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Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

当代医学科学（英文） 2024年第4期44卷 809-819页

作者： chen-guang YAO Zi-jia ZHAO Ting TAN Jiang-ning YAN zhong-wei chen Jun-tao XIONG Han-luo LI Yan-hong wei Kang-hong HU Sino-German Biomedical Center Hubei Provincial Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education & Hubei Province)Key Laboratory of Fermentation Engineering(Ministry of Education)National"111"Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan 430068China Centerfor Evaluation of Hubei Medical Products Administration Wuhan 430068China

Objective:Lindqvist-type polyoxometalates(POMs)exhibit potential antitumor *** study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying ***:Using different cancer cell lines,the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side *** colony formation assay,autophagy detection,mitochondrial observation,qRT-PCR,Western blotting,and animal model were used to evaluate the antitumor activities of POMs against breast cancer cells and the related ***:MO-4,a Lindqvist-type POM linking a proline at its side strain,was selected for subsequent experiments due to its low half maximal inhibitory concentration in the inhibition of proliferation of breast cancer *** was found that MO-4 induced the apoptosis of multiple types of breast cancer ***,MO-4 activated intracellular mitophagy by elevating mitochondrial reactive oxygen species(ROS)levels and resulting in *** vivo,breast tumor growth and distant metastasis were significantly reduced following MO-4 ***:Collectively,the results of the present study demonstrated that the novel Lindqvist-type POM MO-4 may exhibit potential in the treatment of breast cancer.

关键词： antitumor breast cancer mitochondria mitophagy polyoxometalate

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Molecular mechanism of a coastal cyanobacterium Synechococcus *** 7002 adapting to changing phosphate concentrations

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Marine Life Science & Technology 2024年第3期6卷 562-575页

作者： Qiao-wei Sun Yu Gao Jordan Wang Fei-xue Fu cheng-Wen Yong Shuang-Qing Li Hai-Long Huang wei-zhong chen Xin-wei Wang Hai-Bo Jiang School of Marine Sciences Ningbo UniversityNingbo 315211China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China School of Life Sciences Central China Normal UniversityWuhan 430079China Department of Biological Sciences University of Southern CaliforniaLos AngelesCA 90089USA

Phosphorus concentration on the surface of seawater varies greatly with different environments,especially in *** molecular mechanism by which cyanobacteria adapt to fluctuating phosphorus bioavailability is still *** this study,transcriptomes and gene knockouts were used to investigate the adaptive molecular mechanism of a model coastal cyanobacterium Synechococcus *** 7002 during periods of phosphorus starvation and phosphorus recovery(adding sufficient phosphorus after phosphorus starvation).The findings indicated that phosphorus deficiency affected the photosynthesis,ribosome synthesis,and bacterial motility pathways,which recommenced after phosphorus was *** more,most of the metabolic pathways of cyanobacteria were enhanced after phosphorus recovery compared to the control which was kept in continuous phosphorus replete *** on transcriptome,54 genes potentially related to phosphorusdeficiency adaptation were selected and knocked out individually or in *** was found that five mutants showed weak growth phenotype under phosphorus deficiency,indicating the importance of the genes(A0076,A0549-50,A1094,A1320,A1895)in the adaptation of phosphorus *** mutants were found to grow better than the wild type under phosphorus deficiency,suggesting that the products of these genes(A0079,A0340,A2284–86)might influence the adaptation to phosphorus *** analysis revealed that cyanobacteria exposed to highly fluctuating phosphorus concentrations have more sophisticated phosphorus acquisition *** results elucidated that Synechococcus *** 7002 have variable phosphorus response mechanisms to adapt to fluctuating phosphorus concentration,providing a novel perspective of how cyanobacteria may respond to the complex and dynamic environments.

关键词： Synechococcus sp PCC 7002 Phosphorus fluctuation Cyanobacteria ・Gene knockout Molecular mechanism

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Modifying agent selection for Al-7Si alloy by Miedema model

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International Journal of Minerals,Metallurgy and Materials 2012年第2期19卷 131-135页

作者： zhong-wei chen Cui-ying Ma Pei chen State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

To determine the modifying agents for Al-7Si alloys, microstructure observation and mixing enthalpy analysis using Miedema model for Al-7Si alloy with additions of different rare earth elements were performed, and the effects of rare earth elements on the modifica-tion of eutectic silicon morphology were investigated. The results of mixing enthalpy analysis show that these four rare earth elements, La, Sm, Pr, and Ce, which have the large negative mixing enthalpies with Si, can be selected as modifying agents for eutectic silicon morphology. The element with the largest negative mixing enthalpy is Ce. Furthermore, the microstructures indicate that these four elements can effec-tively modify the eutectic （α）Al-Si crystals in Al-7Si alloy, and the most effective one is also Ce. Differential scanning calorimetry （DSC） results show that the eutectic temperature depressions due to the additions of modifying agents are the important reasons for the modification of eutectic （α）Al-Si crystals.

