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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 331-344页

作者： GAO ying RONG wei-dong School of Mathematical Sciences Inner Mongolia University Hohhot 010021 China

This paper studies a class of multiobjective generalized fractional programming problems, where the numerators of objective functions are the sum of differentiable function and convex function, while the denominators are the difference of differentiable function and convex function. Under the assumption of Calmness Constraint Qualification the Kuhn-Tucker type necessary conditions for efficient solution are given, and the Kuhn-Tucker type sufficient conditions for efficient solution are presented under the assumptions of （F, α, ρ, d）-V-convexity. Subsequently, the optimality conditions for two kinds of duality models are formulated and duality theorems are proved.

关键词： operations research multiobjective generalized fractional programming optimality condition duality theorem generalized convexity

Gold nanoparticles functionalized with supramolecular macrocycles

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Chinese Chemical Letters 2013年第7期24卷 545-552页

作者： Hui Li ying-wei Yang State Key Laboratory of Supramolecular Structure and Materials College of Chemistry.Jilin University

Gold nanoparticles （AuNPs） functionalized with supramolecular macrocycles are versatile and diverse hybrid nanomaterials, which combine and enhance the characteristics of the two components. In this mini-review, we summarize the recent research progress on the synthesis and assembly of AuNPs functionalized with different supramolecular macrocyclic compounds, i.e., crown ethers, cyclophanes, cyclodextrins （CDs）, cucurbit[n]urils （CB[n]）, calix[n]arenes, and pillar[n]arenes （PIn]A）. Meanwhile, applications of these supramolecular hybrid nanomaterials in the fields of sensors, biomedicine and plasmonic devices are also presented.

关键词： Supramolecular macrocycles Au nanoparticles Synthesis Assembly Nanomaterials

Applications of pillarenes, an emerging class of synthetic macrocycles

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Science China Chemistry 2014年第9期57卷 1185-1198页

作者： SONG Nan Yang ying-wei State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin University

Synthetic macrocycles, a typical type of building block for molecular recognition and self-assembly, are crucial to supramolecular chemistry and materials science. Since 2008, a new generation of synthetic macrocyclic hosts, pillarenes and their abundant derivatives, which consist of hydroquinone units linked by methylene bridges at 2,5-positions, have been the focus of much research. Numerous studies on their host-guest properties and the fabrication of supramolecular assemblies have demon- strated that pillarenes and their derivatives possess many advantages that facilitate their applications in many research fields. Herein we summarize and classitfy the applications of pillarenes in terms of artificial transmembrane channels, controlled delivery systems, dispersion of carbon hybrid materials, extraction and absorption, liquid crystals, metal-organic frameworks, sensing and detection, stabilization of nanoparticles （Au/Ag/CdTe）, and other typical biological applications. We also provide an overview of future developments in pillarene chemistry.

关键词： drug delivery host-guest interactions macrocycles pillarenes supramolecular materials

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桑葚微胶囊对酸奶品质与风味的影响

食品与发酵工业 2025年第1期51卷 312-321页

作者：卢钏燚周静赵涛魏春菊贺禧王颖雷激西华大学食品与生物工程学院四川成都610039 川渝共建特色食品重庆市重点实验室四川成都610039 食品微生物四川省重点实验室四川成都610039

针对桑葚易腐烂、加工过程中活性成分稳定性差的问题,该研究以桑葚为原料制备桑葚微胶囊,最大限度保存和利用桑葚全果中的营养成分,并用其制备桑葚微胶囊酸奶(mulberry microencapsulated yogurt,MY),同时以桑葚冻干粉酸奶(mulberry fre... 详细信息

针对桑葚易腐烂、加工过程中活性成分稳定性差的问题,该研究以桑葚为原料制备桑葚微胶囊,最大限度保存和利用桑葚全果中的营养成分,并用其制备桑葚微胶囊酸奶(mulberry microencapsulated yogurt,MY),同时以桑葚冻干粉酸奶(mulberry freeze-dried powdered yogurt,FY)、普通酸奶(normal yogurt,NY)为对照,考察桑葚微胶囊对酸奶品质与风味的影响。结果表明,桑葚微胶囊添加量为1.5 g/100 mL时酸奶感官品质最佳;3种酸奶贮藏期间(21 d),MY的质构特性、pH值和感官更趋稳定,乳酸菌总数和桑葚活性成分含量均最高且被更好地保留,贮藏21 d时乳酸菌总数为3.65×10^(8)CFU/mL,较FY、NY分别提高15.75%、9.18%(P<0.05),其总酚、黄酮、花青素保留率分别为83.32%、83.87%、73.82%,较FY提高了25.41%、34.51%、55.77%(P<0.05),微胶囊对花青素的保护效果尤为明显。气相离子迁移色谱提示MY中乙酸丁酯、乙酸乙酯等特征性风味物质含量更高,而2-戊酮、正丁醛等具有刺激性气味的物质含量降低,MY具有纯正浓郁的桑葚果香和酸奶香,桑葚微胶囊的添加对增进酸奶风味具有积极作用。综上,桑葚微胶囊使桑葚原料得到充分利用,提升了酸奶的贮藏品质、活性成分稳定性和风味,并显著增强了酸奶的营养价值,该研究不仅解决了桑葚易腐性和活性成分稳定性差的问题,也为桑葚的开发利用以及丰富酸奶类型提供了思路。

