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Perforating and nonperforating indications in repeated surgeries for Crohn's disease

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World Journal of Clinical Cases 2022年第9期10卷 2733-2742页

作者： wei-song shen Xiao-Hui Huang Rui-Qing Liu Chen-Yang Li Yi Li wei-Ming Zhu Department of Gastrointestinal Surgery Peking University People’s HospitalBeijing 100044China Department of General Surgery Chinese PLA General Hospital First Medical CenterBeijing 100853China Department of General Surgery The affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Peking University School of Nursing Peking University School of NursingBeijing 100191China Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

BACKGROUND Despite advances in medical therapy for Crohn’s disease(CD),most patients with CD require repeated resection *** To analyze the perforating and nonperforating indications of repeated CD operations and identify the anastomosis characteristics for postoperative *** We retrospectively reviewed 386 patients who underwent at least one resection for CD between 2003 and *** characteristics of each surgery were *** and multivariate analyses were performed to determine risk factors for *** The indication for reoperation in CD tends to be the same as that for primary operation,i.e.,perforating disease tends to represent as perforating disease and nonperforating as *** was found between the first surgery and second surgery in terms of the indication for the operation(P=0.006),and the indication for the third surgery was also correlated with that for the second surgery(P=0.033).Even if the correlation of surgical indications between repeated operations,the rate of perforating indication for the second and third surgeries was significantly higher than that of the first *** addition,the presence of perforating CD was a predictor of recurrence for both the first and second ***,anastomotic lesions were the most common sites of recurrence after the *** on the importance of anastomosis,anastomosis might be a new type of disease location for the classification of postoperative *** CD not only has stable characteristics but also progresses *** is a progressive surgical indication for Crohn’s *** CD after surgery,anastomosis may be a new classification of disease location.

关键词： Crohn’s Disease Anastomosis Perforation Nonperforating

Palliative Therapy for Gastric Outlet Obstruction Caused by Unresectable Gastric Cancer： A Meta-analysis Comparison of Gastrojejunostomy with Endoscopic Stenting

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Chinese Medical Journal 2016年第9期129卷 1113-1121页

作者： Shi-Bo Bian wei-song shen Hong-Qing Xi Bo wei Lin Chen Department of General Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background： Gastrojejunostomy （G J J） and endoscopic stenting （ES） are palliative treatments for gastric outlet obstruction （GO0） caused by gastric cancer. We compared the outcomes of GJJ with ES by performing a meta-analysis. Methods： Clinical trials that compared GJJ with ES for the treatment of GOO in gastric cancer were included in the meta-analysis. Procedure time, time to resumption of oral intake, duration of hospital stay, patency duration, and overall survival days were compared using weighted mean differences （WMDs）. Technical success, clinical success, procedure-related mortality, complications, the rate of re-obstruction, postoperative chemotherapy, and reintervention were compared using odds ratios （ORs）.Results： Nine studies were included in the analysis. Technical success and clinical success were not significantly different between the ES and GJJ groups. The ES group had a shorter procedure time （WMD = -80.89 min, 95% confidence interval [CI] = -93.99 to -67.78, P 〈 0.001）, faster resumption of oral intake （WMD = -3.45 days, 95% CI = -5.25 to -1.65, P 〈 0.001）, and shorter duration of hospital stay （WMD = -7.67 days, 95% CI = -11.02 to -4.33, P 〈 0.001）. The rate of minor complications was significantly higher in the GJJ group （OR = 0.13, 95% CI = 0.04-0.40, P 〈 0.001）. However, the rates of major complications （OR = 6.91, 95% CI = 3.90-12.25, P 〈 0.001）, re-obstruction （OR = 7.75, 95% CI = 4.06-14.78, P 〈 0.001）, and reintervention （OR = 6.27, 95% CI = 3.36-11.68, P 〈 0.001） were significantly lower in the GJJ group than that in the E S group. Moreover, GJJ was significantly associated with a longer patency duration （WMD = -167.16 days, 95% CI = -254.01 to -89.31, P 〈 0.001） and overall survival （WMD = -103.20 days, 95% CI = -161.49 to -44.91, P = 0.001）. Conclusions： Both GJJ and ES are effective procedures for the treatment of GOO caused by gastric cancer. ES is associated with better short-term outcomes. GJJ is preferable to ES in terms of its lo

