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Postoperative diarrhea in Crohn's disease:Pathogenesis,diagnosis,and therapy

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World Journal of Clinical Cases 2023年第1期11卷 7-16页

作者： En-Hao Wu Zhen Guo wei-ming zhu Department of General Surgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

Diarrhea is a frequent symptom in postoperative patients with Crohn’s diseases(CD),and several different mechanisms likely account for postoperative diarrhea in CD.A targeted strategy based on a comprehensive underst... 详细信息

关键词： Postoperative diarrhea Crohn’s disease Intestinal resection Bile acid malabsorption Treatment

Current status of novel biologics and small molecule drugs in the individualized treatment of inflammatory bowel disease

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World Journal of Gastroenterology 2022年第48期28卷 6888-6899页

作者： Yi-Han Xu wei-ming zhu Zhen Guo Department of General Surgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

Treatment strategies for inflammatory bowel disease(IBD)are rapidly evolving with the development of biologics and small molecule drugs(SMDs).However,these drugs are not guaranteed to be effective in all patients,and a“ceiling effect”of biologic monotherapy may *** issue highlights an unmet need for optimizing the use of biologics and predicting therapeutic ***,the development of new drugs with novel mechanisms of action is urgently needed for patients with primary nonresponse and secondary loss of response to conventional biologics and *** addition,combining different biologics or SMDs has been proposed as a novel strategy to enhance treatment efficacy in IBD,which theoretically has multidimensional anti-inflammatory *** on the current evidence available for IBD,dual targeted therapy may be a promising strategy for refractory IBD patients who have failed in multiple biologic treatments or who have extraintestinal ***,identifying the subgroup of IBD patients who are responding to biological combination therapies is also equally important in stable disease *** this review,we summarize the newly developed biologics and SMDs and the current status of biologics/SMDs to highlight the development of individualized treatment in IBD.

关键词： Inflammatory bowel diseases Biologic Dual targeted therapy Therapeutic drug monitoring Bispecific antibodies

Inhomogeneous Deformation of Multilayered Roll-Bonded Brass/Cu Composites

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Acta Metallurgica Sinica(English Letters) 2015年第5期28卷 600-607页

作者： Nan Jia ming-wei zhu Yi-Ran Zheng Tong He Xiang Zhao Key Laboratory for Anisotropy and Texture of Materials (ATM) Northeastern University Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Research Institute Northeastern University

The deformation gradients in multilayered hot roll-bonded composite materials incorporating two dissimilar face-centered cubic metals, i.e., brass and Cu, were investigated by characterizing the deformation microstructure, hardness and texture at different thickness positions of the composites. For the constitutive metals, the center part of each metal sheet forms the substructure containing coarse grains, while the ultrafine grains and significant shear banding form in the outer part. As deformation increases, the cross-interface shear occurs in the Cu sheet of the composites. Then, grain fragmentation, shear banding and dynamic recovery become the main factors that influence hardness of the metal. Moreover, in the co-deformed composites, the interface between brass and Cu plays a role in texture developments of the individual metals.

关键词： Deformation Multilayers Brass/Cu composites Texture

Effect of Metformin on Tyrosine Kinase Autophosphorylation of Erythrocyte Insulin Receptor from Women with Polycystic Ovary Syndrome

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Journal of Reproduction and Contraception 2012年第3期23卷 150-158页

作者： ming-wei zhu Yang LI Jin-fang LIN The Obstetrics and Gynecology Hospital Fudan University Shanghai 200011 China

Objective To document the possible effect of tyrosine kinase autophosphorylation on erythrocyte insulin-receptor after 12 weeks of metformin administration from the women with polycystic ovary syndrome （PCOS）. Methods Thirty non-obese （BMI〈25 kg/m2） healthy women with normal reproductive cycles were evaluated by conventional criteria as the control 30 non-obese women with PCOS were categorized as nob-PCOS group, 40 obese women with PCOS （BMI 25 kg/m2） were categorized as ob-PCOS group. Subjects with PCOS were given metformin 850 mg/d for 12 weeks. The autophosphorylation of insulin receptor p Yl158, pyl162/1163 and insulin receptor-fl subunit （IR-~） from the solubilised erythrocyte were detected by ELISA. Results 1） Only the autophosphorylation level of p Yl l 58 in nob-PCOS and ob-PCOS groups was lower （P〈O.05） than that in control group and it can be increased after insulin stimulation （P〈O.05）; no similar changes were found in pYl162/1163 （P〉O.05）, even insulin-stimulated insulin receptor （P〉O.05） from both of PCOS groups. 2） After metformin administration, the p Y1158, p Y1162/p Y1163 autophosphorylation levels were increased （P〈O.O1） and further increased after plus insulin stimulation in vitro （P〈0. 01）. The p Y1162/1163 autophosphorylation level was increased in nob-PCOS group （P〈0.01） and ob-PCOS group （P〈0.05）. 3） No difference was found in concentration of IR-B between control group and both of PCOS groups following metformin administration （P〉0.05）. In summary, oral administration of metformin led to an significant increase in tyrosine kinase activity in both groups of PCOS. Conclusion The impairment of tyrosine autophosphorylation at pYl158 may contribute to insulin resistance, the tyrosine kinase activity per receptor of solubilised erythrocytes were significantly increased by metformin administration and the effect of metformin on insulin-receptor tyrosine kinase activity appeared to be independent of either of these variables.

关键词： polycystic ovary syndrome (PCOS) metformin insulin receptors tyrosineautophosphorylation erythrocytes

Role of mesenteric component in Crohn’s disease:A friend or foe?

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1536-1549页

作者： Yi Yin Zhen-Xing zhu zhun Li Yu-Sheng Chen wei-ming zhu Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

Crohn’s disease(CD)is a complex and relapsing gastrointestinal disease with mesenteric *** mesenteric neural,vascular,and endocrine systems actively take part in the gut dysbiosis-adaptive immunity-mesentery-body axis,and this axis has been proven to be *** abnormalities of morphology and function of the mesenteric component are associated with intestinal inflammation and disease progress of CD via responses to afferent signals,neuropeptides,lymphatic drainage,adipokines,and functional *** hypertrophy of mesenteric adipose tissue plays important roles in the pathogenesis of CD by secreting large amounts of adipokines and representing a rich source of proinflammatory or profibrotic *** vascular alteration,including angiogenesis and lymphangiogenesis,is concomitant in the disease course of *** note,the enlarged and obstructed lymphatic vessels,which have been described in CD patients,are likely related to the early onset submucosa edema and being a cause of *** function of mesenteric lymphatics is influenced by endocrine of mesenteric nerves and ***,the structure of the mesenteric lymphatic vessels in hypertrophic mesenteric adipose tissue is mispatterned and ruptured,which can lead to lymph *** lymph factors can in turn stimulate adipose tissue to proliferate and effectively elicit an immune *** identification of the role of mesentery and the crosstalk between mesenteric tissues in intestinal inflammation may shed light on understanding the underlying mechanism of CD and help explore new therapeutic targets.

关键词： Crohn’s disease Mesenteric nerves Angiogenesis Lymphatic drainage Mesenteric adipose tissue

Perforating and nonperforating indications in repeated surgeries for Crohn's disease

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World Journal of Clinical Cases 2022年第9期10卷 2733-2742页

作者： wei-Song Shen Xiao-Hui Huang Rui-Qing Liu Chen-Yang Li Yi Li wei-ming zhu Department of Gastrointestinal Surgery Peking University People’s HospitalBeijing 100044China Department of General Surgery Chinese PLA General Hospital First Medical CenterBeijing 100853China Department of General Surgery The affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Peking University School of Nursing Peking University School of NursingBeijing 100191China Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

BACKGROUND Despite advances in medical therapy for Crohn’s disease(CD),most patients with CD require repeated resection *** To analyze the perforating and nonperforating indications of repeated CD operations and identify the anastomosis characteristics for postoperative *** We retrospectively reviewed 386 patients who underwent at least one resection for CD between 2003 and *** characteristics of each surgery were *** and multivariate analyses were performed to determine risk factors for *** The indication for reoperation in CD tends to be the same as that for primary operation,i.e.,perforating disease tends to represent as perforating disease and nonperforating as *** was found between the first surgery and second surgery in terms of the indication for the operation(P=0.006),and the indication for the third surgery was also correlated with that for the second surgery(P=0.033).Even if the correlation of surgical indications between repeated operations,the rate of perforating indication for the second and third surgeries was significantly higher than that of the first *** addition,the presence of perforating CD was a predictor of recurrence for both the first and second ***,anastomotic lesions were the most common sites of recurrence after the *** on the importance of anastomosis,anastomosis might be a new type of disease location for the classification of postoperative *** CD not only has stable characteristics but also progresses *** is a progressive surgical indication for Crohn’s *** CD after surgery,anastomosis may be a new classification of disease location.