关键词：桑葚微胶囊酸奶稳定性风味气相色谱-离子迁移谱

Inhibition of Eukaryotic Initiating Factor eIF4E Overcomes Abemaciclib Resistance in Gastric Cancer

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Current Medical Science 2023年第5期43卷 927-934页

作者： Huo-long ZHA wei CHEN wei SHI ying-ying LIAO Department of Gastroenterology Renmin HospitalHubei University of MedicineShiyan 442000China Department of Critical Care Medicine Taihe HospitalHubei University of MedicineShiyan 442000China

Objective Aberrant activating mutations in cyclin-dependent kinases 4 and 6(CDK4/6)are common in various cancers,including gastroesophageal *** CDK4/6 inhibitors,such as abemaciclib and palbociclib,have been approved for breast cancer treatment,their effectiveness as a monotherapy remains limited for gastroesophageal *** present study explored the underlying mechanism of abemaciclib *** Abemaciclib-resistant gastric cancer cell lines were generated,and the phospho-eukaryotic translation initiation factor 4E(p-eIF4E)and eIF4E expression was compared between resistant and parental cell *** order to analyze the role of eIF4E in cell resistance,siRNA knockdown was *** effectiveness of ribavirin alone and its combination with abemaciclib was evaluated in the gastric cancer xenograft mouse *** The upregulation of eIF4E was a common feature in gastric cancer cells exposed to prolonged abemaciclib *** cancer cells with increased eIF4E levels exhibited a better response to eIF4E inhibition,especially those that were resistant to ***,which is an approved anti-viral drug,significantly improved the efficacy of abemaciclib,both in vitro and in vivo,by inhibiting ***,ribavirin effectively suppressed the abemaciclib-resistant gastric cancer growth in mice without causing *** These findings suggest that targeting eIF4E can enhance the abemaciclib treatment for gastric cancer,proposing the potential combination therapy of CDK4/6 inhibitors with ribavirin for advanced gastric cancer.

关键词： eIF4E CDK4/6 ribavirin gastric cancer resistance

Unique biogenesis and kinetics of hornwort Rubiscos revealed by synthetic biology systems

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Molecular Plant 2024年第12期17卷 1833-1849页

作者： Zhen Guo Oh Tanner Ashton Robison Dan Hong Loh Warren Shou Leong ang Jediael Zheng ying Ng Fay-wei Li Laura Helen Gunn School of Integrative Plant Science Cornell UniversityIthacaNY 14853USA Boyce Thompson Institute IthacaNY 14853USA Max Planck Institute for Terrestrial Microbiology 35043 MarburgGermany Department of Cell and Molecular Biology Uppsala University75124 UppsalaSweden

Hornworts are the only land plants that employ a pyrenoid to optimize Rubisco’s CO_(2) fixation,yet hornwort Rubisco remains poorly *** we assembled the hornwort Anthoceros agrestis Rubisco(AaRubisco)using the Arabidopsis thaliana SynBio expression system and observed the formation of stalled intermediates,prompting us to develop a new SynBio system with *** cognate *** successfully assembled AaRubisco and Rubisco from three other hornwort *** *** Rubisco,AaRubisco assembly is not dependent on RbcX or *** characterization reveals that hornwort Rubiscos exhibit a range of catalytic rates(3–10 s−1),but with similar affinity(∼30μM)and specificity(∼70)for CO_(2).These results suggest that hornwort Rubiscos do not comply with the long-held canonical catalytic trade-off observed in other land plants,providing experimental support that Rubisco kinetics may be phylogenetically ***,we observed a 50%increase in AaRubisco catalytic rates when RbcX was removed from our SynBio system,without any reduction in *** biology,biochemistry,and proteomic analysis suggest that subtle differences in Rubisco large-subunit interactions,when RbcX is absent during biogenesis,increases the accessibility of active sites and catalytic turnover ***,this study uncovered a previously unknown Rubisco kinetic parameter space and provides a SynBio chassis to expand the survey of other Rubisco *** discoveries will contribute to developing new approaches for engineering Rubisco with superior kinetics.

关键词： hornworts CO_(2)fixation Rubisco synthetic biology structural biology assembly factors

Functional Proteomics Driven by Chemical and Computational Approaches

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Chinese Journal of Chemistry 2022年第5期40卷 628-634页

作者： ying Chen wei Qin Chu Wang College of Chemistry and Molecular Engineering Peking UniversityBeijing100871 China Peking-Tsinghua Center for Life Science Peking UniversityBeijing100871 China Beijing National Laboratory for Molecular Sciences Peking UniversityBeijing100871 China Synthetic and Functional Biomolecules Center Peking UniversityBeijing100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Peking UniversityBeijing100871 China

Functional proteomics is a powerful approach to globally investigate protein functions and their biological ***-based protein profiling(ABPP)has been widely applied to explore the activity and ligandability of proteins in complex biological ***,we summarized our efforts in developing chemical probes and chemical proteomic pipelines to identify protein targets of certain post-translational modifications(PTMs),covalent drugs,natural products and cellular ***,computer-aided proteomic strategies were developed to globally identify functional residues including hyper-reactive cysteines,active sites of selenoproteins and proximal anchors for protein activation.