关键词： Endoscopic Stenting Gastric Cancer Gastric Outlet Obstruction Gastrojejunostomy

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru shen Zheng song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

Discrete Numerical Study on Type II Fracture of Partially Detached Concrete Panels in Cold Region

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Structural Durability & Health Monitoring 2025年第1期19卷 167-191页

作者： Huayi Zhang Maobin song Lei shen Nizar Faisal Alkayem Maosen Cao College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210024China Haihe River Huaihe River and Xiaoqinghe River Basin Water Conservancy Management and Service Center of Shandong ProvinceJinan250100China College of Mechanics and Engineering Science Hohai UniversityNanjing211100China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-ﬁlled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during con-struction,the inﬂuence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefﬁcient on the bending stiffness are analyzed parametrically by the numerical simula-tion technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placementﬁrst and then prestress-tensioning is proposed.

关键词： Beam-string structure(BSS) concrete-ﬁlled steel tube(CFST) bending stiffness timing of concrete placement prestress-tensioning

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu shen Hudie wei Hongyu Chen Guoqiang Ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

Comparison of Therapeutic Efficacy between Gastrectomy with Transarterial Chemoembolization Plus Systemic Chemotherapy and Systemic Chemotherapy Alone in Gastric Cancer with Synchronous Liver Metastasis

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Chinese Medical Journal 2015年第16期128卷 2194-2201页

作者： Sen-Feng Liu Can-Rong Lu Hai-Dong Cheng Hong-Qing Xi Jian-Xin Cui Ji-Yang Li wei-song shen Lin Chen Department of General Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background：Systemic chemotherapy （SC） is the recommended treatment for gastric cancer with liver ***,the improvement in survival has been *** aim of this study was to compare the therapeutic efficacy of gastrectomy with transarterial chemoembolization plus SC （GTC） and SC alone for gastric cancer with synchronous liver ***：From January 2008 to December 2013,107 gastric cancer patients with synchronous liver metastasis attending the four participating centers were enrolled in this multicenter,ambispective,controlled cohort *** who underwent GTC （n =32） were compared with controls who were received SC alone （n =75）.The primary endpoints of the study were overall survival （OS） and progression-free survival （PFS）.The secondary endpoints were response rate to treatment and treatment-related adverse ***：The median OS was 14.0 months （95% confidence interval [CI]：13.1-14.9 months） in the GTC treatment group and 8.0 months （95% CI：6.6-9.4 months） in SC group,this difference being statistically significant （P 〈 0.001）.The median PFS was significantly longer in the GTC than in the SC group （5 months,95% CI：2.2-7.8 months vs.3 months,95% CI：2.3-3.4 months,respectively）（P 〈 0.001）.The rate of response to treatment was significantly better in the GTC than the SC group （59.4% vs.37.4%,respectively）（P =0.035）.According to multivariate analysis,OS in patients receiving combination treatment was significantly correlated with the size （P =0.037） and extent of liver metastases （P 〈 0.001）.PFS was also correlated with the extent of liver metastases （P =0.003）.Conclusions：GTC is more effective than SC alone in patients with gastric cancer with synchronous liver *** therapy prolongs the survival of selected gastric cancer patients with synchronous liver metastasis.

关键词： Chemotherapy Gastrectomy Gastric Cancer Liver Metastases Transcatheter Arterial Chemoembolization

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li wei Yue Nam‑Young Kim Yang Li Guozhen shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin shen Guimei Zhang Chunxiao wei Panpan Zhao Yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs