalytic(NC)subunit binds a second substrate and promotes the conversion of the intermediate in the C subunit into the final *** the release of the product,the C subunit becomes the NC subunit,and the previous NC subunit becomes the C *** elucidate the detailed mechanism behind this cooperative catalysis,we have conducted microsecond-scale MD simulations along the reaction *** simulations indicate that the substrate in the NC subunit induces W185 and Y141 adopting an open conformation in the C *** opening of W185(C)facilitates the entry of catalytic water,enhancing the catalytic activity for product formation,while the opening of Y141(C)creates an unfavorable environment for product binding,promoting its *** interaction network analysis reveals that the substrate in the NC subunit can induce conformational changes through a conserved water chain at the interface.

关键词： enzyme catalysis molecular dynamics cooperative effect pre-reaction state

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental Study on Consolidation Properties of Hydrate-Bearing Fine-Grained Sediments Collected from the Shenhu Area of the Northern South China Sea

引用

Journal of Ocean University of China 2024年第4期23卷 981-990页

作者： wei Ruchun LIU Lele jia Chao dong Xiao BU Qingtao ZHANG Yongchao LIU Changling WU Nengyou School of Water Conservancy and Environment University of JinanJinan 250022China Shandong Engineering Research Center of Marine Exploration and Conservation Ocean University of ChinaQingdao 266100China Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266237China Institute of Marine Science and Technology Shandong UniversityQingdao 266232China

Mechanical properties of hydrate-bearing fine-grained sediments are crucial to effectively mitigate environmental risks caused by artificial and natural decomposition of natural gas hydrates,and the decomposition can induce laterally confined *** explore the effect of natural gas hydrates on laterally confined compression properties,consolidation tests are conducted on remolded hydrate-free and hydrate-bearing samples by using natural fine-grained sediments collected from the northern South China Sea as the host sediments,and empirical equations are developed based on the analyses of consolidation *** results show that vertical loading induces a reduction in void ratio,and the reduction increases with decreasing hydrate saturation when samples are subjected to the same vertical stress *** compression index of samples is about 0.53 whether there is hydrate or not,but the yield stress of samples increases sharply with increasing hydrate saturation once beyond the critical *** coefficient of volume compression and the coefficient of consolidation of hydrate-bearing samples both increase firstly and then decrease to a relative stable level with increasing vertical stress,and the transition occurs at 200 *** average consolidation degree with elapsed time increases rapidly under low vertical stresses,slowly under median vertical stresses,and under high vertical stresses,the consolidation increases a little faster but still slower than those under low vertical stresses.

关键词： natural gas hydrate stiffness compression index hydraulic permeability geohazard

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：