关键词： Crohn’s Disease Anastomosis Perforation Nonperforating

Optical Transient Source AT2021lfa:A Possible“Dirty Fireball”

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Research in Astronomy and Astrophysics 2024年第4期24卷 124-133页

作者： Xue-Mei Ye Da-ming wei Yi-ming zhu Zhi-Ping Jin Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China

AT2021lfa,also known as ZTF21aayokph,was detected by the Zwicky Transient Facility on 2021 May 4,a 05:34:48 ***-up observations were conducted using a range of ground-based optical telescopes,as wel as Swift/XRT and VLA ***2021lfa is classified as an“orphan afterglow”candidate due to its rapid flux decline and its reddened color(g-r=0.17±0.14 mag).For an optical transient source without promp gamma-ray detection,one key point is to determine its burst *** we measure the burst time through fitting the initial bump feature of AT2021lfa and obtain its burst time as 2021 May 3,at 22:09:50 *** afterglowpy,we model the multi-band afterglow of AT2021lfa and find that the standard model canno reproduce the late radio observations *** that the microphysical parameters ε_(e),ε_(B)(the energy fraction given to electrons and magnetic field),andξN(the fraction of accelerated electrons)may vary with time we then model the afterglow of AT2021lfa taking into account the temporal evolution of the physical parameters ε_(e),ε^(B),and ξ_(N) and find in this case the multi-wavelength observations can be reproduced *** initial Lorentz factor of AT2021lfa can be estimated from the peak time of the early afterglow,which yields a value of about 18 suggesting that AT2021lfa should be classified as a“dirty fireball.”From the upper limit for the prompt emission energy of AT2021lfa,we obtain that the radiation efficiency is less than 0.02%,which is much smaller than that of ordinary gamma-ray bursts(GRBs).It is also interesting that the fitted values of jet angle and viewing angle are very large,θ_(c)~0.66 rad,θ_(v)~0.53 rad,which may lead to the low Lorentz factor and radiation *** compared with GRB afterglow samples,it is evident that the onset bump timescale of AT2021lfa satisfies the empirical relationships observed in GRB ***,the luminosity of AT2021lfa falls within the range of observations for GRB samples;howeve

关键词： gamma-rays:ISM methods:numerical radiation mechanisms:non-thermal

New Diterpenoid Alkaloids from Spiraea japonica var. Ovalifolia

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Chinese Chemical Letters 2001年第2期12卷 147-150页

作者： Guo Ying ZUO Hong Ping HE Xin HONG wei ming zhu Yi ming HU Xiao Sheng YANG Xiao Jiang HAO Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 Kunming 43 Hospital PLAKunming 650032 The Key Laboratory of Chemistry for Natural Products ofGuizhou Province and Chinese Academy of Sciences Guiyang 550002

Five new diterpenoid alkaloids. 19-O-deethlyspiramine N (1), deacetylspiramine S (2), spiramidine A (3), spiramidine B (4) and deacetylspiramine F (5) were isolated from the aerial parts of Spirae japonica L. f. var o... 详细信息

关键词： Rosaceae Spireae japonica L. f. var. ovalifolia diterpenoid alkaloids

Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization

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Petroleum Science 2024年第1期21卷 674-682页

作者： Jing He Kun zhu wei Jiang Dong-Ao zhu Lin-Hua zhu Hai-Yan Huang Wen-Shuai zhu Hua-ming Li Institute for Energy Research Jiangsu UniversityZhenjiang212013JiangsuChina College of Chemistry and Chemical Engineering Hainan Normal UniversityKey Laboratory of Water Pollution Treatment and Resource Reuse of Hainan ProvinceHaikou571158HainanChina

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel *** this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall *** with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an *** sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of ***,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in *** work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

关键词： Metal-organic frameworks Doped Bimetallic N-hydroxyphthalimide Aerobic processes Oxidative desulfurization