关键词： aluminum alloys silicon alloys modifying agents rare earth elements microstructure enthalpy

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Microtextural evolution of different TRC AA8006 alloy sections with homogenization

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International Journal of Minerals,Metallurgy and Materials 2015年第3期22卷 292-301页

作者： zhong-wei chen Long-fei Shen Jing Zhao State Key Laboratory of Solidification Processing Northwestern Polytechnical University

Grain microtexture evolution in twin-roll cast AA8006 alloy sheets subjected to different treatments was investigated using elec- tron backscatter diffraction. The textures of rolling-transverse and normal-transverse sections were characterized in original as-cast twin-roll casting and cold-rolled samples as well as samples homogenized at 500℃for 8 h and at 580℃ for 4 h. It is found that grains on both the rolling-transverse and normal-transverse sections of cold-rolled samples are made fmer by rolling deformation and coarsened after homog- enization. Annealing temperature has a stronger effect on the microstructural evolution than annealing time. The grain growth direction is parallel to the normal-transverse section, while grain deformation is more stable on the rolling direction than on the normal direction. The rolling orientations display more obvious anisotropy on the normal-transverse sections than on the rolling-transverse sections. Grain recrys- tallization and growth occur much easier on the normal-transverse section than on the rolling-transverse section for samples homogenized at 500℃ for 8 h. A special misorientation relationship between cold deformation texture, such as S orientation { 123 } 〈634〉 and cube orienta- tion 〈110〉Xaxis [cubic], and recrystallization texture after homogenization, such as R orientation { 124}〈211〉 and P orientation {011 }〈122〉, is observed.

关键词： aluminum alloys textures twin-roll casting homogenization

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Microstructure and microhardness of nanostructured Al-4.6Cu-Mn alloy ribbons

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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 860-867页

作者： zhong-wei chen Qin-ying Fan Kai Zhao State Key Laboratory of Solidification Processing Northwestern Polytechnical University

The microstructural characteristics and microhardness of nanostructured Al-4.6Cu-Mn ribbons produced by melt spinning were investigated using field-emission gun scanning electron microscopy, transmission electron microscopy, and hardness testing, and the results were compared to those of similar ribbons manufactured by direct-chill casting. It is shown that the nanostructure of the as-melt-spun ribbons consists of α-Al dendrites with a secondary dendrite arm spacing of approximately 0.55-0.80 μm and ultrafine eutectic crystals of a nanosized scale of approximately 100-200 nm on dendritic boundaries. The solidification time and cooling rate of 46-μm-thick ribbons were estimated to be 1.3 × 10-6 s and 4.04 × 106 K·s-1, respectively. At an aging temperature of 190°C, the coherent θ″ phase in aged ribbons gradually transforms into nanoscale θ′-phase platelets as the aging time is extended from 2 to 8 h; the rod-like morphology of the T(Al20Cu2Mn3) dispersoid with 120-160-nm diameter also forms, which results in peak aging hardness. The precipitation behaviors of aged ribbons cannot be changed at the high cooling rates of as-cast ribbons. However, a finer and more uniformly distributed microstructure and a supersaturated solid solution at a high cooling rate can shorten the time required to obtain a certain aging hardness before peak hardness.

关键词： aluminum-copper-manganese alloys nanoribbons melt

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Microstructure and texture evolution of TRC A8006 alloy by homogenization

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International Journal of Minerals,Metallurgy and Materials 2013年第5期20卷 433-439页

作者： zhong-wei chen Jing Zhao Xiao-lei Hao State Key Laboratory of Solidification Processing Northwestern Polytechnical University

The microstructure and texture evolution of twin-roll cast A8006 alloy by homogenization were characterized using scanning and transmission electron microscopy, and the microhardness was tested as well. According to the relation- ship between dendritic arm spacing and cooling rate the cooling rate of the as-cast twin-roll cast A8006 sheet of 6 mm in thickness was estimated as 1.48×10^3 K·s^-1. It is found that the grains and the nanostructural precipitates of the twin-roll cast sheet become coarser after homogenization at 580℃ for 4 h in comparison with those after homogenization at 500℃ for 8 h. The textures formed after cold rolling and became weaker during homogenization. The increase in hardness of the as-cast twin-roll cast sheets is related in hardness after homogenization can to the supersaturated a-A1 solid solution and be attributed to the coarsening of grains and fine microstructure, but the decrease Al6Fe（Mn） precipitates.

