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HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 344-352页

作者： Qing-Zhi Hu Zhen-Rui Cao wei-xiong zheng Min-Jie Zhao Jun-Hua Gong Cong Chen Zhong-Jun Wu Rui Tao Department of Hepatobiliary Surgery Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China c Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Ischemia-reperfusion injury(IRI)poses a significant challenge to liver transplantation(LT).The underlying mechanism primarily involves overactivation of the immune *** shock protein 110(HSP110)functions as a molecular chaperone that helps stabilize protein ***:An IRI model was established by performing LT on Sprague-Dawley rats,and HSP110 was silenced using ***-eosin staining,TUNEL,immunohistochemistry,ELISA and liver enzyme analysis were performed to assess IRI following *** blotting and quantitative reverse transcription-polymerase chain reaction were conducted to investigate the pertinent molecular ***:Our findings revealed a significant increase in the expression of HSP110 at both the mRNA and protein levels in the rat liver following LT(P<0.05).However,when rats were injected with siRNAHSP110,IRI subsequent to LT was notably reduced(P<0.05).Additionally,the levels of liver enzymes and inflammatory chemokines in rat serum were significantly reduced(P<0.05).Silencing HSP110 with siRNA resulted in a marked decrease in M1-type polarization of Kupffer cells in the liver and downregulated the NF-κB pathway in the liver(P<0.05).Conclusions:HSP110 in the liver promotes IRI after LT in rats by activating the NF-κB pathway and inducing M1-type polarization of Kupffer *** HSP110 to prevent IRI after LT may represent a promising new approach for the treatment of LT-associated IRI.

关键词： Ischemia-reperfusion injury Liver transplantation Inflammation HSP110 Heat shock proteins NF-κB

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Clinicopathologic features of 112 cases with mantle cell lymphoma

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Cancer Biology & Medicine 2015年第1期12卷 46-52页

作者： Dong-Mei Zhou Gang Chen xiong-wei zheng wei-Feng Zhu Bao-Zhen Chen Department of Pathology Key Laboratory of Cancer Translational Medicine of FujianTeaching Hospital of Fujian Medical UniversityFujian Tumor Hospital

Objective： This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma （MCL）. Methods： Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization （FISH） detected a break in the CCND 1 gene. The t-test was used in the statistical analysis. Results： All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CDS-MCL. IgH/CCND 1 polyploid was observed in 2 classic cases. Conclusion： MCL is a type of special immunophenotypic B-cell lymphoma, The prognoses ofblastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.

关键词： Mantle cell lymphoma (MCL) immunohistochemistry fluorescence in situ hybridization (FISH) prognosis

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Fluorescent carbon dots synthesized in solid phase and air for application in LEDs

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Nano Research 2024年第9期17卷 8495-8503页

作者： wei-Jie zheng Zhao-Nan Sun Yi-Ming Wang Huan-Ming xiong Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200438China

Carbon dots(CDs)have been widely adopted as optical materials because of their excellent luminescent ***,most of the reported synthetic methods are conducted in solvents,especially hydrothermal/solvothermal reactions,leading to intractable problems such as toxic and flammable solvents,complex and inseparable by-products,and dangerously high pressures and ***-phase synthesis of CDs in air is an effective solution to overcome the above issues,but solid reactions always result in uncontrolled growth and agglomeration of *** this study,some inorganic salts are selected as catalysts for synthesizing CDs in solid states and air,which also play as dispersants to hinder CDs *** the meantime,some aromatic derivatives containing hydroxyl and amino groups are chosen as carbon sources,ground with the optimized catalyst,and then heated together in *** production yields are affected by the reaction time and reactant ratio,while the graphitization degrees of the CDs are determined by the reaction *** IG/ID value of their Raman spectra increases from 0.59 to 0.85,and the particle size decreases from 2.5 to 1.4 nm when the synthesis temperature is increased from 200 to 280℃.The as-prepared CDs show emission peaks ranging from 366 to 606 nm,with the photoluminescence(PL)quantum yield up to 53%.Their emission color variation mainly results from different carbon sources,which can be ascribed to the differences in the element composition,functional groups,and graphitic nitrogen content of these *** dispersing CDs of different concentrations into polyvinyl alcohol(PVA)and combining them with blue LEDs,cold,standard,and warm white light emitting devices(WLEDs)are prepared,with a color rendering index(CRI)up to *** the as-prepared CDs have antioxidant ability at high temperature,the as-prepared WLEDs have long lifespans,remaining the effective white luminescence after 72 h continuous work.

关键词： carbon dot solid-phase synthesis white LED photoluminescence inorganic salt catalysis

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An Example of Embedded Singular Continuous Spectrum for Discrete Schrödinger Operators

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1837-1849页

作者： zheng Qi FU xiong LI Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

We present an example of a potential such that the corresponding discrete Schrödinger operator has singular continuous spectrum embedded in the absolutely continuous spectrum.

