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Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

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Chinese Chemical Letters 2015年第3期26卷 334-338页

作者： Yan Wu wei-qi chen Yu-qing Zhao Hu-Ri Piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of EducationYanbian University College of Pharmacy Department of Chemistry Fudan University School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow *** antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines（i.e.,PC-3and LNCa P cells）,and their cytotoxicities were evaluated using a standard MTT *** 4c,4h,4p,4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol,which was used as a reference standard.

关键词： antitumor adenocarcinoma toward silica batch shorter spectrometer incubated equiv acetate

RESEARCH ON STABILITY OF OPEN BOTTOM STORAGE PLATFORM

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Journal of Hydrodynamics 1999年第2期11卷 14-19页

作者： qi Xin-yuan Jin chen-yi chen wei-qi chen Juan-fang(China Ship Scientific Research Center, Wuxi 214082, P. R. China) China Ship Scientific Research Cent Wuxi China

In this paper, we present a new type of offshore structure, open bottomstorage platform, and its theoretical and experimental studies of its stability. In order tooptimize the design of column length and storage tank of the open bottom storage platform, we discuss the effect of air chamber length and storage on the stability of open bottom storage platform.

关键词： ocean engineering open bottom storage platform stability

In vitro degradation of MAO/PLA coating on Mg-1.21Li-1.12Ca-1.0Y alloy

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Frontiers of Materials Science 2014年第4期8卷 343-353页

作者： Rong-Chang ZENG wei-chen qi Ying-wei SONG qin-Kun HE Hong-Zhi CUI En-Hou HAN College of Materials Science and Engineering Shandong University of Science and Technology Qingdao 266590 China State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology Qingdao 266590 China National Engineering Center for Corrosion Control Institute of Metals Research Chinese Academy of Sciences Shenyang 110016 China

Magnesium and its alloys are promising biomaterials due to their biocompatibility and osteoinduction. The plasticity and corrosion resistance of commercial magnesium alloys cannot meet the requirements for degradable biomaterials completely at present. Particularly, the alkalinity in the microenvironment surrounding the degradation, implants, resulting from the arises a major concern. Micro arc oxidation （MAO） and poly（lactic acid）（PLA） composite （MAO/PLA）coating on biomedical Mg- 1.21Li-1.12Ca-1.0Y alloy was prepared to manipulate pH variation in an appropriate range. Surface morphologies were discerned using SEM EMPA. AM corrosion resistance was evaluated via electrochemical Polarization and impedance and hydrogen volumetric method. The results demonstrated that the MAO coating predomlnantly consisted of MgO, Mg2SiO4 and YzO3. The composite coating markedly improved the corrosion resistance of the alloy. The rise in solution pH for the MAO/PLA coating was tailored to a favorable range of 7.5-7.8 The neutrallzation caused by the alkalinity of MAO and Mg substrate and acidification of PLA was probed. The reSult designates that MAOI PLA composite coating on Mg-1.21Li-1.12Ca-1.0Y alloys may be a promising biomedical coating.

关键词： magnesium alloy micro.arc oxidation (MAO) poly(lactic acid)(PLA) biomaterial degradation

Bilateral congenital uveal coloboma concurrent with retinal detachment

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 364-366页

作者： Zi-Jing Huang Jing-Sheng Yi wei-qi chen Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong Shantou 515041Guangdong ProvinceChina

Dear Editor,We are writing to present a bilateral uveal coloboma concurrent with retinal detachment(RD)in a 16-year-old *** are rare,congenital and potentially blinding malformations caused by incomplete closure of em... 详细信息

关键词： incomplete closure concurrent

Surgical treatment for proliferative diabetic retinopathy with ocular albinism

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 479-482页

作者： Zi-Jing Huang Ding-Guo Huang wei-qi chen Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong Shantou 515041Guangdong ProvinceChina

Dear Editor,We are writing to present an uncommon case of a45-year-old woman with bilateral proliferative diabetic retinopathy (PDR) and ocular albinism (OA).Albinism is a group of inherited disorders of tyrosinase ac... 详细信息

关键词： ocular proliferative diabetic

Advances in coatings on biodegradable magnesium alloys

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Journal of Magnesium and Alloys 2020年第1期8卷 42-65页