关键词： aluminum alloys homogenization microstructure textures hardness

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Effect of rare earth samarium addition on the kinetics of precipitation in Al-Cu-Mn casting alloy

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International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 155-161页

作者： zhong-wei chen Ming-jun Tang Kai Zhao State Key Laboratory of Solidification Processing Northwestern Polytechnical University

The mechanical properties of Al-Cu-Mn casting alloy mainly depend on the morphology, distribution, size, and number ofθ′（Al2Cu） precipitates. In this study, we have analyzed the effect of rare earth samarium （Sm） addition on the kinetics of precipitation in the Al-Cu-Mn casting alloy by using differential scanning calorimetry （DSC） and high-resolution transmission electron microscopy. Thermal ef-fect peaks that are attributed to the formation and the dissolution of Guinier-Preston （GP） zone andθ′phase were identified from the DSC curves. The activation energy ofθ′formation was calculated by using both the Kissinger method and the analytical model, and the corre-sponding results were compared. Results suggest that the activation energy ofθ′formation in Al-Cu-Mn alloy is dramatically higher than that in Al-Cu-Mn-Sm alloy. Accordingly, it is concluded that the addition of rare earth Sm decreases the activation energy ofθ′formation and promotes the formation ofθ′precipitates.

关键词： aluminum copper alloys rare earth additions samarium precipitation kinetics

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Aerobic degradation of methyl tert-butyl ether by a Proteobacteria strain in a closed culture system

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Journal of Environmental Sciences 2007年第1期19卷 18-22页

作者： zhong wei-hong chen Jian-meng LU Zheng chen Dong-zhi chen Xiao College of Biological and Environmental Engineering Zhefiang University of Technology Hangzhou 310032 China

The contamination of methyl ten-butyl ether （MTBE） in underground waters has become a widely concerned problem all over the world. In this study, a novel dosed culture system with oxygen supplied by H2O2 was introduced for MTBE aerobic biodegradation. After 7 d, almost all MTBE was degraded by a pure culture, a member of β-Proteobacteria named as PMI, in a closed system with oxygen supply, while only 40% MTBE was degraded in one without oxygen supply. Dissolved oxygen （DO） levels of the broth in closed systems respectively with and without H2O2 were about 5-6 and 4 mg/L. Higher DO may improve the activity of monooxygemase, which is the key enzyme of metabolic pathway from MTBE to tert-butyl alcohol and finally to CO2, and may result in the increase of the degrading activity of PM1 cell. The purge and trap GC-MS result of the broth in closed systems showed that tea-butyl alcohol, isopronol and acetone were the main intermediate products.

关键词： methyl tert-butyl ether biodegradation β-Proteobacteria intermediate products

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Computational Simulation of Sodium Doublet Line Intensities in Multibubble Sonoluminescence

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Chinese Physics Letters 2019年第10期36卷 90-93页

作者： Jin-Fu Liang Yu An wei-zhong chen School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025 Department of Physics Tsinghua UniversityBeijing 100084 Institution of Acoustics Nanjing UniversityNanjing 210093 Key Laboratory of Radio Astronomy of Guizhou Province Guiyang 550025

We perform a computational simulation of the fluid dynamics of sodium doublet(Na-D)line emissions from one sonoluminescing bubble among the cavitation bubbles in argon-saturated Na hydroxide(NaOH)aqueous *** simulation includes the distributions of acoustic pressures and the dynamics of cavitation bubbles by numerically solving the cavitation dynamic equation and bubble-pulsation *** simulation results demonstrate that when the maximum temperature inside a luminescing bubble is relatively low,two emission peaks from excited Na are prominent within the emission spectra,at wavelengths of 589.0 and 589.6 *** the maximum temperature of the bubble increases,the two peaks merge into one peak and the full width at half maximum of this peak *** calculations match with the observations of Na-D line emissions from MBSL occurring in aqueous solutions of NaOH under an argon gas.

关键词： equation. bubble cavitation

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Texture evolution of Al-Mg-Li aeronautical alloys in in-situ tension

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International Journal of Minerals,Metallurgy and Materials 2012年第12期19卷 1100-1106页

作者： zhong-wei chen Jing Zhao Shi-shun Li State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

Texture evolution in extruded and hot-rolled Al-Mg-Li aeronautical alloys during in-situ tension was investigated by using elec-tron backscattered diffraction （EBSD）. A field emission scanning electron microscope （FE-SEM） and a MICROTEST-5000 tensile stage were used to carry out in-situ tension tests and observations. The crystallographic texture of the extruded sample changed from weak cube texture {001}〈100〉 to texture {018}〈081〉 during tension fracture. However, strong Brass {110}〈112〉 in the hot-rolled sample was modi-fied into a mixture texture component of Brass {110}〈112〉 and S {123}〈634〉 during tension fracture. Texture evolution in the two samples during tension can be explained by the rotation of grain orientation.

关键词： aluminum lithium alloys textures tensile testing extrusion hot rolling

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