关键词： Activity-based protein profiling Proteomics Protein modifications Protein design Target deconwolution

Anomalies of Precipitation over China on Days with Tropical Cyclone Activity over the Bay of Bengal: Role of Moisture Transport

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Journal of Meteorological Research 2024年第2期38卷 368-382页

作者： Na wei ying LI Xiaoting FAN Nanjing Joint Institute for Atmospheric Sciences Nanjing 210041 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200433

Tropical cyclones over the Bay of Bengal(BoBTC)affect the precipitation over China,with distinct seasonal and daily *** study quantitatively examines the daily standardized precipitation anomalies(SPAs)over China on the days with BoBTC activities(storm-days)and related circulations,based on rainfall measurements at surface meteorological stations and ECMWF reanalysis data on a 0.25°×0.25°resolution during *** positive SPA is found over the stations in the two adjacent regions around BoB(Southwest China in May/November and southern Tibetan Plateau in October)and three distant regions(Southeast China and the northeastern boundary of the Qinghai-Tibet Plateau in May,and central North China in October).The SPA distributions are remarkably consistent with the integrated water vapor transport(IVT)*** IVT is found associated with the interaction between southwesterly(southerly)of the BoBTC circulation and low-level monsoonal flow in May(midlevel westerly in winter months).The probabilities of extreme precipitation(EP)occurrences over the above regions all increase on *** adjacent regions,EP is significantly correlated with the northward IVT anomalies to the east of BoBTC circulation,which strengthen the water vapor input through the southern *** IVT anomalies are stronger in May,benefited by the deep monsoonal southwesterlies than those in *** distant regions,EP is more closely related to the IVT anomaly extending back from *** moisture from BoB concentrates along a local low-level convergence line over Southeast China,being further facilitated by coexistence of the BoBTC depression and midlevel westerly trough in *** results highlight the interactions between BoBTCs and local weather systems that influence the general precipitation anomalies and occurrence of EP over China,especially over distant regions.

关键词： tropical cyclone Bay of Bengal precipitation anomaly moisture transport

Turán Number of the Family Consisting of a Blow-up of a Cycle and a Blow-up of a Star

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Acta Mathematica Sinica,English Series 2023年第10期39卷 1980-1988页

作者： Zhi wei WU Li ying Kang Department of Mathematics Shanghai UniversityShanghai 200444P.R.China

Let F={H_(1),...,H_(k)}(k≥1)be a family of *** Tur´an number of the family F is the maximum number of edges in an n-vertex{H_(1),...,H_(k)}-free graph,denoted by ex(n,F)or ex(n,{H_(1),H_(2),...,H_(k)}).The blow-up of a graph H is the graph obtained from H by replacing each edge in H by a clique of the same size where the new vertices of the cliques are all *** this paper we determine the Tur´an number of the family consisting of a blow-up of a cycle and a blow-up of a star in terms of the Tur´an number of the family consisting of a cycle,a star and linear forests with k edges.

关键词： Tur´an number extremal graph blow-up cycle star

PARAMETRIC STUDY ON THE THRUST OF BUBBLY WATER RAMJET WITH A CONVERGING-DIVERGING NOZZLE

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Journal of Hydrodynamics 2009年第5期21卷 591-599页

作者： FU ying-jie wei ying-jie ZHang Jia-zhong School of Astronautics Harbin Institute of Technology Harbin 150001 China

To predict the thrust of bubbly water ramjet with a converging-diverging nozzle, the physical processes occurring in the diffuser, mixing chamber and nozzle were analyzed. The mathematical models were constructed separately under the restrictions of certain assumptions. The bubbly nozzle flow was examined using a two-fluid model and accomplished by specifying the water velocity distribution in the nozzle. The numerical analysis of flow field in the nozzle shows that the Mach number at the throat is 1.009, near unity, and supersonic bubble flow appears behind the throat. There is greater thrust produced by bubbly water ramjet, compared with single-phase air ramjets. Subsequently, the influences of vessel velocity, air mass flow rate, inlet area Ai, area ratio （i.e., mixing chamber to inlet area Am/Ai）, and initial bubble radius on the thrust were emphatically investigated. Results indicate that the thrust increases with the increase of air mass flow rate, inlet area and the area ratio, and the decrease of initial bubble radius. However, the thrust weakly depends on the vessel velocity. These analytical and numerical results are useful for further investigation of bubbly water ramjet engine.

关键词： bubbly water ramjet converging-diverging nozzle bubbly flow ramjet thrust numerical simulation