关键词： Sparse potentials singular continuous spectrum Prüfer variables

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Convex-up Style of Deformation within Grabens in Regions of Incomplete Crossing Conjugate Normal Faults: A Numerical Simulation Investigation and Case Study

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Journal of Earth Science 2024年第3期35卷 839-849页

作者： zheng Li Kai Wang xiong xiong Bing Zhou School of Geophysics and Geomatics China University of GeosciencesWuhan 430074China State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China Department of Earth Sicences Khalifa UniversityAbu DhabiUnited Arab Emirates

Crossing conjugate normal faults(CCNFs)are extensively developed in many hydrocarbon-producing basins,generally existing in the form of incomplete ***,the effect of the non-conjugate zone of the CCNFs on the conjugate relay zone post late tectonic action has not been previously *** use 3D elastic-plastic modeling to investigate the influence of incomplete(i.e.,partially intersecting)CCNFs on the pattern of deformation of strata in the intersection region.A series of model simulations were performed to examine the effects of horizontal tectonic extension,fault size,and fault depth on the deformation of conjugate relay zones of incomplete *** analyses yielded the following results.(1)The model of incomplete conjugation predicts a convex-up style of deformation in the conjugate graben region superimposed on overall subsidence under applied horizontal tectonic extension.(2)The degree of convex-up deformation of the conjugate graben depends on the influence of the non-conjugate zone on the conjugate relay zone,which varies with the amount of horizontal tectonic extension,fault size,and fault burial depth.(3)Our results indicate that incomplete CCNFs can form convex-up deformation,similar to that in the Nanpu Sag area and provide a sound understanding of hydrocarbon migration and accumulation.

关键词： incomplete conjugate normal fault conjugate graben convex-up deformation hydrocarbons Nanpu Sag tectonics.

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Source model of the 2018 M_(w)7.5 Papua New Guinea earthquake constrained by InSAR measurements: Insight into a blind rupture beneath the New Guinea Highlands

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Geodesy and Geodynamics 2024年第4期15卷 315-325页

作者： wei Chen Tianchen Sheng wei xiong Key Laboratory of Earthquake Geodesy Institute of SeismologyChina Earthquake AdministrationWuhan 430071China Qinghai Provincial Basic Surveying and Mapping Institute Xining 810001China School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China

The Southern Highland Fold and Thrust Belt(SHFTB),the boundary of the Australian plate and the New Guinea Highland block,significantly contributes to the convergent deformation along the plate ***,due to the lack of observation data,the detailed slip pattern of the SHFTB and the orogenic mechanism beneath the New Guinea Highlands remains *** 25 February 2018,the M_(w)7.5 Papua New Guinea(PNG)earthquake struck the southeastern segment of the *** detailed rupture characteristics of this event is significant for further clarifying the inter-seismic slip pattern along the ***,the coseismic deformation field of this earthquake was obtained using high-resolution ALOS-2 satellite *** find that the 2018 M_(w)7.5 PNG earthquake ruptured a large-scaled fault(SHFTB)extending to the lower crust(deeper than 20 km)beneath the New Guinea Highlands,with a dip angle of 24°.The slips on the fault plane are equivalent to moment magnitudes of M_(w)*** major asperities with thrust-dominated slip of up to 3.94 m are detected on the fault *** finding implies that the slip pattern on the eastern segment of the SHFTB is dominated by thrust,rather than with significant sinistral movement,as previously *** tectonic deformation across the New Guinea Highlands is possibly concentrated on the large-scale fault SHFTB and primarily controls the intra-continental orogeny in the central Papua New Guinea.

关键词： 2018M_(w)7.5PapuaNewGuineaearthquake The Southern Highlands Fold-and-Thrust Belt InSAR Slipdistribution Seismicrisk

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Ferroptosis:a critical mechanism of N^(6)-methyladenosine modification involved in carcinogenesis and tumor progression

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Science China(Life Sciences) 2024年第6期67卷 1119-1132页

作者： Qingqing wei Changning Xue Mengna Li Jianxia wei Lemei zheng Shipeng Chen Yumei Duan Hongyu Deng Faqing Tang wei xiong Ming Zhou NHC Key Laboratory of Carcinogenesis Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Cancer Research Institute and School of Basic Medical Sciences Central South UniversityChangsha 410078China The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Central South UniversityChangsha 410078China Hunan Key Laboratory of Oncotarget Gene Hunan Key Laboratory of Cancer MetabolismHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China

Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid *** occurs when multiple redoxactive enzymes are ectopically expressed or show abnormal ***,the precise regulation of ferroptosis-related molecules is mediated across multiple levels,including transcriptional,posttranscriptional,translational,and epigenetic levels.N^(6)-methyladenosine(m^(6)A)is a highly evolutionarily conserved epigenetic modification in *** m^(6)A modification is commonly linked to tumor proliferation,progression,and therapy resistance because it is involved in RNA metabolic ***,accumulating evidence suggests that dysregulated ferroptosis caused by the m^(6)A modification drives tumor *** this review,we summarized the roles of m^(6)A regulators in ferroptosis-mediated malignant tumor progression and outlined the m^(6)A regulatory mechanism involved in ferroptosis *** also analyzed the potential value and application strategies of targeting m^(6)A/ferroptosis pathway in the clinical diagnosis and therapy of tumors.

关键词： ferroptosis m6A modification RNA methylation m^(6)A regulator tumor progression

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On-surface synthesis and characterization of polyynic carbon chains

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National Science Review 2024年第3期11卷 192-199页

作者： Wenze Gao wei zheng Luye Sun Faming Kang zheng Zhou wei Xu Interdisciplinary Materials Research Center School of Materials Science and Engineering Tongji University

Carbyne, an elusive sp-hybridized linear carbon allotrope, has fascinated chemists and physicists for decades. Due to its high chemical reactivity and extreme instability, carbyne was much less explored in contrast to the sp2-hybridized carbon allotropes such as graphene. Herein, we report the on-surface synthesis of polyynic carbon chains by demetallization of organometallic polyynes on the Au（111） surface;the longest one observed consists of ～60 alkyne units（120 carbon atoms）. The polyynic structure of carbon chains with alternating triple and single bonds was unambiguously revealed by bond-resolved atomic force microscopy. Moreover, an atomically precise polyyne, C14, was successfully produced via tip-induced dehalogenation and ring-opening of the decachloroanthracene molecule(C14Cl10) on a bilayer NaCl/Au（111） surface at 4.7 K, and a band gap of 5.8 eV was measured by scanning tunnelling spectroscopy,in a good agreement with the theoretical HOMO–LUMO gap（5.48 eV）.

关键词： polyyne scanning probe microscopy carbon allotrope on-surface synthesis organometallic polyyne

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Accurately tracking hypersonic gliding vehicles via an LEO mega-constellation in relay tracking mode

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Journal of Systems Engineering and Electronics 2024年第1期35卷 211-221页

作者： LI Zhao WANG Yidi zheng wei College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

In order to effectively defend against the threats of the hypersonic gliding vehicles(HGVs),HGVs should be tracked as early as possible,which is beyond the capability of the ground-based *** benefited by the developing megaconstellations in low-Earth orbit,this paper proposes a relay tracking mode to track HGVs to overcome the above *** whole tracking mission is composed of several tracking intervals with the same *** each tracking interval,several appropriate satellites are dispatched to track the *** that are planned to take part in the tracking mission are selected by a new derived observability *** tracking performances of the proposed tracking mode and the other two traditional tracking modes,including the stare and track-rate modes,are compared by *** results show that the relay tracking mode can track the whole trajectory of a HGV,while the stare mode can only provide a very short tracking ***,the relay tracking mode achieve higher tracking accuracy with fewer attitude controls than the track-rate mode.

关键词： target tracking mega-constellation hypersonic gliding vehicle(HGV) sensor selection observability analysis

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Improving the spaceborne GNSS-R altimetric precision based on the novel multilayer feedforward neural network weighted joint prediction model

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Defence Technology（防务技术） 2024年第2期32卷 271-284页

作者： Yiwen Zhang wei zheng Zongqiang Liu Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China China Academy of Aerospace Science and Innovation Beijing 100176China State Key Laboratory of Space-Ground Integrated Information Technology Beijing Institute of Satellite Information EngineeringBeijing 100194China

Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at the global scale required for underwater *** present,there are still research gaps for GNSS-R altimetry under this mode,and its altimetric capability cannot be specifically ***,GNSS-R satellite constellations that meet the global altimetry needs to be ***,the matching precision prediction model needs to be established to quantitatively predict the GNSS-R constellation altimetric ***,the GNSS-R constellations altimetric precision under different configuration parameters is calculated,and the mechanism of the influence of orbital altitude,orbital inclination,number of satellites and simulation period on the precision is analyzed,and a new multilayer feedforward neural network weighted joint prediction model is ***,the fit of the prediction model is verified and the performance capability of the model is tested by calculating the R2 value of the model as 0.9972 and the root mean square error(RMSE)as 0.0022,which indicates that the prediction capability of the model is ***,using the novel multilayer feedforward neural network weighted joint prediction model,and considering the research results and realistic costs,it is proposed that when the constellation is set to an orbital altitude of 500 km,orbital inclination of 75and the number of satellites is 6,the altimetry precision can reach 0.0732 m within one year simulation period,which can meet the requirements of underwater navigation precision,and thus can provide a reference basis for subsequent research on spaceborne GNSS-R sea surface altimetry.

关键词： GNSS-R satellite constellations Sea surface altimetric precision Underwater navigation Multilayer feedforward neural network

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