作者： Zheng-Zheng Yin wei-chen qi Rong-Chang Zeng Xiao-Bo chen Chang-Dong Gu Shao-Kang Guan Yu-Feng Zheng Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China Department of Orthopaedics and Traumatology Li KaShing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Engineering RMIT UniversityCarltonVIC 3053Australia School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China State Key Laboratory for Turbulence and Complex Systems and Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China

The clinic applications of bioabsorbable magnesium(Mg)and its alloys have been significantly restricted owing to their poor corrosion *** elemental alloying,surface modification and functionality is a major approach to increasing corrosion resistance for magnesium *** article reviews the cutting-edge advances and progress of biodegradable surface coatings upon Mg alloys over the last decades,aims to build up a knowledge framework of surface modification on biodegradable Mg alloys.A considerable number of conversion,deposition,mechanical and functional coatings and their preparation methods are *** emphasis has been placed on the composition of chemical conversion and deposited coatings to overcome the disadvantages of adhesion,corrosion resistance and biocompatibility of a single coating for biomedical *** issues have been addressed on the integration of the structural and functional factors of the composite coatings.

关键词： Magnesium alloy Biomaterial Corrosion resistance Coating Biodegradability

Visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 860-863页

作者： wei-qi chen Vishal Jhanji Hao-Yu chen Gui-Hua Zhang Ping Hou Joint Shantou International Eye Center Shantou University and the Chinese University of Hong Kong Department of Ophthalmology and Visual Sciences the Chinese University of Hong Kong

AIM:To investigate the visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy ***:In this prospective case series, consecutive patients who underwent combined phacoemulsification and pars plana vitrectomy(PPV) under sub-Tenon anesthesia between October 2008 and September 2009 were enrolled. The patients were asked whether they could see the light of the operating microscope or not between various surgical steps with their contralateral eye being ***:A total of 163 eyes of 163 patients were enrolled in this study. After their contralateral eyes were covered, 152(93.3%) patients said that they could not see any light at least during one of the surgical steps. All eyes recovered to at least light perception on the first postoperative day. The incidence of no light perception during the surgery was not related to demographic factors, including age, gender, or type of ocular ***:The incidence of no light perception during combined phacoemulsification and vitrectomy under sub-Tenon anesthesia was high in our *** should be duly informed about this temporary but potential intraoperative event.

关键词： visual impact sub-Tenon anesthesia phacoemulsification vitrectomy

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闭合在可压气体射流上的空泡数学模型

船舶力学 2022年第12期26卷 1737-1748页

作者：陈玮琪北京机电工程研究所北京100074

为了揭示推进器可压缩气体射流穿透空泡的机理,用理论方法研究空泡与可压缩气体射流之间的相互作用,通过分析空泡在气体射流上的特殊闭合方式并结合动量守恒定理,建立空泡与可压缩气体射流相互作用的数学模型。在新模型中,首次以解析表... 详细信息

为了揭示推进器可压缩气体射流穿透空泡的机理,用理论方法研究空泡与可压缩气体射流之间的相互作用,通过分析空泡在气体射流上的特殊闭合方式并结合动量守恒定理,建立空泡与可压缩气体射流相互作用的数学模型。在新模型中,首次以解析表达式的形式给出气体射流总压的上、下阈值范围,并发现该阈值是两个射流面积比的函数。如果喷射压力低于下阈值,则气体射流根本不能穿透空泡;如果射流总压高于上阈值,气体射流则全部穿透空泡;如果射流总压在上下阈值之间,则射流分为两部分,一部分返回空泡内,另一部分则穿透空泡,并从物理上解释了这部分气体射流穿透空泡的机理。新模型还给出了计算穿透空泡的可压气体射流流量的新公式。Paryshev公式是本文新公式在小空化数及不可压缩条件下的一个特例。

关键词：空泡超空泡空泡闭合模型可压缩气体射流

水下空泡航行体载荷及推力最大值的最小化问题

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船舶力学 2016年第8期20卷 929-934页

作者：陈玮琪中国船舶科学研究中心水动力学重点实验室江苏无锡214082

研究了带空泡水下航行体在规定距离内从初速加速到预定速度的一维水弹道优化问题,利用变分法求出了水下航行体加速过程中最大推力达到最小的最优弹道理论解,此解也可作为航行体最大载荷达到最小的理论解。

关键词：空泡水动力弹道优化变分法极大极小问题